Article
Engineering, Biomedical
Afeng Yang, Yun Bai, Xia Dong, Teng Ma, Dunwan Zhu, Lin Mei, Feng Lv
Summary: The biomaterial-mediated combined cell vaccines provide an innovative strategy for cancer immunotherapy by combining tumor cell and DC vaccines with a hydrogel and nanoadjuvant. This approach enhances the immunogenicity of cell vaccines, promotes antigen presentation, and inhibits tumor growth effectively, showing promising potential for improving cancer immunotherapy.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Bo Teng, Ping'an Ma, Jun Lin
Summary: This article reviews nanoadjuvants and their structure-function relationships, as well as their applications in cancer therapy. The article first introduces different types of adjuvants and then discusses their mechanisms. It summarizes the methods for evaluating immune effects of adjuvants. The authors particularly focus on the structure-function relationships of nanoadjuvants and explore their impact on immune activities. Finally, the safety of adjuvants is discussed, and representative advancements of nanoadjuvants in tumor immunotherapy and other therapies are presented.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Pan Zheng, Hao Chen, Ping'an Ma, Jun Lin
Summary: A new type of nanoadjuvant SiAl was synthesized in this study, which can significantly enhance immune response in therapeutic cancer vaccines and has potential for breast cancer treatment.
Article
Biotechnology & Applied Microbiology
Xiaoyan Xin, Xiaoyue Ni, Kang Shi, Jie Shao, Yanqiu Zhang, Xin Peng, Wen Yang, Chuanshuai Tian, Wen Zhou, Bing Zhang
Summary: Immunotherapy has great potential in cancer therapy, but uncontrolled biodistribution of drugs may lead to side effects. This study reports the development of an iodine-rich nanoadjuvant for photo-immunotherapy, which can effectively kill tumors and serve as a CT contrast agent for detection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle
Summary: The discovery of tumor antigens has led to the development of cancer vaccines, but many antigens lack immunogenicity. Adjuvants are added to vaccine formulations to trigger immune responses. Aging can lead to immunosenescence and chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nasser Hashemi Goradel, Mahnaz Nemati, Azam Bakhshandeh, Arash Arashkia, Babak Negahdari
Summary: Cancer vaccines have been developed as an interesting cancer immunotherapy approach to deliver tumor antigens and adjuvants to antigen-presenting cells (APCs). Nanotechnology-based vaccines, known as nanovaccines, address the limitations of traditional vaccines by co-delivering antigens and adjuvants to lymphoid organs and APCs, leading to potent anti-tumor immune responses. The formation of nanocomplexes between antigens and adjuvants based on electrostatic interactions has shown promising results in enhancing immune responses. This article summarizes the various platforms for developing cancer vaccines, discusses the advantages of using delivery systems, and focuses on the potential of nanocomplexes formation as cancer nanovaccine platforms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Hao Chen, Qi Meng, Jing Li, Chunzheng Yang, Wenying Zhang, Xinyang Li, Di Han, Pan Zheng, Ping'an Ma, Jun Lin
Summary: This article compares three commonly used mesoporous silica nanoparticles (MSNs) and finds that TMSN performs better than others in antigen loading, cellular uptake, ROS generation, lymph node targeting, immune activation, and therapeutic efficiency, providing a new paradigm for revealing the structure-function relationship of mesoporous silica nanoadjuvants, paving the way for their future clinical application.
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Chemistry, Multidisciplinary
Fangmin Chen, Tianliang Li, Huijuan Zhang, Madiha Saeed, Xiaoying Liu, Lujia Huang, Xiyuan Wang, Jing Gao, Bo Hou, Yi Lai, Chunyong Ding, Zhiai Xu, Zuoquan Xie, Min Luo, Haijun Yu
Summary: This study discovered that iron oxide nanoparticles (IONPs) can significantly enhance the production of type-I interferon (IFN-I) and achieve a dosage-sparing effect when combined with the STING agonist MSA-2. Acid-ionizable copolymers are coassembled with IONPs and MSA-2 to concentrate STING activation in lymph nodes and improve antigen cross-presentation. The iron nanoadjuvant PEIM effectively delivers antigens to antigen-presenting cells (APCs) and induces a potent and durable antitumor immune response.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Weiqi Wang, Qiwen Zhu, Yilan Jin, Jing Gao, Jianan Li, Xiaohua Zheng, Weidong Gao, Madiha Saeed, Weizhong Sheng, Haijun Yu
Summary: This study reports a self-immolated nanoadjuvant that enhances the effectiveness of cancer vaccination immunotherapy. The nanoadjuvants accumulate at the tumor site and release immune activators and photosensitizers in a specific manner. By activating immune cells and inducing immunogenic cell death of tumor cells, this nanoadjuvant effectively inhibits tumor growth and generates sustained immunological memory in a mouse model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hao Tian, Guohao Wang, Wei Sang, Lisi Xie, Zhan Zhang, Wenxi Li, Jie Yan, Ye Tian, Jie Li, Bei Li, Yunlu Dai
Summary: A phenolic nanoadjuvant has been developed to enhance the maturation of dendritic cells (DCs) and improve the efficacy of cancer immunotherapy. This nanoadjuvant promotes the activation of the cGAS-STING pathway and sensitizes tumors to PD-L1 checkpoint blockade immunotherapy, resulting in inhibiting tumor growth and restraining lung metastasis.
Review
Pharmacology & Pharmacy
Han Sun, Yu Zhang, Ge Wang, Wen Yang, Yingjie Xu
Summary: Significant technological innovations in the past two decades have made messenger RNA (mRNA) a promising option for various medical applications such as vaccines, protein replacement therapies, and genome engineering. The success of COVID-19 mRNA vaccines has sparked new interest in using mRNA for cancer treatment. In vitro-transcribed (IVT) mRNAs, delivered via lipid nanoparticles, can stimulate immune responses or provide additional beneficial proteins for cancer therapy. This review focuses on the molecular design, delivery systems, and clinical indications of mRNA therapies in cancer treatment.
Article
Chemistry, Applied
Danyang Wang, Yongjuan Zou, Ning Wang, Jie Wu
Summary: We developed an emulsion using chitosan hydrochloride salt (CSCL) as stabilizer, which effectively loaded antigens and slowed down antigen release. The emulsion showed strong immune responses and generated memory T cells in adaptive immunity.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Article
Chemistry, Multidisciplinary
Yue Yin, Xiaoyang Li, Haixia Ma, Jie Zhang, Di Yu, Ruifang Zhao, Shengji Yu, Guangjun Nie, Hai Wang
Summary: The research team developed a transformable hydrogel that can generate nanovaccines for up to 30 days after injection, showing promising potential for effective cancer immunotherapy.
Article
Engineering, Biomedical
Hanseul Park, Dongyoon Kim, Byounggook Cho, Junho Byun, Yong Sook Kim, Youngkeun Ahn, Jin Hur, Yu-Kyoung Oh, Jongpil Kim
Summary: CRISPR/Cas9 magnetoplexes have shown effective in vivo therapeutic gene targeting in myocardial infarction, potentially applicable for a broad range of cardiac failures.
Article
Critical Care Medicine
Charles-Herve Vacheron, Alain Lepape, Anne Savey, Anais Machut, Jean Francois Timsit, Philippe Vanhems, Quoc Viet Le, Julia Egbeola, Maelle Martin, Virginie Maxime, Paul-Simon Pugliesi, Delphine Maucort-Boulch, Arnaud Friggeri
Summary: This study found a higher incidence of ventilator-associated pneumonia among COVID-19 patients compared to the general ICU population. The microbiological ecology and resistance pattern were similar between the two groups, except for a lower rate of methicillin-resistant Staphylococcus aureus in the COVID-19 exposed patients.
CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Jaiwoo Lee, Dongyoon Kim, Quoc-Viet Le, Yu-Kyoung Oh
Summary: Immunotherapy shows promise in cancer treatment by utilizing the host immune system to fight cancer. Researchers have developed various nanoparticles delivery systems to enhance the efficacy of immunotherapy drugs. Additionally, they have studied strategies to modulate the tumor immune environment, such as surface-ligand modification and combining with an external stimulus.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Engineering, Biomedical
Quoc-Viet Le, Jaiwoo Lee, Junho Byun, Gayong Shim, Yu-Kyoung Oh
Summary: In this study, artificial dendritic cell-mimicking DNA microflowers (DM-AI) were developed for programming T cell stimulation. DM-AI showed high ex vivo expansion of cytotoxic T cells and induced recruitment and expansion of T cells in tumor tissues. Treatment with DM-AI also prevented tumor recurrence and growth in mice.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Gayong Shim, Sieon Jeong, Jung Leem Oh, Yeongseon Kang
Summary: Translation: Photorensponsive nanoparticles are a novel drug delivery system that can improve drug delivery efficiency by remotely controlling the in vivo behavior of drugs. Lipid-based nanoparticles containing photosensitive substances are drug formulations with good biocompatibility and controlled drug release. However, further research and development are needed to improve their application performance.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Jaiwoo Lee, Junho Byun, Gayong Shim, Yu-Kyoung Oh
Summary: This study reports a targeted anti-fibrotic peptide-delivery system that effectively reduces liver fibrosis by utilizing fibroblast activation protein to release an antifibrotic peptide.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jinwon Park, Quoc-Viet Le, Yina Wu, Jaiwoo Lee, Yu-Kyoung Oh
Summary: A tolerogenic nanovaccine has been developed and tested on an animal model of multiple sclerosis. The nanovaccine delivers a self-antigen to dendritic cells, blocking the interaction between immune cells and reducing interferon gamma secretion. The results show that the nanovaccine has significant preventive and therapeutic effects in the experimental autoimmune encephalomyelitis (EAE) model.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Jaiwoo Lee, Quoc-Viet Le, Seungbeom Ko, Sungtaek Kang, Robert B. Macgregor, Gayong Shim, Yu-Kyoung Oh
Summary: We report the development of polymeric DNA-supported gold clusters that achieve interparticle plasmon-coupling, generate immunotherapeutic effects at the tumor tissue, but decluster in the bloodstream. These gold clusters, supported by polyCpG DNA, exhibit higher light-to-heat conversion efficiency and inter-particle plasmon-coupling effect compared to monomer CpG-bound gold nanoparticles. In addition, the declustering behavior in the bloodstream enables these gold clusters to effectively treat tumors with minimal side effects.
Article
Biotechnology & Applied Microbiology
Quoc-Viet Le, Jaiwoo Lee, Seungbeom Ko, Hyunjung Kim, Thien Y. Vu, Yearn Seong Choe, Yu-Kyoung Oh, Gayong Shim
Summary: Metal chelator-based contrast agents are commonly used in cancer diagnosis. However, their rapid clearance and nonspecific accumulation in the body require large doses for effective tumor imaging, which compromises safety. This study presents an enzyme-responsive metal delivery system that selectively activates tumor uptake of gadolinium (Gd), resulting in enhanced contrast performance with an extended half-life. The system was found to be highly specific and safe in in vivo experiments, making it a promising theranostic agent for MR-guided radiotherapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nguyen Thi Hai Yen, Jung-Hwa Oh, Nguyen Thi Van Anh, Quoc-Viet Le, Se-Myo Park, Young Jin Park, Yong-Soon Cho, Kyoung-Sik Moon, Huy Truong Nguyen, Jae-Gook Shin, Nguyen Phuoc Long, Dong Hyun
Summary: This study conducted multi-specimen molecular characterization in rats treated with different doses of indomethacin to investigate its toxicity mechanism. The results showed that a dose of 10 mg/kg of indomethacin caused significant metabolic changes and kidney injury. Analysis revealed an oxidant-antioxidant imbalance and dysfunction of mitochondria, which resulted in the dysregulation of metabolites and genes related to the kidney, as well as the suppression of amino acid and fatty acid metabolism. These findings provide insights into the mechanism of indomethacin toxicity and suggest potential targets for reducing its toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
Jaeseong Lee, Sungtaek Kang, Hyeseon Park, Jeong Gil Sun, Eun Chae Kim, Gayong Shim
Summary: Lymph nodes are important organs that control immune cells and provide a pathway for tumors to spread. Nanoparticles offer several advantages for effective lymphatic delivery, including tailored size for migration and targeting of specific cells. Existing contrast agents are not able to selectively target metastatic lymph nodes, but nanoparticles can achieve this goal. Additionally, functionalized nanoparticles can deliver anticancer drugs to metastatic lymph nodes. This review discusses the use of nanoparticles for lymphatic mapping and highlights design considerations for detecting metastatic lymph nodes. Future directions for lymph node-targeting nanoparticles are also suggested.
Review
Pharmacology & Pharmacy
Songhee Kim, Boseung Choi, Yoojin Kim, Gayong Shim
Summary: Recently, lipid nanoparticles have gained prominence as RNA delivery vehicles, especially with the approval of preventative vaccines. Through microfluidic processes, nucleic acids such as RNA and proteins can be effectively incorporated into lipid nanoparticles, making them promising for various biopharmaceuticals. The successful development of mRNA therapies has further enhanced the potential of lipid nanoparticles as a delivery approach for biopharmaceuticals.
Article
Engineering, Biomedical
Junho Byun, Yina Wu, Jaiwoo Lee, Jung Suk Kim, Gayong Shim, Yu-Kyoung Oh
Summary: Cold atmospheric plasma is used to generate on-site hydrogel in the tumor environment, facilitating the uptake of tumor-associated antigens and nanoadjuvants by dendritic cells. This promotes the activation of immune cells and enhances the anti-tumor response.