Article
Oncology
Debora D'Angelo Papaiz, Flavia Eichemberger Rius, Ana Luisa Pedroso Ayub, Clarice S. Origassa, Hemant Gujar, Diogo de Oliveira Pessoa, Eduardo Moraes Reis, Jeremie Nsengimana, Julia Newton-Bishop, Christopher E. Mason, Daniel J. Weisenberger, Gangning Liang, Miriam Galvonas Jasiulionis
Summary: In addition to mutations, epigenetic alterations contribute significantly to malignant transformation and tumor progression. By analyzing the methylome and transcriptome data, this study identified the relationship between changes in promoter and/or gene body DNA methylation and gene expression during different stages of melanoma progression. Two genes, Adcy3 and Inpp4b, were found to affect tumor growth and metastasis. The findings were validated by comparing them with clinical data from primary melanoma cohorts, suggesting potential prognostic markers.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Kazem Nejati-Koshki, Chris-Tiann Roberts, Ghader Babaei, Mojgan Rastegar
Summary: Epigenetic mechanisms control gene expression and cellular identity, with DNA methylation being an important epigenetic modification. Methyl-CpG-Binding Protein 2 (MeCP2) is a reader of DNA methylation and plays key roles in cellular identity and function. Recent studies have uncovered MeCP2's involvement in tumorigenesis of various human cancers, highlighting its potential oncogenic properties. This article provides an overview of the emerging role of MeCP2 as an oncogene in different types of human cancer.
Review
Medicine, General & Internal
Oscar Rapado-Gonzalez, Jose Luis Lopez-Cedrun, Rafael Lopez-Lopez, Ana Maria Rodriguez-Ces, Maria Mercedes Suarez-Cunqueiro
Summary: Oral carcinogenesis is a multistep process involving multiple genetic and epigenetic alterations. Aberrant promoter hypermethylation leading to gene silencing is an important epigenetic event in cancer development, with potential as a biomarker for early diagnosis and therapy. Detection of methylated genes in saliva could be a noninvasive approach for oral cancer screening and early diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Jianwei Feng, Xinyue Meng
Summary: Abnormal epigenetic modifications are closely related to tumor occurrence and development in breast cancer. Histone modifications play important roles and therapeutic methods targeting these modifications are under research and development. However, further studies are needed to investigate the underlying mechanisms and refine the treatment methods.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Chenhui Ma, Bofang Wang, Weigao Pu, Huanhuan Ma, Kewei Song, Na Wang, Xiaobo Deng, Hao Chen
Summary: By systematically evaluating the association between the methylation status of multiple gene promoters and gastric cancer, this study found a higher frequency of CpG island methylation in gastric cancer tissues compared to non-neoplastic tissues. Furthermore, the aberrant promoter methylation of multiple genes might be involved in the early development and progression of gastric cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yuanyuan Wu, Juan Du
Summary: This study aimed to investigate the role of LINC00467 in the growth and metastasis of gastric cancer (GC). The results showed that LINC00467 promoted the methylation of the Reprimo promoter by recruiting DNMT1, leading to decreased expression of Reprimo. Knockdown of LINC00467 weakened the malignant properties of GC cells and reduced tumorigenesis and metastasis in vivo.
Article
Oncology
Chih-Ming Ho, Ting-Lin Yen, Tsai -Yen Chien, Shih-Hung Huang
Summary: CpG-island methylation plays a role in ovarian cancer progression and is associated with survival outcomes. Differential promoter methylation of tumor suppressor genes (TSGs) was observed, with RASSF1A hypomethylation and increased aggressiveness in mesenchymal-like OCSPCs. Overexpression of CCND2 and CDKN2B reduced the aggressiveness of mesenchymal-like OCSPCs and may serve as potential therapeutic targets for EOC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Colin F. Davenport, Tobias Scheithauer, Alessia Dunst, Frauke Sophie Bahr, Marie Dorda, Lutz Wiehlmann, Doan Duy Hai Tran
Summary: Downregulation of multiple tumor suppressor genes is crucial in cancer formation, with epigenetic modifications playing a significant role. Using nanopore sequencing technology, the study identified potential TSGs in HCC and demonstrated the tumor suppressor function of GCK in inhibiting HCC cell proliferation through lactate accumulation-induced energy crisis. These findings offer valuable insights for further understanding tumorigenesis in human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Juan Ramon Tejedor, Alfonso Penarroya, Javier Gancedo-Verdejo, Pablo Santamarina-Ojeda, Raul F. Perez, Sara Lopez-Tamargo, Ana Diez-Borge, Juan J. Alba-Linares, Nerea Gonzalez-del-Rey, Rocio G. Urdinguio, Cristina Mangas, Annalisa Roberti, Virginia Lopez, Teresa Morales-Ruiz, Rafael R. Ariza, Teresa Roldan-Arjona, Monica Meijon, Luis Valledor, Maria Jesus Canal, Daniel Fernandez-Martinez, Maria Fernandez-Hevia, Paula Jimenez-Fonseca, Luis J. Garcia-Florez, Agustin F. Fernandez, Mario F. Fraga
Summary: This study utilized a multi-omics approach to identify gene candidates with strong correlations between DNA methylation and gene expression in human colorectal cancer (CRC) samples and colon cancer cell lines. The researchers used CRISPR-Cas9 epigenome editing tools to modulate the DNA methylation status of 56 promoters previously linked with epigenetic repression in CRC and assessed the functional consequences. Overall, the epigenetic modulation had a mild impact on gene expression reactivation and cancer cell viability, but the reactivation of RSPO2 was associated with impaired cell proliferation in p53(-/-) cancer cell lines.
CLINICAL EPIGENETICS
(2023)
Review
Gastroenterology & Hepatology
JianRu Wen, SiXiu Deng, YuHua Bi, LiJuan Qiao, Hui Xu
Summary: This study aims to investigate the correlation between the methylation status of multiple gene promoters and gastric cancer. The results show that a higher frequency of CpG islands methylation was identified in gastric cancer tissues, suggesting that aberrant polygene methylation might be associated with the initial onset and progression of gastric cancer. Therefore, the DNA methylation of these genes may serve as underlying epigenetic biomarkers, providing a promising molecular diagnostic approach for human gastric cancer clinical diagnosis.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Oncology
Sadegh Rajabi, Catherine Alix-Panabieres, Arshia Sharbatdar Alaei, Raziyeh Abooshahab, Heewa Shakib, Mohammad Reza Ashrafi
Summary: This review discusses the inactivation mechanisms and alterations of tumor-suppressor genes in thyroid cancer in order to identify more effective treatment options.
Article
Gastroenterology & Hepatology
Amisha Bharti, Amrita Ghosh Kar, Deepika Singh, Mumtaz Ahmad Ansari, Mallika Tewari, Gopeshwar Narayan, Sunita Singh
Summary: This study investigated the expression profile and promoter methylation status of BNIP3 in gallbladder cancer (GBC). The results demonstrated a down regulation of BNIP3 and frequent hypermethylation of its promoter in GBC samples. The study suggests that promoter hypermethylation may be a common mechanism for the downregulation of BNIP3 in GBC.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Cell Biology
Mark Tomas Mc Auley
Summary: Ageing is a biological process characterized by physical decline and increased risk of mortality over time, with recent evidence linking epigenetic mechanisms like DNA methylation to age-related diseases. Evolutionary theory provides insights into how genes impact fitness at different ages, and how DNA methylation changes are associated with age onset pathology.
AGEING RESEARCH REVIEWS
(2021)
Article
Ophthalmology
Aikaterini K. Seliniotaki, Maria Lithoxopoulou, Stella Moutzouri, Emmanouil Bouras, Elisavet Diamanti, Nikolaos Ziakas, Pia Lundgren, Ann Hellstrom, Anna-Bettina Haidich, Asimina Mataftsi
Summary: The purpose of this study was to investigate the association between platelet parameters and postnatal weight gain with treatment-requiring ROP. The findings suggest that platelet count and platelet transfusions are associated with the development of TR-ROP, while platelet volume, number of thrombopenic episodes, and WSDS are not.
ACTA OPHTHALMOLOGICA
(2023)
Article
Oncology
Robert Carreras-Torres, Andre E. Kim, Yi Lin, Virginia Diez-Obrero, Stephanie A. Bien, Conghui Qu, Jun Wang, Niki Dimou, Elom K. Aglago, Demetrius Albanes, Volker Arndt, James W. Baurley, Sonja I. Berndt, Stephane Bezieau, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Xuechen Chen, David Conti, Christopher H. Dampier, Matthew A. M. Devall, David A. Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Kristina M. Jordahl, Eric Kawaguchi, Temitope O. Keku, Anshul Kundaje, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John L. Morrison, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A. Newcomb, Mireia Obon-Santacana, Shuj Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoen, Anna Shcherbina, Martha L. Slattery, Mariana C. Stern, Yu-Ru Su, Catherine M. Tangen, Duncan C. Thomas, Yu Tian, Konstantinos K. Tsilidis, Cornelia M. Ulrich, Fräuronzel J. B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Tjeng Wawan Cenggoro, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Li Hsu, Ulrike Peters, Victor Moreno, W. James Gauderman
Summary: A genome-wide interaction scan revealed novel genetic loci associated with the risk of colorectal cancer in relation to smoking. The identified loci were found to be involved in tumor suppression and immune response. These findings have important implications for potential prevention treatments.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Biochemical Research Methods
Verena Heise, Constance Holman, Hung Lo, Ekaterini Maria Lyras, Mark Christopher Adkins, Maria Raisa Jessica Aquino, Konstantinos I. Bougioukas, Katherine O. Bray, Martyna Gajos, Xuanzong Guo, Corinna Hartling, Rodrigo Huerta-Gutierrez, Miroslava Jindrova, Joanne P. M. Kenney, Adrianna P. Kepinska, Laura Kneller, Elena Lopez-Rodriguez, Felix Muehlensiepen, Angela Richards, Gareth Richards, Maximilian Siebert, James A. Smith, Natalie Smith, Nicolai Stransky, Sirpa Tarvainen, Daniela Sofia Valdes, Kayleigh L. Warrington, Nina-Maria Wilpert, Disa Witkowska, Mirela Zaneva, Jeanette Zanker, Tracey L. Weissgerber
Summary: Open, reproducible, and replicable research practices are crucial in scientific research. Grassroots-level training, often conducted by early career researchers for early career researchers, can provide a platform for learning new practices. This study outlines ten simple rules for participants of such training courses to implement robust research practices in their own projects. These rules include prioritizing and planning the implementation process, managing implementation problems, and integrating reproducible research and open science practices into future research careers. Strategies for course organizers to prepare and support participants during the implementation process are also discussed.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Review
Mathematical & Computational Biology
Konstantinos I. Bougioukas, Theodoros Diakonidis, Anna C. Mavromanoli, Anna-Bettina Haidich
Summary: An overview of reviews aims to collect, assess, and synthesize evidence from multiple systematic reviews on a specific topic. A free R package called ccaR is introduced to assess the overlap of primary studies in an overview of reviews using the corrected cover area index. This package can assist overview authors, methodologists, and reviewers in calculating the CCA index and creating publication-ready heatmaps.
RESEARCH SYNTHESIS METHODS
(2023)
Review
Biology
Paschalis Devranis, Emilia Vassilopoulou, Vasileios Tsironis, Panagiotis Marios Sotiriadis, Michail Chourdakis, Michalis Aivaliotis, Magdalini Tsolaki
Summary: This study systematically reviewed the evidence of three dietary patterns, the Mediterranean diet, the ketogenic diet, and the MIND diet, for the prevention of cognitive decline. The analysis showed that all three dietary interventions could slow the rate of cognitive decline.
Article
Nutrition & Dietetics
Androniki Papaemmanouil, Dimitra Rafailia Bakaloudi, Konstantina Gkantali, Georgios Kalopitas, Simeon Metallidis, Georgios Germanidis, Michael Chourdakis
Summary: The study found that handgrip strength (HGS) could be used as an indicator of clinical outcomes in COVID-19 patients, while phase angle (PhA) does not seem to have a clinical impact. However, further research is needed to validate the results of our study.
Article
Nutrition & Dietetics
Antigoni Tranidou, Themistoklis Dagklis, Emmanuella Magriplis, Aikaterini Apostolopoulou, Ioannis Tsakiridis, Violeta Chroni, Eirini Tsekitsidi, Ioustini Kalaitzopoulou, Nikolaos Pazaras, Michail Chourdakis
Summary: This study aims to identify the relationship between adherence to a Mediterranean diet before conception and the risk of gestational diabetes mellitus (GDM) in Greek pregnant women. The study found that high adherence to a Mediterranean diet before pregnancy is associated with a lower incidence of GDM. Additionally, pre-pregnancy consumption of meat is associated with a higher risk of GDM.
Article
Nutrition & Dietetics
Antigoni Tranidou, Emmanuela Magriplis, Ioannis Tsakiridis, Nikolaos Pazaras, Aikaterini Apostolopoulou, Michail Chourdakis, Themistoklis Dagklis
Summary: The study aimed to evaluate the impact of gestational weight gain (GWG) up to 23(+6) weeks of gestation on the development of Gestational Diabetes Mellitus (GDM). A cohort of 5948 pregnant women in Northern Greece was assessed. Data on pre-pregnancy and during pregnancy anthropometric features were collected, and a Generalized Linear Regression Model (GLM) was used for analysis. The results showed that GDM likelihood increased with maternal age and pre-pregnancy BMI. In women with normal pre-pregnancy weight, excessive weight gain was associated with higher odds of GDM. Furthermore, obese women who transitioned from BMI > 35 kg/m(2) to BMI >= 40 kg/m(2) had an increased likelihood of GDM. Therefore, closer monitoring for GDM may be needed in older pregnant women, and recommended GWG for obese women may need further evaluation.
Review
Biochemistry & Molecular Biology
Evangelia Kotzakioulafi, Dimitra Rafailia Bakaloudi, Lydia Chrysoula, Xenophon Theodoridis, Christina Antza, Ilias Tirodimos, Michail Chourdakis
Summary: Diabetes mellitus type 2 (DMT-2) is on the rise and its complications are a major contributor to cardiovascular disease and overall mortality. Adopting a Mediterranean diet (MD) has been found effective in preventing and managing DMT-2. This meta-analysis investigates the role and extent of MD adherence in DMT-2 prevention.
Article
Oncology
Niki Dimou, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K. Aglago, Emmanouil Bouras, Peter T. Campbell, Graham Casey, Steven Gallinger, Stephen B. Gruber, Mark A. Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C. Stern, Yu Tian, Kostas K. Tsilidis, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephane Bezieau, Stephanie A. Bien, D. Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Xuechen Chen, David V. Conti, Christopher H. Dampier, Matthew Devall, David A. Drew, Jane C. Figueiredo, Graham G. Giles, Andrea Gsur, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O. Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A. Newcomb, Christina C. Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Peter C. Scacheri, Robert E. Schoen, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Cornelia M. Ulrich, Caroline Y. Um, Franzel J. B. van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O. Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W. James Gauderman, Marc J. Gunter, Ulrike Peters
Summary: Diabetes is a risk factor for colorectal cancer, but the mechanisms and genetic variants affecting this relationship are still unclear. Through genome-wide gene-environment interaction analysis, it was found that variations in insulin signaling gene (SLC30A8) and immune function gene (LRCH1) may modify the association between diabetes and colorectal cancer risk.
BRITISH JOURNAL OF CANCER
(2023)
Review
Nutrition & Dietetics
Xenophon Theodoridis, Michail Chourdakis, Lydia Chrysoula, Violeta Chroni, Ilias Tirodimos, Konstantina Dipla, Eugenia Gkaliagkousi, Areti Triantafyllou
Summary: The aim of this study was to assess the effect of adherence to the DASH diet on hypertension risk. Results from a systematic review and meta-analysis of 12 studies showed that high adherence to the DASH diet was associated with a lower risk of hypertension. These findings support the importance of lifestyle changes in reducing hypertension risk.
Article
Nutrition & Dietetics
Aikaterini Apostolopoulou, Antigoni Tranidou, Violeta Chroni, Ioannis Tsakiridis, Emmanuella Magriplis, Themistoklis Dagklis, Michail Chourdakis
Summary: This study examined the relationship between maternal nutrition during pre-pregnancy and early pregnancy and the incidence of small-for-gestational-age neonates in women with gestational diabetes mellitus. The findings suggest that higher fat intake and lower intake of carbohydrates, fiber, magnesium, and copper during early pregnancy are associated with an increased risk of small-for-gestational-age neonates. These results emphasize the importance of assessing and modifying maternal nutrition in reducing the risk of gestational diabetes mellitus and its associated complications.
Article
Medicine, General & Internal
Ariadni Fouza, Anneta Tagkouta, Maria Daoudaki, Maria Stangou, Asimina Fylaktou, Konstantinos Bougioukas, Aliki Xochelli, Lampros Vagiotas, Efstratios Kasimatis, Vasiliki Nikolaidou, Lemonia Skoura, Aikaterini Papagianni, Nikolaos Antoniadis, Georgios Tsoulfas
Summary: This study examined B cell phenotypes in kidney transplant recipients and found that patients can be stratified into different clusters based on the combination of phenotypic heterogeneity, naive B cells, and glomerular filtration rate using unsupervised machine learning.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Konstantina Psatha, Laxmikanth Kollipara, Elias Drakos, Elena Deligianni, Konstantinos Brintakis, Eustratios Patsouris, Albert Sickmann, George Z. Rassidakis, Michalis Aivaliotis
Summary: The activation of wild-type p53 protein in human lymphoma is a promising therapeutic strategy. An in vitro integrative comparative multi-omics analysis of different lymphoma types before and after p53 activation can shed light on the molecular mechanisms involved. Our findings provide valuable insights into the role of specific proteins and pathways in lymphoma pathogenesis and the global effect of nutlin-3a, which can guide targeted studies on lymphoma progression and resistance.
Review
Biochemistry & Molecular Biology
Xenophon Theodoridis, Areti Triantafyllou, Lydia Chrysoula, Fotios Mermigkas, Violeta Chroni, Konstantina Dipla, Eugenia Gkaliagkousi, Michail Chourdakis
Summary: The objective of this study was to systematically review the literature and perform a meta-analysis to evaluate the effect of adherence to the DASH diet on blood pressure. The results showed that greater adherence to the DASH diet had a beneficial effect on blood pressure compared to lower adherence. Future studies should aim to standardize adherence tools and utilize rigorous study designs to further understand the potential benefits of adherence to the DASH diet in blood pressure management.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
