Article
Chemistry, Applied
Ivan A. Yaremenko, Yulia Yu. Belyakova, Arina A. Demina, Peter S. Radulov, Igor V. Alabugin, Alexander O. Terent'ev
Summary: A selective reaction between bridged ozonides and Fe(II) salts has been found to proceed through O-O and C-C scissions and halogenation, leading to the formation of alpha-halogen substituted delta-ketoesters and delta-diketones in yields of 15-72%. This overall sequence demonstrates how a temporary peroxide functionality can be used to replace the acyl group within an acetoacetic ester unit with a halogen.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Wengang Xu, Qi Shao, Congjian Xia, Qiao Zhang, Yadi Xu, Yingguo Liu, Mingbo Wu
Summary: A novel protocol for selective defluoroalkylation of polyfluoroarenes with accessible alcohols was reported using photoredox and hydrogen atom transfer (HAT) strategies with the assistance of Lewis acids under visible light irradiation. The protocol exhibited broad scope, excellent regioselectivity, and mild conditions. Mechanistic studies revealed that the reaction proceeded via Lewis acid-promoted HAT and sequential addition to polyfluoroarenes.
Review
Chemistry, Organic
Xin Zhang, Yaoyao Mei, Yangyang Li, Jingang Hu, Dayun Huang, Yicheng Bi
Summary: This review discusses the advances of aryl diazonium salts in light-mediated reactions, categorizing them into five groups based on the types of bond formations. Various reactions such as radical addition, metal-catalyzed coupling, and C-H activation are discussed in this context.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Zhengshan Luo, Zequn Xing, Rui Gao, Yufang Han, Jun Ren, Zhongwen Wang
Summary: We have developed a visible-light-mediated formal [4 + 2] cycloaddition of arylcyclobutylamines with olefins, using QXPT-NPhCN as an organic photocatalyst. The corresponding cycloadducts could be obtained from electron-deficient olefins, aryl olefins, and exocyclic olefins. By adding K3PO4, the cycloadditions can be significantly promoted. This method allows the efficient synthesis of 2-functionalized cyclohexylamines, including those with spiro-skeletons.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Physics, Condensed Matter
Yaroslava Lykhach, Viktor Johanek, Armin Neitzel, Tomas Skala, Nataliya Tsud, Klara Beranova, Josef Myslivecek, Olaf Brummel, Joerg Libuda
Summary: The decomposition mechanisms of ethanol and ethylene glycol on different CeO2 films were studied, and it was found that the decomposition pathways and products varied under different conditions.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2022)
Article
Chemistry, Organic
Peng-Cheng Cui, Zheng-Chun Yin, Guan-Wu Wang
Summary: The visible-light-promoted C4-selective phosphorylation of unprefunctionalized pyridine and quinoline derivatives has been achieved. This Minisci-type protocol offers highly regioselective access to C4-phosphorylation products with good functional group tolerance and moderate to good yields via cross dehydrogenation coupling under mild conditions. Mechanistic studies demonstrate that the C4-phosphorylation products are obtained through a radical pathway.
Article
Chemistry, Organic
Menghui Song, Hongyan Zhou, Ganggang Wang, Ben Ma, Yajing Jiang, Jingya Yang, Congde Huo, Xi-Cun Wang
Summary: A new visible-light-promoted transfer hydrogenation of azobenzenes has been developed, with the reactions proceeding smoothly in methanol at ambient temperature in the presence of B(2)pin(2). Azobenzenes with diverse functional groups were reduced to hydrazobenzenes with a high yield of up to 96%. Preliminary mechanistic studies suggest that the hydrogen atom comes from the solvent and the transformation occurs via a radical pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qihang Guo, Dongpo Lu, Yihui Mao, Zhan Lu
Summary: An efficient method for the synthesis of isoquinolinone derivatives via photopromoted carboamination of alkynes is developed. Starting from the readily available propargyl alcohol derivatives, the polycyclic isoquinolinone derivatives could be obtained with good aryl and heterocycle tolerance. Both terminal and alkyl substituted alkynes could be employed. This protocol is operationally easy and easily conducted on a gram-scale. A possible mechanism involving radical addition and cyclization following aromatization was proposed.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Miao Wang, Jinglan Wen, Yahao Huang, Peng Hu
Summary: An efficient method has been developed for selective degradation of styrene-related plastics under gentle conditions through multiple oxidation, catalyzed with inexpensive iron salts under visible light using oxygen as a green oxidant. Furthermore, simple iron salts could be used as additives for degradable plastics.
