Arginine dipeptides affect insulin aggregation in a pH- and ionic strength-dependent manner

The effect of arginine glutamate on the stability of monoclonal antibodies in solution

(2014) Priscilla Kheddo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Specific Decrease in Solution Viscosity of Antibodies by Arginine for Therapeutic Formulations

(2014) Naoto Inoue et al.   MOLECULAR PHARMACEUTICS

Therapeutic protein aggregation: mechanisms, design, and control

(2014) Christopher J. Roberts   TRENDS IN BIOTECHNOLOGY

l-Arginine induces protein aggregation and transformation of supramolecular structures of the aggregates

(2013) Ekaterina Smirnova et al.   AMINO ACIDS

Thermodynamic and Fluorescence Analyses to Determine Mechanisms of IgG1 Stabilization and Destabilization by Arginine

(2013) Masakazu Fukuda et al.   PHARMACEUTICAL RESEARCH

Effects of Ionic Strength and Sugars on the Aggregation Propensity of Monoclonal Antibodies: Influence of Colloidal and Conformational Stabilities

(2013) Shuntaro Saito et al.   PHARMACEUTICAL RESEARCH

Protein-Associated Cation Clusters in Aqueous Arginine Solutions and Their Effects on Protein Stability and Size

(2012) Vincent Vagenende et al.   ACS Chemical Biology

Interactions of formulation excipients with proteins in solution and in the dried state

(2011) Satoshi Ohtake et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

(2011) Tim J. Kamerzell et al.   ADVANCED DRUG DELIVERY REVIEWS

Different effects of l-arginine on the heat-induced unfolding and aggregation of proteins

(2011) Andrejus Cirkovas et al.   BIOLOGICALS

Arginine controls heat-induced cluster-cluster aggregation of lysozyme at around the isoelectric point

(2011) Shunsuke Tomita et al.   BIOPOLYMERS

Acceleration of protein aggregation by amphiphilic peptides: Transformation of supramolecular structure of the aggregates

(2011) N. V. Artemova et al.   BIOTECHNOLOGY PROGRESS

Why do solution additives suppress the heat-induced inactivation of proteins? Inhibition of chemical modifications

(2011) Shunsuke Tomita et al.   BIOTECHNOLOGY PROGRESS

Effects of arginine on heat-induced aggregation of concentrated protein solutions

(2011) Dhawal Shah et al.   BIOTECHNOLOGY PROGRESS

Formation of supramolecular structures of a native-like protein in the presence of amphiphilic peptides: Variations in aggregate morphology

(2011) Natalya Artemova et al.   FEBS LETTERS

Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges

(2011) Christopher J. Roberts et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Arginine increases the solubility of alkyl gallates through interaction with the aromatic ring

(2011) Ryosuke Ariki et al.   JOURNAL OF BIOCHEMISTRY

Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients

(2011) Robert J Falconer et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

High‐Throughput Assessment of Thermal and Colloidal Stability Parameters for Monoclonal Antibody Formulations

(2011) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Understanding the Synergistic Effect of Arginine and Glutamic Acid Mixtures on Protein Solubility

(2011) Diwakar Shukla et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multimerization and Aggregation of Native-State Insulin: Effect of Zinc

(2011) Yisheng Xu et al.   LANGMUIR

pH-dependent self-association of zinc-free insulin characterized by concentration-gradient static light scattering

(2010) Arun K. Attri et al.   BIOPHYSICAL CHEMISTRY

Solubilization of aromatic and hydrophobic moieties by arginine in aqueous solutions

(2010) Jianguo Li et al.   JOURNAL OF CHEMICAL PHYSICS

Formulation Development of Therapeutic Monoclonal Antibodies Using High-Throughput Fluorescence and Static Light Scattering Techniques: Role of Conformational and Colloidal Stability

(2010) Deborah S. Goldberg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine

(2010) L. Ito et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Ternary System of Solution Additives with Arginine and Salt for Refolding of Beta-Galactosidase

(2010) Akiko Fujimoto et al.   PROTEIN JOURNAL

L-Arginine hydrochloride increases the solubility of folded and unfolded recombinant plasminogen activator rPA

(2010) Alexander Tischer et al.   PROTEIN SCIENCE

Effect of Arginine on Protein Aggregation Studied by Fluorescence Correlation Spectroscopy and Other Biophysical Methods†

(2009) Ranendu Ghosh et al.   BIOCHEMISTRY

Tyrosine Autofluorescence as a Measure of Bovine Insulin Fibrillation

(2009) Innocent B. Bekard et al.   BIOPHYSICAL JOURNAL

Indispensable structure of solution additives to prevent inactivation of lysozyme for heating and refolding

(2009) Tsuneyoshi Matsuoka et al.   BIOTECHNOLOGY PROGRESS

Formulation and manufacturability of biologics

(2009) Steven J Shire   CURRENT OPINION IN BIOTECHNOLOGY

A spectroscopic investigation into the interaction between bile salts and insulin in alkaline aqueous solution

(2009) Zhang Yong et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Multi-variate approach to global protein aggregation behavior and kinetics: Effects of pH, NaCl, and temperature for α-chymotrypsinogen A

(2009) Yi Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Suppression of Insulin Aggregation by Heparin

(2008) Katie Giger et al.   BIOMACROMOLECULES

Differences in the Effects of Solution Additives on Heat- and Refolding-Induced Aggregation

(2008) H. Hamada et al.   BIOTECHNOLOGY PROGRESS

Arginine Increases the Solubility of Coumarin: Comparison with Salting-in and Salting-out Additives

(2008) A. Hirano et al.   JOURNAL OF BIOCHEMISTRY

Role of cation–π interactions in single chain ‘all-alpha’ proteins

(2007) Remila L. Martis et al.   JOURNAL OF THEORETICAL BIOLOGY