Article
Biochemistry & Molecular Biology
Ryuhei Takemoto, Tetsuro Kamiya, Taku Atobe, Hirokazu Hara, Tetsuo Adachi
Summary: In M2-like macrophages, both HIF1α and STAT3 are essential for LOX induction, while the loss of FOXO1 facilitates HIF1α binding to the lox promoter region, promoting LOX induction.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Hsiao-Yen Ma, Qingling Li, Weng Ruh Wong, Elsa-Noah N'Diaye, Patrick Caplazi, Hannah Bender, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Claire Emson, Hans Brightbill, Lucinda Tam, Robert Newman, Merone Roose-Girma, Wendy Sandoval, Ning Ding
Summary: This study reveals that LOXL4 is the main LOX family member involved in pathological collagen cross-linking and lung fibrosis, while the genetic ablation of LOXL2 has a limited effect on these processes.
Review
Biochemistry & Molecular Biology
Philip C. Trackman, Yaser Peymanfar, Sayon Roy
Summary: Lysyl oxidases are multifunctional proteins involved in the biosynthesis and maturation of connective tissues. Their overexpression is associated with fibrosis and cancer, while their propeptide has tumor-suppressing effects. In diabetic retinopathy, lysyl oxidases are overexpressed and their propeptide levels are elevated. Further research is needed to understand the activities and mechanisms of lysyl oxidase propeptide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Mona Mohamadzaheri, Hadi Cheraghi, Darioush Shirani, Ali Hatamkhani
Summary: This study investigated the significance of cell-free DNA (cfDNA) and cfDNA integrity index in monitoring the therapeutic response of transmissible venereal tumors (TVT) to vincristine, and compared them with lysyl oxidase activity. The results suggest that short cfDNA, the cfDNA integrity index, and lysyl oxidase activity can serve as diagnostic biomarkers and potential prognostic indicators in TVT patients.
BMC VETERINARY RESEARCH
(2022)
Article
Medicine, General & Internal
Jinfeng Zhu, Chen Luo, Jiefeng Zhao, Xiaojian Zhu, Kang Lin, Fanqin Bu, Zhonglin Yu, Feilong Zou, Zhengming Zhu
Summary: The study revealed that high expression of LOX in gastric cancer tissues is significantly associated with poor overall survival, LOX overexpression is closely correlated with T-stage progression in gastric cancer, and LOX is an independent factor affecting the prognosis of gastric cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I. Made Winarsa Ruma, I. Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka, Masakiyo Sakaguchi
Summary: LOXL4 is upregulated in breast cancer cells and interacts with annexin A2 and integrin beta-1 to promote breast cancer progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Guillermo A. Martinez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petaisto, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Maki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Summary: Integrin alpha 11 beta 1 is upregulated in human and mouse skin tumors, particularly in high-grade tumors. Deficiency of alpha 11 reduces tumor cell proliferation and tumor burden, but results in the presence of thick and regularly aligned collagen bundles in tumors. This study reveals the role of alpha 11 beta 1 in skin tumorigenesis and highlights the need for further research to understand its molecular mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xuanrui Zhang, Jiapeng Huang, Yingyu Zhou, Zhen Hong, Xiaoping Lin, Shanshan Chen, Yongnong Ye, Zheqing Zhang
Summary: The bone mass changes that occur during childhood play a crucial role in maximizing peak bone mass and preventing osteoporosis in adulthood. This study found that an appropriate plasma retinol concentration and higher intake of vitamin A and beta-carotene may improve bone mineral content in children aged 6-9 years.
Article
Cell Biology
Jiao Liu, Yang Liu, Yuan Wang, Changfeng Li, Yangchun Xie, Daniel J. Klionsky, Rui Kang, Daolin Tang
Summary: TMEM164 plays a key role in mediating autophagosome formation during iron-dependent ferroptosis, promoting cell death. High expression of TMEM164 is associated with improved survival and increased immune cell infiltration.
Review
Cell Biology
Carmen Rodriguez, Noelia Puente-Moncada, Russel J. Reiter, Ana M. Sanchez-Sanchez, Federico Herrera, Jezabel Rodriguez-Blanco, Cristina Duarte-Olivenza, Maria Turos-Cabal, Isaac Antolin, Vanesa Martin
Summary: Multiple oncogenic pathways and local microenvironmental conditions converge on regulating cancer cell metabolism, with melatonin considered a therapeutic target due to its reported antitumor effects. High concentrations of melatonin have shown effectiveness in reducing cell growth and inducing cell death in certain types of tumors, suggesting its potential role in regulating glucose metabolism in cancer cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jette Lengefeld, Chia-Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Omer H. Yilmaz, Angelika Amon
Summary: The size of stem cells plays a crucial role in their function, with small size being important for maintaining stem cell potential. Enlargement of hematopoietic stem cells under conditions of decreased function is associated with reduced proliferation and altered metabolism. Preventing stem cell enlargement can help prevent the loss of stem cell potential in exhausting conditions.
Article
Biochemistry & Molecular Biology
Qiuchen Guo, Duanchen Sun, Alexander S. Barrett, Sonali Jindal, Nathan D. Pennock, Matthew W. Conklin, Zheng Xia, Elizabeth Mitchell, Ravikant Samatham, Naomi Mirza, Steven Jacques, Sheila Weinmann, Virginia F. Borges, Kirk C. Hansen, Pepper J. Schedin
Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.
Article
Chemistry, Multidisciplinary
Jinwon Park, Jung Suk Kim, Geon Yang, Hobin Lee, Gayong Shim, Jaiwoo Lee, Yu Kyoung Oh
Summary: The researchers designed LOX-responsive nanoparticles to interact with the collagen matrix in the tumor microenvironment. In vitro experiments showed that these nanoparticles could bind to LOX-secreting CT26 cells, but this binding was blocked by a LOX inhibitor. In mouse experiments, the addition of the LOX inhibitor did not significantly change the antitumor efficacy of the nanoparticles. However, without the LOX inhibitor, a single administration of the nanoparticles provided sustained responsiveness to near-infrared irradiation and ablation of primary tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Aishwarya Subramanian, Mathew Hall, Huayun Hou, Marat Mufteev, Bin Yu, Kyoko E. Yuki, Haruka Nishimura, Anson Sathaseevan, Benjamin Lant, Beibei Zhai, James Ellis, Michael D. Wilson, Mads Daugaard, W. Brent Derry
Summary: This study identifies a conserved functional role of alternative polyadenylation in oncogenic Ras function, revealing the impact of cfim-1/CFIm25 on cell migration and the previously unknown regulator mrp-5/ABCC1 through experiments in Caenorhabditis elegans and human cells.
Article
Orthopedics
Phong K. K. Nguyen, Kaitlyn Hall, Iverson Holt, Catherine K. K. Kuo
Summary: This study suggests that treatment with recombinant LOX (rLOX) has minimal effects on the morphology and behaviors of developing tendon cells. This indicates that future rLOX-based therapeutic strategies can enhance tendon mechanical properties without adverse effects on tendon cell morphology and behaviors.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Margherita Puppo, Hanna Taipaleenmki, Eric Hesse, Philippe Clzardin
Summary: Bone metastases are common complications in patients with advanced cancer and current treatments are palliative. Research suggests that non-coding RNAs may play a crucial role in bone metastasis formation, offering potential therapeutic targets and biomarkers for improved treatment outcomes.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Oncology
Souvik Das, Philippe Clezardin, Said Kamel, Michel Brazier, Romuald Mentaverri
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Mathilde Bouchet, Alexandra Laine, Cyril Boyault, Mathilde Proponnet-Guerault, Emmanuelle Meugnier, Lamia Bouazza, Casina W. S. Kan, Sandra Geraci, Soumaya El-Moghrabi, Hector Hernandez-Vargas, Claire Benetollo, Yuji Yoshiko, Martine Duterque-Coquillaud, Philippe Clezardin, Julien C. Marie, Edith Bonnelye
Article
Oncology
Caterina F. Donini, Myriam El Helou, Anne Wierinckx, Balazs Gyorffy, Sophie Aires, Aurelie Escande, Severine Croze, Philippe Clezardin, Joel Lachuer, Mona Diab, Sandra E. Ghayad, Beatrice Fervers, Vincent Cavailles, Veronique Maguer-Satta, Pascale A. Cohen
FRONTIERS IN ONCOLOGY
(2020)
Article
Medicine, General & Internal
Robert E. Coleman, Peter I. Croucher, Anwar R. Padhani, Philippe Clezardin, Edward Chow, Marie Fallon, Theresa Guise, Simone Colangeli, Rodolfo Capanna, Luis Costa
NATURE REVIEWS DISEASE PRIMERS
(2020)
Article
Biochemistry & Molecular Biology
Francesco Pantano, Martine Croset, Keltouma Driouch, Natalia Bednarz-Knoll, Michele Iuliani, Giulia Ribelli, Edith Bonnelye, Harriet Wikman, Sandra Geraci, Florian Bonin, Sonia Simonetti, Bruno Vincenzi, Saw See Hong, Sofia Sousa, Klaus Pantel, Giuseppe Tonini, Daniele Santini, Philippe Clezardin
Summary: This study identified ITGA5 as a mediator of breast-to-bone metastasis, with high expression correlating with poor bone metastasis-free survival. Silencing ITGA5 impaired tumor cell functions and bone metastasis, while inhibition with M200 showed similar effects.
Review
Physiology
Philippe Clezardin, Rob Coleman, Margherita Puppo, Penelope Ottewell, Edith Bonnelye, Frederic Paycha, Cyrille B. Confavreux, Ingunn Holen
Summary: Skeletal metastases are common complications of many cancers, significantly impacting patients' quality of life. The multistage process of bone metastasis involves various cellular and molecular mechanisms. While existing bone-targeted agents have made progress, further research and more effective treatment options are still needed.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Cell Biology
Nico Hinz, Anke Baranowsky, Michael Horn, Malte Kriegs, Freya Sibbertsen, Daniel J. Smit, Philippe Clezardin, Tobias Lange, Thorsten Schinke, Manfred Juecker
Summary: This study demonstrates that AKT3 plays a crucial role in promoting bone metastasis in breast cancer cells without enhancing tumor-induced osteolysis.
Review
Endocrinology & Metabolism
Margherita Puppo, Manoj K. Valluru, Philippe Clezardin
Summary: Bone metastasis is a complication of advanced breast cancer, and miRNAs play a significant role in driving breast cancer bone metastasis. Research on miRNAs and their targets is crucial for understanding the mechanisms of bone metastasis, guiding treatment, and early prediction.
CURRENT OSTEOPOROSIS REPORTS
(2021)
Article
Oncology
E. Massy, Jc Rousseau, M. Gueye, E. Bonnelye, M. Brevet, L. Chambard, M. Duruisseaux, O. Borel, C. Roger, R. Guelminger, J. B. Pialat, E. Gineyts, L. Bouazza, M. Millet, Jm Maury, P. Clezardin, N. Girard, Cyrille B. Confavreux
Summary: Periostin may serve as a biomarker for predicting survival in lung adenocarcinoma patients, with high levels associated with poorer overall survival.
JOURNAL OF BONE ONCOLOGY
(2021)
Review
Oncology
Cyrille B. Confavreux, Helene Follet, David Mitton, Jean Baptiste Pialat, Philippe Clezardin
Summary: Significant progress has been made in treating cancer patients and stage-IV bone metastatic patients, improving survival and focusing on fracture risk evaluation to guide physician decisions. Emerging tools like personalized numerical simulations are being developed for assessing bone tumoral strength and fracture risk, with the next generation expected to integrate multiple loadings and real-life conditions for personalized-medicine approaches.
Article
Oncology
Hao Xu, Marie-Helene Lafage-Proust, Lamia Bouazza, Sandra Geraci, Philippe Clezardin, Bernard Roche, Francoise Peyrin, Max Langer
Summary: This study used synchrotron radiation microcomputed tomography (SR-mu CT) to investigate the effect of anti-angiogenic drugs on bone metastasis. The results suggest that combined anti-angiogenic drug treatment can reduce bone resorption at an early stage and affect bone microvascular structure at a later stage.
Article
Oncology
Xavier Rousset, Denis Maillet, Emmanuel Grolleau, David Barthelemy, Sara Calattini, Marie Brevet, Julie Balandier, Margaux Raffin, Florence Geiguer, Jessica Garcia, Myriam Decaussin-Petrucci, Julien Peron, Nazim Benzerdjeb, Sebastien Couraud, Jean Viallet, Lea Payen
Summary: The study established a chicken CAM model to analyze the dissemination and metastasis mechanisms of human tumor cells effectively, providing a novel attempt towards personalized medicine.
Review
Oncology
Margherita Puppo, Mariam Jaafar, Jean-Jacques Diaz, Virginie Marcel, Philippe Clezardin
Summary: This review discusses the roles of microRNAs and snoRNAs in the metastatic progression of cancer in bone. Dysregulation of microRNA and snoRNA expression in primary cancer cells leads to the acquisition of metastatic properties. Additionally, microRNAs and snoRNAs can act as intercellular mediators and remotely modulate the function of resident bone cells. Furthermore, the review explores the potential of microRNAs and snoRNAs as biomarkers and therapeutic targets in cancer treatments.
Review
Oncology
Pia Fahme, Farah Ramadan, Diep Tien Le, Kieu-Oanh Nguyen Thi, Sandra E. Ghayad, Nader Hussein, Chantal Diaz, Martine Croset, Philippe Clezardin, Pascale A. Cohen
Summary: ZNF217 oncogene promotes cancer progression, pluripotency and resistance to therapy. High expression levels of ZNF217 are associated with poor prognosis in several cancers. ZNF217 shapes cancer growth through epigenetic mechanisms, including DNA methylation, interactions with noncoding RNAs, and epitranscriptome refining. Noncoding RNAs and DNA methylation status of ZNF217 locus can be potential biomarkers for poor prognosis and therapeutic response.