Article
Chemistry, Physical
Xinyan Lv, Yaohang Cheng, Yingxiao Zong, Qingyun Wang, Guanghui An, Junke Wang, Guangming Li
Summary: In this study, a visible-light-mediated Ru-catalyzed para-alkylation of anilines was reported. The reaction showed high efficiency and mild conditions, with good functional group tolerance for late-stage functionalization of natural products and drugs.
Review
Chemistry, Multidisciplinary
Alexey A. Festa, Olga A. Storozhenko, Leonid G. Voskressensky, Erik V. van der Eycken
Summary: The use of visible light-promoted chemistry in halogenation and halofunctionalisation reactions has significant impact.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Chengyihan Gu, Shuaishuai Wang, Qingran Zhang, Jin Xie
Summary: In this communication, a photocatalyzed amidation strategy is reported for the synthesis of tertiary amides from carboxylic acids and tertiary amines via C-N bond cleavage. The reaction shows a wide scope of applicability with structurally diverse carboxylic acids, providing moderate-to-good yields of the desired products. The strategy offers an alternative approach to address the regioselectivity between nucleophilic functional groups and complements classical amidation protocols.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Ting-Ting Yuan, Jing Chen, Le Nhan Pham, Sayan Paul, Lorenzo V. White, Jialong Li, Ping Lan, Michelle L. Coote, Martin G. Banwell, Yu-Tao He
Summary: Efficient and versatile syntheses of methylene-bridged bis-heterocycles are described, which involve a visible light-mediated radical-relay sequence. This process begins with the homolysis of O-H bonds contained within & beta;,& gamma;-unsaturated oximes, generating oxygen-centred radicals that add to the tethered olefin. The resulting carbon-centered radical is then trapped by an added N-heteroarenium salt. These findings provide new insights into alkoxy radical-mediated transformations and access to new molecular scaffolds with potential applications in various settings.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Organic
Ashish Kumar Sahoo, Dinabandhu Barik, Binoyargha Dam, Bhisma K. Patel
Summary: The use of visible-light mediated C-S bond formation has gained popularity in organic chemistry due to its sustainability, simplicity, and mild reaction conditions. This review focuses on metal-free conditions and categorizes the C-S bond formation into difunctionalization of alkenes and alkynes, C-H functionalization, and radical cyclization. Each section provides detailed explanations and selected examples to illustrate the proposed mechanisms.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Parul Garg, Tavinder Singh, Anand Singh
Summary: This study describes the photochemical functionalization of alkoxyoxazoles with trimethylsilyl azide and N,N-dimethylanilines. These C-N bond forming reactions proceed with the assistance of organic dyes as photocatalyst and molecular oxygen, leading to oxidative ring-opening and access to novel chemical space. The unusual demethylative C-N bond formation in the case of N,N-dimethylanilines establishes a new reactivity pattern for these precursors.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Anhua Hu, Jing-Jing Guo, Hui Pan, Haoming Tang, Zhaobo Gao, Zhiwei Zuo
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Organic
Jing-Jing Guo, Anhua Hu, Zhiwei Zuo
TETRAHEDRON LETTERS
(2018)
Article
Multidisciplinary Sciences
Anhua Hu, Jing-Jing Guo, Hui Pan, Zhiwei Zuo
Article
Chemistry, Multidisciplinary
Kaining Zhang, Liang Chang, Qing An, Xin Wang, Zhiwei Zuo
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Multidisciplinary Sciences
Hao Cheng, Xin Wang, Liang Chang, Yilin Chen, Lingling Chu, Zhiwei Zuo
