Metabolic and redox signaling in the retina

The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress

(2016) Xin Mei et al.   ANTIOXIDANTS & REDOX SIGNALING

The mitochondrial pyruvate carrier in health and disease: To carry or not to carry?

(2016) Tom Bender et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative measures for redox signaling

(2016) Ché S. Pillay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic acceleration and the evolution of human brain size and life history

(2016) Herman Pontzer et al.   NATURE

The eyes of Tullimonstrum reveal a vertebrate affinity

(2016) Thomas Clements et al.   NATURE

Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa

(2016) Wei Wang et al.   Cell Reports

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

(2016) Elvir Becirovic et al.   PLoS Genetics

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

(2015) Thomas Hildebrandt et al.   BIOLOGICAL CHEMISTRY

Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment

(2015) Gaku Terauchi et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Rods Feed Cones to Keep them Alive

(2015) Jacek Krol et al.   CELL

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

(2015) Najate Aït-Ali et al.   CELL

Photoreceptor Evolution: Ancient ‘Cones’ Turn Out to Be Rods

(2015) Eric J. Warrant   CURRENT BIOLOGY

Single-Photon Sensitivity of Lamprey Rods with Cone-like Outer Segments

(2015) Ala Morshedian et al.   CURRENT BIOLOGY

Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival

(2015) Shan Ma et al.   EXPERIMENTAL EYE RESEARCH

Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage

(2015) G. Elachouri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

(2015) Aditya Venkatesh et al.   JOURNAL OF CLINICAL INVESTIGATION

NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage

(2015) Wenjun Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Sugar for sight

(2015) Connie Cepko et al.   NATURE

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

(2015) Thomas Burgoyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional organization of nascent rod outer segment disk membranes

(2015) Stefanie Volland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

From zero to six double bonds: phospholipid unsaturation and organelle function

(2015) Bruno Antonny et al.   TRENDS IN CELL BIOLOGY

Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

(2015) Dennis S. Rice et al.   Nature Communications

Cancer metabolism of cone photoreceptors

(2015) Thierry Léveillard   Oncotarget

Spontaneous Regeneration of Human Photoreceptor Outer Segments

(2015) Jonathan C. Horton et al.   Scientific Reports

Riboflavin (vitamin B2) and oxidative stress: a review

(2014) Marziyeh Ashoori et al.   BRITISH JOURNAL OF NUTRITION

Membrane Protein Transport in Photoreceptors: The Function of PDE 

(2014) W. Baehr   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The Retinal Pigment Epithelium Utilizes Fatty Acids for Ketogenesis

(2014) Jeffrey Adijanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

(2014) Leah C. Byrne et al.   JOURNAL OF CLINICAL INVESTIGATION

Spare the Rod, Spoil the Degeneration

(2014) Thierry Léveillard   JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS

ROSics: Chemistry and proteomics of cysteine modifications in redox biology

(2014) Hee-Jung Kim et al.   MASS SPECTROMETRY REVIEWS

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina

(2014) K. J. Lindsay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Jurassic ornithischian dinosaur from Siberia with both feathers and scales

(2014) P. Godefroit et al.   SCIENCE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cysteine Oxidative Posttranslational Modifications

(2013) Heaseung S. Chung et al.   CIRCULATION RESEARCH

Sequence Determinants of GLUT1 Oligomerization

(2013) Julie K. De Zutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and Consequences of CysteineS-Glutathionylation

(2013) Christina L. Grek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Signaling in Cones

(2013) Ammaji Rajala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of phototransduction, vertebrate photoreceptors and retina

(2013) Trevor D. Lamb   PROGRESS IN RETINAL AND EYE RESEARCH

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Regulation of Cell Survival and Death by Pyridine Nucleotides

(2012) Shin-ichi Oka et al.   CIRCULATION RESEARCH

An explanation for the Warburg effect in the adult mammalian retina

(2012) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity

(2012) Céline Jaillard et al.   HUMAN MOLECULAR GENETICS

Birds have paedomorphic dinosaur skulls

(2012) Bhart-Anjan S. Bhullar et al.   NATURE

Eye shape and the nocturnal bottleneck of mammals

(2012) M. I. Hall et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

℮-conome: an automated tissue counting platform of cone photoreceptors for rodent models of retinitis pigmentosa

(2011) Emmanuelle Clérin et al.   BMC Ophthalmology

The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress

(2010) T Cronin et al.   CELL DEATH AND DIFFERENTIATION

Phototransduction and the Evolution of Photoreceptors

(2010) Gordon L. Fain et al.   CURRENT BIOLOGY

Proteomic Profiling of a Layered Tissue Reveals Unique Glycolytic Specializations of Photoreceptor Cells

(2010) Boris Reidel et al.   MOLECULAR & CELLULAR PROTEOMICS

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

TXNL6 Is a Novel Oxidative Stress-Induced Reducing System for Methionine Sulfoxide Reductase A Repair of α-Crystallin and Cytochrome C in the Eye Lens

(2010) Lisa A. Brennan et al.   PLoS One

Rod-Derived Cone Viability Factor for Treating Blinding Diseases: From Clinic to Redox Signaling

(2010) T. Leveillard et al.   Science Translational Medicine

What drives cell morphogenesis: A look inside the vertebrate photoreceptor

(2009) Breandán Kennedy et al.   DEVELOPMENTAL DYNAMICS

The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina

(2009) Sacha Reichman et al.   HUMAN MOLECULAR GENETICS

The Expensive Brain: A framework for explaining evolutionary changes in brain size

(2009) Karin Isler et al.   JOURNAL OF HUMAN EVOLUTION

The Thioredoxin-like Protein Rod-derived Cone Viability Factor (RdCVFL) Interacts with TAU and Inhibits Its Phosphorylation in the Retina

(2009) Ram Fridlich et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional Cone Rescue by RdCVF Protein in a Dominant Model of Retinitis Pigmentosa

(2009) Ying Yang et al.   MOLECULAR THERAPY

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-κB activity

(2008) Xiao Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

Color vision in the black howler monkey ( Alouatta caraya)

(2008) ANTÔNIO C. ARAÚJO et al.   VISUAL NEUROSCIENCE

Focus on Molecules: Interphotoreceptor retinoid-binding protein (IRBP)

(2007) Federico Gonzalez-Fernandez et al.   EXPERIMENTAL EYE RESEARCH