A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
出版年份 2016 全文链接
标题
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K
作者
关键词
NES, XPO1, Recurrent mutation, Chronic lymphocytic leukemia, Cellular assay
出版物
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 24, Pages 4685-4699
出版商
Springer Nature
发表日期
2016-06-16
DOI
10.1007/s00018-016-2292-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia
- (2016) N. A. Amin et al. CLINICAL CANCER RESEARCH
- Mechanistic Insights from Structural Analyses of Ran-GTPase-Driven Nuclear Export of Proteins and RNAs
- (2016) Yoshiyuki Matsuura JOURNAL OF MOLECULAR BIOLOGY
- Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling
- (2015) F. Conforti et al. CLINICAL CANCER RESEARCH
- Reprint of “Nuclear transport factors: global regulation of mitosis”
- (2015) Douglass J Forbes et al. CURRENT OPINION IN CELL BIOLOGY
- Low frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
- (2015) N. Winkelmann et al. HAEMATOLOGICA
- Molecular pathogenesis of CLL and its evolution
- (2015) David Rodríguez et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells
- (2015) Charlotte M. Huijts et al. JOURNAL OF IMMUNOLOGY
- Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport
- (2015) Igor Arregi et al. PLoS One
- Low frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
- (2015) N. Winkelmann et al. HAEMATOLOGICA
- Structural Basis of Targeting the Exportin CRM1 in Cancer
- (2015) Achim Dickmanns et al. Cells
- Allosteric control of the exportin CRM1 unraveled by crystal structure analysis
- (2014) Thomas Monecke et al. FEBS Journal
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- Genomic and molecular characterization of esophageal squamous cell carcinoma
- (2014) De-Chen Lin et al. NATURE GENETICS
- Atomic basis of CRM1-cargo recognition, release and inhibition
- (2014) Ho Yee Joyce Fung et al. SEMINARS IN CANCER BIOLOGY
- The evolving role of nuclear transporters in cancer
- (2014) Asfar S. Azmi SEMINARS IN CANCER BIOLOGY
- Prognostic impact and targeting of CRM1 in acute myeloid leukemia
- (2013) K. Kojima et al. BLOOD
- KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
- (2013) Julia Etchin et al. BRITISH JOURNAL OF HAEMATOLOGY
- CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas
- (2013) Fang Zhou et al. MEDICAL ONCOLOGY
- Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
- (2013) Qingxiang Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of a Truncation Mutant of the Nuclear Export Factor CRM1 Provides Insights into the Auto-Inhibitory Role of Its C-Terminal Helix
- (2013) Cyril Dian et al. STRUCTURE
- Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
- (2012) R. Lapalombella et al. BLOOD
- Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
- (2012) P. Ranganathan et al. BLOOD
- Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors
- (2012) Ori Kalid et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Inhibition of CRM1-Mediated Nucleocytoplasmic Transport: Triggering Human Melanoma Cell Apoptosis by Perturbing Multiple Cellular Pathways
- (2012) Gaurav Pathria et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A 2.1-Å-Resolution Crystal Structure of Unliganded CRM1 Reveals the Mechanism of Autoinhibition
- (2012) Natsumi Saito et al. JOURNAL OF MOLECULAR BIOLOGY
- CRM1 Blockade by Selective Inhibitors of Nuclear Export Attenuates Kidney Cancer Growth
- (2012) Hiromi Inoue et al. JOURNAL OF UROLOGY
- Electrostatic Interactions Involving the Extreme C Terminus of Nuclear Export Factor CRM1 Modulate Its Affinity for Cargo
- (2011) Abigail M. Fox et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
- (2011) Xose S. Puente et al. NATURE
- An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1
- (2010) Masako Koyama et al. EMBO JOURNAL
- NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
- (2010) Thomas Güttler et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for leucine-rich nuclear export signal recognition by CRM1
- (2009) Xiuhua Dong et al. NATURE
- Structural basis for assembly and disassembly of the CRM1 nuclear export complex
- (2009) Xiuhua Dong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- EXPRESSION OF CRM1 IN HUMAN GLIOMAS AND ITS SIGNIFICANCE IN P27 EXPRESSION AND CLINICAL PROGNOSIS
- (2009) Aiguo Shen et al. NEUROSURGERY
- Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP
- (2009) T. Monecke et al. SCIENCE
- Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics
- (2009) Verena Fetz et al. SENSORS
- Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer
- (2008) Aurelia Noske et al. CANCER
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started