Article
Chemistry, Analytical
Lahcen Hssaini, Rachid Razouk, Jamal Charafi, Karim Houmanat, Hafida Hanine
Summary: This study investigated the lipid properties of fig seeds from four cultivars, revealing high oil yield and unsaturation rate. The calculated desaturation pathway ratios and balance between omega-6 and omega-3 in the samples suggest their potential contribution to a healthier diet. The findings highlight the application potential of fig seed oil in food and nutraceutical products.
VIBRATIONAL SPECTROSCOPY
(2021)
Article
Food Science & Technology
Natka Curko, Katarina Lukic, Ana Jurinjak Tusek, Sandra Balbino, Tomislava Vukus Pavicic, Marina Tomasevic, Ivana Radojcic Redonikovic, Karin Kovac Ganic
Summary: The aim of this study was to increase the value of the oil fraction of grape wine pomace by improving oil yield and maintaining quality. Two green extraction methods, including supercritical CO2 extraction and pulsed electric fields assisted supercritical CO2 extraction, were compared with conventional cold pressing. The parameters of pulsed electric fields pretreatment and supercritical CO2 extraction played a crucial role in improving extraction yield and selectively extracting sterols and nonflavonoids.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ali Sabra, Thomas Netticadan, Champa Wijekoon
Summary: Grapes are a rich source of bioactive compounds with antioxidant, anti-inflammatory, and anti-carcinogenic activities. These compounds have wide applications in food and nutraceutical industries, and are linked to reducing the incidence of cardiovascular disease and hypertension.
Article
Plant Sciences
Miguel Angel Rincon-Cervera, Abdallah Lahlou, Tarik Chileh-Chelh, Svetlana Lyashenko, Rosalia Lopez-Ruiz, Jose Luis Guil-Guerrero
Summary: This study analyzed the seeds of 24 Arecaceae species and found that they are rich in fatty acids and phenolic compounds. Some species' seeds can be used as raw materials for healthy oilseed production and have anti-tumor activity. The results suggest that Arecaceae seeds are a cheap source of health-promoting compounds.
Article
Agronomy
Latifa Azaroual, Ali Liazid, Fouad El Mansouri, Jamal Brigui, Ana Ruiz-Rodriguez, Gerardo F. Barbero, Miguel Palma
Summary: A method utilizing microwave-assisted extraction for extracting phenolic compounds from grape seeds and skins was developed and optimized, leading to stable conditions for extraction. The repeatability and intermediate precision of the method were found to be excellent based on the results obtained.
Article
Chemistry, Applied
Svetlana Lyashenko, Maria Jose Gonzalez-Fernandez, Sargilana Borisova, El-Hassan Belarbi, Jose Luis Guil-Guerrero
Summary: This study analyzed seeds from selected Mertensia species for their rich GLA content and minor functional compounds, revealing that Mertensia sibirica and Mertensia maritima spp. asiatica had the highest levels of gamma-linolenic acid. Mertensia sibirica also showed the greatest levels of sterols, phenolics, and tocopherols, making it a potential new source of GLA-rich oils for pharmaceutical and food industries.
Article
Chemistry, Applied
Shyam Sundar, Balwinder Singh, Amritpal Kaur
Summary: This research investigated the effects of hot-air (HAP) and infra-red (IRP) pretreatments on the physicochemical characteristics, phenolic composition, and stability attributes of white (WCO) and black chia seed oil (BCO). Higher HAP and IRP exposure duration and temperature significantly increased phenolic compounds, oxidative stability, and Maillard reaction products, while decreasing L*, b*, chroma, and hue values. HAP at 180°C for 15 min resulted in the highest levels of phenolic acids, flavonoids, and hydroxybenzoic acids in the oil. Additionally, HAP was found to be more effective than IRP in improving oil yield, oxidative stability, and phenolic profile.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Agriculture, Multidisciplinary
Daniel Cozzolino
Summary: Phenolic compounds play a significant role in the quality of grapes and wine. Vibrational spectroscopy techniques have shown value in measuring these compounds, but their adoption is hindered by accessibility and price limitations.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Plant Sciences
Romy Moukarzel, Amber K. Parker, Olaf J. Schelezki, Scott M. Gregan, Brian Jordan
Summary: This study investigates the impact of temperature changes on the microclimate of grapevine bunches during veraison, and the results show significant effects on fresh weight, total soluble solids, anthocyanins, phenolics, and amino acids in grape berries. The accumulation of amino acids increased at mid-ripening and ripening stage with the higher temperature. This study provides valuable insights for developing adaptation strategies for viticulture in the future.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Nutrition & Dietetics
Camelia Munteanu, Mihaela Mihai, Francisc Dulf, Andreea Ona, Leon Muntean, Floricuta Ranga, Camelia Urda, Daria Pop, Tania Mihaiescu, Sorin Marian Marza, Ionel Papuc
Summary: This pilot study investigated the impact of hemp seeds on blood biochemical changes in diabetic rats. The study analyzed the composition, antioxidant activity, and identification of phenols and fatty acids in industrial hemp seeds. The experiment showed that high doses of hemp seeds reduced diabetes-induced biochemical damage in rats, possibly due to their high content of active compounds. Further research is needed to identify the specific hemp compounds responsible for these effects and to conduct longer-term studies for a more comprehensive understanding.
Article
Chemistry, Applied
Esther Gomez-Mejia, Custodio Lobo Roriz, Sandrina A. Heleno, Ricardo Calhelha, Maria Ines Dias, Jose Pinela, Noelia Rosales-Conrado, Maria Eugenia Leon-Gonzalez, Isabel C. F. R. Ferreira, Lillian Barros
Summary: Mulberry seeds are rich in tocopherols while grape seeds are rich in organic acids; grape seeds are characterized by catechin oligomers as the main phenolic compound, while mulberry seeds are characterized by ellagic acid derivatives; Both exhibit high antimicrobial activity and inhibitory effects on oxidation.
Article
Chemistry, Medicinal
Silvia Blanco, Maria Sapatinha, Mick Mackey, Julie Maguire, Simona Paolacci, Susana Goncalves, Helena Maria Lourenco, Rogerio Mendes, Narcisa Maria Bandarra, Carla Pires
Summary: This study aimed to determine the optimal growing season and harvest time for Alaria esculenta to maximize biomass production and quality. Results showed that the biomass production was significantly higher for seaweed deployed in October. The seaweed had a high content of useful bio compounds with antioxidant and anti-hypertensive activities.
Article
Chemistry, Applied
Elenilson G. Alves Filho, Lorena Mara A. Silva, Thamires O. Lima, Paulo R. V. Ribeiro, Cristine S. Vidal, Erika S. S. Carvalho, Janice I. Druzian, Aline T. B. Marques, Kirley M. Canuto
Summary: The study evaluated the impact of grape maturity and maceration time on the chemical composition of wines, as well as their chemical stability. It was found that wines made from unripe grapes had higher levels of phenolic acids and short-chain organic acids, while wines from overripe grapes had increased levels of proanthocyanidins and flavonoids. Stable wines were produced from overripe grapes containing more galacturonic acid.
Article
Plant Sciences
Yara Salem, Hiba N. Rajha, Lambertus A. M. van den Broek, Carl Safi, Arnoud Togtema, Maria Manconi, Maria Letizia Manca, Esperance Debs, Zeina Hobaika, Richard G. Maroun, Nicolas Louka
Summary: Grape seeds from Lebanese autochthonous grape varieties were subjected to multi-step biomass fractionation, resulting in the recovery of lipids, polyphenols, and proteins. The designed zero-waste approach has the potential to improve the valorization of grape seeds from these two Lebanese grape varieties.
Article
Horticulture
Okan Levent
Summary: The present investigation aimed to reveal the differences among almond genotypes in terms of their physicochemical properties, volatile composition, fatty acid, and mineral profile. The results showed significant variations in chemical composition and mineral content among different almond varieties, which could be attributed to their origin.
Article
Chemistry, Applied
Alessio Alesci, Angelo Fumia, Anthea Miller, Concetta Calabro, Antonello Santini, Nicola Cicero, Patrizia Lo Cascio
Summary: This study found that spirulina has an immunostimulant effect on zebrafish liver macrophages, increasing their numbers and inducing aggregation. These findings are not only significant for studying complementary feed for fish immune cells but also contribute to a better understanding of the immune mechanisms in vertebrates.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ian M. R. Blanco, Raquel de Melo Barbosa, Julita M. P. Borges, Silvio A. B. Vieira de Melo, Ramon dos Santos El-Bacha, Cesar Viseras, Patricia Severino, Elena Sanchez-Lopez, Eliana B. B. Souto, Elaine Cabral-Albuquerque
Summary: Traditional medicine uses resin oils from plants for medicinal purposes, and this study focuses on understanding their pharmacological properties. Liposomes containing resin oils or extracts from Copaifera sabulicola leaves were prepared and characterized. The liposomes showed cytotoxic effects against cancer cells and have potential applications in chemotherapy.
Review
Health Care Sciences & Services
Raquel da Ana, Anna Gliszczynska, Elena Sanchez-Lopez, Maria L. Garcia, Karolline Krambeck, Andjelka Kovacevic, Eliana B. Souto
Summary: Oxidation of lipids and lipoproteins contributes to inflammation processes that promote the development of eye diseases. Targeting lipid metabolism to treat ocular diseases is an interesting and effective approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Andrea V. Machado, Luana R. O. Menezes, Adilson A. M. Santana, Maria N. Marques, Adriana K. de Lima, Amanda Cano, Patricia Severino, Eliana B. Souto, Juliana C. Cardoso
Summary: This work describes a new hair dyeing method using geniposide to react with the amino group in hair keratin. The study evaluated the effects of reaction conditions on color change, hair morphology, and mechanical properties. The results showed that geniposide treatment can significantly change hair color and affect its mechanical properties and morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Camilla A. S. Valenca, Ana A. T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto, Sona Jain
Summary: The global problem of antibiotic resistance is a serious threat to the treatment of infectious diseases. New antimicrobials and improved delivery systems are needed. Bacterial secondary metabolites have potential as antimicrobial agents, but few molecules make it to the clinical phase.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cristina Galocha-Leon, Cristina Antich, Ana Voltes-Martinez, Juan A. Marchal, Mireia Mallandrich, Lyda Halbaut, Maria J. Rodriguez-Lagunas, Eliana B. Souto, Beatriz Clares-Naveros, Patricia Galvez-Martin
Summary: This study developed a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for the treatment of superficial skin injuries. The hydrogel, using poloxamer 407 as a biomaterial, showed excellent physical, mechanical, morphological, and biological properties. It demonstrated high swelling capacity and did not affect the viability and healing capacity of keratinocytes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Marismar F. do Nascimento, Clauberto R. de Oliveira, Juliana C. Cardoso, Natalia C. T. Bordignon, Rogerio Gondak, Patricia Severino, Eliana B. Souto, Ricardo L. C. de Albuquerque Jr
Summary: This study aimed to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid. The results showed that GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Jose M. de Oliveira Junior, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this work was to develop a dense lamellar scaffold for tracheal tissue regeneration using phenolic compounds from Psidium guajava Linn. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed chemical interactions between the polymers and cross-linking of phenolic compounds. Morphological analyses showed scaffolds with porosity and a porous surface structure. The addition of phenolic compounds modulated the morphological and mechanical properties of the scaffolds.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Isabella S. A. Peres, Kiara A. O. Conceicao, Larissa A. F. Silva, Nadia G. Khouri, Cristiana M. P. Yoshida, Viktor O. C. Concha, Massimo Lucarini, Alessandra Durazzo, Antonello Santini, Eliana B. Souto, Patricia Severino
Summary: This article discusses the nutraceutical and pharmaceutical applications of Dragon's Blood, focusing on its antioxidant properties. Through literature research analysis, the current status and future development directions of this topic are explored. The study reveals that Dragon's Blood extracts possess various activities such as anti-inflammatory, wound healing, antidiarrheal, anticancer, antirheumatic, antiseptic, and antioxidant effects, which provide novel perspectives for its use in the food and pharmaceutical industries.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Pharmacology & Pharmacy
Smita Khairnar, Elena Sanchez-Lopez, Eliana B. Souto, Kamalinder K. Singh
Summary: Microspheres-enriched ocular gels were developed as a controlled release system for moxifloxacin hydrochloride. The ocular gel containing microspheres showed improved drug release, penetration, and therapeutic efficacy, with reduced administration frequency, which may improve patient compliance to ocular treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Andy Wai Kan Yeung, Natalia Ksepka, Maima Matin, Dongdong Wang, Eliana B. Souto, Jivko Stoyanov, Javier Echeverria, Devesh Tewari, Jaroslaw Olav Horbanczuk, Massimo Lucarini, Alessandra Durazzo, Joanna Marchewka, Vasil Pirgozliev, Ren-You Gan, Nikolay T. Tzvetkov, Kamil Wysocki, Farhan Bin Matin, Olena Litvinova, Anupam Bishayee, Hari Prasad Devkota, Amr El-Demerdash, Mladen Brncic, Antonello Santini, Olaf. K. Horbanczuk, Michel-Edwar Mickael, Michal Lawinski, Niranjan Das, Bodrun Naher Siddiquea, Dalibor Hrg, Atanas G. Atanasov
Summary: This study provides a quantitative literature analysis on the influence of diet on non-alcoholic fatty liver disease (NAFLD). The analysis reveals that China and the United States are significant contributors to this field, and key dietary compounds such as resveratrol and polyphenols are frequently mentioned and cited, showing potential benefits for NAFLD in both human and animal studies.
ANIMAL SCIENCE PAPERS AND REPORTS
(2023)