Article
Chemistry, Applied
Zhaomin Zheng, Qilin Huang, Yu Kang, Yonggang Liu, Wei Luo
Summary: The study investigated the influence of molecular size and chain conformation of water-soluble yeast beta-glucan on its interaction with Dectin-1, revealing that higher molecular weight beta-glucan exhibited a spherical conformation while smaller molecular weight beta-glucan showed a stiff chain conformation. The interaction between beta-glucan and Dectin-1 was found to be easier for spherical beta-glucan with longer side chains.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Fan Yang, Shang Shang, Mengfei Qi, Yajinjing Xiang, Lingmin Wang, Xinyi Wang, Tao Lin, Doudou Hao, Jiajia Chen, Jia Liu, Qing Wu
Summary: This review summarizes the recent advances in the application of yeast glucan particles (YGPs) in oral targeted delivery systems, including their structure, preparation methods, drug encapsulation, and characterization. It highlights the mechanism and validation of the target recognition interaction between YGPs and macrophages, and presents inspiring cases to demonstrate the promising applications of yeast cells. The future opportunities and challenges that YGPs may face are also emphasized in this article.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Acoustics
Hongjie Yuan, Yan He, Hua Zhang, Xia Ma
Summary: This study investigated the effects and mechanisms of ultrasound-assisted enzymolysis on the solubilization and modification of yeast beta-glucan. The results showed that ultrasound enhanced the solubility and antioxidant activities of yeast beta-glucan, leading to smaller particles and improved stability in water.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Cell Biology
Jiao Wang, Di Zhao, Cheng-Zhi Ding, Feng Guo, Li-Na Wu, Feng-Jiao Huang, Yan-Ling Liu, Shui-Ying Zhao, Ying Xin, Sheng-Nan Ma, Hong-Fei Ji, Xiang Wang, Li-Rui Wei
Summary: miR-194 suppresses GLP-1 synthesis in L cells by inhibiting TCF7L2-mediated gcg transcription and Foxa1-mediated pcsk1 transcription, while also being involved in PA-induced apoptosis of L cells.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Applied
Dominik Rotrekl, Petra Salamunova, Lenka Parakova, Ondrej Bado, Ivan Salon, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Zongbao Zhou, Jiangwei Xiao, Sheng Huang, Hengpeng Wu, Shuwen Guan, Tingting Wu, Shan Yu, Shuai Huang, Botao Gao
Summary: In this study, a multifunctional degradable hemostatic sponge based on carboxymethylated yeast beta-glucan (CMYG) was developed. The CMYG sponge demonstrated rapid blood absorption, tissue adhesion, and good in vitro biocompatibility. Compared to a commercial product, the CMYG sponge achieved faster hemostasis and reduced blood loss in liver injury rat models, and also showed outstanding antioxidant, anti-infection, anti-inflammatory, and cell proliferation effects, making it a promising candidate for clinical management of uncontrollable hemorrhage and wound repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yanmin Cui, Xuedong Han, Xiaopei Hu, Tuoping Li, Suhong Li
Summary: In this study, the structural and physicochemical properties of beta-glucans from Lentinula edodes, yeast, and oat were compared using HPLC and FT-IR analysis. Different micro surfaces and structures were observed for beta-glucans from different species. Additionally, the antioxidant activities and alpha-glucosidase inhibitory activity varied among the beta-glucans.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Roohallah Saberi Riseh, Mozhgan Gholizadeh Vazvani, John F. Kennedy
Summary: By extracting beta-glucan as an inducing agent, plant diseases can be effectively controlled, and beta-glucan plays a crucial role in the interaction between plants and pathogens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Yongxia Xu, Yanan Lv, Yiming Yin, Honglei Zhao, Shumin Yi, Xuepeng Li, Jianrong Li
Summary: The effects of yeast beta-glucan on the aggregation and flavour adsorption capacity of Spanish mackerel myosin were investigated. YG increased the surface hydrophobicity and active sulfhydryl content of myosin, promoted its unfolding, and enhanced its flavour-binding capacity. However, lengthy heat treatment and YG addition accelerated the cross-linking and aggregation of myosin, leading to a reduction in flavour-binding sites.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Acoustics
Xia Ma, Lin Dong, Yan He, Shiwen Chen
Summary: Through the combined degradation of ultrasonic waves and H2O2, the solubility of yeast β-glucan (YG) was improved, resulting in a new product called YGUH. The optimal solubilization conditions were a reaction time of 4 hours, ultrasonic power of 3 W/mL, and H2O2 concentration of 24%. Ultrasound-assisted H2O2 degradation greatly improved the free radical scavenging activity of YG.
ULTRASONICS SONOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Mubashir Hassan, Saba Shahzadi, Richard F. Ransom, Andrzej Kloczkowski
Summary: Medicinal mushrooms are potential sources of valuable medicines, possessing significant therapeutic properties and being used as medications for various diseases. They have a wide range of important biological activities and can be used as antioxidants, anti-inflammatory, anticancer, and antidiabetic agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Pilanee Vaithanomsat, Nutthamon Boonlum, Chanaporn Trakunjae, Waraporn Apiwatanapiwat, Phornphimon Janchai, Antika Boondaeng, Kanokwan Phalinphattharakit, Hataitip Nimitkeatkai, Amnat Jarerat
Summary: This study focused on the recovery of beta-glucan (BG) from yeast using alkaline and enzymatic processes. It was found that alkaline treatment resulted in higher purity and solubility of BG compared to enzymatic treatment. Fourier transform infrared and nuclear magnetic resonance spectroscopy confirmed the purity and functional properties of BG obtained from different recovery methods and raw materials.
Review
Immunology
M. Elizabeth Deerhake, Mari L. Shinohara
Summary: Dectin-1, a C-type lectin receptor expressed on myeloid cells, recognizes beta-glucans and induces antifungal proinflammatory immune responses. Apart from its known role in fungal infections, Dectin-1 has been found to promote tolerance, anti-inflammatory, and neuroprotective responses in certain contexts. Studies in neuroimmunology suggest potential new therapeutic approaches for modifying innate immune responses in neurological disorders.
TRENDS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yujie Guo, Huiyu Ma, Qilin Huang
Summary: This study investigated the adsorption behavior of Pb2+ by oxidized yeast beta-glucans (OYG) and their protective effects on lead-induced cytotoxicity in PC12 cells. The results showed that OYG effectively adsorbed lead and protected cells from its toxic effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Shayane da Silva Milhorini, Fernanda Fogagnoli Simas, Fhernanda Ribeiro Smiderle, Liana Inara de Jesus, Fabio Rogerio Rosado, Eduardo Luis Longoria, Marcello Iacomini
Summary: This study focused on extracting polysaccharides from the fruiting bodies of the giant M. titans mushroom and evaluated their physicochemical properties. It was found that the extracted beta-glucans from M. titans could form gel under suitable conditions, showing potential industrial application as thickening or gelling agents.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Hu Tu, Mengxiang Zhu, Bo Duan, Lina Zhang
Summary: Cellulose, as the most abundant sustainable polymer, has the potential to act as an ideal substitute for plastics due to its low cost, wide availability, and biodegradability. Recent achievements in developing cellulose green solvents and regenerated cellulose materials with high strength through bottom-up approaches have shown potential applications in textiles, biomedicine, energy storage, packaging, etc. Importantly, these cellulose-based materials can be biodegraded in soil and oceans, reducing environmental pollution.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Applied
Yongtao Yang, Xiaojuan Xu, Qiang Wang
Summary: The study evaluated the effects of potassium sulfate (K2SO4) on the properties of different rice starches, showing that increasing K2SO4 concentration led to higher gelatinization temperatures and lower swelling capacities, resulting in decreased pasting viscosities. Waxy rice starch (WRS) exhibited the most significant changes in response to K2SO4.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Bingchao Duan, Siwei Zou, Ying Sun, Xiaojuan Xu
Summary: In this study, nucleic acid aptamers were attached to the polydeoxyadenylic acid (poly(dA)) tail to enhance tumor-targeting and cellular internalization. The results showed improved cellular uptake of s-LNT/poly(dA) composites in cancer cells, as well as increased internalization of LNT-FITC in cancer cells after aptamer conjugation. In vivo experiments confirmed enhanced accumulation of the composites at the tumor site. This work provides a novel strategy for utilizing triplex beta-glucan as delivery vectors with active tumor-targeting capabilities.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Liqin Cai, Daofa Ying, Xichao Liang, Mengxiang Zhu, Xinghuan Lin, Qi Xu, Zongwei Cai, Xiaojuan Xu, Lina Zhang
Summary: A novel cationic polyelectrolyte microsphere (CCQM) with superior adsorption capabilities for anionic dyes and heavy metal ions was successfully synthesized. CCQM showed ultrafast adsorption rate and ultra-efficient adsorption capacity, surpassing most reported absorbents. Its adsorption mechanism involved cation exchange, chelating effect, proton exchange, complex formation, electrostatic interaction, and hydrogen bonding. Additionally, CCQM exhibited excellent recyclability, antibacterial viability, and biodegradability, making it a promising candidate for wastewater treatment applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Polymer Science
Huanhuan Chen, Ningyue Liu, Fangzhou He, Qingye Liu, Xiaojuan Xu
Summary: This review article focuses on the research progress of β-glucans extracted from different fungi, with a particular emphasis on the structure, conformational characteristics, and biological activities of β-glucans from Auricularia auricula judae, Lentinus edodes, and yeast. Additionally, the potential therapeutic applications of β-glucan-derived nanocomposite biomaterials are addressed.
Article
Chemistry, Multidisciplinary
Baoquan Jia, Dingna Liu, Chengyu Niu, Qili Yu, Jie Ren, Qingye Liu, Haiqiang Wang
Summary: The development of adsorbents using byproducts or waste from industrial and agricultural production is a significant strategy for removing heavy metals from polluted water. In this study, a novel chitin/EM@Fe3O4 nanocomposite hydrogel was synthesized and exhibited excellent adsorption efficiency for Pb2+. The adsorption behavior was influenced by factors such as pH, concentration, temperature, and time, and followed pseudo-second-order kinetics and Langmuir isotherm. Thermodynamic analysis revealed an endothermic and spontaneous process.
Article
Materials Science, Biomaterials
Xiaojun Li, Yue Cheng, Jianfeng Zhang, Yarui Hou, Xiaojuan Xu, Qingye Liu
Summary: A novel strategy for fabricating bilayer hydrogel actuators based on the asymmetric distribution of crystalline regions was proposed, resulting in improved sensitivity to stimuli. The actuation behaviors are strongly dependent on experimental parameters such as pH, PVA content, and chemical-crosslinking density. Programmable 3D shape transformations can be achieved using designed 2D geometric patterns in the bilayer hydrogel, allowing for successful capture and transportation of cargo.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Food Science & Technology
Yujun Wan, Xiaojuan Xu, Robert G. Gilbert, Mitchell A. Sullivan
Summary: This review aims to increase understanding of the structure and function relationships of beta-glucans in treating type 2 diabetes by examining their detailed structural characteristics and anti-diabetic mechanisms, with the goal of expanding their applications.
Article
Chemistry, Applied
Huanhuan Chen, Ying Sun, Xiaojuan Xu, Qifa Ye
Summary: This study investigated the use of yeast-derived beta-(1, 3)-glucans to fabricate nanoparticles for the targeted delivery of methotrexate in the treatment of rheumatoid arthritis. The nanoparticles showed good biocompatibility and were effectively internalized by macrophages, leading to the reduction of pro-inflammatory factors in inflamed tissues. This work provides a safe alternative strategy for the clinical treatment of rheumatoid arthritis using beta-glucan nanoparticles as carriers.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Shihao Hu, Junqiao Wang, Shaoping Nie, Qiang Wang, Xiaojuan Xu
Summary: In this study, it was demonstrated that apple pectin and tomato pectin are high-ester and low-ester polysaccharides, respectively, with different properties under different conditions. The pectic polysaccharides showed semi-rigid chain conformations in NaNO3 aqueous solution and higher stiffness in water due to electrostatic repulsion. Under shear, the pectic polysaccharides exhibited shear-thickening behavior, which was stronger for those with longer side chains and higher molecular weight.
Article
Engineering, Environmental
Liqin Cai, Lina Zhang, Xiaojuan Xu
Summary: This study presents a stable and reusable homogeneous catalyst of ultra-small silver nanoparticles loaded triple-helix beta-glucan nanomaterial for efficient degradation of dyes and 4-nitrophenol in wastewater. The catalyst effectively disperses and stabilizes silver nanoparticles using Ag-O bonds in water, showing high catalytic efficiency. The research provides a novel strategy for designing eco-friendly homogeneous catalysts in wastewater treatment and expands the application of natural polysaccharides in synthetic catalysis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xinghuan Lin, Lina Zhang, Bo Duan
Summary: A polyphenol-mediated self-assembly strategy was developed to enhance the strength and toughness of chitin hydrogels. These hydrogels showed high modulus and strength, while sacrificing bonds dissipated energy and led to high toughness. The hydrogels exhibited considerable antibacterial properties and excellent biocompatibility.
MATERIALS HORIZONS
(2021)
Article
Nanoscience & Nanotechnology
Kun Chen, Liqin Cai, Shixi Yang, Shuang Peng, Jinguo Huang, Jinglei Xu, Ziang Lu, Xiaojuan Xu, Boshi Fu, Lina Zhang, Xiang Zhou
Summary: The study developed a prodrug delivery system based on beta-(1 -> 3)-D-glucan modified with cisplatin, showing high anticancer activity and low toxicity. This system utilizes nanomaterials loaded with platinum prodrugs to effectively target and release in tumors, demonstrating significant antitumor properties in vitro and in vivo.
ACS APPLIED BIO MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Junmei Wang, Qiaoyun Cheng, Shengyao Feng, Lina Zhang, Chunyu Chang
Summary: This study fabricates mechano-thermo-chromic hydrogels with uniform interference colors by shearing tunicate cellulose nanocrystals and locking them into poly(N-isopropylacrylamide) networks. The oriented TCNC/PNIPAM hydrogels not only enhance mechanical properties but also show reversible responsiveness to tensile force, compression, and temperature. This work offers a new strategy for designing sustainable and stretchable optical devices with applications in sensors, environmental monitoring, and anti-counterfeiting labels.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Physical
Hu Tu, Kang Xie, Xinghuan Lin, Ruquan Zhang, Feng Chen, Qiang Fu, Bo Duan, Lina Zhang
Summary: By combining chemically-physically double cross-linking and stretching orientation strategies, a highly ordered cellulose nanofiber network and edge-hydroxylated boron nitride nanosheets (BNNS-OH) structure were constructed to fabricate a cellulose/BNNS-OH composite film with superior thermal conductivity. The composite film exhibited anisotropic thermal conductivity properties and excellent heat dissipation capabilities for cooling communication devices, while also showing potential for communication devices encapsulation and providing a new avenue for preparing highly oriented composite materials.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
