Article
Engineering, Multidisciplinary
Chae Syng Lee, Yajie Zhai, Brian Rodrigues
Summary: The heart relies on fatty acids for energy production, obtained from various sources including lipoprotein lipase (LPL). Diabetes can alter how the heart generates energy, leading to the development of diabetic cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Chae Syng Lee, Yajie Zhai, Rui Shang, Trevor Wong, Aurora J. Mattison, Haoning Howard Cen, James D. Johnson, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
Summary: The study found that flow-induced mechanical forces can increase the release of heparanase from endothelial cells, affecting cardiac metabolism. The release of heparanase is mediated by activation of purinergic receptors and protein kinase D, and is augmented in diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Summary: GPIHBP1 is a crucial partner for LPL in lipolytic processing of lipoproteins, stabilizing LPL structure and preserving activity. It captures LPL and shuttles it to the capillary lumen. The AD of GPIHBP1 accelerates LPL binding, preserves LPL activity, and allows LPL to move across ECs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S. J. Davies
Summary: High plasma TG and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease, regulated in part by ANGPTL3. This study found that ANGPTL8 is not necessary for EL inhibition, indicating that targeting ANGPTL8 for hypertriglyceridemia or cardiovascular disease may have different outcomes than targeting ANGPTL3.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Multidisciplinary Sciences
Wenxin Song, Anne P. Beigneux, Thomas A. Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, Hyesoo Jung, Anh P. Tran, Yiping Tu, Caitlyn Tran, Gabriel Birrane, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Peter Tontonoz, Haibo Jiang, Michael Ploug, Loren G. Fong, Stephen G. Young
Summary: This study reveals that the GPIHBP1-transported LPL can detach and move into the EC glycocalyx, where it plays a role in the intravascular processing of triglyceride-rich lipoproteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Article
Cell Biology
John E. Le Lay, Qun Du, Minal B. Mehta, Nicholas Bhagroo, B. Timothy Hummer, Judith Falloon, Glenn Carlson, Anton Rosenbaum, ChaoYu Jin, Holly Kimko, Lan-Feng Tsai, Steven Novick, Bill Cook, David Han, Chang Yeop Han, Tomas Vaisar, Alan Chait, Sotirios K. Karathanasis, Christopher J. Rhodes, Boaz Hirshberg, Melissa M. Damschroder, Judith Hsia, Joseph S. Grimsby
Summary: HDL levels play a crucial role in cardiovascular disease, and inhibiting endothelial lipase can increase HDL-C, improve lipoprotein profiles, and reduce cardiovascular risk when combined with other medications.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Multidisciplinary Sciences
Melissa Valussi, Johannes Besser, Katharina Wystub-Lis, Sven Zukunft, Manfred Richter, Thomas Kubin, Thomas Boettger, Thomas Braun
Summary: The study demonstrates the importance of miR-1/133a in preventing cardiomyocyte dedifferentiation and cell cycle entry in the adult heart by suppressing FGFR1 and OSMR. Short-term depletion of miR-1/133a protects cardiomyocytes against ischemia, while prolonged loss leads to heart failure. Therefore, miR-1/133a plays a crucial role in maintaining the differentiated state of cardiomyocytes.
Article
Multidisciplinary Sciences
Sean A. Murphy, Matthew Miyamoto, Anais Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S. An, David A. Kass, Hideki Uosaki, Alexandre R. Colas, Chulan Kwon
Summary: Cardiomyocyte maturation and the acquisition of phenotypes at the single cell level were analyzed in this study, revealing that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift. The study provides a single-cell roadmap of heterogeneous transitions coupled to cellular features.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Reproductive Biology
Kazuki Takasaki, Takayuki Ichinose, Yuko Miyagawa, Shiho Fukui, Kei Hashimoto, Haruka Nishida, Yuko Takahashi, Haruko Hiraike, Koji Saito, Yuko Sasajima, Kazunori Nagasaka
Summary: This study investigated two cases of granulosa cell tumors (GCTs) to find a biomarker for evaluating treatment and predicting recurrence. The findings suggest that serum vascular endothelial growth factor (VEGF) levels can be used as a clinical biomarker for disease progression in GCTs and to determine the efficacy of bevacizumab therapy.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Hematology
Amy Pei-Ling Chiu, Andrea Wan, Nathaniel Lal, Dahai Zhang, Fulong Wang, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Ying Wang, Brian Rodrigues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2015)
Article
Cardiac & Cardiovascular Systems
Haibo Li, Yingchun Han, Rong Qi, Yuhui Wang, Xiaohong Zhang, Maomao Yu, Yin Tang, Mengyu Wang, Ya-Nan Shu, Wei Huang, Xinfeng Liu, Brian Rodrigues, Mei Han, George Liu
CARDIOVASCULAR RESEARCH
(2015)
Review
Medical Laboratory Technology
Prasanth Puthanveetil, Andrea Wan, Brian Rodrigues
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2015)
Review
Biochemistry & Molecular Biology
Amy Pei-Ling Chiu, Andrea Wan, Brian Rodrigues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Cardiac & Cardiovascular Systems
Fulong Wang, Jocelyn Jia, Nathaniel Lal, Dahai Zhang, Amy Pei-Ling Chiu, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
CARDIOVASCULAR RESEARCH
(2016)
Article
Endocrinology & Metabolism
Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D. Johnson, Timothy J. Kieffer, Bahira Hussein, Brian Rodrigues
Article
Cardiac & Cardiovascular Systems
Amy Pei-Ling Chiu, Denise Bierende, Nathaniel Lal, Fulong Wang, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Melissa M. Page, Sos Skovso, Haoning Cen, Amy P. Chiu, Derek A. Dionne, Daria F. Hutchinson, Gareth E. Lim, Marta Szabat, Stephane Flibotte, Sunita Sinha, Corey Nislow, Brian Rodrigues, James D. Johnson
Article
Endocrinology & Metabolism
Ying Wang, Amy Pei-Ling Chiu, Katharina Neumaier, Fulong Wang, Dahai Zhang, Bahira Hussein, Nathaniel Lal, Andrea Wan, George Liu, Israel Vlodavsky, Brian Rodrigues
Article
Cardiac & Cardiovascular Systems
Fulong Wang, Thomas Pulinilkunnil, Stephane Flibotte, Corey Nislow, Israel Vlodaysky, Bahira Hussein, Brian Rodrigues
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Karanjit Puri, Nathaniel Lal, Rui Shang, Sanjoy Ghosh, Stephane Flibotte, Roger Dyer, Bahira Hussein, Brian Rodrigues
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Review
Cardiac & Cardiovascular Systems
Fulong Wang, Jocelyn Jia, Brian Rodrigues
CANADIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Nathaniel Lal, Amy Pei-Ling Chiu, Fulong Wang, Dahai Zhang, Jocelyn Jia, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)