Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment

(2014) Sara Pedron et al.   ADVANCED MATERIALS

Enhanced live cell imaging via photonic crystal enhanced fluorescence microscopy

(2014) Weili Chen et al.   ANALYST

Instruction of hematopoietic lineage choice by cytokine signaling

(2014) Max Endele et al.   EXPERIMENTAL CELL RESEARCH

Kit Regulates Maintenance of Quiescent Hematopoietic Stem Cells

(2014) L. A. Thoren et al.   JOURNAL OF IMMUNOLOGY

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment

(2014) Sofieke Klamer et al.   Cell Adhesion & Migration

Structural and Biochemical Modification of a Collagen Scaffold to Selectively Enhance MSC Tenogenic, Chondrogenic, and Osteogenic Differentiation

(2014) Steven R. Caliari et al.   Advanced Healthcare Materials

Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells

(2013) Maude L. Cuchiara et al.   Acta Biomaterialia

Photonic crystal enhanced microscopy for imaging of live cell adhesion

(2013) Weili Chen et al.   ANALYST

Hypoxia and Metabolic Properties of Hematopoietic Stem Cells

(2013) Cheng Cheng Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells

(2013) Annamarija Raic et al.   BIOMATERIALS

This Niche Is a Maze; An Amazing Niche

(2013) Maher Hanoun et al.   Cell Stem Cell

Biomechanical force in blood development: Extrinsic physical cues drive pro-hematopoietic signaling

(2013) Hyun Jung Lee et al.   DIFFERENTIATION

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Regulation of Hematopoietic Stem Cell Behavior by the Nanostructured Presentation of Extracellular Matrix Components

(2013) Christine Anna Muth et al.   PLoS One

Cell-Laden Hydrogels in Integrated Microfluidic Devices for Long-Term Cell Culture and Tubulogenesis Assays

(2013) Nathan P. Gabrielson et al.   Small

Concise Review: Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells

(2013) Julianne N. P. Smith et al.   STEM CELLS

Regulation of hematopoietic stem cells by bone marrow stromal cells

(2013) Bryan A. Anthony et al.   TRENDS IN IMMUNOLOGY

Microfluidic Generation of Gradient Hydrogels to Modulate Hematopoietic Stem Cell Culture Environment

(2013) Bhushan P. Mahadik et al.   Advanced Healthcare Materials

Identifying Differentiation Stage of Individual Primary Hematopoietic Cells from Mouse Bone Marrow by Multivariate Analysis of TOF-Secondary Ion Mass Spectrometry Data

(2012) Jessica F. Frisz et al.   ANALYTICAL CHEMISTRY

The significance of integrin ligand nanopatterning on lipid raft clustering in hematopoietic stem cells

(2012) Eva Altrock et al.   BIOMATERIALS

The combined influence of substrate elasticity and ligand density on the viability and biophysical properties of hematopoietic stem and progenitor cells

(2012) Ji S. Choi et al.   BIOMATERIALS

Cord blood-hematopoietic stem cell expansion in 3D fibrin scaffolds with stromal support

(2012) Mónica S. Ventura Ferreira et al.   BIOMATERIALS

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells

(2012) C. Nishida et al.   BLOOD

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells

(2012) L. M. Calvi et al.   BLOOD

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling

(2012) Elizabeth Csaszar et al.   Cell Stem Cell

Hematopoietic Stem Cell Heterogeneity Takes Center Stage

(2012) Michael R. Copley et al.   Cell Stem Cell

Advances in tracking hematopoiesis at the single-cell level

(2012) Konstantinos D. Kokkaliaris et al.   CURRENT OPINION IN HEMATOLOGY

The hematopoietic stem cell niche-home for friend and foe?

(2012) Daniela S. Krause et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

The expanding frontier of hematopoietic cell transplantation

(2012) Thomas R. Spitzer et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Hypoxia improves expansion potential of human cord blood-derived hematopoietic stem cells and marrow repopulation efficiency

(2012) Sushmita Roy et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility

(2012) C. Lee-Thedieck et al.   JOURNAL OF CELL SCIENCE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Focal Adhesion Kinase Regulates the Localization and Retention of Pro-B Cells in Bone Marrow Microenvironments

(2012) S.-Y. Park et al.   JOURNAL OF IMMUNOLOGY

Automated analysis of single stem cells in microfluidic traps

(2012) Stefan A. Kobel et al.   LAB ON A CHIP

Hematopoietic stem cell mobilization: updated conceptual renditions

(2012) H Bonig et al.   LEUKEMIA

Artificial Niches: Biomimetic Materials for Hematopoietic Stem Cell Culture

(2012) Cornelia Lee-Thedieck et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Natural Killer Cell Differentiation from Hematopoietic Stem Cells: A Comparative Analysis of Heparin- and Stromal Cell–Supported Methods

(2011) Steven A. Dezell et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The effect of anisotropic collagen-GAG scaffolds and growth factor supplementation on tendon cell recruitment, alignment, and metabolic activity

(2011) Steven R. Caliari et al.   BIOMATERIALS

3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche

(2011) Isabelle Leisten et al.   BIOMATERIALS

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells

(2011) M. B. Sharma et al.   HAEMATOLOGICA

The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in

(2011) Armin Ehninger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular Matrix Functionalized Microcavities to Control Hematopoietic Stem and Progenitor Cell Fate

(2011) Ina Kurth et al.   MACROMOLECULAR BIOSCIENCE

Long-term single-cell imaging of mammalian stem cells

(2011) Timm Schroeder   NATURE METHODS

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

(2011) Véronique Lecault et al.   NATURE METHODS

Dynamic niches in the origination and differentiation of haematopoietic stem cells

(2011) Leo D. Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concise Review: Cord Blood Banking, Transplantation and Induced Pluripotent Stem Cell: Success and Opportunities

(2011) Mahendra Rao et al.   STEM CELLS

Micromarrows—Three-Dimensional Coculture of Hematopoietic Stem Cells and Mesenchymal Stromal Cells

(2011) Matthew M. Cook et al.   TISSUE ENGINEERING PART C-METHODS

Hematopoietic stem and progenitor cell trafficking

(2011) Irina B. Mazo et al.   TRENDS IN IMMUNOLOGY

The effect of incorporation of SDF-1α into PLGA scaffolds on stem cell recruitment and the inflammatory response

(2010) Paul T. Thevenot et al.   BIOMATERIALS

Toward modeling the bone marrow niche using scaffold-based 3D culture systems

(2010) Nunzia Di Maggio et al.   BIOMATERIALS

Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood

(2010) C. G. Brunstein et al.   BLOOD

Leukemia and hematopoietic stem cells: Balancing proliferation and quiescence

(2010) Craig D. Jude et al.   CELL CYCLE

Hematopoietic Stem Cell Heterogeneity: Subtypes, Not Unpredictable Behavior

(2010) Timm Schroeder   Cell Stem Cell

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Maintenance and expansion of hematopoietic stem/progenitor cells in biomimetic osteoblast niche

(2010) Jing Tan et al.   CYTOTECHNOLOGY

Hematopoietic stem cells in co-culture with mesenchymal stromal cells - modeling the niche compartments in vitro

(2010) D. Jing et al.   HAEMATOLOGICA

Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function

(2010) Brahmananda R. Chitteti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Three-dimensional culture of mouse bone marrow cells within a porous polymer scaffold: effects of oxygen concentration and stromal layer on expansion of haematopoietic progenitor cells

(2010) Hirotoshi Miyoshi et al.   Journal of Tissue Engineering and Regenerative Medicine

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Surface-bound stem cell factor and the promotion of hematopoietic cell expansion

(2009) Michael R. Doran et al.   BIOMATERIALS

The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering

(2009) Ciara M. Murphy et al.   BIOMATERIALS

Surface plasmon resonance imaging of cells and surface-associated fibronectin

(2009) Alexander W Peterson et al.   BMC CELL BIOLOGY

Hematopoietic stem and progenitor cells in adhesive microcavities

(2009) Ina Kurth et al.   Integrative Biology

Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells

(2009) Thomas Walenda et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cell–cell interaction networks regulate blood stem and progenitor cell fate

(2009) Daniel C Kirouac et al.   Molecular Systems Biology

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Engineering anatomically shaped human bone grafts

(2009) Warren L. Grayson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Cytokines Can Instruct Lineage Choice

(2009) M. A. Rieger et al.   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

The Mechanical Environment of Bone Marrow: A Review

(2008) Umut Atakan Gurkan et al.   ANNALS OF BIOMEDICAL ENGINEERING

The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system

(2008) Shelly R. Peyton et al.   BIOMATERIALS

In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry

(2008) Joan E. Nichols et al.   BIOMATERIALS

The effect of photopolymerization on stem cells embedded in hydrogels

(2008) Natalja E. Fedorovich et al.   BIOMATERIALS

Microarchitecture of Three-Dimensional Scaffolds Influences Cell Migration Behavior via Junction Interactions

(2008) Brendan A.C. Harley et al.   BIOPHYSICAL JOURNAL

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases

(2008) I. L. Weissman et al.   BLOOD

Exploring Hematopoiesis at Single Cell Resolution

(2008) Michael A. Rieger et al.   CELLS TISSUES ORGANS

Mouse hematopoietic stem cell identification and analysis

(2008) Grant A. Challen et al.   CYTOMETRY PART A

Perturbation of single hematopoietic stem cell fates in artificial niches

(2008) Matthias P. Lutolf et al.   Integrative Biology

The hematopoietic stem cell niche: what are we trying to replicate?

(2008) Michael Hines et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Imaging of the cell surface interface using objective coupled widefield surface plasmon microscopy

(2008) M. Mahadi Abdul Jamil et al.   JOURNAL OF STRUCTURAL BIOLOGY

Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model

(2008) C. Jungreuthmayer et al.   MEDICAL ENGINEERING & PHYSICS

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Mechanical Stimulation of Osteoblasts Using Steady and Dynamic Fluid Flow

(2008) Michael J. Jaasma et al.   TISSUE ENGINEERING PART A

In Vivo Recruitment of Hematopoietic Cells Using Stromal Cell–Derived Factor 1 Alpha–Loaded Heparinized Three-Dimensional Collagen Scaffolds

(2008) Bellinda A. Bladergroen et al.   TISSUE ENGINEERING PART A