NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling

(2019) Ana Martin-Hurtado et al.   Scientific Reports

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

NRF2 addiction in cancer cells

(2018) Hiroshi Kitamura et al.   CANCER SCIENCE

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

ABCF2 , an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

(2017) Lingjie Bao et al.   MOLECULAR CARCINOGENESIS

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

(2017) Julia E Neumann et al.   NATURE MEDICINE

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

(2017) A Szczepny et al.   ONCOGENE

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate

(2016) Jiwon Jang et al.   CELL

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment

(2016) Ann Hanna et al.   Molecular Cancer

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells

(2016) Li Li et al.   NATURE CELL BIOLOGY

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

Endocytic Control of Cellular Signaling at the Primary Cilium

(2016) Lotte B. Pedersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

(2016) Shasha Tao et al.   Scientific Reports

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Cell cycle progression by the repression of primary cilia formation in proliferating cells

(2013) Hidemasa Goto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription

(2013) Tongde Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

(2012) V. M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Do cilia put brakes on the cell cycle?

(2011) Peter K. Jackson   NATURE CELL BIOLOGY

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

(2011) Sehyun Kim et al.   NATURE CELL BIOLOGY

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH