Article
Engineering, Biomedical
Zhaoyu Ma, Heyou Han, Yanli Zhao
Summary: Mitochondria play critical roles in regulating the proliferation and apoptosis of cancer cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems has attracted increasing attention in recent years. Understanding the mechanisms of mitochondrial dysfunction is important for efficient disease treatment and translating therapeutic strategies into the clinic.
Review
Pharmacology & Pharmacy
Pedro Cruz-Nova, Alejandra Ancira-Cortez, Guillermina Ferro-Flores, Blanca Ocampo-Garcia, Brenda Gibbens-Bandala
Summary: Nanoparticles have great potential in cancer treatment, as they can be combined with different molecules to improve therapeutic efficacy and reduce side effects. They can be used to enhance chemotherapy and radiation therapy, increase blood circulation time, and improve treatment outcomes through targeted delivery. Additionally, radiolabeled nanoparticles can be used for diagnosis, drug delivery, and photothermal therapy.
Article
Nanoscience & Nanotechnology
Yufei Feng, Guozhao Qin, Shuyuan Chang, Zhongxu Jing, Yanyan Zhang, Yanhong Wang
Summary: The novel dual-functional liposome system possessing both extracellular charge reversal and mitochondrial targeting properties significantly enhances drug accumulation in mitochondria and triggers apoptosis of cancer cells. The results demonstrate that the charge reversed and mitochondria-targeted liposomes facilitate cellular internalization and mitochondrial accumulation for enhanced antitumor effect. Therefore, this liposome system represents a promising anticancer drug delivery system for improved therapeutic efficacy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, James G. Shamul, Elyahb Allie Kwizera, Xiaoming He
Summary: Mitochondria are critical organelles for producing energy in cells and can be targeted for cancer therapy. Mitochondria-targeting nanotechnologies have shown high efficacy for cancer treatment both in vitro and in vivo, and can be intelligently designed based on the characteristics of the tumor microenvironment.
Article
Chemistry, Applied
Lin Li, Peng Zhang, Congcong Li, Yan Guo, Kaoxiang Sun
Summary: This study developed a polysaccharide-based charge-switchable nanoformulation to enhance the efficacy of the anticancer drug DOX, showing promising stability and pH-sensitivity. The nanoformulation significantly improved cellular uptake, apoptosis/necrosis rates, and tumor inhibition in vivo, with a 226% enhancement compared to free DOX.
CARBOHYDRATE POLYMERS
(2021)
Review
Nanoscience & Nanotechnology
Khaled S. Allemailem, Ahmad Almatroudi, Mohammed A. Alsahli, Aseel Aljaghwani, Asmaa M. El-Kady, Arshad Husain Rahmani, Amjad Ali Khan
Summary: The dysregulation of mitochondria plays a significant role in cancer initiation and progression. Targeting mitochondria with therapeutic drugs using nanotechnology presents a promising approach for cancer treatment, but it is a challenging task due to multiple barriers. Novel mitochondria-selective compounds and approved nanoformulations show potential as effective anticancer agents but further research is needed to fully understand their mechanisms and optimize their use in clinical applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Medicinal
Renshuai Zhang, Na Xiao, Qi Xu, Qiuyu Gong, Fandong Kong, Hongfei Jiang
Summary: Mitochondria has been identified as a target for tumor therapy. This study developed a mitochondria-targeting anticancer agent, MT-1, which specifically accumulates in mitochondria and binds to GR. MT-1 damages the morphology and function of mitochondria, inhibits mitochondrial respiration and glycolysis, and binds to a new site of GR to inhibit its activity. This provides a potential novel strategy for tumor therapy by targeting novel sites of GR in mitochondria.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Jiejie Sun, Jingzhou Liu, Chunhong Gao, Jinpeng Zheng, Jinbang Zhang, Yaning Ding, Wei Gong, Meiyan Yang, Zhiping Li, Yuli Wang, Yang Yang, Chunsheng Gao
Summary: In this study, a neuronal mitochondria-specific PARP inhibitor olaparib was developed and red blood cell-coated nanostructured lipid carriers were designed for targeted delivery to brain neuronal mitochondria. The results showed that this approach effectively improved mitochondrial function and prevented neuronal cell death caused by excessive activation of mitochondrial PARP.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Chih-Sheng Chiang, Bo-Jie Huang, Jui-Yu Chen, Wee Wei Chieng, Seh Hong Lim, Wei Lee, Weoi-Cherng Shyu, Long-Bin Jeng
Summary: The study evaluated the therapeutic efficacy and safety of fucoidan nanoparticles (FuNPs) in treating breast cancer, finding that they have strong anti-tumor and anti-metastatic abilities. This opens up new possibilities for the development of inherently therapeutic nanomedicines.
Article
Chemistry, Multidisciplinary
Futing Yang, Wenjie Yu, Qiying Yu, Xiyu Liu, Chunping Liu, Chong Lu, Xinghua Liao, Yi Liu, Na Peng
Summary: This study synthesized a novel amphiphilic copolymer to encapsulate a porphyrinic metal-organic framework via self-assembly, loaded a carbon monoxide releasing molecule, and coated it with hyaluronic acid. The nanosystem sequentially localized to mitochondria and activated the production of ROS upon near-infrared light excitation, while simultaneously releasing CO. This combined approach significantly enhanced the antitumor efficacy of PDT both in vitro and in vivo.
Article
Chemistry, Medicinal
Bo Fang, Xue Chen, Xingui Zhou, Xindan Hu, Yan Luo, Zhigang Xu, Cheng-He Zhou, Jiang-Ping Meng, Zhong-Zhu Chen, Chunsheng Hu
Summary: This study presents platinum(IV) compounds with multiple-bond ligands, which exhibited superior activity against tumor cells, proliferation, and metastasis compared to cisplatin. Compounds 2 and 5 with meta-substituted groups showed excellent performance. Research further demonstrated that compounds 2 and 5 had appropriate reduction potential and outperformed cisplatin in cellular uptake, reactive oxygen species response, apoptosis regulation, DNA damage-related gene up-regulation, and drug-resistant cell activity. The title compounds displayed better antitumor potential and fewer side effects in vivo compared to cisplatin. Introduction of multiple-bond ligands improved absorption, overcame drug resistance, and exhibited potential for mitochondrial targeting and inhibition of tumor cell detoxification.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yujeong Moon, Man Kyu Shim, Jiwoong Choi, Suah Yang, Jinseong Kim, Wan Su Yun, Hanhee Cho, Jung Yeon Park, Yongju Kim, Joon-Kyung Seong, Kwangmeyung Kim
Summary: In this study, the researchers propose a new strategy to enhance cancer immunotherapy by using anti-PD-L1 peptide-conjugated prodrug nanoparticles (PD-NPs). The PD-NPs are taken up by cancer cells and release the drug, resulting in the disruption of immune-suppressing pathways and the enhancement of T lymphocyte immune responses. The results show that PD-NPs accumulate in tumor tissues and recruit a large amount of immune cells, leading to effective antitumor effects. This strategy has the potential to overcome the toxicity and low response rate issues in current cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Pharmacology & Pharmacy
Qiuyi Li, Cheng Chen, Jinxia Kong, Lian Li, Junlin Li, Yuan Huang
Summary: This study reveals that mitochondrial-targeted delivery of doxorubicin can greatly enhance immunogenic cell death through the generation of reactive oxygen species and the promotion of endoplasmic reticulum stress and release of mitochondrial-associated damage molecules. To overcome immunosuppression, a tumor stimuli-responsive nano vehicle was developed for targeted induction of immunogenic cell death and PD-L1 blockade, resulting in significant activation of antitumor immune responses and robust antitumor efficacy in mouse models.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Hamide Sena Ozbay, Samiye Yabanoglu-Ciftci, Ipek Baysal, Merve Gultekinoglu, Cemil Can Eylem, Kezban Ulubayram, Emirhan Nemutlu, Rezan Topaloglu, Fatih Ozaltin
Summary: The study aimed to develop mitochondria-targeted nanoparticles loaded with CoQ(10) for the treatment of CoQ(10) nephropathies, showing enhanced efficacy in improving mitochondrial function and high safety profile.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Engineering, Chemical
