Knockout Mouse Models for Peroxiredoxins

Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury

(2019) Xiaocen Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peroxiredoxin II negatively regulates BMP2-induced osteoblast differentiation and bone formation via PP2A Cα-mediated Smad1/5/9 dephosphorylation

(2019) Kyeong-Min Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli

(2019) Man Sup Kwak et al.   Redox Biology

The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases

(2019) Agnieszka Jezierska-Drutel et al.   BMC CANCER

PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis

(2019) Qiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling

(2019) Mi Hye Kim et al.   Redox Biology

The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma

(2018) Xin Guo et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis

(2018) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

(2018) Ondrej Kuda et al.   DIABETES

Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice

(2018) Sun-Ji Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin 5 regulates adipogenesis-attenuating oxidative stress in obese mouse models induced by a high-fat diet

(2018) Mi Hye Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation

(2018) Jung-Hak Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury

(2018) Wanwan Guo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Peroxiredoxin I deficiency increases LPS‑induced lethal shock in mice

(2018) Hu‑Nan Sun et al.   Molecular Medicine Reports

Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

(2018) Takujiro Homma et al.   Oxidative Medicine and Cellular Longevity

Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes

(2018) Aron B. Fisher et al.   Redox Biology

Peroxiredoxin I maintains luteal function by regulating unfolded protein response

(2018) Hyo-Jin Park et al.   Reproductive Biology and Endocrinology

Ensembl 2019

(2018) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice

(2018) Tomohisa Takagi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin 2 regulates PGF2α-induced corpus luteum regression in mice by inhibiting ROS-dependent JNK activation

(2017) Sun-Ji Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension

(2017) Enrica Federti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms

(2017) Hassan Melhem et al.   Journal of Crohns & Colitis

Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes

(2017) Jin Young Baek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Peroxiredoxin 6 suppresses Muc5ac overproduction in LPS-induced airway inflammation through H2O2-EGFR-MAPK signaling pathway

(2017) Dong Yang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

(2017) Dong Hoon Kang et al.   Nature Communications

Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa1

(2016) Burak Ozkosem et al.   BIOLOGY OF REPRODUCTION

Featured Article: Accelerated decline of physical strength in peroxiredoxin-3 knockout mice

(2016) Yong-Gang Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages

(2016) José Pablo Vázquez-Medina et al.   FASEB JOURNAL

Peroxiredoxin 1 Contributes to Host Defenses againstMycobacterium tuberculosis

(2016) Kazunori Matsumura et al.   JOURNAL OF IMMUNOLOGY

A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6

(2016) Aron B. Fisher et al.   JOURNAL OF LIPID RESEARCH

Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis

(2016) Sara L. Sorrell et al.   KIDNEY INTERNATIONAL

Overview on Peroxiredoxin

(2016)   MOLECULES AND CELLS

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression

(2016) Hassan Nassour et al.   Scientific Reports

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis

(2015) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin II Negatively Regulates Lipopolysaccharide-Induced Osteoclast Formation and Bone Loss via JNK and STAT3

(2015) Hyojung Park et al.   ANTIOXIDANTS & REDOX SIGNALING

Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress

(2015) Haitao Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin II Is an Antioxidant Enzyme That Negatively Regulates Collagen-stimulated Platelet Function

(2015) Ji Yong Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources

(2015) Janan T. Eppig et al.   MAMMALIAN GENOME

Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo

(2015) Ayodeji A. Asuni et al.   NEUROCHEMISTRY INTERNATIONAL

Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice

(2015) Burak Ozkosem et al.   Redox Biology

Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes

(2014) F. Pacifici et al.   DIABETES

The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence

(2014) Alessandro Matté et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis

(2014) Kwang-Pyo Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells

(2014) C.-S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis

(2013) F. Rolfs et al.   CANCER RESEARCH

Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and Is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization

(2013) Dong Hoon Kang et al.   CIRCULATION

Reactive Oxygen Species in the Immune System

(2013) Yuhui Yang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress

(2013) Takaaki Ito et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells

(2013) H. Y. Won et al.   JOURNAL OF IMMUNOLOGY

Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation

(2013) Sun-Uk Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells

(2013) Sun-Uk Kim et al.   STEM CELLS

Peroxiredoxin III and Sulfiredoxin Together Protect Mice from Pyrazole-Induced Oxidative Liver Injury

(2012) Soo Han Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species mediated DNA damage is essential for abnormal erythropoiesis in peroxiredoxin II−/− mice

(2012) Tae-Ho Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability

(2012) Ying-Hao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

(2012) Ying-Hao Han et al.   BMB Reports

Amelioration of cisplatin-induced nephrotoxicity in peroxiredoxin I-deficient mice

(2012) Kosuke Okada et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Role of peroxiredoxin-2 in protecting RBCs from hydrogen peroxide-induced oxidative stress

(2012) E. Nagababu et al.   FREE RADICAL RESEARCH

Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure

(2012) R. Yanagisawa et al.   JOURNAL OF BIOCHEMISTRY

Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

(2012) Ester Zito et al.   MOLECULAR CELL

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis

(2011) Nigar Fatma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I

(2011) Norihiro Kikuchi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Roles of Peroxidase and Phospholipase A2 Activities of Peroxiredoxin 6 in Protecting Pulmonary Microvascular Endothelial Cells Against Peroxidative Stress

(2011) Yu-Chin Lien et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 3 Is a Key Molecule Regulating Adipocyte Oxidative Stress, Mitochondrial Biogenesis, and Adipokine Expression

(2011) Joo Young Huh et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E–Deficient Mice

(2011) Jong-Gil Park et al.   CIRCULATION RESEARCH

Peroxiredoxin 6 Phosphorylation and Subsequent Phospholipase A2Activity Are Required for Agonist-mediated Activation of NADPH Oxidase in Mouse Pulmonary Microvascular Endothelium and Alveolar Macrophages

(2011) Shampa Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Alternatively Transcribed Form of Peroxiredoxin IV Gene That Is Specifically Expressed in Spermatids of Postpubertal Mouse Testis

(2011) Sun Hee Yim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides

(2011) Sue Goo Rhee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial Cells

(2011) Dong Hoon Kang et al.   MOLECULAR CELL

In-depth analysis of cysteine oxidation by the RBC proteome: Advantage of peroxiredoxin II knockout mice

(2011) Hee-Young Yang et al.   PROTEOMICS

Structure-based Insights into the Catalytic Power and Conformational Dexterity of Peroxiredoxins

(2010) Andrea Hall et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury

(2010) Isaac K. Sundar et al.   EXPERIMENTAL LUNG RESEARCH

Comparison of glutathione peroxidase 1 and peroxiredoxin 6 in protection against oxidative stress in the mouse lung

(2010) Geng Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs

(2010) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family

(2010) Laura Soito et al.   NUCLEIC ACIDS RESEARCH

Role of Peroxiredoxin III in the Pathogenesis of Pre-eclampsia as Evidenced in Mice

(2010) Lianqin Li et al.   Oxidative Medicine and Cellular Longevity

Analysis of the peroxiredoxin family: Using active-site structure and sequence information for global classification and residue analysis

(2010) Kimberly J. Nelson et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure

(2009) Eri Kubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Antioxidant Enzyme Prdx1 Controls Neuronal Differentiation by Thiol-Redox-Dependent Activation of GDE2

(2009) Ye Yan et al.   CELL

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

(2009) Juxiang Cao et al.   EMBO JOURNAL

Typical 2-Cys peroxiredoxins - structures, mechanisms and functions

(2009) Andrea Hall et al.   FEBS Journal

The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism

(2009) Robert M. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma

(2009) Ken-ichiro Inoue et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Peroxiredoxin III-deficiency Sensitizes Macrophages to Oxidative Stress

(2009) L. Li et al.   JOURNAL OF BIOCHEMISTRY

Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation

(2009) J. R. Roede et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage

(2009) Sun-Uk Kim et al.   NEUROBIOLOGY OF AGING

Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice

(2008) Thorsten Eismann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peroxiredoxin 2 and Peroxide Metabolism in the Erythrocyte

(2008) Felicia M. Low et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 4knockout results in elevated spermatogenic cell death via oxidative stress

(2008) Yoshihito Iuchi et al.   BIOCHEMICAL JOURNAL

Peroxiredoxin1 Prevents Excessive Endothelial Activation and Early Atherosclerosis

(2008) Janka Kisucka et al.   CIRCULATION RESEARCH

Crucial role of peroxiredoxin III in placental antioxidant defense of mice

(2008) Lianqin Li et al.   FEBS LETTERS

Peroxiredoxin 6 as an antioxidant enzyme: Protection of lung alveolar epithelial type II cells from H2O2‐induced oxidative stress

(2008) Yan Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Gene expression profiling related to the enhanced erythropoiesis in mouse bone marrow cells

(2007) Hee-Young Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY