Macrophage cell death in microbial infections

Neisseria gonorrhoeaesurvives within and modulates apoptosis and inflammatory cytokine production of human macrophages

(2015) Alice Château et al.   CELLULAR MICROBIOLOGY

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

(2015) Jens Kortmann et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin

(2015) Tyler D. Scherr et al.   mBio

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

(2015) Larissa D. Cunha et al.   Nature Communications

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain

(2015) Lisa Kunsmann et al.   Scientific Reports

Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection

(2015) Wenhan Zhu et al.   PLoS Pathogens

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

(2015) Norberto González-Juarbe et al.   PLoS Pathogens

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

(2015) Jason H. Melehani et al.   PLoS Pathogens

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

Pseudomonas Exotoxin A: optimized by evolution for effective killing

(2015) Marta Michalska et al.   Frontiers in Microbiology

Bacterial Exotoxins and the Inflammasome

(2015) Allison J. Greaney et al.   Frontiers in Immunology

Distinct Macrophage Fates after in vitro Infection with Different Species of Leishmania: Induction of Apoptosis by Leishmania (Leishmania) amazonensis, but Not by Leishmania (Viannia) guyanensis

(2015) Jarina Pena DaMata et al.   PLoS One

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cell-to-cell transfer ofLeishmania amazonensisamastigotes is mediated by immunomodulatory LAMP-rich parasitophorous extrusions

(2014) Fernando Real et al.   CELLULAR MICROBIOLOGY

The Macrophage Paradox

(2014) Jordan V. Price et al.   IMMUNITY

Unmethylated CpG motifs in the L. donovani DNA regulate TLR9-dependent delay of programmed cell death in macrophages

(2014) Sushmita Das et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus

(2014) Francis Alonzo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Quantitative Proteomics of theNeisseria GonorrhoeaeCell Envelope and Membrane Vesicles for the Discovery of Potential Therapeutic Targets

(2014) Ryszard A. Zielke et al.   MOLECULAR & CELLULAR PROTEOMICS

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors

(2014) András N. Spaan et al.   Nature Communications

Microbial Egress: A Hitchhiker's Guide to Freedom

(2014) Ana Traven et al.   PLoS Pathogens

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Programmed cell death in Legionella infection

(2013) Mary Speir et al.   Future Microbiology

Leishmania donovaniPrevents Oxidative Burst-mediated Apoptosis of Host Macrophages through Selective Induction of Suppressors of Cytokine Signaling (SOCS) Proteins

(2013) Supriya Srivastav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1  Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo

(2013) K. C. Barry et al.   JOURNAL OF IMMUNOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses

(2013) S. L. Lage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

Enterohemorrhagic Escherichia coli Hemolysin Employs Outer Membrane Vesicles to Target Mitochondria and Cause Endothelial and Epithelial Apoptosis

(2013) Martina Bielaszewska et al.   PLoS Pathogens

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages

(2013) Arwa Abu Khweek et al.   Frontiers in Cellular and Infection Microbiology

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Efferocytosis Is an Innate Antibacterial Mechanism

(2012) Constance J. Martin et al.   Cell Host & Microbe

TheCoxiella burnetiitype IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial level

(2012) Leonie Klingenbeck et al.   CELLULAR MICROBIOLOGY

Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner

(2012) Magali Perret et al.   CELLULAR MICROBIOLOGY

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome

(2012) Dirk Holzinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Cell death in parasitic protozoa: regulated or incidental?

(2012) William R. Proto et al.   NATURE REVIEWS MICROBIOLOGY

The protein SdhA maintains the integrity of the Legionella-containing vacuole

(2012) E. A. Creasey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Offense and defense: microbial membrane vesicles play both ways

(2012) Ian A. MacDonald et al.   RESEARCH IN MICROBIOLOGY

Efficient Capture of Infected Neutrophils by Dendritic Cells in the Skin Inhibits the Early Anti-Leishmania Response

(2012) Flavia L. Ribeiro-Gomes et al.   PLoS Pathogens

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

The influence of early neutrophil-Leishmania interactions on the host immune response to infection

(2012) Flavia L. Ribeiro-Gomes et al.   Frontiers in Cellular and Infection Microbiology

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils

(2011) Deboraci Brito Prates et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting of Neisserial PorB to the mitochondrial outer membrane: an insight on the evolution of β-barrel protein assembly machines

(2011) Jhih-Hang Jiang et al.   MOLECULAR MICROBIOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Acinetobacter baumannii Secretes Cytotoxic Outer Membrane Protein A via Outer Membrane Vesicles

(2011) Jong Sook Jin et al.   PLoS One

The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis

(2011) Marcelo S. F. Pereira et al.   Frontiers in Microbiology

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

(2010) H. J. Newton et al.   CLINICAL MICROBIOLOGY REVIEWS

An update on Legionella

(2010) Jordi Carratalà et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1

(2010) X. Du et al.   MOLECULAR AND CELLULAR BIOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein

(2010) A. Luhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease

(2010) Christel Cazalet et al.   PLoS Genetics

Temporal and spatial trigger of post-exponential virulence-associated regulatory cascades byLegionella pneumophilaafter bacterial escape into the host cell cytosol

(2009) Maëlle Molmeret et al.   ENVIRONMENTAL MICROBIOLOGY

Meningococcal Porin PorB Prevents Cellular Apoptosis in a Toll-Like Receptor 2- and NF- B-Independent Manner

(2009) P. Massari et al.   INFECTION AND IMMUNITY

Phenol‐Soluble Modulin α3 Enhances the Human Neutrophil Lysis Mediated by Panton‐Valentine Leukocidin

(2009) Isamu Hongo et al.   JOURNAL OF INFECTIOUS DISEASES

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection

(2009) Oliver Kepp et al.   PLoS Pathogens

Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

(2009) Vera Kozjak-Pavlovic et al.   PLoS Pathogens

Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: Apoptosis as infection-promoting factor

(2008) Tamás Laskay et al.   IMMUNOBIOLOGY

Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis

(2008) Lilian Afonso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE