Regio‐ and Enantioselective Synthesis of Trifluoromethyl‐Substituted Homoallylic α‐Tertiary NH 2 ‐Amines by Reactions Facilitated by a Threonine‐Based Boron‐Containing Catalyst

Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives

(2019) Volodymyr Sukach et al.   ORGANIC LETTERS

Enantioselective Friedel–Crafts Alkylation Reaction of Heteroarenes with N‐Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

(2019) Masamichi Miyagawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Addition of an Allyl Group to Ketones Containing a Tri-, a Di-, or a Monohalomethyl Moiety. Stereochemical Control Based on Distinctive Electronic and Steric Attributes of C–Cl, C–Br, and C–F Bonds

(2019) Diana C. Fager et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Umpolung Allylation/2-Aza-Cope Rearrangement for the Construction of α-Tetrasubstituted α-Trifluoromethyl Homoallylic Amines

(2019) Chong Shen et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of α-Tetrasubstituted α-Trifluoromethyl Homoallylic Amines by Ir-Catalyzed Umpolung Allylation of Imines

(2019) Yingwei Wang et al.   ORGANIC LETTERS

Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin

(2019) Jinbin Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Catalytic Allylation of Acyclic Ketiminoesters: Synthesis of α-Fully-Substituted Amino Esters

(2019) Urmibhusan Bhakta et al.   ORGANIC LETTERS

A Catalytic Approach for Enantioselective Synthesis of Homoallylic Alcohols Bearing a Z-Alkenyl Chloride or Trifluoromethyl Group. A Concise and Protecting Group-Free Synthesis of Mycothiazole

(2019) Ryan J. Morrison et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

γ-, Diastereo-, and Enantioselective Addition of MEMO-Substituted Allylboron Compounds to Aldimines Catalyzed by Organoboron-Ammonium Complexes

(2018) Amir H. Hoveyda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Catalytic Asymmetric Vinylogous Additions of α,β- and β,γ-Butenolides to Polyfluorinated Alkynyl Ketimines

(2018) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of transition state stabilization by non-covalent interactions in organocatalysis: application of atomic and functional-group partitioned symmetry-adapted perturbation theory to the addition of organoboron reagents to fluoroketones

(2018) Brandon W. Bakr et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Control of chemoselectivity in asymmetric tandem reactions: Direct synthesis of chiral amines bearing nonadjacent stereocenters

(2018) Zhe Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel-Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

(2018) Ryohei Yonesaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Use of a (β-Amidoallyl)boronate as a Nucleophilic Reagent in Catalytic Enantioselective Addition to Isatins

(2017) Tetsuya Sengoku et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Practical, Broadly Applicable, α-Selective, Z-Selective, Diastereoselective, and Enantioselective Addition of Allylboron Compounds to Mono-, Di-, Tri-, and Polyfluoroalkyl Ketones

(2017) Farid W. van der Mei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis

(2017) Thach T. Nguyen et al.   NATURE

Catalytic diastereo- and enantioselective additions of versatile allyl groups to N–H ketimines

(2017) Hwanjong Jang et al.   Nature Chemistry

α-Trifluoromethylated tertiary homoallylic amines: diastereoselective synthesis and conversion into β-aminoesters, γ- and δ-aminoalcohols, azetidines and pyrrolidines

(2017) Fabienne Grellepois et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphine-Catalyzed Asymmetric Synthesis of α-Quaternary Amine via Umpolung γ-Addition of Ketimines to Allenoates

(2017) Peng Chen et al.   ORGANIC LETTERS

Lewis Acid Catalyzed Borotropic Shifts in the Design of Diastereo- and Enantioselective γ-Additions of Allylboron Moieties to Aldimines

(2016) Farid W. van der Mei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-Catalyzed Asymmetric Umpolung Addition of Trifluoromethyl Ketimines to Morita-Baylis-Hillman Carbonates

(2016) Peng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical and Broadly Applicable Catalytic Enantioselective Additions of Allyl-B(pin) Compounds to Ketones and α-Ketoesters

(2016) Daniel W. Robbins et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis

(2016) Ming Joo Koh et al.   NATURE

Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions

(2016) KyungA Lee et al.   Nature Chemistry

Catalytic asymmetric umpolung reactions of imines

(2015) Yongwei Wu et al.   NATURE

Double-Bond Isomerization: Highly Reactive Nickel Catalyst Applied in the Synthesis of the Pheromone (9Z,12Z)-Tetradeca-9,12-dienyl Acetate

(2015) Felicia Weber et al.   ORGANIC LETTERS

Highly Enantioselective Construction of Fluoroalkylated Quaternary Stereocenters via Organocatalytic Dehydrated Mannich Reaction of Unprotected Hemiaminals with Ketones

(2015) Sheng Zhang et al.   ORGANIC LETTERS

An Efficient, Practical, and Enantioselective Method for Synthesis of Homoallenylamides Catalyzed by an Aminoalcohol-Derived, Boron-Based Catalyst

(2014) Hao Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective N-Heterocyclic Carbene Catalyzed Aza-Benzoin Reaction of Enals with Activated Ketimines

(2013) Li-Hui Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly efficient asymmetric construction of quaternary carbon-containing homoallylic and homopropargylic amines

(2013) Tao Guo et al.   CHEMICAL COMMUNICATIONS

Simple organic molecules as catalysts for enantioselective synthesis of amines and alcohols

(2013) Daniel L. Silverio et al.   NATURE

Highly enantioselective zinc/BINOL-catalyzed alkynylation of α-ketoimine ester: a new entry to optically active quaternary α-CF3α-amino acids

(2011) Gaochao Huang et al.   CHEMICAL COMMUNICATIONS

Quaternary centres bearing nitrogen (α-tertiary amines) as products of molecular rearrangements

(2011) Jonathan Clayden et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines

(2011) Miguel Yus et al.   CHEMICAL REVIEWS

Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update

(2011) Shu̅ Kobayashi et al.   CHEMICAL REVIEWS

Highly Diastereoselective and Stereodivergent Dihydroxylations of Acyclic Allylic Amines: Application to the Asymmetric Synthesis of 3,6-Dideoxy-3-amino-l-talose

(2011) Kristína Csatayová et al.   ORGANIC LETTERS

Enantioselective Organocatalytic Synthesis of Quaternary α-Amino Acids Bearing a CF3Moiety

(2011) Ralph Husmann et al.   ORGANIC LETTERS

N-(Heteroarenesulfonyl)prolinamides-Catalyzed Aldol Reaction between Acetone and Aryl Trihalomethyl Ketones

(2011) Noriyuki Hara et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect

(2011) Yun-Lin Liu et al.   ORGANIC LETTERS

Highly Enantioselective Construction of a Quaternary Carbon Center of Dihydroquinazoline by Asymmetric Mannich Reaction and Chiral Recognition

(2008) Biao Jiang et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Tertiary Alcohols and α-Tertiary Amines via Cu-Catalyzed C−C Bond Formation to Ketones and Ketimines

(2008) Masakatsu Shibasaki et al.   CHEMICAL REVIEWS

Catalytic Asymmetric Alkylations of Ketoimines. Enantioselective Synthesis ofN-Substituted Quaternary Carbon Stereogenic Centers by Zr-Catalyzed Additions of Dialkylzinc Reagents to Aryl-, Alkyl-, and Trifluoroalkyl-Substituted Ketoimines

(2008) Peng Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ammonium-directed dihydroxylation of 3-aminocyclohex-1-enes: development of a metal-free dihydroxylation protocol

(2008) Caroline Aciro et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Convenient enantioselective synthesis of β-trifluoromethyl-β-aminoketones by organocatalytic asymmetric Mannich reaction of aryl trifluoromethyl ketimines with acetone

(2008) Volodymyr A. Sukach et al.   TETRAHEDRON-ASYMMETRY