Leaving no-one behind: how CENP-E facilitates chromosome alignment

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

(2019) Min Wu et al.   Nature Communications

A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore

(2019) Carmen Taveras et al.   CELL CYCLE

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

(2019) Yuejia Huang et al.   CELL RESEARCH

Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity

(2019) Manas Chakraborty et al.   Nature Communications

Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers

(2018) Nikita Gudimchuk et al.   BIOPHYSICAL JOURNAL

Chromosome Segregation Is Biased by Kinetochore Size

(2018) Danica Drpic et al.   CURRENT BIOLOGY

Disentangling the molecular determinants for Cenp‐F localization to nuclear pores and kinetochores

(2018) Alessandro Berto et al.   EMBO REPORTS

The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases

(2018) Giuseppe Ciossani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubules assemble near most kinetochores during early prometaphase in human cells

(2018) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning

(2018) Toni McHugh et al.   JOURNAL OF CELL BIOLOGY

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore–microtubule attachments

(2018) Luke A. Helgeson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment

(2018) Go Itoh et al.   Scientific Reports

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

(2018) Jonne A. Raaijmakers et al.   Cell Reports

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

(2018) Vladimir A Volkov et al.   eLife

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

(2018) Marion E. Pesenti et al.   MOLECULAR CELL

Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion

(2018) Jose-Antonio Rodriguez-Rodriguez et al.   CURRENT BIOLOGY

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment

(2018) Cláudia Pereira et al.   CURRENT BIOLOGY

Structure of the RZZ complex and molecular basis of its interaction with Spindly

(2017) Shyamal Mosalaganti et al.   JOURNAL OF CELL BIOLOGY

CENP-F couples cargo to growing and shortening microtubule ends

(2017) Gil Kanfer et al.   MOLECULAR BIOLOGY OF THE CELL

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Insights from biochemical reconstitution into the architecture of human kinetochores

(2016) John R. Weir et al.   NATURE

SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores

(2016) Teng Li et al.   Nature Communications

Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway

(2015) Anna A. Ye et al.   CURRENT BIOLOGY

TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment

(2015) Miroslav P. Milev et al.   JOURNAL OF CELL BIOLOGY

Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules

(2015) Vladimir A. Volkov et al.   JOURNAL OF CELL BIOLOGY

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

(2015) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore

(2015) Takashi Akera et al.   NATURE CELL BIOLOGY

Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

(2015) Valentin Magidson et al.   NATURE CELL BIOLOGY

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules

(2015) Kenji Iemura et al.   Nature Communications

Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes

(2015) Danica Drpic et al.   Cell Reports

CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites

(2015) Tiaojiang Xiao et al.   Cell Reports

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

Kinetochore–microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E

(2014) Benjamin Vitre et al.   MOLECULAR BIOLOGY OF THE CELL

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces

(2014) Marin Barisic et al.   NATURE CELL BIOLOGY

Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK

(2013) Roshan L. Shrestha et al.   CURRENT BIOLOGY

The Microtubule Binding Properties of CENP-E's C-Terminus and CENP-F

(2013) Vivek Musinipally et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

(2013) Nikita Gudimchuk et al.   NATURE CELL BIOLOGY

Multiple domains of human CLASP contribute to microtubule dynamics and organization in vitro and in Xenopus egg extracts

(2012) Kieren Patel et al.   Cytoskeleton

The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Microtubule Capture by Mitotic Kinesin Centromere Protein E (CENP-E)

(2012) Harjinder S. Sardar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint

(2012) Yige Guo et al.   JOURNAL OF CELL BIOLOGY

A Nonmotor Microtubule Binding Site in Kinesin-5 Is Required for Filament Crosslinking and Sliding

(2011) Joshua S. Weinger et al.   CURRENT BIOLOGY

A Non-Motor Microtubule Binding Site Is Essential for the High Processivity and Mitotic Function of Kinesin-8 Kif18A

(2011) Monika I. Mayr et al.   PLoS One

Interhead tension determines processivity across diverse N-terminal kinesins

(2011) S. Shastry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

Mitotic Kinesin CENP-E Promotes Microtubule Plus-End Elongation

(2010) Harjinder S. Sardar et al.   CURRENT BIOLOGY

The Plk1-dependent Phosphoproteome of the Early Mitotic Spindle

(2010) Anna Santamaria et al.   MOLECULAR & CELLULAR PROTEOMICS

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

(2010) K. W. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

(2009) Andrew F. Powers et al.   CELL

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microtubule Turnover and Poleward Flux

(2009) Stefano Maffini et al.   CURRENT BIOLOGY

The ATPase Cycle of the Mitotic Motor CENP-E

(2009) Steven S. Rosenfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromosome congression in the absence of kinetochore fibres

(2009) Shang Cai et al.   NATURE CELL BIOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

(2009) Jennetta W Hammond et al.   PLOS BIOLOGY

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether

(2008) Yumi Kim et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation Relieves Autoinhibition of the Kinetochore Motor Cenp-E

(2008) Julien Espeut et al.   MOLECULAR CELL

SUMO-2/3 Modification and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis

(2008) Xiang-Dong Zhang et al.   MOLECULAR CELL

The mitotic kinesin CENP-E is a processive transport motor

(2008) H. Yardimci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA