Article
Chemistry, Multidisciplinary
Yaou Duan, Jiarong Zhou, Zhidong Zhou, Edward Zhang, Yiyan Yu, Nishta Krishnan, Daniela Silva-Ayala, Ronnie H. Fang, Anthony Griffiths, Weiwei Gao, Liangfang Zhang
Summary: Nanoparticles coated with natural cell membranes, particularly macrophage membrane-coated nanoparticles, show promise in drug delivery and neutralization applications. This study demonstrates the use of genetic engineering to enhance the in vivo residence times of macrophage-coated nanoparticles, resulting in improved performance. The study highlights the effectiveness of genetic modification in extending the residence times and suggests the potential application of this approach to other cell membrane-coated nanoparticles.
Article
Cell Biology
Xiangyu Zhang, Santosh Kumar Misra, Parikshit Moitra, Xiuli Zhang, Se-Jin Jeong, Jeremiah Stitham, Astrid Rodriguez-Velez, Arick Park, Yu-Sheng Yeh, William E. Gillanders, Daping Fan, Abhinav Diwan, Jaehyung Cho, Slava Epelman, Irfan J. Lodhi, Dipanjan Pan, Babak Razani
Summary: Dysfunction of the macrophage lysosomal system is a characteristic of atherosclerosis, and acidic nanoparticles can be used to rescue this dysfunction and treat the disease.
Article
Engineering, Biomedical
Yuyu Li, Junyi Che, Lei Chang, Meng Guo, Xue Bao, Dan Mu, Xuan Sun, Xin Zhang, Wen Lu, Jun Xie
Summary: This study reports a modified-macrophage-membrane-coated nanoparticle drug delivery system that efficiently targets endothelial cells and escapes endocytosis by macrophages under an inflammatory environment. In a mouse model, the system successfully reduces atherosclerotic plaque load and improves plaque stability, providing a potential therapeutic strategy for the treatment of atherosclerosis in cardiovascular diseases.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Pan Zhang, Xing Lai, Mao-Hua Zhu, Mei Long, Xue-Liang Liu, Zi-Xiang Wang, Yifan Zhang, Run-Jie Guo, Jing Dong, Qin Lu, Peng Sun, Chao Fang, Mei Zhao
Summary: Saikosaponin A (SSA) has been shown to suppress proliferation, migration, and tube formation of endothelial cells, as well as inhibit angiogenesis in various models. It was found to inhibit tumor growth by blocking the VEGFR2-mediated signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Pengbo Ning, Huimin Yao, Fuyu Du, Jingtong Yuan, Yuqiong Xia, Peng Yang, Xin Chen, Zhiping Rao, Xinan Wang
Summary: In this study, a gene reprogramming macrophage membrane-encapsulated drug-loading nanoplatform was developed for HER2+ cancer therapy based on the co-assembly of poly (lactic-co-glycolic acid) (PLGA) nanoparticles and engineered modified macrophage membranes. This nanoplatform exhibited excellent HER2-targeting ability and synergistically inhibited HER2+ cancer cells or mice tumor growth by inducing apoptosis and blocking the PI3K/AKT signaling pathway.
MOLECULAR PHARMACEUTICS
(2023)
Article
Energy & Fuels
Sara Ghandehari, Mohammad Taghi Goodarzi, Jafar Izadi Nia, Masoud Homayouni Tabrizi
Summary: The aim of this study was to load kombucha-fermented extract (KFE) on PLGA nanoparticles (KFE-PNPs) to increase bioavailability and to evaluate its anti-cancer effects. The results showed that KFE-PNPs had stable nanoparticle characteristics, selectively killed cancer cells, promoted apoptosis, and inhibited angiogenesis.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Chemistry, Multidisciplinary
Cailing Chen, Meiyu Song, Yangyang Du, Ying Yu, Chunguang Li, Yu Han, Fei Yan, Zhan Shi, Shouhua Feng
Summary: Cell-membrane-coated nanoparticles, particularly those derived from tumor-associated macrophages (TAMM), show promise as an antitumor therapeutic strategy. TAMM exhibit unique antigen-homing affinity capacity and immune compatibility, with potential to enhance antitumor immunity efficiency via activation of antigen-presenting cells and production of tumor-specific effector T cells in metastatic tumors. TAM-membrane-based photodynamic immunotherapy offers a new personalized approach to tumor therapy.
Article
Multidisciplinary Sciences
Da Zou, Zeming Wu, Xin Yi, Yue Hui, Guangze Yang, Yun Liu, Tengjisi, Haofei Wang, Anastasia Brooks, Haolu Wang, Xin Liu, Zhi Ping Xu, Michael S. Roberts, Huajian Gao, Chun-Xia Zhao
Summary: Cell membrane-coated nanoparticles are a promising type of nanomaterials for immune evasion and targeted delivery. The preservation of membrane protein properties on these nanoparticles and their consequent interactions with biological systems are still largely unknown.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Juan C. Fraire, Elnaz Shaabani, Maryam Sharifiaghdam, Matthias Rombaut, Charlotte Hinnekens, Dawei Hua, Jana Ramon, Laurens Raes, Eduardo Bolea-Fernandez, Toon Brans, Frank Vanhaecke, Peter Borghgraef, Chaobo Huang, Felix Sauvage, Tamara Vanhaecke, Joery De Kock, Ranhua Xiong, Stefaan De Smedt, Kevin Braeckmans
Summary: Biolistic delivery with light-triggered self-assembled nanobombs can efficiently transfect mammalian cells by propelling smaller nanoprojectiles through the cell membrane using vapor bubble formation. It outperforms electroporation in terms of transfection yield.
NATURE COMMUNICATIONS
(2022)
Article
Instruments & Instrumentation
Rawnaq Esa, Eliana Steinberg, Arie Dagan, Zhanna Yekhtin, Katerina Tischenko, Ofra Benny
Summary: This study synthesized a compound, AD-3281, which effectively inhibits the enzymatic activity of MetAp2 and suppresses the proliferation of cancer and endothelial cells, as well as impairs tube formation of endothelial cells. The compound showed high anti-cancer activity in vivo, reducing angiogenesis and tumor proliferation. The researchers also developed a stable nano-formulation using biodegradable PLGA nanoparticles, which increased cellular availability and uptake, and improved transport in 3D cultures.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Eliana B. Souto, Marta Espina, Maria Luisa Garcia, Marta Switalska, Joanna Wietrzyk, Anna Gliszczynska, Elena Sanchez-Lopez
Summary: Cancer is a leading cause of death worldwide, but there is still a need for an effective treatment with minimal adverse effects. Diclofenac, a non-steroidal anti-inflammatory drug, has shown promise as an antitumoral agent, but its prolonged use can lead to adverse effects. In this study, biodegradable polymeric nanoparticles were used to deliver diclofenac in a controlled manner, resulting in prolonged release and demonstrating antitumoral effects without cytotoxicity to non-tumoral cells.
Review
Pharmacology & Pharmacy
Nimeet Desai, Dhwani Rana, Shreya Pande, Sagar Salave, Jyotsnendu Giri, Derajram Benival, Nagavendra Kommineni
Summary: Bioinspired membrane-coated nanosystems have emerged as a promising approach for targeted cancer theranostics. This review provides an in-depth investigation into their potential, including cell membrane sources, isolation techniques, nanoparticle core selection, coating methods, and characterization. Strategies to enhance their multi-functionality, applications in cancer diagnosis and therapeutics, and recent advances are also discussed, offering valuable insights into precise cancer theranostics.
Review
Chemistry, Physical
Ying Qu, Bingyang Chu, Jianan Li, Hanzhi Deng, Ting Niu, Zhiyong Qian
Summary: Inflammation-associated diseases have a high incidence and lack effective treatments. Macrophage-biomimetic nanoplatforms, with their targeted drug delivery and neutralizing capabilities, have shown remarkable therapeutic efficacy and application potential.
Article
Chemistry, Physical
Huaxing Dai, Qianyu Yang, Rong Sun, Yue Zhang, Qingle Ma, Yifan Shen, Beilei Wang, Yitong Chen, Jialu Xu, Bo Tian, Fang Xu, Chao Wang
Summary: This study demonstrates that accumulation of silica nanoparticles in the liver can induce resistance to immune checkpoint blockade therapy by affecting T cell frequency and tumor infiltration. The findings provide a new mechanism insight into ICB resistance.
Article
Pharmacology & Pharmacy
Linda Elberskirch, Ronan Le Harzic, Dietrich Scheglmann, Gerhard Wieland, Arno Wiehe, Maria Mathieu-Gaedke, Hartwig R. A. Golf, Hagen von Briesen, Sylvia Wagner
Summary: Developing new tumor models for anticancer drug screening is a challenge, with conventional cell-based and in vivo animal models having their limitations. The HET-CAM-based intestinal tumor model shows potential advantages in studying the accumulation and efficacy of nano-formulated photosensitizers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Hongqiao Cai, Xinlun Dai, Xingren Guo, Lingxiao Zhang, Kunxia Cao, Fei Yan, Bai Ji, Yahui Liu
Summary: CuS-ATMi@TGF-beta NPs are designed to be highly photo-stable and specifically target tumors for effective low-temperature photothermal therapy, showing promising results in inhibiting tumor growth while minimizing damage to normal tissues.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Siyu Wang, Yue Song, Kunxia Cao, Lingxiao Zhang, Xuedong Fang, Fangfang Chen, Shouhua Feng, Fei Yan
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nanomedicine-based photothermal therapy (PTT) has shown promising results for solid tumor ablation, providing a potential therapeutic strategy for CRC.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Applied
Songrui Li, Xuerong Song, Yuhan Wang, Zhiru Hu, Fei Yan, Guodong Feng
Summary: A novel ratiometric fluorescence nanosensor based on carbon dots for lysosomal pH sensing was successfully developed, demonstrating great potential for applications in cell imaging.
Article
Chemistry, Multidisciplinary
Lingxiao Zhang, Yue Song, Kunxia Cao, Yangyang Du, Mingda Han, Zhan Shi, Fei Yan, Shouhua Feng
Summary: Despite recent advances in targeted therapies and immunotherapies in acute myeloid leukemia, ferrotherapy using iron-based compounds offers a novel approach to bypass chemoresistance. However, overexpression of ferroportin in cancer cells may limit the efficacy of ferrotherapy and lead to systemic toxic effects. The development of a hepcidin-based nanocomposite shows promise as an epigenetic drug and immunotherapeutic agent for treating leukemia.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Kunxia Cao, Yangyang Du, Xin Bao, Mingda Han, Rui Su, Jiuxia Pang, Shujun Liu, Zhan Shi, Fei Yan, Shouhua Feng
Summary: In this study, FTO inhibitor-loaded GSH-bioimprinted nanocomposites were developed to selectively target leukemia cells, especially leukemia stem cells (LSCs), and induce cell death by disrupting intracellular redox status. Additionally, the nanocomposites increased m(6)A RNA modification levels and enhanced the efficacy of immune therapy.
Article
Engineering, Biomedical
Qing Li, Rui Su, Xin Bao, Kunxia Cao, Yangyang Du, Nanya Wang, Jianfeng Wang, Fan Xing, Fei Yan, Keke Huang, Shouhua Feng
Summary: Programmed cell death protein 1 (PD-1)/Programmed Cell Death Ligand 1 (PD-L1) blockade immunotherapy is limited by low response rates in many patients. This study developed a nanoplatform that induces immunogenic cell death and enhances tumor immunotherapy through synergistic effects with ferrotherapy. The combination of glycyrrhetinic acid-based nanomaterials and ferumoxytol improved T-cell immune response and showed potential for treating cancer.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Xinlun Dai, Xin Li, Yahui Liu, Fei Yan
Summary: This article discusses the progress in anti-tumor immune checkpoint blockade (ICB) therapy and nanoparticle-mediated photothermal therapy (PTT), as well as the pre-clinical trials of combined PTT/ICB therapy. Nanoparticles offer advantages such as increased tumor-targeting ability, high drug-loading capacity, and satisfactory biocompatibility, which can enhance the anti-tumor effects when combined with ICB therapy.
MATERIALS & DESIGN
(2022)
Article
Nanoscience & Nanotechnology
Jianhua Liu, Yue Song, Yiqiao Wang, Mingda Han, Chunxi Wang, Fei Yan
Summary: Cancer immunotherapy has shown great potential in treating metastatic tumors and preventing recurrence. However, the limitations of low patient response rates and toxicity have hindered its effectiveness. This study presents a nanoplatform using gold nanorods for enhanced photothermal immunotherapy against prostate cancer by combining NIR-II-mediated photothermal therapy and N-6-methyladenosine (m(6)A) demethylase inhibition. The results show that the nanoplatform specifically targets prostate tumor cells and successfully eliminates tumors under laser irradiation. Mechanistically, the nanoplatform triggers the release of the demethylase inhibitor, leading to increased mRNA methylation and decreased stability of PDL1 transcripts. The study suggests that this synergistic approach could be an effective strategy for cancer immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Yangyang Du, Xinlun Dai, Mingda Han, Zhihua Wang, Yiqiao Wang, Zhan Shi, Fei Yan, Shouhua Feng
Summary: This article introduces a photothermal immunotherapy method triggered by near-infrared light, which shows promise in cancer treatment. By combining gene expression modification and immune cell activation, the study successfully inhibits primary tumor growth, suppresses metastasis, and prevents tumor recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yue Song, Lingxiao Zhang, Yiqiao Wang, Mingda Han, Zhihua Wang, Ning Wang, Bingru Shao, Runan Li, Kunxia Cao, Meiyu Song, Yangyang Du, Fei Yan
Summary: A bimetallic metal-organic framework (MOF)-based biomimetic nanoplatform, AFMMB, is developed for dual epigenetic therapy against cancer. AFMMB selectively targets leukemic cells and leukemia stem cells, thereby enhancing T-cell-mediated immune response through the induction of autophagy and inhibition of DNA methylation. AFMMB also shows potential for suppressing the growth and metastasis of solid tumors, indicating a pan-cancer effect. Clinical validation of AFMMB is warranted.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Xinlun Dai, Xin Li, Yangyang Du, Mingda Han, Zhihua Wang, Yiqiao Wang, Fei Yan, Yahui Liu
Summary: A nanoplatform (GSBVVP) combining photothermal therapy (PTT) with dual blockade of VEGF and PD-L1 was designed to enhance the immune response for HCC treatment. This nanoplatform released a PD-L1 inhibitor upon NIR-II triggering, increasing the infiltration of CD8+ T cells and inhibiting VEGF secretion by tumor cells. Animal studies showed that GSBVVP-mediated photothermal immunotherapy significantly inhibited tumor growth, metastasis, and recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Jianhua Liu, Yue Song, Yiqiao Wang, Mingda Han, Chunxi Wang, Fei Yan
Summary: Cancer immunotherapy has made significant progress in recent years, but low patient response rates and dose-limiting toxicity remain major limitations. Researchers have designed a nanoplatform based on gold nanorods for enhanced photothermal immunotherapy against prostate cancer. The study highlights the importance of synergistic m6A RNA methylation and photothermal therapy in cancer immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