Xingchu Gong, Junlin Guo, Jingjing Pan, Zhenfeng Wu
Summary: The translation discusses the quality standards for Fructus Corni established based on the effects of the manufacturing processes, including critical process parameters, critical quality attributes, and the calculation of design space, as well as the method to set quality standards for Fructus Corni.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Review
Plant Sciences
Ruifang Yuan, Dingkun Zhang, Jinhui Yang, Zhenfeng Wu, Chuanhong Luo, Li Han, Fangli Yang, Junzhi Lin, Ming Yang
Summary: This study reviewed the pathogenesis of migraines, the application of plant essential oils in migraine treatment, and further explored the material basis and mechanism of action of plant essential oils against migraines. Results suggest that 10 types of plant essential oils could relieve migraine symptoms, with 16 monomers potentially playing a role in migraine treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Fen Yu, Na Wan, Qin Zheng, Yuanhui Li, Ming Yang, Zhenfeng Wu
Summary: The study revealed that ultrasound pretreatment and microwave pretreatment can reduce extraction time, increase yield, and enhance DPPH radical-scavenging activity of kumquat peel essential oil. Compared to microwave pretreatment, ultrasound pretreatment showed higher essential oil yield and antioxidant activity.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Na Wan, Hao Xie, Fen Yu, Yuanhui Li, Qin Zheng, Zhenfeng Wu
Summary: Ultrasound-assisted vacuum extraction was applied to improve the efficiency and quality of Kumquat peel essential oil. Results showed that ultrasound-assisted vacuum extraction allowed higher essential oil yield and antioxidant activity, and reduced extraction time compared to traditional methods.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Food Science & Technology
Xuecheng Wang, Shijun Xu, Zhicheng Wu, Yuanhui Li, Yaqi Wang, Zhenfeng Wu, Genhua Zhu, Ming Yang
Summary: This study investigated the use of ultrasound-assisted vacuum drying (UAVD) as a new approach to improve the efficiency in drying Schisandra chinensis extract powder. The results showed that UAVD significantly reduced drying time, increased drying efficiency, and improved product quality compared to conventional vacuum drying (CVD).
FOOD SCIENCE & NUTRITION
(2022)
Article
Nutrition & Dietetics
Mei Yang, Zongde Jiang, Mingchun Wen, Zhenfeng Wu, Minyu Zha, Wen Xu, Liang Zhang
Summary: This study compared the effects of storage years on the chemical composition and bioactivity of Citrus reticulata Chachi peel. The content of hesperidin decreased, while nobiletin, 3,5,6,7,8,3 ',4 '-heptamethoxyflavone, and tangeretin increased with the increase of storage time. The antioxidant activity of the peel was enhanced. Phenolic acids, flavonol glycosides, fatty acids, and alkyl glycosides were marker compounds for distinguishing the storage time of the peel.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
N. Wan, Y. Li, X. Y. Huang, Y. H. Li, Q. Zheng, Z. F. Wu
Summary: The chemical composition of Cinnamomum camphora leaves' essential oils from different habitats in China was analyzed using GC-MS, and their antimicrobial activities were evaluated. The study identified 30 compounds, with a predominance of oxygenated monoterpenes. Cluster analysis and principal component analysis showed a correlation between the habitats and the chemical constituents of the essential oils. The essential oil extracted from leaves harvested in Jinxi exhibited the strongest antibacterial property.
