Article
Nutrition & Dietetics
Ilham Lhilali, Noura Zouine, Aziza Menouni, Lode Godderis, Marie-Paule Kestemont, Adil El Midaoui, Samir El Jaafari, Younes Filali-Zegzouti
Summary: This study developed and validated a sun exposure score (SES) and found a significant correlation between SES and serum 25-hydroxyvitamin D levels in women of childbearing age. The results suggest that the SES could be used as a clinical tool to assess vitamin D levels in this population.
Review
Nutrition & Dietetics
Rasha Shraim, Conor MacDonnchadha, Lauren Vrbanic, Ross McManus, Lina Zgaga
Summary: Vitamin D is crucial for good health and its production is influenced by environmental and personal factors, including genetics. Understanding gene-environment interactions (GxE) is important for determining vitamin D status. This review aimed to examine the methods used in GxE studies on vitamin D and report on the effect estimates. The review included 7 studies and provided recommendations for future GxE research in vitamin D.
Article
Orthopedics
Mohammad Ali, Zakir Uddin
Summary: This study aimed to determine the prevalence of 25-hydroxyvitamin D deficiency among patients with musculoskeletal disorders (MSDs) and identify associated factors. The results showed that over half of the patients had vitamin D deficiency, which was associated with higher body mass index, lower sun exposure time, lower serum calcium levels, and urban living.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Nutrition & Dietetics
Shou-En Wu, Wei-Liang Chen
Summary: This study investigates the serum 25-hydroxy-vitamin D (25(OH)D) levels in healthy US civilians and identifies that sun exposure can compensate for low dietary vitamin D intake. Moderate sun exposure appears to be a simple and costless means for the public to increase their vitamin D levels.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Karolina Sledzinska, Piotr Landowski, Michal A. Zmijewski, Barbara Kaminska, Konrad Kowalski, Anna Liberek
Summary: The study showed that IBD children have higher levels of vitamin D compared to controls, but a significant portion still lack optimal vitamin D levels. Despite the higher level of vitamin D, IBD children had lower calcium levels compared to healthy controls, with no correlation to disease activity or location of lesions in the gastrointestinal tract.
Article
Multidisciplinary Sciences
Pernilla Stridh, Ingrid Kockum, Jesse Huang
Summary: This study examined the relationship between serum 25-hydroxyvitamin D levels and the age of first symptom onset in recently diagnosed MS patients. The results showed no association between serum 25-hydroxyvitamin D levels and age at MS onset, but a negative correlation was observed with CSF IgG index. Further investigation is needed to explore this correlation.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Christina Kate Langley, Gladys Leopoldine Onambele-Pearson, David Thomas Sims, Ayser Hussain, Aidan John Buffey, Holly Leigh Bardwell, Christopher Ian Morse
Summary: The study compared the differences in vitamin D levels, musculoskeletal health, and function between men with cerebral palsy and those without neurological impairments, finding that the former had poorer musculoskeletal outcomes despite similar levels of vitamin D.
Article
Nutrition & Dietetics
Shohei Kuraoka, Masako Oda, Hiroshi Mitsubuchi, Kimitoshi Nakamura, Takahiko Katoh
Summary: There is a link between vitamin D deficiency and impaired height growth in young children, regardless of stature. Reduced outdoor activity, especially during winter, increases the risk of vitamin D deficiency.
Review
Medicine, General & Internal
Cristina Oana Marginean, Lorena Elena Melit, Reka Borka Balas, Anca Meda Vasiesiu, Tudor Fleseriu
Summary: Vitamin D plays a role not only in bone health and calcium metabolism, but also in autophagy, modulation of the gut microbiota, immune functions, and intestinal barrier integrity. It can be obtained from sunlight, diet, and supplements. Recent studies have shown its potential effects on H.pylori eradication, celiac disease, cystic fibrosis, and inflammatory bowel disease. However, more research is needed to fully understand the complex impact of vitamin D on gastrointestinal homeostasis.
