Article
Biochemistry & Molecular Biology
Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajaram
Summary: The present study investigates the effect and molecular mechanism of N-(2-hydroxyphenyl)-2-phenazinamine (NHP) from Nocardiopsis exhalans on human lung cancer cells. NHP exhibits excellent cytotoxic activity against A549 and H520 lung cancer cells at a concentration of 75 μg/mL, damaging the mitochondrial membrane and nucleus through oxidative stress. NHP causes nuclear condensation, induces apoptosis, down-regulates oncogenic genes, and upregulates apoptosis marker genes in lung cancer cells. NHP may have potential as an anticancer drug for lung cancer treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Sayanta Dutta, Sushweta Mahalanobish, Sukanya Saha, Mullicka Mandal, Sanchari Begam, Pritam Sadhukhan, Sumit Ghosh, Goutam Brahmachari, Parames C. Sil
Summary: Selective initiation of programmed cell death in cancer cells was achieved by a synthetic bis-coumarin derivative 3 l, which demonstrated promising cytotoxic ability and apoptosis induction specifically in human renal carcinoma cells (SKRC-45). This compound modulated apoptotic pathways and inhibited NF-kappa B nuclear localization, resulting in reduced proliferation, survival, and migration ability of SKRC-45 cells. In an in vivo tumor model, 3 l exhibited an anticancer effect without affecting kidney function.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Umesh Prasad Yadav, Arshad J. Ansari, Sahil Arora, Gaurav Joshi, Tashvinder Singh, Harsimrat Kaur, Nilambra Dogra, Raj Kumar, Santosh Kumar, Devesh M. Sawant, Sandeep Singh
Summary: A series of imido-heterocycle compounds were synthesized and evaluated for their anticancer potential. Compound 4h showed the best anticancer activity, inhibiting cell cycle and inducing apoptosis in multiple cancer cell lines. The inhibitory effect on MDA-MB-231 mammosphere formation was also observed.
BIOORGANIC CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Sara A. Al-Shun, Fardous F. El-Senduny, Mohamed A. Ismail, Wael M. El-Sayed, Farid A. Badria, Magdy M. Youssef
Summary: The study investigated different monocationic arylthiophene derivatives as potential chemotherapeutic agents against HCC. Compound 2j showed the highest cytotoxicity among the tested compounds, with a selectivity index indicating safety to normal cells. It was found to inhibit HepG2 cell migration and division, induce apoptosis, and sensitize standard anticancer drugs.
Article
Biochemistry & Molecular Biology
Hend A. A. Abd El-wahab, Hany S. Mansour, Ahmed M. Ali, Raafat El-Awady, Tarek Aboul-Fadl
Summary: This study describes the design of a series of 3-arylidene-2-oxindole derivatives through docking studies, and examines their cytotoxicity and effects on key proteins. These molecules show variable anticancer effects and may have multiple cellular targets.
BIOORGANIC CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Hanaa Y. Ahmed, Eman M. El Gazzar, Nesreen Safwat, Monda M. M. Badawy
Summary: This study found that Aspergillus nidulans can produce Rhodopin pigment, and the anti-cancer activity of this pigment is enhanced by 10 Gy of ionizing radiation, while exhibiting low cytotoxic activity against normal cells.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Davinder Singh, Tenzen Yodun, Gulshan Kumar, Javeed Ahmad Tali, Harshita Tiwari, Jasvinder Singh, Amit Nargotra, Abhilash Samykutty, Shashank Singh, Ravi Shankar
Summary: A library of 49 analogs of imidazo[1,2-a]pyridine with various substitutions have been synthesized and evaluated for their anticancer activity. Compound 5b exhibited the best potential against multiple cancer cell lines, inducing apoptosis and inhibiting the AKT pathway.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
David Tsuyoshi Hiramatsu Castro, Daniel Ferreira Leite, Debora da Silva Baldivia, Helder Freitas dos Santos, Sikiru Olaitan Balogun, Denise Brentan da Silva, Carlos Alexandre Carollo, Kely de Picoli Souza, Edson Lucas dos Santos
Summary: In this study, a novel compound was isolated, identified, and its chemical structure was determined from the roots of Senna velutina. The compound showed anticancer activity against melanoma and leukemic cell lines through apoptosis and other cell death pathways. These findings suggest that this compound has potential applications in cancer therapy.
Article
Biochemistry & Molecular Biology
Esraa Tariq Nagy, Abdullah A. S. Ahmed, Elshaymaa I. Elmongy, Saad M. EL-Gendy, Ibrahim Elmadbouh, Ibrahim El Tantawy El Sayed, Mabrouk Attia Abd Eldaim, Ahmed A. El-Gokha
Summary: The cytotoxic activity of 11(4-Aminophenylamino)neocryptolepine (APAN) on HepG2 and HCT-116 carcinoma cell lines was evaluated, and the molecular mechanism through which it exerts its cytotoxic activity was investigated. APAN had highest affinity for protein tyrosine kinase 6 enzyme, and molecular docking studies confirmed its binding affinity scores for relevant proteins. APAN induced cytotoxicity in HepG2 and HCT-116 cells, increased expression of apoptotic proteins, and reduced expression of proliferative proteins.
Article
Biochemistry & Molecular Biology
Katarzyna Zurawska, Marcin Stokowy, Patryk Kapica, Monika Olesiejuk, Agnieszka Kudelko, Katarzyna Papaj, Magdalena Skonieczna, Wieslaw Szeja, Krzysztof Walczak, Anna Kasprzycka
Summary: The study successfully achieved the addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals, producing corresponding thiadiazole derivatives of N-glycosides. These derivatives showed a pro-apoptotic effect on HCT-116 and HeLa cells, while MCF-7 cells exhibited resistance to the tested compounds.
Article
Pharmacology & Pharmacy
Sahar M. AlMotwaa, Waad A. Al-Otaibi
Summary: The synthesized nanoemulsion containing Pulicaria crispa essential oil and gemcitabine showed a synergistic effect in inhibiting cancer cell growth and inducing apoptosis. This formulation may reduce the dose of gemcitabine and eliminate its associated side effects.
Article
Chemistry, Inorganic & Nuclear
Chinmoy Biswas, Arnab Chatterjee, Vinu Vijayan, Chandra Shekhar Purohit, Manikantan Syamala Kiran, Rajarshi Ghosh
Summary: This article reports the synthesis and structural characterization of a dinuclear silver(I) complex 1, which exhibits selective anticancer activity against liver cancer cells. The anticancer activity of 1 is achieved through induction of mitochondrial death via Reactive Oxygen Species (ROS).
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Jun-Hyuk Han, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee
Summary: Initially classified as an apoptotic caspase, caspase-8 has now been found to play significant roles in regulating inflammatory processes. Recent research has shown its involvement in modulating inflammatory responses, inflammasome activation, cell death, and cytokine induction. This review summarizes the latest advances in understanding how caspase-8 impacts inflammatory reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Mohammed Muqtader Ahmed, Md. Khalid Anwer, Farhat Fatima, Mohammed F. Aldawsari, Ahmed Alalaiwe, Amer S. Alali, Abdulrahman I. Alharthi, Mohd Abul Kalam
Summary: In this study, lipid-polymer hybrid nanoparticles (LPHNPs) were fabricated using lipoid-90H and chitosan, and loaded with the anticancer drug sunitinib malate (SM). The optimized formulation, SLPN4, showed suitable size, stability, and drug release rate. It exhibited potent cytotoxicity against MCF-7 breast cancer cells and could be a promising therapy option for breast cancer.
Article
Chemistry, Analytical
Xueqing Tao, Wei Zou, Yan Qin, Chunyi Tong, Bin Liu
Summary: By designing a peptide probe and reduced graphene oxide, a new biosensing system was constructed for accurate detection and intracellular imaging of caspase-8 activity. The proposed method exhibited a linear response range and low detection limit in vitro, and successfully monitored the upregulation of intracellular caspase-8 activity.
Article
Physics, Applied
Muntadher I. I. Rahmah, Hasan Sh. Majdi, Waleed Khaild Al-Azzawi, Moayad Jabbar Rasn, Hadi Hassan Jasim, Majid S. S. Jabir, Roonak Abdul Salam A. Alkareem, Taha M. M. Rashid
Summary: A zinc oxide-silver doped with graphite and nitrogen (ZnO/Ag doped with C/N) heterostructure was prepared and used for the photodegradation of methylene blue (MB) dye under sunlight irradiation. The characterization results showed the presence of ZnO, Ag, and C nanoparticles, and confirmed the high-absorption ability in the visible area. The photocatalysis results demonstrated the efficient degradation of MB dye by the prepared ZnO/Ag doped with C/N heterostructure under sunlight irradiation.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2023)
Article
Biochemistry & Molecular Biology
Amal A. Alyamani, Mastafa H. Al-Musawi, Salim Albukhaty, Ghassan M. Sulaiman, Kadhim M. Ibrahim, Elsadig M. Ahmed, Majid S. Jabir, Hassan Al-Karagoly, Abed Alsalam Aljahmany, Mustafa K. A. Mohammed
Summary: The aim of this study was to create an antibacterial agent for wound dressing by using nanofibers loaded with Cordia myxa fruit extract (CMFE) in a polycaprolactone/chitosan (PCL/CH) matrix. Various characteristics including morphology, physicochemical properties, surface wettability, antibacterial activity, cell viability, and drug release were examined. The addition of CMFE in PCL/CH increased swelling capability and weight loss. The nanofiber mat showed uniform topology and exhibited excellent antimicrobial activity against various bacteria. The inclusion of CMFE also resulted in lower water contact angle, high porosity, and swelling. The drug release from the nanofiber mat followed non-Fickian diffusion. The nanofiber membrane demonstrated cytocompatibility and can be utilized as an effective wound dressing material.
Article
Physics, Multidisciplinary
Mayyadah H. Mohsin, Khawla S. Khashan, Ghassan M. Sulaiman
Summary: In this paper, hexagonal BN, Gd2O3 nanoparticles, and BN@Gd2O3 hybrid nanocomposites were synthesized by novel laser ablation in liquid. Various analytical techniques were used to investigate their structural and optical properties. The results showed the formation of h-BN NPs, sheet-like and spherical nanoparticles, hexagonal-type nanoflake of Gd2O3, and needle-like shapes. The optical energy gap of h-BN, Gd2O3, and h-BN@Gd2O3 was found to be in the range of (4.5-5.5) eV.
Article
Chemistry, Physical
Ali J. J. Hadi, Uday M. M. Nayef, Majid S. S. Jabir, Falah A-H. Mutlak
Summary: Nanoparticles of Titanium dioxide were fabricated using laser irradiation technique and their physical properties were characterized. The prepared nanoparticles exhibited spherical appearance with average diameters ranging from 19nm to 26nm. The nanoparticles showed significant antibacterial efficacy against Staphylococcus aureus and anticancer activity against prostate cancer cell line PC-3. These findings suggest that the prepared nanoparticles could be a potential candidate for biomedical applications.
SURFACE REVIEW AND LETTERS
(2023)
Article
Materials Science, Biomaterials
Sumaiya Naeema Hawar, Zainab K. Taha, Atyaf Saied Hamied, Hanady S. Al-Shmgani, Ghassan M. Sulaiman, Sobhy E. Elsilk
Summary: This study evaluated the antifungal activities of secondary metabolites from Paecilomyces sp. against the pathogenic fungus Rhizoctonia solani. The results showed that the secondary metabolites of Paecilomyces possessed inhibitory effects on the radial growth of Rhizoctonia solani. The ethyl acetate extract of Paecilomyces sp. contained several important chemical components.
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2023)
Review
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali K. Albuhadily, Ali I. Al-Gareeb, Mayyadah F. Rafeeq
Summary: It has been shown that metabolic syndrome is associated with the neuropathology of Alzheimer's disease. The components of metabolic syndrome, including central obesity, hypertension, insulin resistance, and dyslipidemia, have negative effects on the pathogenesis of Alzheimer's disease through different mechanisms such as activation of the renin-angiotensin system, inflammatory signaling pathways, neuroinflammation, brain insulin resistance, mitochondrial dysfunction, and oxidative stress. Targeting these molecular pathways in metabolic syndrome could be a potential therapeutic strategy for managing Alzheimer's disease in high risk individuals, although the underlying mechanisms are not fully understood.
AGEING RESEARCH REVIEWS
(2023)
Article
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Ali K. Albuhadily
Summary: Prolactin appears to have a neuroprotective effect against Parkinson's disease neuropathology by inhibiting inflammation and protecting against neuroinflammation. Further research is needed to fully understand the potential role and mechanisms.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha, Daniel J. Klionsky
Summary: This study explores the protective and harmful effects of autophagy in the pathogenesis of multiple sclerosis (MS). Autophagy can prevent the progression of MS by reducing oxidative stress and inflammatory disorders, but over-activated autophagy can worsen the neuropathology of MS. Additionally, autophagy can modulate cell proliferation and affect demyelination and remyelination. Overall, autophagy plays a significant role in the pathogenesis of MS.
Article
Chemistry, Medicinal
Omar Messaoudi, Ibrahim Benamar, Ahmed Azizi, Salim Albukhaty, Yasmina Khane, Ghassan M. Sulaiman, Mounir M. Salem-Bekhit, Kaouthar Hamdi, Sirine Ghoummid, Abdelhalim Zoukel, Ilhem Messahli, Yacine Kerchich, Farouk Benaceur, Mohamed M. Salem, Mourad Bendahou
Summary: In this study, hybrid nanoparticles synthesized through the green method showed significant antimicrobial activity and the ability to remove biofilm.
Article
Biotechnology & Applied Microbiology
Ameer A. Imarah, Majid S. Jabir, Ali H. Abood, Ghassan M. Sulaiman, Salim Albukhaty, Hamdoon A. Mohammed, Riaz A. Khan, Hayder M. Al-Kuraishy, Ali Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. Najm, Sabrean F. Jawad
Summary: In this study, the cytotoxic effects of graphene oxide nanoparticles (GONPs) were evaluated using MTT assays, observation of apoptotic markers, and oxidative stress. Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations confirmed the toxicity of GONPs, while the levels of glutathione showed a reduction compared to the control. The alterations in cytochrome CYP2E1, glutathione, malondialdehyde, and caspase-3 suggest an interlinked relationship.
Article
Chemistry, Physical
Aswan Al-Abboodi, Salim Albukhaty, Ghassan M. Sulaiman, Mohammed A. A. J. Al-Saady, Majid S. Jabir, Mosleh M. Abomughaid
Summary: A novel class of nanomaterials, called subunit nano vaccines, has shown great potential in delivering antigens in a safe and effective manner. Functionalized superparamagnetic iron oxide nanoparticle (SPION) surfaces with conjugated malaria protein (vaccine) and carboxyl groups possess high protein binding capacity. The study demonstrates that functionalized SPIONs conjugated to the PyMSP1(19) antigen can be used for controlled antigen release and potentially applied in various types of antigens.
Article
Agriculture, Multidisciplinary
Mahasen Khudier, Hassan A. Hammadi, Hiba T. Atyia, Hassan Al-Karagoly, Salim Albukhaty, Ghassan M. Sulaiman, Yaser H. Dewir, Hameed B. Mahood
Summary: Green synthesized selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract were evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli, and Corynebacterium diphtheriae. The synthesized nanoparticles exhibited spherical shape and uniform size. The results showed that the nanoparticles had a significant inhibitory effect on bacterial growth, making them a desirable option for preventing bacterial infections.
COGENT FOOD & AGRICULTURE
(2023)
Review
Medicine, General & Internal
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Majid S. Jabir, Salim Albukhaty
Summary: This review explores how metformin improves insulin sensitivity through the FGF21-dependent pathway in patients with T2DM. The results show that metformin enhances FGF21 signaling in T2DM, providing a novel mechanism for improving glucose homeostasis and metabolic disorders.
EGYPTIAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Chemistry, Physical
Yasameen K. Al-Majedy, Hiba H. Ibraheem, Ali Abdullah Issa, Majid S. Jabir, Buthenia A. Hasoon, Hanady S. Al-Shmgani, Ghassan M. Sulaiman
Summary: Coumarins and their derivatives, such as coumarinyl chalcone, have significant pharmacological effects, including antioxidant, antibacterial, and anticancer activity. This study synthesized different compounds and evaluated their biomedical properties, finding that compound (C) exhibited the highest antioxidant and antibacterial activity and inhibited the growth of breast cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2024)