Review
Nanoscience & Nanotechnology
Guowang Cheng, Yujing Liu, Rui Ma, Guopan Cheng, Yucheng Guan, Xiaojia Chen, Zhenfeng Wu, Tongkai Chen
Summary: Parkinson's disease (PD) is a neurodegenerative disease that is becoming increasingly prevalent, especially among older individuals. The development of novel anti-PD drugs is urgently needed, but the blood-brain barrier (BBB) poses a challenge due to its selective permeability. Nanotechnology offers a solution by enhancing BBB permeability, and recent research has shown that nanomaterials can improve PD symptoms through their own nano-bio effects.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Analytical
Na Wan, Jing Lan, Zhenfeng Wu, Xinying Chen, Qin Zheng, Xingchu Gong
Summary: In this study, the steam distillation process of volatile oil from Angelicae sinensis Radix was optimized using quality-by-design concept. By establishing kinetic models and identifying key process parameters, the study provides important insights for the production of Angelicae sinensis Radix volatile oil.
Article
Multidisciplinary Sciences
Guowang Cheng, Xueliang Liu, Yujing Liu, Yao Liu, Rui Ma, Jingshan Luo, Xinyi Zhou, Zhenfeng Wu, Zhuang Liu, Tongkai Chen, Yu Yang
Summary: This study introduces a novel therapeutic approach using ultrasmall nanoscale coordination polymers for the treatment of Parkinson's disease. The NCPs effectively scavenge excessive radicals and suppress neuroinflammation, reducing PD symptoms.
Article
Pharmacology & Pharmacy
Qun Wang, Rui Ma, Piaoxue Liu, Guowang Cheng, Qi Yang, Xiaojia Chen, Zhenfeng Wu, Dongsheng Yuan, Tongkai Chen
Summary: This study developed biodegradable nanoparticles to deliver Ginkgolide B as a treatment for Parkinson's disease. The nanoparticles showed sustained drug release and protected against neuronal cytotoxicity. Pharmacokinetic studies demonstrated higher accumulation of the nanoparticles in plasma and brain. Animal models also showed positive outcomes with this nanoparticle treatment.
Article
Biochemistry & Molecular Biology
Dongyun Guo, Yiqin Yang, Yi Wu, Yang Liu, Lan Cao, Yan Shi, Na Wan, Zhenfeng Wu
Summary: In this study, the chemical components of essential oils from different germplasm resources of Artemisia argyi Folium (A. argyi) were analyzed using electronic nose and GC/MS. The results showed that electronic nose combined with chemometrics can distinguish the essential oils of A. argyi from different germplasm, and GC/MS identified the main bioactive components. The combination of electronic nose, GC/MS, and chemometrics can be used as reliable techniques to identify different germplasm resources of A. argyi, providing reference value for quality evaluation and selection of high-quality varieties.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Analytical
Xinying Chen, Dongyun Guo, Xingchu Gong, Na Wan, Zhenfeng Wu
Summary: In this study, the steam distillation process for extracting volatile oils from Forsythia suspensa and Lonicera japonica was optimized using the concept of quality by design. Critical process parameters, including liquid/material ratio, distillation time, and collection temperature, were identified through literature review and single-factor experiments. A mathematical model was established to quantify the relationship between process parameters, raw material properties, and volatile oil yield, which was validated through a verification experiment. The results showed that the main contribution to the volatile oil came from Forsythia suspensa when it was distilled together with Lonicera japonica, and the volatile oil yield from the combination was not higher than that from Lonicera japonica.
Article
Biochemistry & Molecular Biology
Min Xie, Ying Chen, Yong Sun, Yarou Gao, Zhenfeng Wu, Ruiyu Wu, Rui Li, Shixi Hong, Minyan Wang, Yiping Zou, Hua Zhang, Yaokun Xiong
Summary: Moslae herba is a functional food ingredient or nutraceutical due to its rich bioactive components. The research investigated the effects of different temperatures on the drying characteristics, bioactive compounds, and flavor changes during the hot air-drying process. The results showed that drying at 60 degrees C enhanced the final quality by significantly reducing drying time and maintaining bioactive compounds.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)