Review
Oncology
Agata Malek, Maciej Strzemski, Joanna Kurzepa, Jacek Kurzepa
Summary: This paper presents the current state of knowledge regarding the mechanisms of anticancer activity of bee venom, showing its strong potential in inducing apoptosis and inhibiting the cell cycle of tumor cells without affecting normal cells significantly. Animal studies also support the safety of venom doses effective in vitro. This information is valuable for planning future clinical trials.
Article
Integrative & Complementary Medicine
Maher Obeidat, Ihab F. F. Al-khraisat, Da'san M. M. Jaradat, Bayan Y. Y. Ghanim, Qasem M. M. Abdallah, Duaa Abu Arqoub, Duaa Sabbah, Ola M. M. Al-Sanabra, Tawfiq Arafat, Nidal A. A. Qinna
Summary: This study collected Jordanian crude bee venom (JCBV) during different seasons and investigated its in vitro antitumor effects. It was found that JCBV collected during springtime had the highest content of melittin (MEL), which showed apoptotic and cell cycle arrest effects on K562 leukemia cells. The study concludes that the application of bee venom in chemotherapy needs further research and should carefully consider the correlation between bee genotype, collection time, and MEL concentration in JCBV.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Food Science & Technology
Jasmin Katrin Badawi
Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Article
Food Science & Technology
Seongjae Bae, Hyemin Gu, Mi-Gyeong Gwon, Hyun-Jin An, Sang-Mi Han, Sun-Jae Lee, Jaechan Leem, Kwan-Kyu Park
Summary: Bee venom and melittin can alleviate skin infections caused by Streptococcus pyogenes and have anti-inflammatory effects.
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Minhaj Ahmad Khan, Rajnish Kumar, Tarun Kumar Upadhyay
Summary: Apitherapy using bee products, especially honeybee venom, has gained recognition globally in cancer therapeutics. Bee products, including honeybee venom, have shown significant potential in strengthening the immune system and improving human health.
Article
Biology
Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Guenter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre, Eckart Stolle, Bjoern M. von Reumont
Summary: Most venom genes in Hymenoptera are shared by all members of the clade, with single gene co-option being the primary source and gene duplication contributing to diversification. Only a few venom proteins, such as melittin and anthophilin1, appear to be unique to the bee lineage, suggesting that most venom proteins predate the evolution of the aculeate stinger and the mega-radiation of hymenopterans.
Article
Multidisciplinary Sciences
Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, Gyoergy Panyi, Glenn F. King, Samuel D. Robinson
Summary: Most bee species have the ability to sting humans, causing painful reactions. This study investigates the venom composition of the Australian great carpenter bee and finds that it is similar to the venoms of other social bee species. The venom can directly activate mammalian sensory neurons and induce pain behaviors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Asli Elif Tanugur-Samanc, Meral Kekecoglu
Summary: This research paper aimed to determine the characteristics of Anatolian bee venom through analyzing its chemical content and microbiological properties. The results showed that Anatolian bee venom has a high phospholipase A2 content, similar levels of apamin compared to other countries, and melittin content within standard values. The bee venom samples exhibited high sugar content and minimal microbial development, with no Staphylococcus aureus detected.
Article
Food Science & Technology
Karolina Bodlakova, Jan Cerny, Helena Sterbova, Roman Guran, Ondrej Zitka, Dalibor Kodrik
Summary: This study investigated the physiological responses of American cockroaches to honeybee venom. The results showed that bee venom caused severe stress and destruction of muscle cell ultrastructure in the cockroaches. The venom also regulated the levels of substances in the cockroaches' haemolymph and the activity of digestive enzymes. Furthermore, it significantly reduced vitellogenin levels in female cockroaches and had an impact on dopamine and glutathione levels.
Review
Pharmacology & Pharmacy
Peiying Shi, Shihui Xie, Jiali Yang, Yi Zhang, Shuo Han, Songkun Su, Hong Yao
Summary: This study reviewed the recent progress in the pharmacological effects and mechanisms of bee venom (BV) and its main components against various diseases. It identified the target proteins and signaling pathways involved, and bioinformatically predicted the potential effects and mechanisms on diseases. The review provides new insights into the therapeutic effects of BV and its main components.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ghada H. Mansour, Mohammed A. El-Magd, Dalia H. Mahfouz, Ismail A. Abdelhamid, Magda F. Mohamed, Nada S. Ibrahim, Abdel Hady A. Abdel Wahab, Emad M. Elzayat
Summary: The study found that Bee Venom and its active component, Melittin, when combined with Sorafenib, have a synergistic anticancer effect on HepG2 cells, potentially representing a new enhancing strategy for HCC treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Shaymaa Abdulmalek, Nouf I. Mostafa, Marwa Gomaa, Mohamed El-Kersh, Ayman Elkady, Mahmoud Balbaa
Summary: This study focuses on the development of biodegradable chitosan nanoparticles for the release of bee venom into liver cancer cells. The surface-modified nanoparticles can target EGFR-overexpressed liver cancer cells and have higher cytotoxicity and inhibitory effects on tumor growth.
Article
Biochemistry & Molecular Biology
Hafsa Er-Rouassi, Meryem Bakour, Soumaya Touzani, Miguel Vilas-Boas, Soraia Falcao, Catherine Vidal, Badiaa Lyoussi
Summary: This study evaluated the potential effect of bee venom and its major components on a mouse model of peripheral nerve injury. The results showed that bee venom treatment was more effective for behavioral recovery. After 4 weeks, the facial motoneurons in the BV-treated group showed normal labeling, while no such restoration was observed in the other groups.
Article
Biochemistry & Molecular Biology
Irina Tanuwidjaja, Lidija Svecnjak, Domenika Gugic, Marko Levanic, Slaven Juric, Marko Vincekovic, Mirna Mrkonjic Fuka
Summary: The study found that honey bee venom exhibited high antibacterial activity against a broad spectrum of potentially pathogenic bacteria, with efficiency comparable to conventional antibiotics in certain cases. This suggests the therapeutic potential of honey bee venom as an alternative antimicrobial compound in combating antibiotic resistance.
Article
Biochemistry & Molecular Biology
Radoslaw Grebowski, Joanna Saluk, Michal Bijak, Janusz Szemraj, Paulina Wigner
Summary: Bladder cancer is the 10th most common form of cancer globally, and chronic inflammation may play a role in its development and progression. This study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) in IL-6 and IL-8 genes and bladder cancer development, as well as the impact of bladder cancer on the expression and methylation of IL-6 and IL-8 promoters in PBMCs. The study found no association between the studied SNPs and bladder cancer occurrence. However, bladder cancer patients had decreased IL-6 and IL-8 mRNA expression levels and higher methylation status of the IL-6 promoter compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Michal Bijak
Summary: T-2 toxin has adverse effects on Hs68 cell mitochondria, causing mitochondrial dysfunction and mtDNA damage, which can result in cell death.
Article
Genetics & Heredity
Malgorzata Drzewiecka, Anna Gajos-Michniewicz, Grazyna Hoser, Dominika Jasniak, Gabriela Barszczewska-Pietraszek, Przemyslaw Sitarek, Piotr Czarny, Janusz Piekarski, Maciej Radek, Malgorzata Czyz, Tomasz Skorski, Tomasz Sliwinski
Summary: Inhibition of HDACs shows potential as an anti-cancer therapy due to its disruption of acetylation in cancer cells. This study demonstrates that the combination of HDAC inhibitors, alkylating agents, and PARP inhibitors enhances the treatment of melanoma by increasing DNA double strand breaks and reducing cell survival. The findings suggest that HDACs play a role in melanoma cell resistance to methylating agent-based therapies.
Review
Biochemistry & Molecular Biology
Tomasz Kowalczyk, Anna Merecz-Sadowska, Mansour Ghorbanpour, Janusz Szemraj, Janusz Piekarski, Michal Bijak, Tomasz Sliwinski, Radoslaw Zajdel, Przemyslaw Sitarek
Summary: The use of essential oils from the Lamiaceae family has shown great potential in dermatology, with antioxidant, anti-inflammatory, wound-healing, anti-aging, anti-melanogenic, and anticancer activities. Nanotechnology has enabled the development of modern formulations for the topical application of these oils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwinski, Maksymilian Stela, Michal Bijak
Summary: This study demonstrates that T-2 toxin has genotoxic effects on human skin fibroblast cells, potentially causing damage to nuclear DNA and leading to changes in gene expression related to inflammation and repair processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Anna Merecz-Sadowska, Przemyslaw Sitarek, Tomasz Kowalczyk, Karolina Zajdel, Mariusz Jecek, Pawel Nowak, Radoslaw Zajdel
Summary: Anthocyanins are flavonoid compounds found in fruits and vegetables, which contribute to their color and offer various health benefits due to their biological properties. Malvidin, one of the most well-known anthocyanidins, and its glycosides have been shown in multiple studies to possess anti-carcinogenic, diabetes-control, cardiovascular-disease-prevention, and brain-function-improvement properties. These health benefits are primarily attributed to their antioxidant and anti-inflammatory effects, which are influenced by the modulation of critical genes. This article reviews the biological activity of malvidin and its glycosides and their role in promoting health.
Article
Health Care Sciences & Services
Malgorzata Drzewiecka, Dominika Jasniak, Gabriela Barszczewska-Pietraszek, Piotr Czarny, Anna Kobrzycka, Marek Wieczorek, Maciej Radek, Janusz Szemraj, Tomasz Skorski, Tomasz Sliwinski
Summary: This study demonstrates the potential of combining HDAC inhibitors with PARP1 inhibitors in inducing DNA damage and reducing glioblastoma. This combination therapy holds important implications for the treatment of glioblastoma, the most aggressive type of brain cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Edyta Janik-Karpinska, Rachele Brancaleoni, Marcin Niemcewicz, Wiktor Wojtas, Maurizio Foco, Marcin Podogrocki, Michal Bijak
Summary: Healthcare waste is mainly generated in healthcare facilities, with 15% of it being hazardous. It contains potentially harmful microorganisms that can pose a threat to human health and the environment if not properly treated. Proper waste management measures should be taken to reduce the negative impact.
Review
Oncology
Hossein Maghsoudi, Farhad Sheikhnia, Przemyslaw Sitarek, Nooshin Hajmalek, Sepideh Hassani, Vahid Rashidi, Sadaf Khodagholi, Seyed Mostafa Mir, Faezeh Malekinejad, Fatemeh Kheradmand, Mansour Ghorbanpour, Navid Ghasemzadeh, Tomasz Kowalczyk
Summary: Summary Prostate cancer is a major health concern for men worldwide and is often caused by inflammation in the prostate gland. This article explores the potential of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing and treating prostate cancer by reducing inflammation and inhibiting cancer cell growth and survival. The authors discuss the various mechanisms through which NSAIDs can affect prostate cancer and present evidence from previous studies supporting their use as anti-cancer agents. However, further research is needed to determine optimal dosage, timing, and safety of NSAIDs.
Article
Biochemistry & Molecular Biology
Piotr Czarny, Sylwia Ziolkowska, Lukasz Kolodziej, Cezary Watala, Paulina Wigner-Jeziorska, Katarzyna Blizniewska-Kowalska, Katarzyna Wachowska, Malgorzata Galecka, Ewelina Synowiec, Piotr Galecki, Michal Bijak, Janusz Szemraj, Tomasz Sliwinski
Summary: This study explores the impact of SNPs in genes encoding enzymes involved in mtDNA replication, repair, or degradation on the occurrence, onset, severity, and treatment of MDD. The findings suggest that mtDNA damage and impairment in its metabolism play a crucial role in the development and treatment of depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)