Review
Nanoscience & Nanotechnology
Shiyang Wang, Yue Shi
Summary: Exosomes are small vesicles secreted by living cells, carrying proteins, lipids, RNA, and other important substances for cell-to-cell communication. This review focuses on the effects of immune cell-derived exosomes on tumor cells, immune cells, and other stromal cells in the tumor microenvironment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Oncology
Wen-Chun Lin, You-Tong Lin, Hui-Ching Chao, Yen-Yu Lin, Wei-Lun Hwang
Summary: The quantity and quality of immune cells within the tumour microenvironment (TME) play essential roles in cancer development and management. The immunologically suppressive, so-called 'cold' TME is associated with resistance to therapies and worse clinical outcomes.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yinan Li, Heng Zhang, Caihong Chen, Kailiang Qiao, Zhiyang Li, Jingxia Han, Xu Han, Kun Li, Keguan Lai, Ning Liu, Ang Li, Nannan Xiao, Yan Zhang, Xiangshuai Zhao, Wenqing Gao, Yang Zhang, Huijuan Liu, Tao Sun
Summary: This study suggests that tumor cells may play a role in alleviating sepsis through the secretion of specific exosomes and miRNA. Biomimetic simulation of tumor-suppressive exosomes shows promising potential as a therapeutic method for sepsis and related conditions.
ADVANCED MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Yuan Jiang, Fengbo Wang, Ke Wang, Yongqiang Zhong, Xiaofei Wei, Qiongfen Wang, Hong Zhang
Summary: Exosomes are natural membrane vesicles released from cells that play an important role in cell-cell communication. They have been found to have various roles in brain diseases and have received attention as therapeutic drug carriers for brain drug delivery. Engineered exosomes have shown potential in improving drug uptake efficiency and efficacy. However, challenges still exist in developing exosomes as a drug delivery strategy for brain diseases. Further research in this area is important for its development.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Ye Lu, Zizhao Mai, Li Cui, Xinyuan Zhao
Summary: Mesenchymal stem cell-based therapy is effective for bone regeneration, but clinical translation has limitations. The secretome of mesenchymal stem cells, especially exosomes, has a critical role in bone repair and regeneration. Exosomes, with their nanosized structures and cargo of proteins, lipids, RNAs, growth factors, and cytokines, are being investigated for their potential in bone regenerative medicine. Preconditioning of parental cells and exosome engineering can enhance their regenerative potential, and biomaterial-assisted exosomes have emerged as a promising strategy for bone regeneration. This review discusses the roles of exosomes in bone regeneration, the use of engineered exosomes and biomaterial-assisted exosomes, and the current challenges in translating exosomes to clinical applications.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Xin Zhao, Luoqin Fu, Hai Zou, Yichen He, Yi Pan, Luyi Ye, Yilin Huang, Weijiao Fan, Jungang Zhang, Yingyu Ma, Jinyang Chen, Mingang Zhu, Chengwu Zhang, Yu Cai, Xiaozhou Mou
Summary: Engineered MSC-derived exosomes with high expression of eNOS were shown to improve the biological functions of cells and promote tissue repair in chronic non-healing diabetic wounds. These exosomes significantly enhanced wound closure rate, vascular neogenesis, and matrix remodeling in diabetic mice. They also modulated the inflammatory profile and immune microenvironment at the wound site.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Immunology
Qiujun Zhou, Shenyu Wei, Hui Wang, Yuanyuan Li, Shasha Fan, Yi Cao, Chenglei Wang
Summary: Exosomes, nanoscale vesicles with a phospholipid bilayer structure, are secreted by cells and contain DNA, small RNA, proteins, and other substances that play a role in cell-to-cell communication. T cell-derived exosomes have been extensively studied for their novel role in cell signaling, particularly in tumor immune response. In this review, the functions of exosomes derived from different T cell subsets are discussed, along with their applications in tumor immunotherapy and the associated challenges.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Physical
Xiaoyi Ma, Bingbing Liu, Limin Fan, Yiqiong Liu, Yuge Zhao, Tianbin Ren, Yan Li, Yongyong Li
Summary: This article provides a comprehensive overview of the recent advances in the application of native and engineered exosomes as well as the engineered methods in the treatment of inflammatory diseases. Researchers aim to improve the properties of exosomes, including cargo-loading efficiency, targeting ability, stability, etc., to achieve combined and diverse treatment strategies. The article also concludes the potential application prospects and possible challenges of exosome treatment strategy, offering guidance and suggestions for future research and application of exosomes.
Review
Chemistry, Physical
Xiaoyi Ma, Bingbing Liu, Limin Fan, Yiqiong Liu, Yuge Zhao, Tianbin Ren, Yan Li, Yongyong Li
Summary: Exosomes are cell-free strategy for the treatment of diseases including inflammatory disease. Researchers have developed exosome-based strategies for novel inflammation therapy. These engineered exosomes can improve cargo-loading efficiency, targeting ability, stability, etc., to achieve combined and diverse treatment strategies in inflammation diseases.
Review
Biotechnology & Applied Microbiology
Shaoyang Ma, Yuchen Zhang, Sijia Li, Ang Li, Ye Li, Dandan Pei
Summary: Bone defect repair is a challenging clinical problem, but engineering exosomes have the potential to overcome the limitations of natural exosomes. By regulating their production and function, engineering exosomes can be a solution for bone defect repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jiaci Chen, Peilong Li, Taiyi Zhang, Zhipeng Xu, Xiaowen Huang, Ruiming Wang, Lutao Du
Summary: Exosomes, as nano-sized extracellular vesicles, play an important role in cell-specific material transfer and have potential applications in prognosis, diagnosis, and treatment. Existing exosomal separation techniques have limitations in terms of complexity, time consumption, and low purity, highlighting the need for efficient and simple isolation methods. Microfluidic chips have emerged as a promising technology for exosome isolation. A comprehensive review covering exosomal properties, conventional technologies, emerging isolation strategies, and large-scale production of engineered exosomes is essential.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Zixian Yu, Shujing Lin, Fangfang Xia, Yanlei Liu, Di Zhang, Fei Wang, Yanpu Wang, Qichao Li, Jiaqi Niu, Chengxi Cao, Daxiang Cui, Nengquan Sheng, Jiazi Ren, Zhigang Wang, Di Chen
Summary: The ExoSD chip is a highly integrated platform for exosome separation and detection, capable of efficiently separating and detecting gastric cancer cell-derived exosomes with high recovery and purity.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Biochemistry & Molecular Biology
Yasunari Matsuzaka, Ryu Yashiro
Summary: Self-tolerance is a process that protects against self-reactive B and T cells through negative selection, programmed cell death, and inhibition of regulatory T cells. Exosomes, small extracellular vesicles, can deliver microRNAs to modulate the immune response by regulating gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiuya Li, Yilin Lian, Yukang Wu, Zihui Ye, Jiabao Feng, Yuan Zhao, Xudong Guo, Jiuhong Kang
Summary: In this study, it was found that intramyocardial delivery of plasma exosomes from neonatal mice could help repair the adult heart after acute myocardial infarction (AMI). Cardiac endothelial cells received the majority of exosomal ligands and the pro-angiogenic effect of exosomes was mediated through the recognition of cardiac endothelial cell receptors. This ligand-receptor network provides inspiration for cardiac regeneration post-MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Yana Zabrodskaya, Marina Plotnikova, Nina Gavrilova, Alexey Lozhkov, Sergey Klotchenko, Artem Kiselev, Vladimir Burdakov, Edward Ramsay, Lada Purvinsh, Marja Egorova, Vera Vysochinskaya, Irina Baranovskaya, Alexandra Brodskaya, Roman Povalikhin, Andrey Vasin
Summary: After influenza A virus (IAV) infection, the composition of exosomes secreted by infected cells changes, and these exosomes can reduce the immune response of neighboring uninfected cells, leading to more effective virus replication.
Article
Cardiac & Cardiovascular Systems
Yaqian Duan, Ram Prasad, Dongni Feng, Eleni Beli, Sergio Li Calzi, Ana Leda F. Longhini, Regina Lamendella, Jason L. Floyd, Mariana Dupont, Sunil K. Noothi, Gopalkrishna Sreejit, Baskaran Athmanathan, Justin Wright, Amanda R. Jensen, Gavin Y. Oudit, Troy A. Markel, Prabhakara R. Nagareddy, Alexander G. Obukhov, Maria B. Grant
CIRCULATION RESEARCH
(2019)
Article
Nutrition & Dietetics
Maria De Luca, Denise Vecchie, Baskaran Athmanathan, Sreejit Gopalkrishna, Jennifer A. Valcin, Telisha M. Swain, Rogerio Sertie, Kennedy Wekesa, Glenn C. Rowe, Shannon M. Bailey, Prabhakara R. Nagareddy
Article
Cardiac & Cardiovascular Systems
Gopalkrishna Sreejit, Ahmed Abdel-Latif, Baskaran Athmanathan, Rahul Annabathula, Ashish Dhyani, Sunil K. Noothi, Gregory A. Quaife-Ryan, Annas Al-Sharea, Gerard Pernes, Dragana Dragoljevic, Hind Lal, Kate Schroder, Beatriz Y. Hanaoka, Chander Raman, Maria B. Grant, James E. Hudson, Susan S. Smyth, Enzo R. Porrello, Andrew J. Murphy, Prabhakara R. Nagareddy
Review
Cardiac & Cardiovascular Systems
Gian Paolo Fadini, Anurag Mehta, Devinder Singh Dhindsa, Benedetta Maria Bonora, Gopalkrishna Sreejit, Prabhakara Nagareddy, Arshed Ali Quyyumi
EUROPEAN HEART JOURNAL
(2020)
Editorial Material
Medicine, Research & Experimental
Man K. S. Lee, Gopalkrishna Sreejit, Prabhakara R. Nagareddy, Andrew J. Murphy
Letter
Cardiac & Cardiovascular Systems
Gopalkrishna Sreejit, Prabhakara R. Nagareddy
Article
Hematology
Man K. S. Lee, Michael J. Kraakman, Dragana Dragoljevic, Nordin M. J. Hanssen, Michelle C. Flynn, Annas Al-Sharea, Gopalkrishna Sreejit, Camilla Bertuzzo-Veiga, Olivia D. Cooney, Fatima Baig, Elizabeth Morriss, Mark E. Cooper, Emma C. Josefsson, Benjamin T. Kile, Prabhakara R. Nagareddy, Andrew J. Murphy
Summary: Reducing platelet numbers through targeting the antiapoptotic protein Bcl-x(L) can effectively decrease atherosclerosis and reduce cardiovascular disease risk in diabetes, as demonstrated in genetic and pharmacological approaches in this study.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Sreejit Gopalkrishna, Jillian Johnson, Robert M. Jaggers, Albert Dahdah, Andrew J. Murphy, Nordin M. J. Hanssen, Prabhakara R. Nagareddy
Summary: Neutrophils play a dual role in inflammation and wound healing, causing tissue damage while also facilitating healing. Recent studies have revealed their transcriptional activity and ability to influence other cells through cargo release. They have emerged as important regulators in cardiovascular diseases and could be potential targets for therapeutic strategies.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Gopalkrishna Sreejit, Sunil K. Nooti, Robert M. Jaggers, Baskaran Athmanathan, Ki Ho Park, Annas Al-Sharea, Jillian Johnson, Albert Dahdah, Man K. S. Lee, Jianjie Ma, Andrew J. Murphy, Prabhakara R. Nagareddy
Summary: Acute myocardial infarction leads to the accumulation of neutrophils in the bone marrow, where they release IL-1 beta and promote granulopoiesis through specific signaling pathways. Pharmacological and genetic strategies can inhibit this process and improve cardiac function.
Letter
Cardiac & Cardiovascular Systems
Prabhakara R. Nagareddy, Gopalkrishna Sreejit
Review
Cell Biology
Albert Dahdah, Jillian Johnson, Sreejit Gopalkrishna, Robert M. M. Jaggers, Darren Webb, Andrew J. J. Murphy, Nordin M. J. Hanssen, Beatriz Y. Y. Hanaoka, Prabhakara R. R. Nagareddy
Summary: The body's inflammatory response requires immune cells to migrate to the site of inflammation, and this process is facilitated by the vasculature. Neutrophils are important leukocytes involved in this response. This review focuses on the mechanisms of leukocyte migration, particularly neutrophil migration, in conditions such as diabetes and cardiovascular disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Gopalkrishna Sreejit, Ahmed Abdel Latif, Andrew J. Murphy, Prabhakara R. Nagareddy
PHARMACOLOGICAL RESEARCH
(2020)
Review
Immunology
Gopalkrishna Sreejit, Andrew J. Fleetwood, Andrew J. Murphy, Prabhakara R. Nagareddy
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)
Letter
Hematology
Prabhakara R. Nagareddy, Gopalkrishna Sreejit, Mohamed Abo-Aly, Robert M. Jaggers, Lakshman Chelvarajan, Jillian Johnson, Gerard Pernes, Baskaran Athmanathan, Ahmed Abdel-Latif, Andrew J. Murphy
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
