Article
Chemistry, Inorganic & Nuclear
Shun Ge, Jia-Hao Liu, Lishan Gong, Xiu-Fang Mo, Chao Liu, Xiao-Yi Yi, Piao He
Summary: In this study, newly developed complexes of iridium and ruthenium with nitrogen-rich ligand were used for aqueous formic acid (FA) dehydrogenation. The reaction kinetics were investigated and a possible mechanism was proposed. The results showed that the nitrogen-rich ligand was effective for FA dehydrogenation, providing a theoretical basis for the development of new and effective hydrogen release systems.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Soumyadip Patra, Ankit Kumar, Sanjay K. Singh
Summary: Efficient catalytic systems based on arene-Ru(II) complexes with bis-imidazole methane-based ligands were developed for additive-free hydrogen generation from formaldehyde and paraformaldehyde in water. The presence of bis-imidazole methane ligands significantly affected the catalytic performance of the studied catalysts. Among the screened complexes, a complex with the ligand [(eta(6)-p-cymene)RuCl(L)]Cl-+(-) ([Ru]-2) showed the highest turnover number (>20,000) for hydrogen gas generation from paraformaldehyde in water.
INORGANIC CHEMISTRY
(2022)
Correction
Chemistry, Inorganic & Nuclear
Alejandra Gomez-Espana, Jorge L. Lopez-Morales, Belinda Espanol-Sanchez, Pilar Garcia-Orduna, Fernando J. Lahoz, Manuel Iglesias, Francisco J. Fernandez-Alvarez
Summary: This article investigates the catalytic performance of iridium complexes in the dehydrogenation of formic acid and examines the effect of auxiliary ligands on the catalytic performance.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Shun Ge, Lishan Gong, Pingping Yi, Xiufang Mo, Chao Liu, Xiao-Yi Yi, Piao He
Summary: A series of novel Cp*Ir complexes with nitrogen-rich NN bidentate ligands were developed for efficient catalytic dehydrogenation of formic acid in water. The study reveals the influence of ligand structure and water-assisted reaction steps on the catalytic activity, and proposes a plausible reaction mechanism.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Soumik Biswas, Michael J. Blessent, Benjamin M. Gordon, Tian Zhou, Santanu Malakar, David Y. Wang, Karsten Krogh-Jespersen, Alan S. Goldman
Summary: The PCP-pincer iridium complexes exhibit high regioselectivity for the transfer dehydrogenation of n-alkanes, while the closely related PCOP and POCOP complexes do not. The difference in regioselectivity is a true kinetic phenomenon, not a result of isomerization subsequent to the formation of free alpha-olefin. The different regioselectivity of the POCOPIr vs PCPIr catalysts is attributable to the different rate-determining steps of their respective catalytic cycles, which can be explained in terms of different electronic effects of O versus CH2 linker exerted through the pincer aromatic ring.
Article
Chemistry, Multidisciplinary
Xuewen Guo, Felix Unglaube, Udo Kragl, Esteban Mejia
Summary: An efficient metal-free system for the transfer hydrogenation of esters and carbonates is reported, which bypasses the formation of transesterification side-products. The Lewis acid B(C6F5)(3) is used as a catalyst and ammonia borane as a hydrogen donor. This methodology exhibits a wide substrate scope and excellent functional group tolerance, achieving high yields under very mild conditions.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Minjin Yoo, Michael J. Krische
Summary: This research synthesized the potent spliceosome modulator pladienolide B with 10 stereogenic centers in 10 steps. Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium were used to form the C20-C21 and C10-C11 C-C bonds with syn- and anti-diastereoselectivity, respectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Sihang Cheng, Zhongling Lang, Jing Du, Zhilu Du, Yingqi Li, Huaqiao Tan, Yangguang Li
Summary: In this study, a new series of tetrahydroquinoxaline-dioximino iridium complexes were designed and investigated, which showed improved hydrogen evolution performance of formic acid and revealed a possible dehydrogenation mechanism. These findings lay the foundation for the implementation of a green hydrogen economy.
JOURNAL OF CATALYSIS
(2022)
Review
Chemistry, Inorganic & Nuclear
Sourav De, Sabnaz Kazi, Sabyasachi Banerjee, Subhasis Banerjee, Nandan Sarkar, Suraj Kumar Shah, Yung-Chih Kuo, S. K. Ashok Kumar
Summary: This article reviews the literature on the cytotoxic effects and cellular uptake of metal complexes such as ruthenium, iridium, rhodium, and rhenium, with a particular focus on recently developed metal-based complexes. These complexes primarily target DNA and mitochondria, inducing cancer cell apoptosis to reduce adverse drug reactions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Kieran Benn, Kieran Nicholson, Thomas Langer, Stephen P. Thomas
Summary: Cyanation serves as a simple method for introducing nitrile group into organic molecules and installing various functional groups through transition metal catalysis and hydrogen cyanide gas. Electrophilic cyanation of enones can be achieved using main-group catalyst and non-toxic cyanide source, with a broad substrate scope including reducible functional groups. Mechanistic studies suggest an amino-borane intermediate undergoing B-N transborylation for catalytic turnover.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Hong Liu, Wan-Hui Wang, Huatian Xiong, A. Nijamudheen, Mehmed Z. Ertem, Mei Wang, Lele Duan
Summary: This study presents a series of Cp*Ir complexes with a rigid 8-aminoquinoline sulfonamide moiety as highly efficient catalysts for the dehydrogenation of formic acid. The electron-donating and electron-withdrawing groups on the ligands were found to have different effects on the reaction steps, leading to lower optimum pH for catalytic activity with electron-withdrawing groups. Overall, this research provides important insights for catalyst design in organic chemistry.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Physical
Khai Chen Tan, Teng He, Yong Shen Chua, Ping Chen
Summary: The lack of efficient hydrogen storage methods is a technical barrier in implementing hydrogen energy. Liquid organic hydrogen carriers, particularly N-heterocycles, show promise for both on-board and off-board hydrogen storage, but face kinetic barriers that require efficient catalysts for improvement.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Urology & Nephrology
Susana Garcia-Abellan, Vincenzo Passarelli, Manuel Iglesias
Summary: Two Ir complexes, 2a and 2b, with the ligand [Ir(CI)(COD)(NHC)] (COD=1,5-cyclooctadiene), were synthesized through transmetallation from NHC-Ag complexes. Analogously, another Rh complex, 4, was prepared using the same method. By transmetallation from the deprotonated NHC-Ag complex, another Ir complex, 3c, with the ligand [Ir({kappa-C,N-(NHC-acetamide-1H)}(COD)], was synthesized. Similarly, [Ir(CI)(CO)(2)(NHC)] (6) and [Ir({kappa-C,N-(NHC-acetamide-1H)}(CO)(2)] (7) were obtained through carbonylation of 2b and 3c respectively. The catalytic activity of these complexes in formic acid dehydrogenation was evaluated, with the highest turnover frequency (TOF) observed in the presence of a 5:2 HCOOH/Et3N mixture. Stoichiometric experiments suggested COD hydrogenation as the preactivation step.
