Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ

Dietary fatty acids fine-tune Piezo1 mechanical response

(2019) Luis O. Romero et al.   Nature Communications

Rapid flow-induced activation of Gαq/11 is independent of Piezo1 activation

(2019) Nathaniel G. dela Paz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation

(2019) Luyu Liu et al.   JOURNAL OF NEUROSCIENCE

Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors

(2019) Wang Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics

(2018) Yevgen Yudin et al.   Molecular Pain

Piezo2 channel–Merkel cell signaling modulates the conversion of touch to itch

(2018) Jing Feng et al.   SCIENCE

TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels

(2018) Evan O. Anderson et al.   Cell Reports

Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

(2018) Pratibha Narayanan et al.   eLife

Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat

(2018) Dionéia Araldi et al.   NEUROSCIENCE

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

(2018) Wei-Zheng Zeng et al.   SCIENCE

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction

(2017) Marcin Szczot et al.   Cell Reports

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

(2017) Jason Wu et al.   Cell Reports

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

(2017) Vincenzo Prato et al.   Cell Reports

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

(2017) Talisia Quallo et al.   eLife

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

(2017) Doreen Badheka et al.   eLife

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

Familial Gordon syndrome associated with aPIEZO2mutation

(2016) Franz Alisch et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The biophysics of piezo1 and piezo2 mechanosensitive channels

(2016) Luca Soattin et al.   BIOPHYSICAL CHEMISTRY

Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures

(2016) A.A. Mahmud et al.   CLINICAL GENETICS

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

(2016) Zizhen Wu et al.   NATURE NEUROSCIENCE

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gi-protein–coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming

(2016) Dioneia Araldi et al.   PAIN

GABA Blocks Pathological but Not Acute TRPV1 Pain Signals

(2015) Christina Hanack et al.   CELL

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

(2015) Priscila Y. Sato et al.   PHYSIOLOGICAL REVIEWS

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Piezo1 ion channel pore properties are dictated by C-terminal region

(2015) Bertrand Coste et al.   Nature Communications

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

(2015) Roberta Carbonara et al.   Frontiers in Pharmacology

The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells

(2015) Gerald R. V. Hammond et al.   PLoS One

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: Potential roles in acute inflammatory pain

(2014) Mathias Leinders et al.   PAIN

Defining the nociceptor transcriptome

(2014) Matthew Thakur et al.   Frontiers in Molecular Neuroscience

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons

(2013) Zhanfeng Jia et al.   Molecular Brain

Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons

(2012) Miles Steven Evans et al.   HEADACHE

Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres

(2012) Landon D. Baillie et al.   NEUROPHARMACOLOGY

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels

(2011) Yevgen Yudin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE