TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation

Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation

(2019) Hongjin Qu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Fibroblast–Matrix Cross-Talk in Idiopathic Pulmonary Fibrosis: Cross-Links at the Crossroads

(2018) Peter Bitterman   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation

(2018) Raymond S. Oh et al.   JOURNAL OF CELL SCIENCE

Targeting IRF3 as a YAP agonist therapy against gastric cancer

(2018) Shi Jiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

(2018) Jin Xu et al.   Scientific Reports

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

(2018) Satoshi Noguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

(2018) Yujie Deng et al.   Nature Communications

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation

(2017) Matan Shanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting Life Expectancy for Pirfenidone in Idiopathic Pulmonary Fibrosis

(2017) Mark Fisher et al.   Journal of Managed Care & Specialty Pharmacy

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacological management of IPF

(2016) Raphael Borie et al.   RESPIROLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TBK1 inhibitors: a review of patent literature (2011 – 2014)

(2015) Tao Yu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Matrix Biology of Idiopathic Pulmonary Fibrosis

(2014) Victor J. Thannickal et al.   AMERICAN JOURNAL OF PATHOLOGY

Cigarette smoke enhances proliferation and extracellular matrix deposition by human fetal airway smooth muscle

(2014) Elizabeth R. Vogel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

Inhibition of TBK1 attenuates radiation-induced epithelial–mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1

(2014) Wen Liu et al.   LABORATORY INVESTIGATION

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Synthesis and structure–activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

(2012) Edward G. McIver et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TRAF6-Dependent Act1 Phosphorylation by the I B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF- B Activation

(2012) F. Qu et al.   MOLECULAR AND CELLULAR BIOLOGY

TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

(2012) Alice C. Newman et al.   PLoS One

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

I B Kinase  -Dependent Phosphorylation and Degradation of X-Linked Inhibitor of Apoptosis Sensitizes Cells to Virus-Induced Apoptosis

(2011) P. Nakhaei et al.   JOURNAL OF VIROLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY