In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

(2017) John Steven et al.   Frontiers in Immunology

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

(2017) Obinna C. Ubah et al.   Frontiers in Immunology

Loss of Response to Anti-TNFs: Definition, Epidemiology and Management

(2016) Giulia Roda et al.   Clinical and Translational Gastroenterology

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics

(2016) Marisa K. Joubert et al.   PLoS One

Immunogenicity assessment of biotherapeutic products: An overview of assays and their utility

(2015) Meenu Wadhwa et al.   BIOLOGICALS

Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases

(2015) Maria A.V. Willrich et al.   Translational Research

Immunogenicity of Anti-TNF-α Biotherapies: II. Clinical Relevance of Methods Used for Anti-Drug Antibody Detection

(2015) Klaus Bendtzen   Frontiers in Immunology

TNF inhibitors – Mechanisms of action, approved and off-label indications

(2014) Grzegorz Cessak et al.   Pharmacological Reports

Strategic characterization of anti-drug antibody responses for the assessment of clinical relevance and impact

(2014) Suzanna M Tatarewicz et al.   Bioanalysis

Antidrug antibodies to tumour necrosis factor specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective; comment on the article by Vincentet al

(2013) Alfons A den Broeder et al.   ANNALS OF THE RHEUMATIC DISEASES

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

(2013) Geertje J. D. van Mierlo et al.   Journal of Immunotoxicology

Impact of Antibodies to Infliximab on Clinical Outcomes and Serum Infliximab Levels in Patients With Inflammatory Bowel Disease (IBD): A Meta-Analysis

(2012) Kavinderjit S Nanda et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis

(2012) Sandra Garcês et al.   ANNALS OF THE RHEUMATIC DISEASES

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

(2012) Mischa R. Müller et al.   mAbs

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists

(2011) Christophe Lallemand et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Differential effect of drug interference in immunogenicity assays

(2011) Margreet H. Hart et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Relationship between the clinical response to adalimumab treatment and serum levels of adalimumab and anti-adalimumab antibodies in patients with psoriatic arthritis

(2010) A. W. R. van Kuijk et al.   ANNALS OF THE RHEUMATIC DISEASES

Extent and Clinical Consequences of Antibody Formation Against Adalimumab in Patients With Plaque Psoriasis

(2010) Lidian L. A. Lecluse et al.   ARCHIVES OF DERMATOLOGY

Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects

(2010) Matthieu Allez et al.   Journal of Crohns & Colitis

Clinical concerns of immunogenicity produced at cellular levels by biopharmaceuticals following their parenteral administration into human body

(2010) Shunmugaperumal Tamilvanan et al.   JOURNAL OF DRUG TARGETING

Identification and inhibition of drug target interference in immunogenicity assays

(2010) Zhandong D. Zhong et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Solution ELISA as a platform of choice for development of robust, drug tolerant immunogenicity assays in support of drug development

(2010) Alvydas Mikulskis et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Immuno-PCR assays for immunogenicity testing

(2009) Mark Spengler et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of Trough Serum Levels and Immunogenicity on Long-term Outcome of Adalimumab Therapy in Crohn's Disease

(2009) Konstantinos Karmiris et al.   GASTROENTEROLOGY

Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

(2008) T R D J Radstake et al.   ANNALS OF THE RHEUMATIC DISEASES

Immunogenicity of anti-tumor necrosis factor antibodies—toward improved methods of anti-antibody measurement

(2008) Lucien Aarden et al.   CURRENT OPINION IN IMMUNOLOGY