Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90

Mechanisms of Hsp90 regulation

(2016) C. Prodromou   BIOCHEMICAL JOURNAL

Silencing of hepatitis C virus replication by a non-viral vector based on solid lipid nanoparticles containing a shRNA targeted to the internal ribosome entry site (IRES)

(2016) Josune Torrecilla et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Target delivery of small interfering RNAs with vitamin E-coupled nanoparticles for treating hepatitis C

(2016) Liang Duan et al.   Scientific Reports

Global prevalence of pre-existing HCV variants resistant to direct-acting antiviral agents (DAAs): mining the GenBank HCV genome data

(2016) Zhi-wei Chen et al.   Scientific Reports

The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA

(2015) You Li et al.   NATURE REVIEWS MICROBIOLOGY

Genetic Variability of Hepatitis C Virus (HCV) 5’ Untranslated Region in HIV/HCV Coinfected Patients Treated with Pegylated Interferon and Ribavirin

(2015) Iwona Bukowska-Ośko et al.   PLoS One

Evaluation of Canonical siRNA and Dicer Substrate RNA for Inhibition of Hepatitis C Virus Genome Replication – A Comparative Study

(2015) Bruno Carneiro et al.   PLoS One

Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors

(2014) Zhenyu Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Global epidemiology and genotype distribution of the hepatitis C virus infection

(2014) Erin Gower et al.   JOURNAL OF HEPATOLOGY

Daclatasvir plus Sofosbuvir for HCV Infection

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Comparative Effectiveness of Antiviral Treatment for Hepatitis C Virus Infection in Adults: A Systematic Review

(2013) Roger Chou et al.   ANNALS OF INTERNAL MEDICINE

Current and future therapies for hepatitis C virus infection: from viral proteins to host targets

(2013) Muhammad Imran et al.   ARCHIVES OF VIROLOGY

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

(2012) Armin Haupt et al.   BMC CANCER

Hepatitis C virus entry: Role of host and viral factors

(2012) Baila Samreen et al.   INFECTION GENETICS AND EVOLUTION

Therapeutic potential of RNA interference: a new molecular approach to antiviral treatment for hepatitis C

(2012) M. Motavaf et al.   JOURNAL OF VIRAL HEPATITIS

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Inhibition of Hepatitis C Virus Replication by Intracellular Delivery of Multiple siRNAs by Nanosomes

(2012) Partha K Chandra et al.   MOLECULAR THERAPY

Anti-HBV efficacy of combined siRNAs targeting viral gene and heat shock cognate 70

(2012) Zhongqi Bian et al.   Virology Journal

Inhibition of hepatitis C virus replication by single and dual small interfering RNA using an HCV-infected cell model

(2011) Xiao-kang Xing et al.   BIOTECHNOLOGY LETTERS

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

(2011) Daniel R. Caffrey et al.   PLoS One

Inhibition of full length Hepatitis C Virus particles of 1a genotype through small interference RNA

(2011) Muhammad Ansar et al.   Virology Journal

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1

(2010) K W Wen et al.   ONCOGENE

Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism

(2010) X. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons

(2009) D. L. Wyles et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RNAi as a new therapeutic strategy against HCV

(2009) Saba Khaliq et al.   BIOTECHNOLOGY ADVANCES

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

(2009) Yuki Naito et al.   BMC BIOINFORMATICS

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Heat-shock Protein 90 Is Essential for Stabilization of the Hepatitis C Virus Nonstructural Protein NS3

(2009) Saneyuki Ujino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study

(2008) Joseph A. Gredell et al.   BIOTECHNOLOGY AND BIOENGINEERING

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection

(2008) Flávio MG Araújo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