Article
Pharmacology & Pharmacy
Christine N. Habib, Mohamed R. Mohamed, Mariane G. Tadros, Mai F. Tolba, Esther T. Menze, Somia Masoud
Summary: The study found that diosmin (DM) has neuroprotective effects in Parkinson's disease (PD) and can act through various mechanisms such as anti-inflammatory and antioxidative properties. These findings suggest that DM may be a promising candidate for managing the neuropathological course of PD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae-Seek You, Hyang Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Ji-Su Oh, Yo-Seob Seo, Gyeong-Je Lee, Jin-Soo Kim, Heung-Joong Kim, Sun-Kyoung Yu, Jae-Sung Kim
Summary: This study confirmed that 25-HC induces oxiapoptophagy in fibroblasts and modulates the Akt and p53 cellular signaling pathways.
Article
Biochemistry & Molecular Biology
Roberto Ciarcia, Consiglia Longobardi, Gianmarco Ferrara, Serena Montagnaro, Emanuela Andretta, Francesco Pagnini, Salvatore Florio, Lucianna Maruccio, Chiara Lauritano, Sara Damiano
Summary: The extract of the marine microalga Skeletonema marinoi showed anti-tumor activity against the human leukemia cell line K562, reducing cell viability and increasing apoptosis levels. It achieved this through regulation of oxidative stress and antioxidant capacity-related molecular mechanisms.
Article
Biochemistry & Molecular Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus
Summary: This study evaluated the impact of rhein, an anthraquinone compound found in Chinese medicine, on the lysosomal compartment and its indirect influence on cell apoptosis. The results showed that high concentrations of rhein caused oxidative stress and changes in lysosomal membrane permeability, leading to cell apoptosis. In addition, the use of an autophagy inhibitor, chloroquine, enhanced the cytotoxicity of rhein.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Fatih Altintas, Melek Tunc-Ata, Mucahit Secme, Vural Kucukatay
Summary: The study evaluated the cytotoxic, genotoxic, apoptotic, oxidant and antioxidant effects of thymol on HepG2 cell line. Thymol showed cytotoxic and genotoxic effects on HepG2 cells, while having no lethal effect on healthy cells. It also decreased oxidative stress and induced apoptosis in HepG2 cells, without altering the gene expressions associated with apoptosis. The results suggest the potential of thymol in the treatment of liver cancer.
Article
Agriculture, Dairy & Animal Science
Ying Liu, Boxing Sun, Shaoxuan Zhang, Jing Li, Jiajia Qi, Chunyan Bai, Jiabao Zhang, Shuang Liang
Summary: The study demonstrates that glycine significantly alleviates the damage caused by sodium fluoride on porcine testicular Sertoli cells, by reducing oxidative stress, apoptosis, and cellular senescence, among other mechanisms.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Chemistry, Medicinal
Mehari Muuz Weldemariam, Jongmin Woo, Qibin Zhang
Summary: This study used chemical stressors to induce endoplasmic reticulum and mitochondria stress in a rat insuloma INS-1 832/13 beta-cell line. The proteomic changes under stress conditions were analyzed, and differentially expressed proteins were identified. The results revealed perturbation of unfolded protein response related pathways by thapsigargin treatment and significant proteome changes in mitochondria regulatory pathways by rotenone treatment.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Wei Xu, Xi Xiang, Ling Lin, Zhi-Hua Gong, Wen-Jun Xiao
Summary: The study indicates that l-Theanine (LTA) can attenuate intestinal epithelial cell senescence by regulating the cell cycle and inhibiting apoptosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Shoujiao Peng, Shaopeng Yu, Junmin Zhang, Jiange Zhang
Summary: 6-Shogaol, a bioactive compound in ginger, is a novel thioredoxin reductase (TrxR) inhibitor that induces oxidative-stress-mediated apoptosis in HeLa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Guofeng Xu, Shuang Liu, Mingquan Huang, Xue Jiang, Meng Yang
Summary: Cadmium exposure triggers apoptosis in KGN cells by inducing mitochondrial dysfunction, including excessive ROS production and intracellular Ca2+ overload. Activation of downstream signaling pathways following mitochondrial dysfunction may contribute to granulosa cell death and female reproductive toxicity after exposure to Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pathology
Huihua Li, Yujun Shen, Hui Xiao, Wei Sun
Summary: Resveratrol attenuated rotenone-induced inflammation and oxidative stress in BV-2 cells through enhancing the inhibition of STAT1and Keap1 and the upregulation of Nrf2 and SLC7A11.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Monica Curro, Caterina Saija, Alessandra Trainito, Angela Trovato-Salinaro, Maria Paola Bertuccio, Giuseppa Visalli, Daniela Caccamo, Riccardo Ientile