Editorial Material
Chemistry, Multidisciplinary
Liang Chang, Yilin Chen, Zhiwei Zuo
Article
Chemistry, Multidisciplinary
Qing An, Ziyu Wang, Yuegang Chen, Xin Wang, Kaining Zhang, Hui Pan, Weimin Liu, Zhiwei Zuo
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Jianbo Du, Xiaokun Yang, Xin Wang, Qing An, Xu He, Hui Pan, Zhiwei Zuo
Summary: A cerium-catalyzed aerobic oxidative ring expansion method using cyanoanthracene as a co-catalyst has been developed for the rapid construction of challenging macrolactones under visible light conditions, demonstrating the potential to simplify the generation of molecular complexity and enabling the concise synthesis of sonnerlactone.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yuegang Chen, Xin Wang, Xu He, Qing An, Zhiwei Zuo
Summary: Under mild reaction conditions, inexpensive cerium and nickel catalysts enable the use of easily accessible free alcohols as robust carbon pronucleophiles in selective C(sp(3))-C(sp(2)) cross-couplings. The identification of steric benzoate ligands for robust cerium complexes facilitates the synergy of cerium catalysis in emerging metallaphotoredox catalysis. Mechanistic investigations have led to the identification of a tribenzoate cerium(III) complex as a viable intermediate in the reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Liang Chang, Qing An, Lingfei Duan, Kaixuan Feng, Zhiwei Zuo
Summary: This review comprehensively summarizes the recent progress in alkoxy radical-mediated transformations under visible light irradiation. The mechanisms of alkoxy radical generation and their impact on synthetic utilizations are discussed. The catalytic generation of alkoxy radicals from abundant alcohols is still in the early stage, but holds great potential.
Article
Chemistry, Multidisciplinary
Qing An, Yang-Yang Xing, Ruihua Pu, Menghui Jia, Yuegang Chen, Anhua Hu, Shuo-Qing Zhang, Na Yu, Jianbo Du, Yanxia Zhang, Jinquan Chen, Weimin Liu, Xin Hong, Zhiwei Zuo
Summary: The importance of alkoxy radicals in cerium-catalyzed C-H functionalization reactions has been confirmed and the involvement of chlorine radicals has been ruled out. The study also emphasizes the influence of the relative ratio of alcohol to cerium on the reaction selectivity. Furthermore, the selectivity of alkoxy radical generation and the regulatory role of back-electron transfer have been analyzed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Liang Chang, Shun Wang, Qing An, Linxuan Liu, Hexiang Wang, Yubo Li, Kaixuan Feng, Zhiwei Zuo
Summary: The selective functionalization of alkanes has been a long-standing challenge in organic synthesis. Recent advancements in photoredox catalysis have provided exciting opportunities to trigger hydrogen atom transfer (HAT) processes and achieve radical-mediated functionalizations in a more selective manner. This perspective highlights the development of photocatalytic systems and discusses current challenges and future prospects in this field.
Article
Chemistry, Multidisciplinary
Jia Ding, Shuaishuai Luo, Yuanli Xu, Qing An, Yi Yang, Zhiwei Zuo
Summary: A synergistic photocatalytic system using a bisphosphonium catalyst and a cobalt catalyst has been developed for the selective oxidation of benzylic alcohols under oxidant-free and environmentally benign conditions. The system showed high efficiencies for various alcohol substrates and achieved exclusive selectivity for aldehyde products. Furthermore, it proved to be efficient when performed under continuous-flow conditions, using a simple and easily assembled continuous-flow setup.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Chen Yilin, Chang Liang, Zuo Zhiwei
ACTA CHIMICA SINICA
(2019)