OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

Control of mTOR signaling by ubiquitin

(2019) Yao Jiang et al.   ONCOGENE

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Auto-inflammation in a Patient with a Novel Homozygous OTULIN Mutation

(2019) Mohammad Nabavi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

(2019) Rune Busk Damgaard et al.   EMBO Molecular Medicine

Regulation of the endosomal SNX27-retromer by OTULIN

(2019) Aurelia Stangl et al.   Nature Communications

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

(2018) Lucia Taraborrelli et al.   Nature Communications

The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis

(2017) Yutaka Shimizu et al.   HEPATOLOGY

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

Molecular basis for specificity of the Met1-linked polyubiquitin signal

(2016) P. R. Elliott   BIOCHEMICAL SOCIETY TRANSACTIONS

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

(2016) Rune Busk Damgaard et al.   CELL

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death

(2016) Sebastian Kupka et al.   FEBS Journal

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

(2016) Matous Hrdinka et al.   Cell Reports

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

Linear ubiquitination in immunity

(2015) Yutaka Shimizu et al.   IMMUNOLOGICAL REVIEWS

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

(2015) Géraldine Gentric et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

(2014) Tsuyoshi Takiuchi et al.   GENES TO CELLS

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

(2014) Nieves Peltzer et al.   Cell Reports

The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update

(2014) Ming Liu et al.   Protein & Cell

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

(2014) Snehlata Kumari et al.   eLife

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

(2013) Matthias S. Matter et al.   JOURNAL OF HEPATOLOGY

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

(2013) Elena Rivkin et al.   NATURE

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

(2012) Kostas Nikolaou et al.   CANCER CELL

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE