Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol

(2018) Hsia-lien Lin et al.   DRUG METABOLISM AND DISPOSITION

Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents

(2016) Akiko Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Mechanism-Based Inhibition of CYP3A4 by Podophyllotoxin: Aging of an Intermediate Is Important for in Vitro/in Vivo Correlations

(2016) Carlo Barnaba et al.   MOLECULAR PHARMACEUTICS

IgG3 Is the Dominant Subtype of Anti-isoniazid Antibodies in Patients with Isoniazid-Induced Liver Failure

(2014) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Investigations of Heme Ligation and Ligand Switching in Cytochromes P450 and P420

(2013) Yuhan Sun et al.   BIOCHEMISTRY

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

(2013) Imir G. Metushi et al.   HEPATOLOGY

A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET)

(2013) Elena V. Sineva et al.   PLoS One

Reaction of Human Cytochrome P450 3A4 with Peroxynitrite: Nitrotyrosine Formation on the Proximal Side Impairs Its Interaction with NADPH-Cytochrome P450 Reductase

(2012) Hsia-lien Lin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

(2012) Suvi T. M. Orr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Unbound Free Heme in Plant Cells by Differential Acetone Extraction

(2012) Nino A. Espinas et al.   PLANT AND CELL PHYSIOLOGY

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM