Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

(2020) Jinghua Wang et al.   Frontiers in Immunology

Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018)

(2019) William T. McElroy   EXPERT OPINION ON THERAPEUTIC PATENTS

Phase 1 Study of CA-4948, a Novel Inhibitor of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in Patients with R/R Non-Hodgkin Lymphoma (NHL)

(2019) Anas Younes et al.   Clinical Lymphoma Myeloma & Leukemia

Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling

(2018) Saurav De et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis

(2018) Roberto Giacomelli et al.   AUTOIMMUNITY REVIEWS

Remission rate and predictors of remission in patients with rheumatoid arthritis under treat-to-target strategy in real-world studies: a systematic review and meta-analysis

(2018) Chen Yu et al.   CLINICAL RHEUMATOLOGY

Critical role of IL-1α in IL-1β–induced inflammatory responses: cooperation with NF-κBp65 in transcriptional regulation

(2018) Anil K. Singh et al.   FASEB JOURNAL

Altered Expression of MicroRNAs in Rheumatoid Arthritis

(2017) Fataneh Tavasolian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

(2017) Katherine L. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective Effects of Methotrexate against Proatherosclerotic Cytokines: A Review of the Evidence

(2017) Arduino A. Mangoni et al.   MEDIATORS OF INFLAMMATION

Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts

(2017) Erika Della Mina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selected cytokine pathways in rheumatoid arthritis

(2017) Mélissa Noack et al.   Seminars in Immunopathology

IRAK4 Deficiency in a Patient with Recurrent Pneumococcal Infections: Case Report and Review of the Literature

(2017) Karina Gobin et al.   Frontiers in Pediatrics

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis

(2016) J Sode et al.   PHARMACOGENOMICS JOURNAL

A structured literature review of the burden of illness and unmet needs in patients with rheumatoid arthritis: a current perspective

(2016) Peter C. Taylor et al.   RHEUMATOLOGY INTERNATIONAL

A novel NF-κB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis

(2016) Nan Mu et al.   Scientific Reports

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2015) Jasvinder A. Singh et al.   Arthritis & Rheumatology

Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders

(2014) Divya Chaudhary et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes

(2012) Nathan D Chamberlain et al.   ANNALS OF THE RHEUMATIC DISEASES

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

(2012) Kaleb M Pauley et al.   ARTHRITIS RESEARCH & THERAPY

American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials

(2011) D. T. Felson et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus

(2011) M. Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

Evidence for treating rheumatoid arthritis to target: results of a systematic literature search

(2010) M. Schoels et al.   ANNALS OF THE RHEUMATIC DISEASES

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

IRAK-4 Inhibitors for Inflammation

(2009) Zhulun Wang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

IRAK4 in TLR/IL-1R signaling: Possible clinical applications

(2008) Xiaoxia Li   EUROPEAN JOURNAL OF IMMUNOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY