Article
Chemistry, Multidisciplinary
Yuan Ding, Zhongquan Sun, Yong Gao, Sitong Zhang, Caixia Yang, Zhefeng Qian, Lulu Jin, Jiaojiao Zhang, Cheng Zeng, Zhengwei Mao, Weilin Wang
Summary: Clinical trials have shown that combining IDO blockade with immunogenic chemotherapy has great potential in cancer therapy. A hybrid nanomedicine was designed to co-deliver an IDO inhibitor and a chemotherapeutic prodrug, effectively activating chemo-immunotherapy and overcoming the immunosuppressive tumor microenvironment, leading to tumor growth suppression.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: Microneedles have emerged as a promising platform for transdermal drug delivery. Recent research has shown the potential of using microneedles in combination with cell therapy to address localized conditions and improve treatment efficacy. This study provides an overview of the recent advances, applications, challenges, and future prospects of microneedle-assisted cell delivery.
Review
Chemistry, Physical
En Ren, Yanfang Wang, Tingxizi Liang, Hanqi Zheng, Jiaqi Shi, Zesheng Cheng, Hongjun Li, Zhen Gu
Summary: Immunogenic cell death (ICD) is a dying state of the cells that can initiate an adaptive immune response. Local drug delivery systems have gained attention as alternatives to overcome the potential toxicity encountered in intravenous administration. This article provides a brief overview of local drug delivery techniques for ICD inducers and discusses their therapeutic capability, historical context, complexities, potential pitfalls, and opportunities in cancer immunotherapy.
Article
Engineering, Environmental
Xinyi Li, Mengjie Ye, Renzhi Huang, Shengxin Hou, Jiming Xu, Wei Qiu, Mengyun Liang, Yuan Gao, Hengbo Zhang, Peng Xue, Yuejun Kang, Xiaoxiao Shi, Zhigang Xu
Summary: This study presents a natural sericin nanoparticle as an immunogenic cell death (ICD) inducer for cancer immunotherapy based on photothermal therapy (PTT). Compared to traditional photodynamic therapy and sonodynamic therapy, this nanoparticle exhibits higher photothermal conversion efficiency, prolonged circulation time, and enhanced therapeutic effect on tumors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Zhilin Li, Xiaoqin Lai, Shiqin Fu, Long Ren, Hao Cai, Hu Zhang, Zhongwei Gu, Xuelei Ma, Kui Luo
Summary: This article reviews the use of nanostructure-based drug delivery systems (NDDSs) to enhance the effectiveness of tumor immunotherapy. By inducing immunogenic cell death (ICD) and releasing danger-associated molecular patterns (DAMPs) and tumor-associated antigens, in combination with chemotherapy, photodynamic therapy, photothermal therapy, and radiotherapy, the tumor immunosuppressive microenvironment can be improved, resulting in increased sensitivity to immunotherapy and reduced side effects.
Article
Chemistry, Multidisciplinary
Zhu Li, Zhaoyou Chu, Juan Yang, Haisheng Qian, Jiangmei Xu, Benjin Chen, Tian Tian, Hao Chen, Yunsheng Xu, Fei Wang
Summary: In this study, a smart micelle system was developed using an amphiphilic copolymer to encapsulate manganese zinc sulfide nanoparticles and triggered release by near infrared light. The micelles effectively enhanced reactive oxygen species generation, leading to immunogenic cell death and improved antitumor immunity in melanoma.
Article
Nanoscience & Nanotechnology
Hui Zhu, Ke Yang, Huan Yao, Xueying Chen, Shujin Yan, Yiman He, Yang Cao, Jie Luo, Dong Wang
Summary: A multifunctional nanoplatform was synthesized for chemo-photothermal therapy, combining immunogenic cell death with checkpoint blockade, to combat triple-negative breast cancer and distant metastasis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Wenpan Li, Yanhao Jiang, Jianqin Lu
Summary: Tumor immunotherapy, specifically tumor immunogenic cell death (ICD), has shown great potential for cancer therapy. Nanoparticles, such as liposomes, nanostructured lipid carriers, and inorganic nanoparticles, have been widely studied as vehicles for delivering ICD inducers. This review summarizes the strategies of different nanoparticles for ICD-induced cancer immunotherapy and discusses their advantages, disadvantages, and potential solutions. It aims to provide insights into the design of effective nanoparticulate systems for the therapeutic delivery of ICD inducers, ultimately promoting the development of ICD-mediated cancer immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Xiaoli Zhang, Shengxin Hou, Mengyun Liang, Jiming Xu, Mengjie Ye, Yuxin Wang, Feiqiu Wen, Zhigang Xu, Sixi Liu
Summary: The research team synthesized iron-doped poly (2,6-diami-nopyridine) nanoparticles with a fusiform morphology and decorated them with the chemotherapeutic drug doxorubicin to create a multimodal therapy-based nanosystem. This nanosystem exhibited good photothermal conversion rate and could increase the temperature of tumor sites, leading to immunogenic cell death and tumor cell apoptosis. The release of doxorubicin was also promoted, achieving synergistic photothermal/chemo therapy in a breast tumor animal model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Ying Tian, Muhammad Rizwan Younis, Yuxia Tang, Xiang Liao, Gang He, Shouju Wang, Zhaogang Teng, Peng Huang, Longjiang Zhang, Guangming Lu
Summary: The study presented a compact and biocompatible platform using IR-780 loaded MPDA, showing high loading capacity, good solubility and stability, reduced toxicity, and efficient tumor accumulation. The combined PDT/PTT of IR-780@MPDA induced ICD, activating cytotoxic T cells for immunotherapeutic response to breast tumor and significantly suppressing tumor growth in vivo. The platform offered multimodal tumor theranostics with negligible systemic toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Xiaoyan Sun, Jiulong Zhang, Jingya Xiu, Xiufeng Zhao, Chunrong Yang, Dan Li, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: A phenolic-based tumor-permeated nano-framework (EGPt-NF) was developed to improve tumor immunogenicity and enhance the efficacy of cancer immunotherapy. This approach induces immunogenic cell death, downregulates PD-L1 expression, and relieves tumor hypoxia, resulting in an increased antitumor immune response and inhibition of primary tumor and metastasis.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shao-Zhe Wang, Yuxin Guo, Xinping Zhang, Hui-Heng Feng, Shun-Yu Wu, Ya-Xuan Zhu, Hao-Ran Jia, Qiu-Yi Duan, Shi-Jie Hao, Fu-Gen Wu
Summary: A mitochondria-targeting "mito-missile" is constructed, which can achieve targeted photodynamic therapy (PDT)/mild-temperature photothermal therapy (MTPTT) as well as immune cell death (ICD)-induced cancer immunotherapy. This study develops a dendrimer-based nanoplatform for realizing mitochondrion-acting PDT/MTPTT and mitochondrial stress-induced potentiated ICD, providing a guideline for designing effective ICD inducers in the future.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Qilin Li, Jia Liu, Huiling Fan, Lin Shi, Yan Deng, Lei Zhao, Mengxi Xiang, Yunruo Xu, Xulin Jiang, Guobin Wang, Lin Wang, Zheng Wang
Summary: This study introduces a nano system that co-delivers immunogenic chemodrugs and IDO inhibitors to cancer cells, effectively reducing immunosuppression and promoting antitumor immune responses. The system shows promising results in preclinical cancer models, indicating its strong translational potential for clinical applications.
Article
Pharmacology & Pharmacy
Zhenzhen Chen, Qian Zhang, Qinbiao Huang, Zhihong Liu, Lingjun Zeng, Lingna Zhang, Xu Chen, Hongtao Song, Jialiang Zhang
Summary: This study presents a new strategy for inducing immunogenic cell death (ICD) using photothermal MnO2 nanoparticles in tumor immunotherapy. By loading the ICD inducer DOX onto the MnO2 nanoparticles, high photothermal conversion efficiency, efficient tumor targeting, TME-responsive release of DOX, and modulation of the hypoxic TME were achieved. The combination of chemo-photothermal therapy-induced ICD and improvement of the immunosuppressive TME showed a significant synergistic therapeutic effect in a mouse model of triple-negative breast carcinoma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Jianchuan Ran, Tao Liu, Chuanhui Song, Zheng Wei, Chuanchao Tang, Zichen Cao, Huihui Zou, Xinyu Zhang, Yu Cai, Wei Han
Summary: This study demonstrates a rhythmically controlled mild-temperature photothermal therapy (mPTT) using organic photothermal nanoparticles. The rhythm mPTT shows improved antitumor efficacy and induction of tumor-specific immune responses. The temperature-dependent release of damage-associated molecular patterns (DAMPs) during mPTT-induced immunogenic cancer cell death (ICD) enhances immune activation. The results suggest that rhythm mPTT has significant potential for clinical applications in tumor treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yuwei Zheng, Yilang Yan, Liming Lin, Qing He, Huihui Hu, Rui Luo, Dongyi Xian, Jieyi Wu, Yin Shi, Fanpu Zeng, Chuanbin Wu, Guilan Quan, Chao Lu
Summary: This study presents a hybrid hydrogel constructed by combining cationic antibiotic ciprofloxacin with Ti3C2 MXene, which demonstrates efficient bactericidal properties and avoids bacterial rebound.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Analytical
Weiwei Cheng, Weijiang Guan, Yanjun Lin, Chao Lu
Summary: The article presents a direct correlation between cataluminescence (CTL) kinetic curve and oxygen species, offering a way to rapidly discriminate and determine adsorbed oxygen and lattice oxygen in catalysts. The CTL method not only matches well with conventional techniques but also has the advantages of convenient operation, fast response, and low cost.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Jintao Fu, Yixian Zhou, Ting Liu, Wenhao Wang, Yiting Zhao, Ying Sun, Yiming Zhang, Wenxuan Qin, Zhongwei Chen, Chao Lu, Guilan Quan, Chuanbin Wu, Xin Pan
Summary: The research team constructed antibacterial nanoreactors that achieved efficient sterilization by overcoming the limitations of pH and H2O2, and combined photothermal therapy and photodynamic therapy to enhance bactericidal efficiency and broaden the antibacterial spectrum, alleviating antibiotic resistance issues.
Article
Engineering, Environmental
Xiaoqian Feng, Dongyi Xian, Jintao Fu, Rui Luo, Wenhao Wang, Yuwei Zheng, Qing He, Zhan Ouyang, Shaobin Fang, Wancong Zhang, Daojun Liu, Shijie Tang, Guilan Quan, Jianfeng Cai, Chuanbin Wu, Chao Lu, Xin Pan
Summary: A vanadium-based MXene composite nanosheet, 4 K10@V2C, was constructed for disease treatment. It integrates membranolytic, photothermal, and photocatalytic abilities, demonstrating efficient bacteria-killing of focal infections. The nanosheets achieved synergistic membranolytic-photothermal effects against biofilm bacteria and showed impressive in vitro antimicrobial activity. The transdermal delivery of the nanosheets eradicated skin infections with high efficacy and minimal toxicity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Maochao Zheng, Xiaolei Wu, Chao Lu, Wancong Zhang, Shijie Tang, Ying Luo, Daojun Liu
Summary: The development of alternative antimicrobial therapeutics is needed due to the emergence of antibiotic resistance in bacterial pathogens. Polypept(o)ide-based bactericides, which mimic antimicrobial host defense peptides, have shown promise in the treatment of antibiotic-resistant and recurring infections. This review summarizes recent advances in membrane-active polypept(o)ide-based bactericides, focusing on their ability to disrupt bacterial cell walls/membranes and combat acquired antibiotic resistance and biofilm formation.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jingwen Deng, Dongyi Xian, Xiaopeng Cai, Shaoxia Liao, Siqin Lei, Fengyan Han, Yandong An, Qing He, Guilan Quan, Chuanbin Wu, Tingting Peng, Chao Lu, Honghe Zhang
Summary: A surface-engineered vanadium carbide MXene nanoenzyme (MXenzyme) with amino functionalization and gallium doping (Ga/V2C-NH2) is developed to inhibit the development of colitis-associated colorectal cancer and provide an efficient anticancer therapy. MXenzymes have shown great potential to decrease excessive reactive oxygen species and inhibit proinflammatory cytokines, resulting in good anti-inflammatory effects on dextran sulfate sodium-induced acute colitis. Moreover, gallium-doped MXene with an amino-functionalized surface can mediate improved MXene-tumor interactions and inhibitory effects on cell proliferation, achieving precise and efficient chemo-photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Maochao Zheng, Qianqian Yang, Chao Lu, Xiaolei Wu, Wei Yan, Daojun Liu
Summary: In this article, promising opportunities in the field of aggregate science for the discovery of novel disease phototheranostics are highlighted. By employing aggregology and the Jablonski energy level diagram, photosensitizer aggregates with adjustable photophysical properties can be formed, leading to customizable diagnosis and treatment modalities. The review focuses on recent advances in the formation of nanostructured organic photosensitizer aggregates, their photophysical processes, and their applications in disease phototheranostics such as fluorescence imaging, photothermal therapy, photoacoustic imaging, and photodynamic therapy. This comprehensive summary is expected to provide guidance for the construction of nanostructured organic photosensitizer aggregates, establishment of aggregation-photophysical property relationships, and development of novel disease phototheranostic nanomedicines.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Multidisciplinary
Dan Yang, Minglong Chen, Ying Sun, Chaonan Shi, Wenhao Wang, Wanchen Zhao, Ting Wen, Ting Liu, Jintao Fu, Chao Lu, Chuanbin Wu, Guilan Quan, Xin Pan
Summary: Despite obstacles in vaccination, a new antitumor vaccine patch called TCV-DMNs has been developed. It effectively suppresses melanoma and promotes regression of established malignancies. This is achieved through the transdermal delivery of GM-CSF and Tat-beclin 1, which recruit dendritic cells and enhance their antigen presentation capabilities through autophagy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Miao Pan, Chao Lu, Wancong Zhang, Huan Huang, Xingyu Shi, Shijie Tang, Daojun Liu
Summary: Anticancer peptides and polymers can interact with tumor cells to overcome multidrug resistance. In this study, PLO-b-PLF block copolypeptides were prepared and self-assembled into polymeric micelles. The cationic micelles interacted with cancer cells via electrostatic interactions and killed them via membrane lysis. To reduce cytotoxicity, anionic PLO(DCA)-b-PLF was designed to recover anticancer activity in the acidic tumor microenvironment. These PLO-based polypeptides have potential applications in drug-free tumor treatment.
Article
Pharmacology & Pharmacy
Ling Jiang, Huan Huang, Xingyu Shi, Jian Wu, Juexian Ye, Qian Xu, Shaobin Fang, Chuanbin Wu, Rui Luo, Chao Lu, Daojun Liu
Summary: With the increasing awareness of food safety, the use of biocompatible antimicrobials to replace toxic pesticides has become a trend. This study introduces a biocontrol microneedle (BMN) system to expand the application of the food-grade preservative e-PL in fruit preservatives. The e-PL-based microneedle patch has good mechanical properties and high drug loading capacity, allowing for enhanced antimicrobial activity in citrus fruit pericarps and reducing the incidence of invasive fungal infections.
Article
Pharmacology & Pharmacy
Minmin Zhang, Beibei Yang, Xuanyu Luan, Ling Jiang, Chao Lu, Chuanbin Wu, Xin Pan, Tingting Peng
Summary: Dissolving microneedles (MNs) have been developed to improve drug-loading and transdermal delivery efficiency, combining the advantages of injection and transdermal preparations. This study systematically investigated the effects of mold production technologies, micromolding technologies, and formulation parameters on the quality of gas-propelled MNs. The optimized gas-propelled MNs achieved higher drug loading and cumulative transdermal permeability compared to passive MNs. These findings provide detailed guidance for preparing high-quality MNs with enhanced productivity and delivery efficiency.
Article
Nanoscience & Nanotechnology
Xinyi Gao, Fapeng Zhang, Yao Huang, Wanshan Hu, Yangyan Chen, Ling Jiang, Xin Pan, Chuanbin Wu, Chao Lu, Tingting Peng
Summary: This study developed a microneedle-mediated open-loop therapy for the management of psoriasis-diabetes comorbidity. By inhibiting the NF-kappa B signaling pathway, this therapy disrupts the crosstalk between inflammation and insulin resistance, resulting in dual anti-inflammatory and antihyperglycemic properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Ling Jiang, Jiaying Chi, Jiahui Wang, Shaobin Fang, Tingting Peng, Guilan Quan, Daojun Liu, Zhongjie Huang, Chao Lu
Summary: An amphiphilic copolymer, PCPZL, was developed to encapsulate SPIO nanocrystals effectively, forming highly loaded SPIO nanoclusters. PCPZL demonstrated enhanced stability and magnetic properties, making it a promising MRI contrast agent for diagnosing liver diseases and cancers.
Article
Materials Science, Multidisciplinary
Meihong Zhang, Yixian Zhou, Biyuan Wu, Chao Lu, Guilan Quan, Zhengwei Huang, Chuanbin Wu, Xin Pan
Summary: Photodynamic therapy selectively kills tumor cells using reactive oxygen species (ROS), but traditional methods lack sufficient ROS. Metal organic frameworks (MOFs) can convert hydrogen peroxide in tumor tissues into ROS and improve efficiency through their unique pores. Furthermore, MOFs can co-deliver photosensitizers and chemotherapeutic drugs for synergistic tumor cell killing.
MATERIALS ADVANCES
(2023)
Article
Chemistry, Analytical
Youkai Yu, Weijiang Guan, Zhiqin Yuan, Chao Lu
Summary: In this study, a cationic surfactant with an intrinsic aggregation-induced emission emitter is used to enhance the chemiluminescent signal. The formed cationic AIEgen micelles enhance the chemiluminescence intensity through two mechanisms: electrostatic attraction-mediated enrichment and high CRET efficiency. This method enables rapid and sensitive H2O2 detection with favorable selectivity. The experimental results are consistent with standard methods.
ANALYTICAL METHODS
(2022)
