期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 37, 期 7, 页码 1269-1278出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-016-0459-8
关键词
Perinatal hypoxia-ischemia; Metformin; Cognitive deficit; Oligodendrocyte progenitor cells
资金
- bureau of Xuzhou city science and technology [KC15SH037]
Perinatal hypoxia-ischemia (H/I) causes brain injury and myelination damage. Finding efficient methods to restore myelination is critical for the recovery of brain impairments. By applying an H/I rat model, we demonstrate that metformin (Met) treatment significantly ameliorates the loss of locomotor activity and cognition of H/I rat in the Morris water maze and open field task tests. After administration of Met to H/I rat, the proliferation of Olig2+ oligodendrocyte progenitor cells and the expression of myelin basic protein are obviously increased in the corpus callosum. Additionally, the myelin sheaths are more compact and the impairments are evidently attenuated. These data indicate that Met is beneficial for the amelioration of H/I-induced myelination and behavior deficits.
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