Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

Ras-ERK1/2 signaling accelerates the progression of colorectal cancer via mediation of H2BK5ac

(2019) Huanxiang Jia et al.   LIFE SCIENCES

Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation

(2018) Chinky Shiu Chen Liu et al.   JOURNAL OF IMMUNOLOGY

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability

(2017) Jung-Ah Kang et al.   MOLECULES AND CELLS

TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection

(2017) Saumya Maru et al.   PLoS Pathogens

Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction

(2016) Jinseol Rhee et al.   ANNALS OF THE RHEUMATIC DISEASES

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

Abatacept alleviates severe autoimmune symptoms in a patient carrying a de novo variant in CTLA-4

(2016) Sangmoon Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Epigenetic regulation ofKcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+T-cell activation

(2016) Jung-Ah Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development

(2016) Maryam Ghaedi et al.   Cell Reports

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

TCR Signaling in T Cell Memory

(2015) Mark A. Daniels et al.   Frontiers in Immunology

Deltex1 Promotes Protein Kinase Cθ Degradation and Sustains Casitas B-Lineage Lymphoma Expression

(2014) Tzu-Sheng Hsu et al.   JOURNAL OF IMMUNOLOGY

The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation

(2014) Weishan Huang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice

(2014) S Bertin et al.   Mucosal Immunology

NF-κB Activation in T Helper 17 Cell Differentiation

(2014) Sang-Heon Park et al.   Immune Network

The calcium feedback loop and T cell activation: How cytoskeleton networks control intracellular calcium flux

(2013) Noah Joseph et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

STIM1 and STIM2-mediated Ca2+influx regulates antitumour immunity by CD8+T cells

(2013) Carl Weidinger et al.   EMBO Molecular Medicine

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+T cell memory but not to effector differentiation

(2013) Salvador Iborra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transition from Heterotypic to Homotypic PDK1 Homodimerization Is Essential for TCR-Mediated NF- B Activation

(2013) J.-A. Kang et al.   JOURNAL OF IMMUNOLOGY

β-Selection-Induced Proliferation Is Required for αβ T Cell Differentiation

(2012) Taras Kreslavsky et al.   IMMUNITY

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

Differential Regulation of Primary and Memory CD8 T Cell Immune Responses by Diacylglycerol Kinases

(2012) J. Shin et al.   JOURNAL OF IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

Low-strength T-cell activation promotes Th17 responses

(2010) H. A. Purvis et al.   BLOOD

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

(2010) Marzenna Blonska et al.   CELL RESEARCH

K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling

(2010) Haining Huang et al.   IMMUNITY

T Regulatory Cells Maintain Intestinal Homeostasis by Suppressing γδ T Cells

(2010) Sung-Gyoo Park et al.   IMMUNITY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decision checkpoints in the thymus

(2010) Andrea C Carpenter et al.   NATURE IMMUNOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Integrins in immunity

(2009) R. Evans et al.   JOURNAL OF CELL SCIENCE

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells

(2009) Tolunay B. Aydemir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The calcium/NFAT pathway: role in development and function of regulatory T cells

(2009) Masatsugu Oh-hora et al.   MICROBES AND INFECTION

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Spatiotemporal Patterning During T Cell Activation Is Highly Diverse

(2009) K. L. Singleton et al.   Science Signaling

Calcium signaling in lymphocytes

(2008) Masatsugu Oh-hora et al.   CURRENT OPINION IN IMMUNOLOGY

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Diacylglycerol kinases in immune cell function and self-tolerance

(2008) Xiao-Ping Zhong et al.   IMMUNOLOGICAL REVIEWS

Negative regulation of lymphocyte development and function by the Cbl family of proteins

(2008) Fang Huang et al.   IMMUNOLOGICAL REVIEWS

Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases

(2008) Christopher J. Caunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

(2008) Lie Wang et al.   NATURE IMMUNOLOGY

Synergistic control of T cell development and tumor suppression by diacylglycerol kinase   and  

(2008) R. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol kinases: at the hub of cell signalling

(2007) Isabel Mérida et al.   BIOCHEMICAL JOURNAL