A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

(2016) Dominik Sturm et al.   CELL

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

(2016) Yaxue Zeng et al.   MOLECULAR CELL

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

(2015) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

Lin28 promotes the proliferative capacity of neural progenitor cells in brain development

(2015) M. Yang et al.   DEVELOPMENT

Embryonal tumor with abundant neuropil and true rosettes in the brainstem: case report

(2015) Hidetoshi Sato et al.   Journal of Neurosurgery-Pediatrics

Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT trials: clinical findings of a rare disease

(2015) Carsten Friedrich et al.   Journal of Neurosurgery-Pediatrics

Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR

(2015) Hui Yang et al.   Nature Protocols

Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified

(2015) Johannes Nowak et al.   NEURO-ONCOLOGY

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

(2015) Melanie F. Weingart et al.   Oncotarget

Use of arsenic trioxide in remission induction and consolidation therapy for acute promyelocytic leukaemia in the Australasian Leukaemia and Lymphoma Group (ALLG) APML4 study: a non-randomised phase 2 trial

(2015) Harry J Iland et al.   Lancet Haematology

Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma

(2014) Julia Pöschl et al.   ACTA NEUROPATHOLOGICA

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

(2014) Julia Pöschl et al.   ACTA NEUROPATHOLOGICA

CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity

(2014) Tara Spence et al.   ACTA NEUROPATHOLOGICA

MRI Characteristics of Ependymoblastoma: Results from 22 Centrally Reviewed Cases

(2014) J. Nowak et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Neural progenitors, neurogenesis and the evolution of the neocortex

(2014) M. Florio et al.   DEVELOPMENT

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

(2014) Volker Hovestadt et al.   NATURE

Ependymoblastoma of the brainstem: MRI findings and differential diagnosis

(2014) Johannes Nowak et al.   PEDIATRIC BLOOD & CANCER

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

(2013) Volker Hovestadt et al.   ACTA NEUROPATHOLOGICA

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

(2013) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR

(2013) Claudia L Kleinman et al.   NATURE GENETICS

A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes

(2013) Tara Spence et al.   NEURO-ONCOLOGY

let-7 and miR-140 microRNAs coordinately regulate skeletal development

(2013) G. Papaioannou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

(2012) Daniel Grammel et al.   ACTA NEUROPATHOLOGICA

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

(2012) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Constitutive activation of β-Catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system

(2012) Julia Pöschl et al.   DEVELOPMENTAL BIOLOGY

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

(2012) Daniel Picard et al.   LANCET ONCOLOGY

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

(2012) Kristin Stock et al.   NATURE MEDICINE

Determinants of mRNA recognition and translation regulation by Lin28

(2012) Xin-Xiang Lei et al.   NUCLEIC ACIDS RESEARCH

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Rapid Diagnosis of Medulloblastoma Molecular Subgroups

(2011) E. C. Schwalbe et al.   CLINICAL CANCER RESEARCH

Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans

(2011) J Pöschl et al.   ONCOGENE

Genes Expressed in Specific Areas of the Human Fetal Cerebral Cortex Display Distinct Patterns of Evolution

(2011) Nelle Lambert et al.   PLoS One

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes

(2010) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonal Tumors With Abundant Neuropil and True Rosettes

(2009) Marco Gessi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

(2009) Meihua Li et al.   CANCER CELL

Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines

(2008) Robert J Lipinski et al.   BMC CELL BIOLOGY

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE