Article
Oncology
Thomas C. Wright, Mark H. Stoler, Jim Ranger-Moore, Qijun Fang, Patrick Volkir, Mahboobeh Safaeian, Ruediger Ridder
Summary: Triage strategies are necessary for HPV-based cervical cancer screening, with p16/Ki-67 dual-stained immunocytochemistry showing high sensitivity and specificity in identifying high-risk women. This method allows for safe triaging of HPV-positive women and provides reassurance against pre-cancers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Leticia Torres-Ibarra, Attila T. Lorincz, Cosette M. Wheeler, Jack Cuzick, Rubi Hernandez-Lopez, Donna Spiegelman, Leith Leon-Maldonado, Berenice Rivera-Paredez, Pablo Mendez-Hernandez, Eduardo Lazcano-Ponce, Jorge Salmeron
Summary: The study demonstrates that adjunctive testing of HPV16/18-positive women with DS can greatly reduce unnecessary colposcopy referrals while maintaining acceptable sensitivity for CIN2+ and CIN3+.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Li Yu, Xun Chen, Xubin Liu, Lingyan Fei, Hanyu Ma, Tian Tian, Liantang Wang, Shangwu Chen
Summary: This study evaluated the significance of LBC, HR HPV testing, and p16/ki-67 dual-staining in cervical lesion screening. It found that triple detection can distinguish almost all cervical CIN2+ lesions, improving diagnostic specificity and reducing missed diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Cristina Secosan, Andrea Pasquini, Delia Zahoi, Andrei Motoc, Diana Lungeanu, Oana Balint, Aurora Ilian, Ligia Balulescu, Dorin Grigoras, Laurentiu Pirtea
Summary: The study conducted HPV genotyping and dual-staining for p16/Ki-67 in patients undergoing LEEP for evaluating sensitivity and specificity in diagnosing CIN2+ in patients under 30 years old. The findings indicated that dual-staining p16/Ki-67 alone or in combination with HR-HPV and/or colposcopy showed higher specificity for diagnosing biopsy-confirmed CIN2+ in patients under 30 years old.
Article
Oncology
Mariam El-Zein, Walter Gotlieb, Lucy Gilbert, Robert Hemmings, Marcel A. Behr, Eduardo L. Franco
Summary: The study compared the clinical performance of p16/Ki-67 dual-stained cytology and HPV genotyping in detecting cervical intraepithelial neoplasia. The dual-stained cytology showed higher specificity than HPV testing, while HPV testing exhibited higher sensitivity.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Ying Li, Yunfeng Fu, Bei Cheng, Xing Xie, Xinyu Wang
Summary: The Dalton p16/Ki-67 Dual Stain kit demonstrates a lower false positive rate and better efficacy in identifying high-grade cervical intraepithelial neoplasia (CIN) than the CINtec(R) PLUS test in triaging HPV-positive women.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ursula Salobir Gajsek, Andraz Dovnik, Iztok Takac, Urska Ivanus, Tine Jerman, Simona Sramek Zatler, Alenka Repse Fokter
Summary: The dual p16/Ki-67 immunostaining showed high sensitivity and accuracy in detecting CIN2+, with the number of positive cells significantly associated with the probability of CIN2+ detection. Adjusting the cut-off for a positive test from one cell to three cells resulted in a statistically significant and clinically relevant increase in specificity.
RADIOLOGY AND ONCOLOGY
(2021)
Review
Biology
Septimiu Toader Voidazan, Caterina Dianzani, Madalina Aurelia Husariu, Biborka Gered, Sabin Gligore Turdean, Cosmina Cristina Uzun, Zsolt Kovacs, Florin Francisc Rozsnyai, Nicoleta Neagu
Summary: Human papillomaviruses (HPVs) are common sexually transmitted infections responsible for various anogenital and head and neck cancers. Cervical cancer (CC) is the fourth leading cause of death in women with cancer. The progression of a persistent HPV infection to cancer takes 15-20 years and can be preventable through screening. Cervical cytology (Pap smear) is the standard screening test for CC and precancerous lesions. However, these tests cannot predict progression to CC. Therefore, we summarized current scientific data on the role of p16/Ki-67 immunohistostaining, telomerase, and fibronectin in predicting progression to CC.
Article
Oncology
Maria Magkana, Panagiota Mentzelopoulou, Ekaterini Magkana, Andreas Pampanos, Nikolaos Vrachnis, Eleni Kalafati, Georgios Daskalakis, Ekaterini Domali, Nikolaos Thomakos, Alexandros Rodolakis, Nicholas P. Anagnou, Kalliopi Pappa
Summary: p16/Ki-67 dual staining is a highly efficient method for risk stratification of women with mild cervical abnormalities, which can reduce the number of colposcopies required.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Frederique J. Vink, Stefanie Dick, Danielle A. M. Heideman, Lise M. A. De Strooper, Renske D. M. Steenbergen, Birgit I. Lissenberg-Witte, Arno Floore, Jesper H. Bonde, Anja Ostrbenk Valencak, Mario Poljak, Karl U. Petry, Peter Hillemanns, Nienke E. van Trommel, Johannes Berkhof, Maaike C. G. Bleeker, Chris J. L. M. Meijer
Summary: This study evaluates the immunohistochemical expression of p16(ink4a) and Ki-67, known as the immunoscore (IS), in relation to HPV E4 expression and FAM19A4/miR124-2 methylation in high-grade CIN lesions. The findings suggest that these biomarker profiles may help clinicians in decision-making regarding immediate treatment or observation to avoid unnecessary overtreatment of high-grade CIN lesions.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Fangbin Song, Peisha Yan, Xia Huang, Chun Wang, Xinfeng Qu, Hui Du, Ruifang Wu
Summary: HPV genotyping for HPV16/33 could be utilized to optimize the management of HPV-positive, cytology-negative women. Moreover, p16 immunostaining, either alone or combined with extended genotypes, is more effective than HPV genotypes alone in the triage of HPV-positive, cytology-negative women.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Howard D. Strickler, Marla J. Keller, Nancy A. Hessol, Isam-Eldin Eltoum, Mark H. Einstein, Philip E. Castle, L. Stewart Massad, Lisa Flowers, Lisa Rahangdale, Jessica M. Atrio, Catalina Ramirez, Howard Minkoff, Adaora A. Adimora, Igho Ofotokun, Christine Colie, Megan J. Huchko, Margaret Fischl, Rodney Wright, Gypsyamber D'Souza, Jason Leider, Olga Diaz, Lorraine Sanchez-Keeland, Sadeep Shrestha, Xianhong Xie, Xiaonan Xue, Kathryn Anastos, Joel M. Palefsky, Robert D. Burk
Summary: The study found that in women living with HIV, primary human papillomavirus screening (PHS) combined with reflex HPV16/18 genotyping can reduce unnecessary colposcopies, potentially serving as an alternative to co-testing.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Grazyna Stanczuk, Heather Currie, William Forson, Gwendoline Baxter, James Lawrence, Allan Wilson, Timothy Palmer, Marc Arbyn, Kate Cuschieri
Summary: This study evaluates the long-term performance of p16/Ki-67 dual stain cytology (DS) for high-risk HPV (Hr-HPV+) women and suggests that a two-step triage with HPV 16/18 genotyping before LBC or DS can reduce the risk of significant disease in follow-up.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Noely P. C. Lorenzi, Lara Termini, Edson S. Ferreira-Filho, Rafaella A. L. Nunes, Gabriela A. F. Silva, Ana P. Lepique, Adhemar Longatto-Filho, Maricy Tacla, Edmund C. Baracat, Luisa L. Villa, Jose M. Soares-Junior
Summary: The study found that HR-HPV testing based on self-collection is as accurate as testing based on collection by health professionals in detecting women at risk for cervical cancer. Additionally, there was no significant difference in accuracy between self-collected samples when combined with biomarker testing compared to samples collected by health professionals.
CANCER CYTOPATHOLOGY
(2022)
Article
Oncology
Yu Dai, Tingting Chen, Xinyue Li, Changning Zhang, Tingyuan Li, Yuqian Zhao, Yakun Wang, Simiao Chen, Lulu Yu, Mingyue Jiang, Zeni Wu, Jinghong Yang, Wen Chen
Summary: This study found that p16/Ki-67 dual staining showed variations in detecting cervical lesions between premenopausal and postmenopausal women. The accuracy and specificity of this test were higher in premenopausal women compared to postmenopausal women. For women with HR-HPV infection, especially premenopausal women, p16/Ki-67 performed better in identifying cervical CIN2/3 and ASC-US/LSIL lesions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Li Xie, Ying Qian, Yishan Liu, Yixuan Li, Sinong Jia, Herbert Yu, Chunfang Wang, Biyun Qian, Pingping Bao
Article
Dentistry, Oral Surgery & Medicine
Z. Y. Sun, Y. M. Chen, L. Xie, X. Yang, T. Ji
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Oncology
Ying Qian, Li Xie, Lei Li, Tienan Feng, Tengteng Zhu, Ruoyang Wang, Yuqing Yang, Baosen Zhou, Herbert Yu, Biyun Qian
Summary: This study identified an SNP rs12233719 related to SHBG concentrations that was associated with the risk of never-smoking female lung cancer, potentially explaining susceptibility to NSCLC in Chinese women.
Article
Pathology
Sinong Jia, Li Xie, Lei Li, Ying Qian, Jie Wang, Suna Wang, Weituo Zhang, Biyun Qian
Summary: Liquid biopsy has relatively low sensitivity and high specificity in cancer early detection, with cfDNA potentially showing promising value.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Pharmacology & Pharmacy
Jie Wang, Jing Gao, Hong-li Xu, Ying Qian, Li Xie, Herbert Yu, Bi-yun Qian
Summary: This study found a negative association between Citrus fruit intake and lung cancer risk. Moreover, there was a nonlinear dose-response relationship between Citrus intake and lung cancer risk within a certain range.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Chuqing He, Xiaoqing He, Yan Liang, Taotao Sun, Li Yan, Chenfeng Zhu, Xiaoya Zhao, Li Xie, Ben W. Mol, Jian Zhang, J. A. F. Huirne
Summary: This study aims to compare the efficacy of LNG-IUS 52 mg and hysteroscopic niche resection in improving niche-related postmenstrual spotting in a randomized controlled trial involving 208 participants. The primary outcome is the reduction of postmenstrual spotting at 6 months post-randomization, with secondary outcomes including menstrual patterns, blood loss, and complications.
Article
Pathology
Li Xie, Xuedong Du, Suna Wang, Peng Shi, Ying Qian, Weituo Zhang, Xing Tang, Yue Lin, Jie Chen, Lan Peng, Chris Chang Yu, Biyun Qian
Summary: The study evaluated the value of a blood test, CDA (TM), in distinguishing blood samples of healthy individuals from those of cancer patients in routine health checkups. The test showed high specificity and moderate sensitivity, providing an effective way to rapidly and reliably screen healthy individuals from cancer patients in a health checkup setting.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Medicine, General & Internal
Chun Yang, Jiyuan Hui, Li Xie, Junfeng Feng, Jiyao Jiang
Summary: This multicentre observational study aims to evaluate different surgical treatments for acute epidural haematoma (AEDH). The study will collect comprehensive data including clinical information, radiological information, and follow-up data. The primary outcome is the patient's recovery status 6 months after the injury.
Review
Medicine, General & Internal
Zixuan Ma, Jiyuan Hui, Chun Yang, Jiyao Jiang, Li Xie, Junfeng Feng
Summary: This article aims to provide a comprehensive analysis of risk factors and trends in in-hospital mortality among elderly TBI patients through systematic review and meta-analysis. The study will include recent research data and analyze risk factors such as age, gender, cause of injury, severity of injury, neurosurgical intervention, and preinjury antithrombotic therapy. Dose-response meta-analysis for the relationship between age and in-hospital mortality risk will be conducted if sufficient data is available.
Article
Oncology
Weituo Zhang, Xinwei Yun, Tianyu Xu, Xiaoqing Wang, Qiang Li, Tiantian Zhang, Li Xie, Suna Wang, Dapeng Li, Xi Wei, Yang Yu, Biyun Qian
Summary: This study developed an integrated gene profiling model combining expression, SNV, and fusion to predict lymph node metastasis in patients with papillary thyroid cancer. The model showed superior performance compared to single gene expression or mutation classifiers, as well as the TIRADS score. The machine-learning method utilized in this study significantly improved risk stratification of thyroid cancer, aiding in decision-making and reducing unnecessary surgeries.
Article
Medicine, General & Internal
Guiling Liang, Qian Zhu, Xiaoqing He, Xiaofeng Wang, Ling Jiang, Chenfeng Zhu, Li Xie, Zhaoxia Qian, Jian Zhang