Summary: Exposure to rotenone can activate THP-1 monocytes and enhance neurodegeneration, but baicalin at appropriate concentration can protect against neurotoxic processes.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Chenyang Hu, Yanlin Feng, Guangyi Huang, Kaixuan Cui, Matthew Fan, Wu Xiang, Yuxun Shi, Dan Ye, Huiwen Ye, Xue Bai, Fan Xu, Yue Xu, Jingjing Huang
Summary: This study investigated the neuroprotective effects of melatonin on RGC degeneration caused by EAAC1 deletion. The results showed that EAAC1 deletion led to elevated oxidative stress, activation of apoptosis and cellular senescence pathways, and neuroinflammation in RGCs, which were efficiently prevented by melatonin administration. Furthermore, melatonin may exert its neuroprotective effects through modulating NRF2/p53/Sirt1 redox-sensitive signaling pathways.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Neurosciences
Shubhendu M. Shirgadwar, Rahul Kumar, Kumari Preeti, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: This study evaluated the neuroprotective potential of phloretin (PLT) in Parkinson's disease (PD) by modulating the autophagy-antioxidant axis. The results showed that PLT improved locomotive activity and anxiety-like behavior in mice, reduced apoptosis and α-Synuclein expression, and improved the expression of TH and antioxidant proteins. This study provides evidence for PLT as a potential disease-modifying drug for PD management.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Environmental Sciences
Mingquan Huang, Xingjie Li, Shengjun Jia, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Inorganic & Nuclear
Ashapurna Khatua, Eepsita Priyadarshini, Paulraj Rajamani, Amiyakumar Patel, Jitender Kumar, Aparupa Naik, Muthupandian Saravanan, Hamed Barabadi, Abhinav Prasad, Ilora Ghosh, Bernard Paul, Ramovatar Meena
JOURNAL OF CLUSTER SCIENCE
(2020)
Review
Cell Biology
Jie Yang, Xiao-Zhen Zhan, Jonathan Malola, Zhen-Yan Li, Jogendra Singh Pawar, Huan-Tian Zhang, Zhen-Gang Zha
Review
Biochemistry & Molecular Biology
B. Mahalakshmi, Nancy Maurya, Shin-Da Lee, V. Bharath Kumar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Ashapurna Khatua, Abhinav Prasad, Eepsita Priyadarshini, Ishita Virmani, Llora Ghosh, Bernard Paul, Ramovatar Meena, Hamed Barabadi, Amiya Kumar Patel, Muthupandian Saravanan
Article
Biochemistry & Molecular Biology
Carina Magdaleno, Trenton House, Jogendra S. Pawar, Sophia Carvalho, Narendiran Rajasekaran, Archana Varadaraj
Summary: This study explores the impact of fibronectin (FN) matrix on epithelial functions in the context of cancer progression, showing that FN fibril formation decreases during hypoxia, leading to reduced migratory potential. Additionally, disruption of FN fibrils in normal breast cells results in acinar luminal filling, indicating a loss of apicobasal polarity.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Aparna Chakkamadathil Rajeev, Nishi Sahu, Kumar Arvind, Maushumi Deori, Tony Grace, Suma Arun Dev, Vijay Pal Yadav, Ilora Ghosh
Summary: This study investigates the microbial communities of Himalayan and Peninsular river systems in India, revealing significant differences in microbial diversity and distribution of potential pathogens between the two river sediments. Environmental factors such as pH, temperature, salinity, etc., play a crucial role in shaping microbial communities, while potential pathogenic genera and fecal indicators are prevalent in both river systems. It emphasizes the urgent need for monitoring and managing major riverine systems in India to address public health risks associated with untreated sewage discharge.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Saad Mustafa, Jogendra Singh Pawar, Ilora Ghosh
Summary: The study found that Fucoidan induces cytotoxicity in HeLa cells through the generation of ROS and mitochondrial superoxide, as well as ATP loss. Additionally, Fucoidan disrupts HDAC function, leading to autophagy and cellular senescence.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Jake L. Owens, Elena Beketova, Sheng Liu, Qi Shen, Jogendra Singh Pawar, Andrew M. Asberry, Jie Yang, Xuehong Deng, Bennett D. Elzey, Timothy L. Ratliff, Liang Cheng, Richard Choo, Deborah E. Citrin, Thomas J. Polascik, Bangchen Wang, Jiaoti Huang, Chenglong Li, Jun Wan, Chang-Deng Hu
Summary: Prostate cancer is the second leading cause of cancer deaths among American men. Neuroendocrine differentiation (NED) is a process that contributes to cancer progression and resistance to treatment. By mimicking clinical radiotherapy protocol, fractionated ionizing radiation (FIR) can induce NED in prostate cancer cells. This study identifies PRMT5 as a key factor in FIR-induced NED.
MOLECULAR CANCER THERAPEUTICS
(2022)
Review
Food Science & Technology
B. Mahalakshmi, Chih-Yang Huang, Shin-Da Lee, Nancy Maurya, Rudolf Kiefer, V. Bharath Kumar
Summary: Danshen, a traditional Chinese medicine, has been shown to have therapeutic effects in various diseases, with protective, anti-inflammatory, antioxidative, or antiplatelet properties. Research has demonstrated its potential in medical applications for conditions like diabetes, neurological disorders, and cancer, providing a scientific basis for its traditional use in these diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biology
Jogendra S. Pawar, Saad Mustafa, Ilora Ghosh
Summary: Current studies are exploring the anti-cancer properties of natural bioactive compounds found in the human diet. Specifically, compounds such as Chrysin and Capsaicin are being investigated for their ability to disrupt cancer cell growth by altering the cell's redox balance and inducing oxidative stress-induced cell death. These compounds stimulate an overproduction of ROS in cells, leading to disruption of the cellular redox state and loss of mitochondrial membrane potential. Additionally, they induce cell cycle arrest, premature senescence, and apoptosis in a concentration-dependent manner, potentially through interaction with the protein p53.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ashim Chandra Roy, Abhinav Prasad, Ilora Ghosh
Summary: This study reported the phytochemicals present in the methanolic extract of Tupistra nutans Wall. ex Lindl. inflorescence (METNI) and its comparative effect in liver carcinoma HepG2 cells against non-cancerous murine fibroblast F111 cells. The results showed that METNI was rich in unsaturated fatty acids, vitamin E, and anticancer compounds. METNI exhibited inhibitory effects on cell proliferation, as well as antioxidant and UV protection properties, in HepG2 cells, but higher exposure led to intracellular ROS generation and cell cycle alteration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ashim Chandra Roy, Abhinav Prasad, Komal Priya, Priyanka Das, Shivangi Singh, Chandra Ghosh, Ilora Ghosh
Summary: Methanolic extract of Rauvolfia serpentina leaf (MERSL) has been found to have anticancer activity and antioxidant capacity. GC-MS analysis revealed the presence of several anticancer phytochemicals. Cell-based assays confirmed the anticancer activity by reducing cell viability, migration, and revival capacity in hepatocarcinoma and cervical cancer cells.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Abhinav Prasad, Ashapurna Khatua, Yugal Kishore Mohanta, Muthupandian Saravanan, Ramovatar Meena, Ilora Ghosh
Summary: This study demonstrates the effectiveness of a combination therapy using low-dose gold nanoparticles and glutamine deprivation in inhibiting the growth of human cervical cancer cells. The combination treatment resulted in significant inhibition of cell growth and induced cellular uptake of nanoparticles. The therapy also induced oxidative stress conditions and mitochondrial inactivity in the cancer cells.
Article
Infectious Diseases
Nancy Maurya, Devendra Dwarg
Summary: This work aims to explore the legal and environmental implications of the coronavirus disease-2019 outbreak in India. It specifically focuses on both sides of the tragedy, particularly the environmental and legal aspects in the Indian context, while also discussing examples from other countries or global aspects when necessary.
JOURNAL OF GLOBAL INFECTIOUS DISEASES
(2021)