标题
YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 11, Pages 3674
出版商
MDPI AG
发表日期
2018-11-22
DOI
10.3390/ijms19113674
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
- (2018) Helena J. Janse van Rensburg et al. CANCER RESEARCH
- Wnt signalling: conquering complexity
- (2018) Katrin E. Wiese et al. DEVELOPMENT
- Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype
- (2018) Sandybell Anorga et al. FASEB JOURNAL
- Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells
- (2018) Kuo Du et al. GASTROENTEROLOGY
- A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy
- (2018) Masahiro Shibata et al. INTERNATIONAL JOURNAL OF CANCER
- TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
- (2018) Laia Caja et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
- (2018) Tetsuo Toyama et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Paving the Rho in cancer metastasis: Rho GTPases and beyond
- (2018) Sepp Jansen et al. PHARMACOLOGY & THERAPEUTICS
- Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
- (2018) Yoonmi Lee et al. Nature Communications
- YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity
- (2018) Xuhao Ni et al. Cancer Discovery
- YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma
- (2018) Min Hwan Kim et al. Cancer Immunology Research
- Lung cancer and interstitial lung disease: a literature review
- (2018) Jean-Marc Naccache et al. Journal of Thoracic Disease
- YAP/TAZ Activation as a Target for Treating Metastatic Cancer
- (2018) Janine Warren et al. Cancers
- Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
- (2018) Sayan Chakraborty et al. Cancers
- TGF-β Signaling in Lung Health and Disease
- (2018) Akira Saito et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Long noncoding RNA TUG1 promotes cell proliferation and migration of renal cell carcinoma via regulation of YAP
- (2018) Shan Liu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
- (2018) Francesca Zanconato et al. NATURE MEDICINE
- Intracellular and extracellular TGF-β signaling in cancer: some recent topics
- (2018) Kohei Miyazono et al. Frontiers of Medicine
- PRKCI promotes immune suppression in ovarian cancer
- (2017) Sharmistha Sarkar et al. GENES & DEVELOPMENT
- Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics
- (2017) Charles T. Foster et al. GENES & DEVELOPMENT
- Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma
- (2017) Wantae Kim et al. GUT
- TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism
- (2017) Maria Zena Miranda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin
- (2017) Hiba Sabra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
- (2017) J Feng et al. ONCOGENE
- Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome
- (2017) Agnieszka Rybarczyk et al. ONCOLOGY REPORTS
- YAP-mediated mechanotransduction determines the podocyte’s response to damage
- (2017) Markus M. Rinschen et al. Science Signaling
- Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
- (2017) Alexandros Glentis et al. Nature Communications
- YAP regulates cell mechanics by controlling focal adhesion assembly
- (2017) Giorgia Nardone et al. Nature Communications
- Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells
- (2017) Matthew L. Fisher et al. Oncotarget
- Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo
- (2017) Xing Lv et al. Oncotarget
- Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway
- (2017) Sayan Chakraborty et al. Cell Reports
- YAP-mediated mechanotransduction determines the podocyte’s response to damage
- (2017) Markus M. Rinschen et al. Science Signaling
- Yes-Associated Protein 1 Promotes Adenocarcinoma Growth and Metastasis through Activation of the Receptor Tyrosine Kinase Axl
- (2017) Z-L. Cui et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts
- (2017) Satoshi Noguchi et al. Scientific Reports
- Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity
- (2017) Eleni K. Konstantinou et al. Scientific Reports
- YAP/TAZ at the Roots of Cancer
- (2016) Francesca Zanconato et al. CANCER CELL
- Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
- (2016) Xiaobo Wang et al. Cell Metabolism
- The roles of the Hippo pathway in cancer metastasis
- (2016) Helena J. Janse van Rensburg et al. CELLULAR SIGNALLING
- Mechanisms of Hippo pathway regulation
- (2016) Zhipeng Meng et al. GENES & DEVELOPMENT
- YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis
- (2016) S. G. Szeto et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation
- (2016) Dafni-Eleftheria Pefani et al. MOLECULAR CELL
- Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation
- (2016) Yi Tang et al. NATURE CELL BIOLOGY
- Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
- (2016) Raphael Bueno et al. NATURE GENETICS
- ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types
- (2016) Waltraut Lehmann et al. Nature Communications
- Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
- (2016) R. Mehra et al. Cancer Discovery
- Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells
- (2016) Xiao-Yang Dai et al. Oncotarget
- The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis
- (2016) Eunjeong Seo et al. Scientific Reports
- YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts
- (2015) Bram Piersma et al. AMERICAN JOURNAL OF PATHOLOGY
- Hippo and TGF-β interplay in the lung field
- (2015) Akira Saito et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
- (2015) Fei Liu et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- YAP Promotes Malignant Progression ofLkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin
- (2015) Wenjing Zhang et al. CANCER RESEARCH
- Alternative Wnt Signaling Activates YAP/TAZ
- (2015) Hyun Woo Park et al. CELL
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
- (2015) Fa-Xing Yu et al. CELL
- Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector
- (2015) J. Xu et al. CLINICAL SCIENCE
- YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins
- (2015) Silvia Di Agostino et al. EMBO REPORTS
- β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
- (2015) Jing Cai et al. GENES & DEVELOPMENT
- Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway
- (2015) Nam-Gyun Kim et al. JOURNAL OF CELL BIOLOGY
- Functional and Clinical Evidence That TAZ is a Candidate Oncogene in Hepatocellular Carcinoma
- (2015) Yan Guo et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
- (2015) Inge Mannaerts et al. JOURNAL OF HEPATOLOGY
- Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas
- (2015) Ji-Eun Oh et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
- (2015) Francesca Zanconato et al. NATURE CELL BIOLOGY
- Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
- (2015) Spencer C. Wei et al. NATURE CELL BIOLOGY
- Fibrosis — A Common Pathway to Organ Injury and Failure
- (2015) Don C. Rockey et al. NEW ENGLAND JOURNAL OF MEDICINE
- YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells
- (2015) Namrata Bora-Singhal et al. STEM CELLS
- An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
- (2015) Sayan Chakraborty et al. Nature Communications
- Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
- (2015) Upal Basu-Roy et al. Nature Communications
- Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
- (2015) Hongtan Wu et al. Nature Communications
- Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
- (2015) G. Wang et al. Cancer Discovery
- Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
- (2014) S. Song et al. CANCER RESEARCH
- YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
- (2014) Luca Azzolin et al. CELL
- Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer
- (2014) Avnish Kapoor et al. CELL
- KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
- (2014) Diane D. Shao et al. CELL
- VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
- (2014) Wenjing Zhang et al. CELL RESEARCH
- An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer
- (2014) S. Noguchi et al. CLINICAL CANCER RESEARCH
- YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
- (2014) Boon Chuan Low et al. FEBS LETTERS
- Methylation-associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma
- (2014) KE-HONG CHEN et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells
- (2014) Samantha E. Hiemer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic control of YAP and TAZ by the mevalonate pathway
- (2014) Giovanni Sorrentino et al. NATURE CELL BIOLOGY
- Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
- (2014) Biao Ma et al. NATURE CELL BIOLOGY
- Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression
- (2014) Y-L Hsu et al. ONCOGENE
- TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
- (2014) M Bartucci et al. ONCOGENE
- The Biology of YAP/TAZ: Hippo Signaling and Beyond
- (2014) Stefano Piccolo et al. PHYSIOLOGICAL REVIEWS
- In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival
- (2014) Moritz Menzel et al. Pigment Cell & Melanoma Research
- Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of Clear Cell Renal Cell Carcinoma
- (2014) Ute Schütte et al. Translational Oncology
- Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung
- (2014) Alexander W. Lange et al. Journal of Molecular Cell Biology
- A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response
- (2014) Dan Shao et al. Nature Communications
- Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
- (2014) Michael DeRan et al. Cell Reports
- Expression and Clinical Significance of YAP, TAZ, and AREG in Hepatocellular Carcinoma
- (2014) Su-xia Han et al. Journal of Immunology Research
- Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer
- (2013) Weifan Xiao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
- (2013) Mariaceleste Aragona et al. CELL
- NovelYAP1-TFE3fusion defines a distinct subset of epithelioid hemangioendothelioma
- (2013) Cristina R. Antonescu et al. GENES CHROMOSOMES & CANCER
- Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
- (2013) Yong Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- YAP and TAZ Regulate Skin Wound Healing
- (2013) Min-Jung Lee et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma
- (2013) Flore Nallet-Staub et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
- (2013) Fernando Calvo et al. NATURE CELL BIOLOGY
- Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma
- (2013) M. Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
- (2013) Isabel Serrano et al. Nature Communications
- β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
- (2012) Christian Beyer et al. ANNALS OF THE RHEUMATIC DISEASES
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
- (2012) Fa-Xing Yu et al. CELL
- β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
- (2012) Joseph Rosenbluh et al. CELL
- Role of TAZ as Mediator of Wnt Signaling
- (2012) Luca Azzolin et al. CELL
- Quit your YAPing: a new target for cancer therapy
- (2012) B. Z. Stanger GENES & DEVELOPMENT
- Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
- (2012) B. Zhao et al. GENES & DEVELOPMENT
- Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells
- (2012) Wesley M. Konsavage et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
- (2012) Makiko Fujii et al. JOURNAL OF EXPERIMENTAL MEDICINE
- YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
- (2012) T Mizuno et al. ONCOGENE
- Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation
- (2011) Anna P. Lam et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
- (2011) Michelangelo Cordenonsi et al. CELL
- Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
- (2011) Karin Schlegelmilch et al. CELL
- Hippo pathway regulation by cell morphology and stress fibers
- (2011) K.-I. Wada et al. DEVELOPMENT
- Modulating F-actin organization induces organ growth by affecting the Hippo pathway
- (2011) Leticia Sansores-Garcia et al. EMBO JOURNAL
- Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
- (2011) Jinzhu Duan et al. EMBO JOURNAL
- A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
- (2011) Y. Bao et al. JOURNAL OF BIOCHEMISTRY
- Deregulation of Hippo kinase signalling in Human hepatic malignancies
- (2011) Hua Li et al. LIVER INTERNATIONAL
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
- (2011) R. Navab et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
- (2011) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
- (2011) N.-G. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
- (2011) J. R. Rock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma
- (2011) M. R. Tanas et al. Science Translational Medicine
- The Hippo Signaling Pathway in Development and Cancer
- (2010) Duojia Pan DEVELOPMENTAL CELL
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
- (2010) W. R. Henderson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice
- (2009) Akihisa Mitani et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
- (2009) Kandice R. Levental et al. CELL
- Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]
- (2009) D Gareth R Evans GENETICS IN MEDICINE
- Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis
- (2009) W. He et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
- (2009) Jianmin Zhang et al. NATURE CELL BIOLOGY
- Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
- (2008) M. Ota et al. DEVELOPMENT
- TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
- (2008) Q.-Y. Lei et al. MOLECULAR AND CELLULAR BIOLOGY
- TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
- (2008) Xaralabos Varelas et al. NATURE CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started