O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
出版年份 2020 全文链接
标题
O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
作者
关键词
-
出版物
Frontiers in Oncology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-01-17
DOI
10.3389/fonc.2019.01547
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Overview of DNA methylation in adult diffuse gliomas
- (2019) Kosuke Aoki et al. Brain Tumor Pathology
- Posttreatment Effect of MGMT Methylation Level on Glioblastoma Survival
- (2019) Rikke H Dahlrot et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas
- (2019) Bernd Kaina et al. DNA REPAIR
- Gene promoter methylation and cancer: An umbrella review
- (2019) Emmanouil Bouras et al. GENE
- Clinical and Prognostic Significance of O6-Methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Melanoma: A Systematic Meta-Analysis
- (2018) Fang Qi et al. Annals of Dermatology
- Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma
- (2018) Anastasia Chumakova et al. JOURNAL OF NEUROCHEMISTRY
- Transcriptional control of O6 -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma
- (2018) Caroline Happold et al. JOURNAL OF NEUROCHEMISTRY
- Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation
- (2018) Dorthe Aasland et al. JOURNAL OF NEUROCHEMISTRY
- MGMT promoter methylation is not correlated with integrin expression in malignant gliomas: clarifying recent clinical trial results
- (2018) Oliver Schnell et al. MEDICAL ONCOLOGY
- MGMT assessment in pituitary adenomas: comparison of different immunohistochemistry fixation chemicals
- (2018) Alexander S. G. Micko et al. Pituitary
- Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide)
- (2018) Arshad A. Pandith et al. Scientific Reports
- Epigenetic Targeting of Glioblastoma
- (2018) Massimo Romani et al. Frontiers in Oncology
- Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes
- (2018) Alexandros Papachristodoulou et al. JOURNAL OF CONTROLLED RELEASE
- MiR-198 enhances temozolomide sensitivity in glioblastoma by targeting MGMT
- (2017) Er Nie et al. JOURNAL OF NEURO-ONCOLOGY
- Comparative assessment of three methods to analyze MGMT methylation status in a series of 350 gliomas and gangliogliomas
- (2017) Leiming Wang et al. PATHOLOGY RESEARCH AND PRACTICE
- RTOG 0525: A randomized phase III trial comparing standard adjuvant temozolomide (TMZ) with a dose-dense (dd) schedule in newly diagnosed glioblastoma (GBM).
- (2017) M. R. Gilbert et al. JOURNAL OF CLINICAL ONCOLOGY
- Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases
- (2017) Karl-Heinz Tomaszowski et al. Scientific Reports
- Corticosteroids compromise survival in glioblastoma
- (2016) Kenneth L. Pitter et al. BRAIN
- MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response
- (2016) Olivier J. Switzeny et al. Clinical Epigenetics
- Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients
- (2015) Pilar Mur et al. JOURNAL OF NEURO-ONCOLOGY
- Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors
- (2015) Karl-Heinz Tomaszowski et al. MOLECULAR PHARMACEUTICS
- Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM
- (2015) Maja T. Tomicic et al. Oncotarget
- MGMT promoter methylation and correlation with protein expression in primary central nervous system lymphoma
- (2014) L. Toffolatti et al. VIRCHOWS ARCHIV
- Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage
- (2013) A. Paranjpe et al. CARCINOGENESIS
- Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition
- (2013) Feng Wang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma
- (2013) Xiaoyin Jiang et al. JOURNAL OF NEURO-ONCOLOGY
- YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
- (2013) Klaus Mantwill et al. Journal of Translational Medicine
- MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status
- (2012) Pierre Bady et al. ACTA NEUROPATHOLOGICA
- MGMT testing for glioma in clinical laboratories: discordance with methylation analyses prevents the implementation of routine immunohistochemistry
- (2012) Sofia Mason et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy
- (2012) Consolación Melguizo et al. Journal of Translational Medicine
- Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial
- (2012) Annika Malmström et al. LANCET ONCOLOGY
- Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial
- (2012) Wolfgang Wick et al. LANCET ONCOLOGY
- miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
- (2012) W. Zhang et al. NEURO-ONCOLOGY
- A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts
- (2011) Deborah S. Malley et al. ACTA NEUROPATHOLOGICA
- Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours
- (2011) H A Tawbi et al. BRITISH JOURNAL OF CANCER
- Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma
- (2011) Miyuki Uno et al. Clinics
- Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
- (2011) Jörg Felsberg et al. INTERNATIONAL JOURNAL OF CANCER
- Predictive impact of MGMT promoter methylation in glioblastoma of the elderly
- (2011) Guido Reifenberger et al. INTERNATIONAL JOURNAL OF CANCER
- Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells
- (2011) Ryuichi Kanai et al. JNCI-Journal of the National Cancer Institute
- O6-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications
- (2011) A. A. Brandes et al. NEURO-ONCOLOGY
- Tumor O6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib
- (2010) A. J. Watson et al. CLINICAL CANCER RESEARCH
- Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells
- (2010) T Kato et al. GENE THERAPY
- MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma
- (2010) Markus Christmann et al. INTERNATIONAL JOURNAL OF CANCER
- Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma
- (2010) Francesca Pistollato et al. STEM CELLS
- O6-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib
- (2009) A J Watson et al. BRITISH JOURNAL OF CANCER
- Phase II Trial of Gliadel plus O6-Benzylguanine in Adults with Recurrent Glioblastoma Multiforme
- (2009) J. A. Quinn et al. CLINICAL CANCER RESEARCH
- MGMTPromoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951
- (2009) Martin J. van den Bent et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma
- (2009) Jennifer A. Quinn et al. JOURNAL OF CLINICAL ONCOLOGY
- NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide
- (2009) Wolfgang Wick et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma
- (2009) Jennifer A. Quinn et al. NEURO-ONCOLOGY
- Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas
- (2009) Sibille Everhard et al. NEURO-ONCOLOGY
- Anti-O6-Methylguanine-Methyltransferase (MGMT) Immunohistochemistry in Glioblastoma Multiforme: Observer Variability and Lack of Association with Patient Survival Impede Its Use as Clinical Biomarker
- (2008) Matthias Preusser et al. BRAIN PATHOLOGY
- O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy
- (2008) B. Verbeek et al. BRITISH MEDICAL BULLETIN
- Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma
- (2008) D. Beier et al. CANCER RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now