Article
Oncology
Leticia Torres-Ibarra, Attila T. Lorincz, Cosette M. Wheeler, Jack Cuzick, Rubi Hernandez-Lopez, Donna Spiegelman, Leith Leon-Maldonado, Berenice Rivera-Paredez, Pablo Mendez-Hernandez, Eduardo Lazcano-Ponce, Jorge Salmeron
Summary: The study demonstrates that adjunctive testing of HPV16/18-positive women with DS can greatly reduce unnecessary colposcopy referrals while maintaining acceptable sensitivity for CIN2+ and CIN3+.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Ying Li, Yunfeng Fu, Bei Cheng, Xing Xie, Xinyu Wang
Summary: The Dalton p16/Ki-67 Dual Stain kit demonstrates a lower false positive rate and better efficacy in identifying high-grade cervical intraepithelial neoplasia (CIN) than the CINtec(R) PLUS test in triaging HPV-positive women.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Thomas C. Wright, Mark H. Stoler, Jim Ranger-Moore, Qijun Fang, Patrick Volkir, Mahboobeh Safaeian, Ruediger Ridder
Summary: Triage strategies are necessary for HPV-based cervical cancer screening, with p16/Ki-67 dual-stained immunocytochemistry showing high sensitivity and specificity in identifying high-risk women. This method allows for safe triaging of HPV-positive women and provides reassurance against pre-cancers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Yu Dai, Tingting Chen, Xinyue Li, Changning Zhang, Tingyuan Li, Yuqian Zhao, Yakun Wang, Simiao Chen, Lulu Yu, Mingyue Jiang, Zeni Wu, Jinghong Yang, Wen Chen
Summary: This study found that p16/Ki-67 dual staining showed variations in detecting cervical lesions between premenopausal and postmenopausal women. The accuracy and specificity of this test were higher in premenopausal women compared to postmenopausal women. For women with HR-HPV infection, especially premenopausal women, p16/Ki-67 performed better in identifying cervical CIN2/3 and ASC-US/LSIL lesions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Virology
Natsumi Noji, Kaori Okayama, Mizue Oda, Atsuyoshi Shimada, Mitsuaki Okodo
Summary: The study validated a simple manual microdissection (MMD) maneuver and investigated the HPV infection status of single cells isolated from women with multiple-type infections. The MMD procedure efficiently collected single cells, and most multiple-type infection samples exhibited only one genotype.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kehinde C. Okunade, Kabir Y. Badmos, Austin A. Okoro, Iyabo A. Ademuyiwa, Yusuf A. Oshodi, Adebola Adejimi, Nicholas Awolola, Oluchi Ozonu, Hameed S. Adelabu, Gbenga A. Olorunfemi, Alani I. Akanmu, Adekunbiola S. Banjo, Rose Anorlu, Jonathan Berek
Summary: This study aims to evaluate the application of a new screening method, p16/Ki-67 dual staining technology (DUST), in women living with HIV (WLHIV). The study consists of Phase 1 and Phase 2, comparing the performance of DUST to the current screening methods in detecting high-grade cervical intraepithelial neoplasia (CIN2+) and the persistence and progression of CIN1. The findings of this study may provide evidence for improving the screening method and predictive accuracy in WLHIV.
Article
Oncology
Matejka Rebolj, Christopher S. Mathews, Francesca Pesola, Alejandra Castanon, Henry Kitchener
Summary: International cervical screening guidelines suggest that high-risk human papillomavirus (HR-HPV) testing is more effective than liquid-based cytology (LBC) for diagnosing cervical cancer in women aged 24 to 29, as it not only accelerates cancer diagnosis, but also increases the detection of CIN2/3.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Pathology
Yuxin Liu, W. Glenn McCluggage, Teresa M. Darragh, Nada Farhat, Morgan Blakely, Keith Sigel, Wenxin Zheng, William H. Westra, Michael M. Gaisa
Summary: p16 is a valuable diagnostic marker for HPV-associated anogenital lesions, especially for identifying AIN 2/3. Its immunoreactivity correlates well with morphologic diagnoses in the anal region, where block staining offers optimal diagnostic value for AIN 2/3.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Li Yu, Xun Chen, Xubin Liu, Lingyan Fei, Hanyu Ma, Tian Tian, Liantang Wang, Shangwu Chen
Summary: This study evaluated the significance of LBC, HR HPV testing, and p16/ki-67 dual-staining in cervical lesion screening. It found that triple detection can distinguish almost all cervical CIN2+ lesions, improving diagnostic specificity and reducing missed diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Ursula Salobir Gajsek, Andraz Dovnik, Iztok Takac, Urska Ivanus, Tine Jerman, Simona Sramek Zatler, Alenka Repse Fokter
Summary: The dual p16/Ki-67 immunostaining showed high sensitivity and accuracy in detecting CIN2+, with the number of positive cells significantly associated with the probability of CIN2+ detection. Adjusting the cut-off for a positive test from one cell to three cells resulted in a statistically significant and clinically relevant increase in specificity.
RADIOLOGY AND ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Immunology
Cassandra Laurie, Mariam El-Zein, Joseph Tota, Farzin Khosrow-Khavar, Pierre-Paul Tellier, Francois Coutlee, Alexandra de Pokomandy, Eduardo L. Franco
Summary: The study found that there was no significant difference between carrageenan-based gel and placebo gel in clearing HPV infections among gbMSM. This was true for all infections as well as for specific HPV types and different human immunodeficiency virus statuses.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Erika Hurtado-Salgado, Eduardo Ortiz-Panozo, Jorge Salmeron, Rufino Luna-Gordillo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This article examines the prevalence of cervical high-risk human papillomavirus infection in a middle-income country, and explores variation by age, community marginalization, and region. The results provide valuable evidence for developing policies to improve cervical cancer screening strategies.
CANCER CAUSES & CONTROL
(2023)
Review
Oncology
Matti Lehtinen, Ville N. Pimenoff, Belinda Nedjai, Karolina Louvanto, Lisanne Verhoef, Danielle A. M. Heideman, Mariam El-Zein, Martin Widschwendter, Joakim Dillner
Summary: This article is based on a recent scientific session that discussed the risk assessment of cervical cancer in the post-vaccination era. The study highlighted the impact of decreasing prevalence of vaccine-targeted high-risk HPV types on the triage methods for cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL). The research emphasized the importance of evaluating new triage modalities in vaccinated women with CIN/SIL associated with nonvaccine HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
Samantha Morais, Michel D. Wissing, Farzin Khosrow-Khavar, Ann N. Burchell, Pierre-Paul Tellier, Francois Coutlee, Tim Waterboer, Mariam El-Zein, Eduardo L. Franco
Summary: We analyzed the humoral response to natural HPV infection in unvaccinated women and found that the associations between HPV-specific antibodies depended on phylogenetic relatedness.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Wei (Vivian) Wang, Smita Kothari, Hanane Khoury, Linda Niccolai, Suzanne M. Garland, Karin Sundstrom, Gerard de Pouvourville, Paolo Bonanni, Ya-Ting Chen, Eduardo L. Franco
Summary: Assessing progress towards global elimination of cervical cancer requires monitoring vaccination coverage and its impact. A review of HPV-related data systems from seven high-income countries revealed differences in development approach, geographical scope, and data collection methods. The information provided by these data systems can inform improvements to existing prevention programs and the implementation of new programs in other countries.
EXPERT REVIEW OF VACCINES
(2023)
Review
Biology
Parker Tope, Eliya Farah, Rami Ali, Mariam El-Zein, Wilson H. Miller, Eduardo L. Franco
Summary: This study provides a systematic review of pre-pandemic evidence on the association between lag time to cancer diagnosis and treatment and mortality- and morbidity-related outcomes. The results highlight the importance of lag time in cancer care and emphasize the need for standardized methodology in lag time research.
Article
Oncology
Talla Malagon, Samantha Morais, Parker Tope, Mariam El-Zein, Eduardo L. Franco
Summary: By linking data, the study found that non-White racial groups have higher site-specific cancer incidence rates than the overall population. Immigration status is an important modifier of cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Medicine, General & Internal
Cassandra Laurie, Mariam El-Zein, Sarah Botting-Provost, Joseph E. Tota, Pierre-Paul Tellier, Francois Coutlee, Ann N. Burchell, Eduardo L. Franco
Summary: The use of a carrageenan-based gel can reduce the risk of incident genital HPV infections in women without increasing adverse events, which may complement HPV vaccination.
Article
Oncology
Parker Tope, Samantha Morais, Mariam El-Zein, Eduardo L. Franco, Talia Malagon
Summary: Income, a component of socioeconomic status, influences cancer risk as a social determinant of health. This study evaluated the independent associations between individual- and area-level income and site-specific cancer incidence in Canada. The findings suggest that individual- and area-level income have significant effects on cancer incidence, with lower income associated with higher rates of certain cancers and wealthier income associated with higher rates of other cancers.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mariam El-Zein, David Cheishvili, Moshe Szyf, Eduardo L. Franco
Summary: In this study, new methylation markers were identified and validated for their role in cervical intraepithelial neoplasia (CIN) grades and cervical cancer. The methylation state of CA10, DPP10, FMN2 and HAS1 genes were evaluated in independent study populations using next-generation sequencing. The Marker Polygenic Score (MPS) calculated from these genes accurately predicted cervical cancer and showed potential for use in clinical settings. Further evaluation of these biomarkers in prospective studies is needed.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Biology
Eduardo L. Franco, Diane M. Harper
Summary: eLife has released a special issue that discusses the impact of the COVID-19 pandemic on cancer prevention, control, care, and survivorship.
Article
Biology
Mariam El-Zein, Rami Ali, Eliya Farah, Sarah Botting-Provost, Eduardo L. Franco
Summary: This study investigated the effects of the COVID-19 pandemic on cervical cancer screening activities. The survey results showed high cancellation rates for screening appointments and consistent decreases in the number of screening Pap tests and colposcopy procedures across provinces. Approximately 90% of healthcare professionals adopted telemedicine for patient communication.
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)