Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

(2018) Megan M. Senchuk et al.   PLoS Genetics

α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease

(2018) Jason F. Cooper et al.   EXPERIMENTAL NEUROLOGY

Resistance to stress can be experimentally dissociated from longevity

(2018) Dylan J Dues et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans

(2017) Dylan J. Dues et al.   FREE RADICAL BIOLOGY AND MEDICINE

Survival assays using Caenorhabditis elegans

(2017) Hae-Eun H. Park et al.   MOLECULES AND CELLS

Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability

(2017) Anthony L. Luz et al.   TOXICOLOGY

Mitochondrial dynamics and cancer

(2017) Paola Maycotte et al.   TUMOR BIOLOGY

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

(2016) Dylan J. Dues et al.   Aging-US

Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes

(2016) Emily Machiela et al.   NEUROBIOLOGY OF DISEASE

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

(2016) Ara B. Hwang et al.   Aging-US

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

(2016) Saroj G. Regmi et al.   Aging-US

The BCL-2–like protein CED-9 ofC. eleganspromotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion

(2016) Stéphane G. Rolland et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury

(2015) Daniel M. Kaufman et al.   CURRENT BIOLOGY

Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes

(2015) Anthony L. Luz et al.   PLoS One

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Methodological considerations for heat shock of the nematode Caenorhabditis elegans

(2014) Shannin C. Zevian et al.   METHODS

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Hyperfusion during Oxidative Stress Is Coupled to a Dysregulation in Calcium Handling within a C2C12 Cell Model

(2013) Calum J. Redpath et al.   PLoS One

Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

(2013) S. G. Rolland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-Patterned Dynamics of Mitochondrial Fission and Fusion in a Living Cell

(2012) Shiqi Wang et al.   PLoS One

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage

(2010) J. M. Van Raamsdonk et al.   GENETICS

Mitochondrial Fragmentation Leads to Intracellular Acidification in Caenorhabditis elegans and Mammalian Cells

(2010) David Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans

(2009) David G. Breckenridge et al.   CURRENT BIOLOGY

Adaptive Sugar Provisioning Controls Survival of C. elegans Embryos in Adverse Environments

(2009) Harold N. Frazier et al.   CURRENT BIOLOGY

Mitochondrial dynamics and neurodegeneration

(2009) Bingwei Lu   Current Neurology and Neuroscience Reports

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

CED-9 and mitochondrial homeostasis in C. elegans muscle

(2008) F. J. Tan et al.   JOURNAL OF CELL SCIENCE

The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

(2008) Takayuki Kanazawa et al.   PLoS Genetics