Review
Pharmacology & Pharmacy
Madeline P. Sheeley, Chaylen Andolino, Violet A. Kiesel, Dorothy Teegarden
Summary: Vitamin D exerts anti-cancer effects by regulating energy metabolism during cancer progression, including glucose, glutamine, and lipid metabolism, as well as oxidative stress protection.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Philip J. Batterham, Aliza Werner-Seidler, Alison L. Calear, Sonia McCallum, Amelia Gulliver
Summary: Previous research has shown that sleep disturbance is associated with suicidal ideation and attempts. Specifically, difficulties falling asleep are significantly linked to both suicidal ideation and attempts.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
S. S. Habib, H. B. Alhalabi, K. S. Alharbi, O. S. Alghamdi, A. Alghamdi, M. A. Ajarem, M. A. Alqarni
Summary: The study revealed that university students in Saudi Arabia have moderate to low knowledge about Vitamin D, with females showing better understanding. Most students spend less than an hour in the sun during weekdays and have low usage of Vitamin D supplements. Females are more likely to recognize their Vitamin D deficiency and take supplements compared to males.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Vu Tran, Monika Janda, Robyn M. M. Lucas, Donald S. A. McLeod, Bridie S. S. Thompson, Mary Waterhouse, David C. C. Whiteman, Rachel E. E. Neale
Summary: Sun exposure in Australia has both negative and positive effects. It is a major cause of skin cancer, but also promotes vitamin D production. However, despite high levels of UV radiation, a significant portion of the population is vitamin D deficient. Balancing the risks and benefits requires effective communication.
Article
Nutrition & Dietetics
Jeanette M. Andrade, Philip G. Grandoff, Sydney T. Schneider
Summary: This study aimed to determine the relationship between vitamin D intake and self-reported vitamin D deficiency among US adults. The findings showed significant associations between vitamin D deficiency and chronic conditions, vitamin D supplement use, age, and sun exposure. However, there was no significant difference in vitamin D intake from food/beverages on vitamin D deficiency status.
FRONTIERS IN NUTRITION
(2022)
Article
Psychiatry
Huiming Yan, Zhenni Huang, Yao Lu, Yuying Qiu, Meijuan Li, Jie Li
Summary: This study investigated the relationship between metabolic disorders and sleep disturbance in patients with schizophrenia. The results showed that patients with metabolic disorders had more severe sleep problems and lower sleep quality, such as longer sleep latency. There was also a correlation between sleep disturbance and metabolic disorders. Therefore, improving sleep quality is important in preventing metabolic disorders in patients with schizophrenia.
COMPREHENSIVE PSYCHIATRY
(2023)
Review
Food Science & Technology
Luigi Barrea, Claudia Vetrani, Massimiliano Caprio, Marwan El Ghoch, Evelyn Frias-Toral, Rucha J. Mehta, Verna Mendez, Eleonora Moriconi, Stavroula A. Paschou, Agnieszka Pazderska, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This article reviews the evidence and uncertainties surrounding nutritional therapy for patients with type 2 diabetes and obesity, providing guidance for clinical practice.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
Summary: Obesity is an emerging non-communicable disease associated with chronic low-grade inflammation and oxidative stress. The ketogenic diet (KD), characterized by high fat intake, moderate to low protein consumption, and very low carbohydrate intake, has proven to be effective in weight loss and improving the inflammatory state and oxidative stress in individuals with obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Editorial Material
Endocrinology & Metabolism
Luigi Barrea, Giovanna Muscogiuri, Silvia Savastano
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, Research & Experimental
Claudia Vetrani, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: This study aimed to evaluate whether supplementation with medium-chain fatty acids (MCTs) during a very low-calorie ketogenic diet (VLCKD) can enhance weight reduction. The study found that MCTs supplementation significantly decreased body weight, fat mass, and waist circumference, and reduced inflammation. Starting MCTs supplementation a few days before VLCKD showed the best results.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Review
Nutrition & Dietetics
Luigi Barrea, Elisabetta Camajani, Simona Cernea, Evelyn Frias-Toral, Dilusha Lamabadusuriya, Florencia Ceriani, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Ludovica Verde
Summary: This review aims to assess the scientific evidence supporting very low-calorie ketogenic diet (VLCKD) as an effective measure for treating polycystic ovary syndrome (PCOS) and its associated metabolic disorders. Preliminary data suggest significant improvements in weight, metabolic profile, and insulin resistance following VLCKD. However, more research is needed to substantiate these findings.
CURRENT NUTRITION REPORTS
(2023)
Review
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, Renata Simona Auriemma, Claudia Vetrani, Mauro Cataldi, Evelyn Frias-Toral, Gabriella Pugliese, Elisabetta Camajani, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: The aim of this review is to provide an overview of the menopause-related changes in microbiota and their role in the pathogenesis of menopause-related diseases. In addition, evidence on probiotic supplementation as a therapeutic strategy is discussed. Menopause is associated with dysbiosis, and these changes in the composition of microbiota in different sites (gut, vaginal, and oral microbiota) might play a role in the pathogenesis of menopause-related diseases such as osteoporosis, breast cancer, endometrial hyperplasia, periodontitis, and cardiometabolic diseases.
CURRENT NUTRITION REPORTS
(2023)
Review
Endocrinology & Metabolism
G. Pugliese, G. de Alteriis, G. Muscogiuri, L. Barrea, L. Verde, F. Zumbolo, A. Colao, S. Savastano
Summary: Despite the widespread agreement on the lack of pharmacological options for the treatment of Polycystic Ovary Syndrome (PCOS), studies have shown that GLP-1 receptor agonists (GLP-1RA) could be effective in managing the clinical manifestations of PCOS, including weight loss and insulin resistance. However, current studies primarily focus on PCOS patients with obesity, and more research is needed on the lean phenotype and higher doses of GLP-1RA. Furthermore, the potential effects of GLP-1 beyond weight loss still require further investigation, especially in PCOS patients without obesity.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
L. Barrea, L. Verde, E. Camajani, A. S. Sojat, L. Marina, S. Savastano, A. Colao, M. Caprio, G. Muscogiuri
Summary: This narrative review aims to provide further insights into the effects of Very Low-Calorie Ketogenic Diet (VLCKD) on the HPA axis and RAAS in different phases of weight loss and in different clinical settings.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Luigi Barrea, Claudia Vetrani, Ludovica Verde, Evelyn Frias-Toral, Florencia Ceriani, Simona Cernea, Annamaria Docimo, Chiara Graziadio, Devjit Tripathy, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Diet is crucial in the pathogenesis of T2DM. Individualized medical nutritional therapy has been shown to improve outcomes, and various eating patterns have proven benefits for T2DM patients. Personalized meal plans should be considered, with reduced carbohydrate intake and replacement of high GI foods. The quality of fats is important, and supplementation with antioxidants or micronutrients is not recommended.
Correction
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, Elisabetta Camajani, Simona Cernea, Evelyn Frias-Toral, Dilusha Lamabadusuriya, Florencia Ceriani, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
CURRENT NUTRITION REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Claudia Vetrani, Ludovica Verde, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
Summary: High adherence to the Mediterranean Diet, particularly the consumption of fish, is associated with decreased insulin resistance in individuals with overweight/obesity.
Editorial Material
Nutrition & Dietetics
Mikiko Watanabe, Silvia Savastano, Carla Lubrano, Giovanni Spera
Review
Endocrinology & Metabolism
G. Muscogiuri, L. Verde, C. Vetrani, L. Barrea, S. Savastano, A. Colao
Summary: There are gender differences in obesity prevalence and phenotype, body fat distribution, drug efficacy, clinical trial representation, and different secondary effects of bariatric surgery. Gender is an important variable in obesity analysis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)