Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

(2019) Hongwei Du et al.   CANCER CELL

CD33-Specific Chimeric Antigen Receptor T Cells with Different Co-Stimulators Showed Potent Anti-Leukemia Efficacy and Different Phenotype

(2018) Saisai Li et al.   HUMAN GENE THERAPY

Targeting B Cells and Plasma Cells in Autoimmune Diseases

(2018) Katharina Hofmann et al.   Frontiers in Immunology

Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

(2018) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer

(2017) Saul J. Priceman et al.   OncoImmunology

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

A phase 2, randomised, placebo-controlled clinical trial of blisibimod, an inhibitor of B cell activating factor, in patients with moderate-to-severe systemic lupus erythematosus, the PEARL-SC study

(2014) R A Furie et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

(2014) David Isenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy

(2013) P. M. Abraham et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pragmatic approaches to therapy for systemic lupus erythematosus

(2013) Wen Xiong et al.   Nature Reviews Rheumatology

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

B-cell depletion in the treatment of lupus nephritis

(2012) Jon W. Gregersen et al.   Nature Reviews Nephrology

Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity

(2012) Henrik E Mei et al.   ARTHRITIS RESEARCH & THERAPY

Rituximab-treated membranous lupus nephritis: clinical outcome and effects on electron dense deposits

(2011) T. Jonsdottir et al.   ANNALS OF THE RHEUMATIC DISEASES

B cell biomarkers of rituximab responses in systemic lupus erythematosus

(2011) Edward M. Vital et al.   ARTHRITIS AND RHEUMATISM

Long-term efficacy of anti-CD20 antibodies in refractory lupus nephritis

(2011) C Alejandro Arce-Salinas et al.   RHEUMATOLOGY INTERNATIONAL

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

Natural Expression of the CD19 Antigen Impacts the Long-Term Engraftment but Not Antitumor Activity of CD19-Specific Engineered T Cells

(2010) Eleanor J. Cheadle et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE