Article
Physiology
Xiao-Xiao Shi, Mu-Fei Zhu, Ni Wang, Yuan-Jie Huang, Min-Jing Zhang, Chao Zhang, Soomro A. Ali, Wen-Wu Zhou, Chuanxi Zhang, Cungui Mao, Zeng-Rong Zhu
Summary: The study demonstrates the pivotal role of neutral ceramidase (NCER) in female reproduction of the brown planthopper, influencing oocyte maturation, oviposition, and egg hatching rate through regulation of ceramide levels.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C. Saido, Minako Ito
Summary: Neutrophils infiltrate the brain tissue of Alzheimer's disease (AD) when acute colitis occurs, and this infiltration is significantly related to disease progression. Therefore, neutrophil-targeted therapies could reduce A beta accumulation observed in early AD and prevent the increased risk of AD due to colitis.
INFLAMMATION AND REGENERATION
(2023)
Review
Endocrinology & Metabolism
Joshua L. Milstein, Heather A. Ferris
Summary: The brain was once thought to be an insulin-insensitive organ, but now we know that insulin plays important roles in brain function and whole-body metabolism. Brain insulin resistance can lead to metabolic issues and contribute to conditions like obesity and neurodegeneration, such as Alzheimer's disease. Normal insulin signaling is crucial for brain health, affecting mitochondrial functioning and food intake.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Liubov S. Kalinichenko, An-Li Wang, Christiane Muehle, Laila Abdel-Hafiz, Erich Gulbins, Johannes Kornhuber, Andre W. C. Oliveira, Marilia Barros, Joseph P. Huston, Christian P. Mueller
Summary: The study found that neutral ceramidase plays an important role in learning and memory mechanisms in rats and non-human primates, and serum NC activity may predict the performance of certain types of memory.
PHARMACOLOGICAL REPORTS
(2021)
Review
Gastroenterology & Hepatology
Timon E. Adolph, Moritz Meyer, Julian Schwarzler, Lisa Mayr, Felix Grabherr, Herbert Tilg
Summary: Experimental and clinical evidence support the role of metabolic perturbation in gut inflammation in IBD, which is linked to dietary factors. These studies also highlight the connection between metabolism and inflammation in IBD.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Review
Biochemistry & Molecular Biology
Chang-Kee Hyun
Summary: There is considerable comorbidity between metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Dysfunction in the intestinal barrier and pro-inflammatory responses in the intestinal immune system are key factors linking the pathogenesis of these diseases. Disrupted gut microbial composition and alterations in gut microbiota-derived metabolites are also closely related to the development of both metabolic disorders and IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Meng Mei, Maochang Liu, Yan Mei, Jing Zhao, Yang Li
Summary: This article reviews the role and mechanism of sphingolipids in brain insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ga Hee Kim, Yeong Chan Lee, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim
Summary: The study found that patients with inflammatory bowel disease (IBD) have a higher risk of neurodegenerative diseases compared to the non-IBD population. IBD patients aged 40-65 had a higher risk of Parkinson's disease, while patients aged 65 and above had an increased risk of Alzheimer's disease.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Biochemistry & Molecular Biology
Annie Kleynerman, Jitka Rybova, Mary L. Faber, William M. McKillop, Thierry Levade, Jeffrey A. Medin
Summary: Farber disease (FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) are ultra-rare autosomal-recessive disorders caused by ASAH1 gene mutations. These mutations lead to reduced ACDase activity and ceramide accumulation in tissues, resulting in diverse clinical phenotypes. Mouse models have been developed to study the consequences of ceramide accumulation and potential therapies for FD and SMA-PME.
Review
Geriatrics & Gerontology
Nanyang Liu, Yi Wang, Lanye He, Jiahui Sun, Xing Wang, Hao Li
Summary: The study found that a previous diagnosis of inflammatory bowel disease (IBD) does not seem to increase the risk of subsequent all-cause dementia and AD-dementia. Cohort studies show a positive association between IBD patients and all-cause dementia, but it is not related to age and gender.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Guanghui Cui, Shaojie Li, Hui Ye, Yao Yang, Qiuyue Huang, Yingming Chu, Zongming Shi, Xuezhi Zhang
Summary: The study revealed a significant causal association between genetically predicted Parkinson's disease and ulcerative colitis, while there was no causal link between genetically predicted Alzheimer's disease and inflammatory bowel disease. Further animal experiments or population-based observational studies are needed to elucidate the underlying mechanisms between Parkinson's disease and inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sunil Thomas, George C. C. Prendergast
Summary: Longer lifespan increases the risk of age-associated neurodegenerative disorders such as Alzheimer's disease, which is characterized by declines in memory and cognitive function. The development of Alzheimer's disease is linked to the aggregation of beta-amyloid peptides and phosphorylated tau protein in the brain. Recent studies have shown that Bin1, a disease modifier gene, binds to tau and influences its deposition, providing a potential target for therapeutic intervention. Interestingly, tau levels also increase in the colon before the onset of Alzheimer's disease, suggesting a connection between gut health and neurodegenerative disorders.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Mariusz Olczyk, Elzbieta Czkwianianc, Anna Socha-Banasiak
Summary: In recent years, there has been an increase in the incidence of inflammatory bowel diseases in the pediatric population. However, there is a lack of research in this area, especially regarding metabolic disorders in patients with IBD.
Article
Multidisciplinary Sciences
Melissa Vos, Marija Dulovic-Mahlow, Frida Mandik, Lisa Frese, Yuliia Kanana, Sokhna Haissatou Diaw, Julia Depperschmidt, Claudia Boehm, Jonas Rohr, Thora Lohnau, Inke R. Koenig, Christine Klein
Summary: The study reveals the crucial role of ceramide in PINK1-related Parkinson's disease and indicates that adjusting lipid metabolism can improve mitochondrial function, highlighting the connection between ceramide and mitochondria in the pathophysiology of PD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Malin Eh, Alexander Tobias Kaczmarek, Guenter Schwarz, Daniel Bender
Summary: Sulfite oxidase (SOX) is an enzyme that contains both molybdenum and heme, and is responsible for oxidizing sulfite to sulfate. It has been found that one functional subunit in SOX is sufficient for catalysis, and electrons can be transferred between different subunits.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Deep Lata Singh, Vineet Mishra, Tapan Kumar Ghosh, G. Ranga Rao
Summary: Rare earth based metal-organic frameworks (RE-MOFs) are important in energy storage applications. In this study, two new RE-MOFs (Ln-H(2)PDA, Ln=La and Sm) were synthesized using pyridine-2,6-dicarboxylic acid linker. These MOFs showed high specific capacity and the symmetric Swagelok device using Sm-H(2)PDA MOF as working electrodes delivered high energy density and power density.
Editorial Material
Cell Biology
Anila Sharma, Ketan Pandya, Vineet V. Mishra
Summary: This article discusses the discovery of a new allele caused by a nucleotide substitution in the HLA-DRB1 gene.
Article
Transplantation
Pritam Khomane, Hari Shankar Meshram, Subho Banerjee, Priyash Tambi, Himanshu Patel, Ansy Patel, Miteshkumar Jashubhai Makwana, Saurabh Sharma, Vineet Mishra, Vivek B. Kute
Summary: The COVID-19 vaccine policies for solid-organ transplant patients in India vary among centers, with some centers offering vaccination on a voluntary basis while others require it for transplant candidates. The most common vaccine administered is CoviShield, with over 50% of transplant recipients and donors fully vaccinated. The optimal timing for vaccination after transplant is 3 to 6 months, and many transplant centers recommend booster doses.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Nanoscience & Nanotechnology
Deep Lata Singh, Tapan Kumar Ghosh, Vineet Mishra, Shanmugam Ramasamy, Malaya K. Sahoo, Ranga Rao Gangavarapu
Summary: Lanthanides have been found to be useful for the synthesis of nanoporous materials with high coordination environment, which shows great potential in energy storage. By synthesizing lanthanide-based metal-organic frameworks (MOFs), researchers have discovered their excellent electrochemical performance, making them promising for supercapacitor applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Dermatology
Ching-Han Tsao, Wei-Chen Hsieh, Feng-Jen Lin, Ri-Yao Yang, Meng-Ting Chang, Maria Karmella Apaya, Lie -Fen Shyur, Liang-Yin Ke, Christos C. Zouboulis, Fu-Tong Liu
Summary: Sebaceous glands produce lipids that are crucial for maintaining the skin barrier. Galectin-12 protein has been found to regulate sebocyte differentiation and lipid production, playing a positive role in sebaceous lipid metabolism.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shi-Hui Law, Hua-Chen Chan, Guan-Ming Ke, Swetha Kamatam, Gopal Kedihithlu Marathe, Vinoth Kumar Ponnusamy, Liang-Yin Ke
Summary: Despite the availability of cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality. Lipid moieties such as lysophosphatidylcholine (LPC) and ceramide (CER) contribute to atherogenic events. The HFD-fed apoE(-/-) mouse model shows elevated LPC and CER contents, making it suitable for developing LPC- and CER-lowering therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Chia-Chi Cheng, Guan-Ming Ke, Pei-Yu Chu, Liang-Yin Ke
Summary: Norovirus is the leading cause of foodborne gastroenteritis, impacting millions of people worldwide annually. Different genotypes of norovirus exhibit post-translational modifications (PTMs) in their viral antigens, such as glycosylation and phosphorylation, which are associated with viral replication and virulence. Recent advancements in mass spectrometry have led to the discovery of more PTMs, contributing significantly to the prevention and treatment of infectious diseases. However, the mechanisms by which PTMs affect noroviruses are still not well understood. This section reviews the current knowledge on PTMs in noroviruses and their impact on pathogenesis, as well as the strategies and techniques for their identification.
Article
Virology
Po-Kai Chen, Jyun-Hao Chang, Liang-Yin Ke, Jun-Kai Kao, Chang-Hua Chen, Rei-Cheng Yang, Teruki Yoshimura, Etsuro Ito, Jih-Jin Tsai
Summary: A detection method for the NS1 protein based on an ultrasensitive ELISA was developed and evaluated, showing high sensitivity and specificity. This low-cost and easy-to-use method has great potential for clinical diagnosis of DENV, especially in low-income countries.
Article
Mathematical & Computational Biology
Yen-Yi Liu, Chu-Yi Hsu, Ya-Chu Yang, Chien-Hsun Huang, Chih-Chieh Chen
Summary: ProbioMinServer is a platform designed to help researchers access information on probiotics regarding safety and functionality. It provides an integrated approach for evaluating the safety and functionality of probiotic strains and identifying phylogenetically related strains. Using this platform, researchers can quickly and easily retrieve information on various probiotics.
BIOINFORMATICS ADVANCES
(2023)
Meeting Abstract
Immunology
Sanshriti Chauhan, Himanshu Patel, Subho Banerjee, Vivek Kute, Vineet Mishra, Nauka Shah, Priyash Tambi, Ruchir Dave, Akash Shah
Meeting Abstract
Immunology
Hari Shankar Meshram, Vivek Kute, Vineet Mishra, Himanshu Patel, Subho Banerjee, Geeta Parikh, S. Jamal Rizvi, Ansy Patel, Michael Rees, Alvin Roth
Meeting Abstract
Immunology
Hari Shankar Meshram, Sanshriti Chauhan, Nauka Shah, Vivek Kute, Himanshu Patel, Ruchir Dave, Vineet Mishra
Meeting Abstract
Immunology
Sanshriti Chauhan, Himanshu Patel, Vivek Kute, Sudeep Patel, Sudeep Desai, Vineet Mishra
Article
Transplantation
Vivek B. Kute, Hari Shankar Meshram, Sanshriti Chauhan, Nauka Shah, Ansy H. Patel, Himanshu V. Patel, Divyesh Engineer, Subho Banerjee, Ruchir Dave, Vineet V. Mishra
Summary: COVID-19 mortality among organ transplant recipients in India is lower compared with the Western world, attributed to younger age and fewer comorbidities among the Indian population. Older age and chronic graft dysfunction are associated with higher mortality and graft loss. Indian transplant societies have formulated guidelines for transplantation during the COVID-19 era and living donor transplants after recovery from COVID-19 were first described in India. Reports of recovered solid-organ transplant recipients show reassuring long-term outcomes.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