Article
Chemistry, Multidisciplinary
Xiangqing Jia, Zheng Huang
Article
Chemistry, Multidisciplinary
Xinxin Tang, Xiangqing Jia, Zheng Huang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Multidisciplinary
Xinxin Tang, Xiangqing Jia, Zheng Huang
Article
Chemistry, Inorganic & Nuclear
Ziqing Zuo, Songgen Xu, Lei Zhang, Lan Gan, Huaquan Fang, Guixia Liu, Zheng Huang
Article
Chemistry, Multidisciplinary
Xiangqing Jia, Joern Nitsch, Lei Ji, Zhu Wu, Alexandra Friedrich, Florian Kerner, Michael Moos, Christoph Lambert, Todd B. Marder
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Physical
Xiangqing Jia, Ziyan Zhang, Vladimir Gevorgyan
Summary: A novel reaction method has been developed for visible light-induced alkyl-carbamoylation and cyanation of alkenes, leading to the synthesis of amides and nitriles. This method is highly efficient and versatile, allowing for the rapid construction of a wide range of valuable compounds.
Review
Chemistry, Multidisciplinary
Monica Rivas, Vitalii Palchykov, Xiangqing Jia, Vladimir Gevorgyan
Summary: This Review highlights recent advances in visible light-induced C(sp(3))-H bond activations, including amination of olefins and carbonyl compounds, and cross-coupling reactions. These methods rely on converting visible light into chemical energy to generate reactive but controllable radical species, providing a new synthetic platform for mild reaction conditions.
NATURE REVIEWS CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sumon Sarkar, Sidhant Wagulde, Xiangqing Jia, Vladimir Gevorgyan
Summary: This study presents a general, mild, and photoinduced method for selective a-C(sp3)-H borylation of amines. The protocol allows activation of a broad range of acyclic and cyclic amines, enabling highly regio- and diastereoselective syntheses of valuable a-amino-boronates. The utility of this method has been demonstrated in late-stage borylation of structurally complex amines and formal C-H arylation reaction of amines. It is expected to find broad application in organic synthesis and drug discovery.
Article
Multidisciplinary Sciences
Kuan Wang, Lan Gan, Yuheng Wu, Min-Jie Zhou, Guixia Liu, Zheng Huang
Summary: In this study, a novel catalyst was designed for the undirected dehydrogenation of unactivated 1,1-disubstituted ethane to valuable 1,1-disubstituted ethylene. The catalytic system demonstrated high site selectivity and excellent functional group compatibility, making it applicable to late-stage dehydrogenation of complex bioactive molecules. Additionally, the catalyst enabled unprecedented dehydrogenation of polypropene with controllable degree of desaturation, dehydrogenating more than 10 in 100 propene units, leading to functionalized polypropenes.
Article
Chemistry, Multidisciplinary
Feng Yu, Renqing Tao, Lan Gan, Hao Ni, Qi-Kai Kang, Guixia Liu, Zheng Huang
Summary: Here we report a one-pot relay bicatalysis system for constructing C-aryl-C-alkyl bonds using (pincer)Ir-catalyzed alkane transfer dehydrogenation and Fe(OTf)(3)-catalyzed olefin hydroarylation. This system exhibits broad scope and high selectivity for the alkylation of arenes with arylalkanes, making it potentially useful for late-stage alkylation of complex molecules. Experimental mechanistic data provide insights into the factors controlling the regioselectivity.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiangqing Jia, Joern Nitsch, Zhu Wu, Alexandra Friedrich, Johannes Krebs, Ivo Krummenacher, Felipe Fantuzzi, Holger Braunschweig, Michael Moos, Christoph Lambert, Bernd Engels, Todd B. Marder
Summary: Chemical reduction of the compounds produced monoanions with extensive delocalization and open-shell biradicaloid dianions with temperature-dependent population of triplet states, as confirmed by various experimental techniques.
Article
Multidisciplinary Sciences
Xinxin Tang, Lan Gan, Xin Zhang, Zheng Huang
Article
Chemistry, Multidisciplinary
Yulei Wang, Chuan Qin, Xiangqing Jia, Xuebing Leng, Zheng Huang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)