Review
Biotechnology & Applied Microbiology
Guanyu Mu, Yu Qiao, Mingyang Sui, Kenneth T. V. Grattan, Huijuan Dong, Jie Zhao
Summary: This article reviews the applications of acoustic manipulation techniques in the field of biomedical research, including cell manipulation, targeted drug release, and genetic disease diagnosis. Acoustic systems enable high precision positioning and faster transportation speeds, making them suitable for various biomedical tasks.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Shuanghu Wang, Jia Xu, Quan Zhou, Peiwu Geng, Bo Wang, Yunfang Zhou, Kun Liu, Fei Peng, Yingfeng Tu
Summary: This review summarizes recent progress in the biodegradability of micro/nanomotors (MNMs) and their potential applications, including different biodegradable materials and fabrication strategies. Current challenges and future perspectives are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Tianyi Liu, Lei Xie, Cameron-Alexander Hurd Price, Jian Liu, Qiang He, Biao Kong
Summary: Inspired by natural mobile microorganisms, researchers have developed micro/nanomotors (MNMs) that can autonomously move and have made tremendous progress in various biomedical applications. However, controversy and challenges still exist in propulsion mechanisms and motion manipulation of MNMs. Recently, diverse MNMs with different propulsion strategies, morphologies, sizes, porosities, and chemical structures have been fabricated and utilized for various purposes.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Qingliang Yang, Ying Gao, Lei Xu, Weiyong Hong, Yuanbin She, Gensheng Yang
Summary: Enzyme-driven micro/nanomotors stand out from other types due to features like no need for chemical fuel, enhanced cellular uptake, and easy conjugation with therapeutic drugs. This review aims to discuss in depth the enzyme linking approaches and motion control strategies of such motors, highlighting their advantages and limitations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Jianting Zhang, Zhoujiang Chen, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: Self-propelling micro-/nano-motors (MNMs) show enormous potential in various applications, such as drug delivery, by overcoming the challenge of low permeation of biological barriers. Research progress and application of these innovative motor designs are expected to play a crucial role in future clinical practice.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Xi Wang, Dang Zhang, Yu Bai, Jian Zhang, Lei Wang
Summary: This review summarizes the recent progress in cancer treatment based on enzyme-driven micro/nanomotors, including their applications in crossing biological barriers, targeted drug delivery, and photothermal/starvation therapy. The challenges and future development trends in this field are also discussed.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Engineering, Biomedical
Wei Wang, Chao Zhou
Summary: This article discusses the challenges faced by nanomotors, how current nanomotors meet or fall short of these requirements, and tentatively proposes a nanomotor design to conform to the SLOT guideline and inspire practical, functional nanorobots.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Amir Hossein Meisami, Milad Abbasi, Sareh Mosleh-Shirazi, Arezo Azari, Ali Mohammad Amani, Ahmad Vaez, Ali Golchin
Summary: Cancer is a dangerous and life-threatening disease, and micro/nanomotors play an important role in cancer treatment. This paper introduces the progress of micro/nanomotors in cancer detection and treatment, including targeted drug delivery and imaging-guided therapy, as well as discussing the challenges encountered in the medical process. Furthermore, this paper explores the potential growth of micro/nanomotors in medical applications and future research directions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Di Zhang, Shuyi Liu, Jianguo Guan, Fangzhi Mou
Summary: This review focuses on the recent developments of micro/nanorobots (MNRs) in the field of motile-targeting drug delivery. MNRs, with their autonomous movement and navigation, have the potential to deliver therapeutic payloads for effective and safe cancer treatment. The article summarizes the different types of MNRs and their propelling mechanisms, and discusses the challenges and future prospects in biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Shuhao Zhang, Chaoran Zhu, Wanting Huang, Hua Liu, Mingzhu Yang, Xuejiao Zeng, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Yurong Hu, Xiufang Shi, Zhi-Hao Wang
Summary: Oral administration is a convenient way to treat gastrointestinal diseases with good patient compliance, but the nonspecific distribution of drugs can lead to serious side effects. To overcome this, oral drug delivery systems (ODDS) have been developed, but they are limited by physiological barriers in the gastrointestinal tract. Micro/nanomotors (MNMs) have shown potential in targeted drug delivery, and this review comprehensively discusses their applications in overcoming physiological barriers in ODDS for gastrointestinal diseases. This review provides inspiration and direction for MNMs in the therapy of gastrointestinal diseases and advances the clinical application of MNMs in oral drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Xiaocong Chang, Yiwen Feng, Bin Guo, Dekai Zhou, Longqiu Li
Summary: This review categorizes and summarizes nature-inspired micro/nanomotors, which are inspired by nature in terms of morphology, structure, and behavior, and possess interesting morphologies, novel preparation methods, innovative propulsion modes, and broad applications.
Review
Chemistry, Multidisciplinary
Wei Liu, Ya Liu, He Li, Hongmei Nie, Maoye Tian, Wei Long
Summary: Untethered mobile micro-/nanomotors (MNMs) are seen as the next-generation disease treatment tools. However, the complexity of the biological environment and the particularity of disease microenvironment hinder their advances. This review comprehensively addresses the design, imaging, and disease treatment of biomedical MNMs, highlighting intelligent MNMs with biomimetic functionality and chemotactic capability, emphasizing the applicability of different imaging techniques, and focusing on various proof-of-concept studies for the treatment of major diseases. The challenges and limitations of current biomedical MNMs are discussed, inspiring future research towards clinical translation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Ruyi Lin, Wenqi Yu, Xianchun Chen, Huile Gao
Summary: This review highlights the recent progress in utilizing micro/nanomotors for tumor targeting delivery and therapy, focusing on their contributions to different stages of tumor targeting delivery and combination therapy. The current limitations and future directions for further development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ambika Somasundar, Ayusman Sen
Summary: The development of nano and micromotors for actively delivering drugs to disease sites in vivo faces challenges such as safety, biocompatibility, ability to traverse body fluids, and reach cellular targets. Furthermore, scalability and uniformity in production are critical factors.
Review
Chemistry, Multidisciplinary
Jie Wang, Yue Dong, Peng Ma, Yu Wang, Fangyu Zhang, Bocheng Cai, Peng Chen, Bi-Feng Liu
Summary: Cancer is a difficult-to-treat disease due to its high mortality rate and lack of effective diagnostic and treatment tools. Recent advancements in micro-/nanorobot technology provide opportunities for the development of cancer theragnostic platforms, which can enable precise drug delivery and improved permeation.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Jia-Jia Wang, Yong-Zhong Jiang, Yi Lin, Li Wen, Cheng Lv, Zhi-Ling Zhang, Gang Chen, Dai-Wen Pang
ANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Analytical
Jia-Jia Wang, Yi Lin, Yong-Zhong Jiang, Zhenhua Zheng, Hai-Yan Xie, Cheng Lv, Zhi-Liang Chen, Ling-Hong Xiong, Zhi-Ling Zhang, Hanzhong Wang, Dai-Wen Pang
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Jia-Jia Wang, Caishang Zheng, Yong-Zhong Jiang, Zhenhua Zheng, Miao Lin, Yi Lin, Zhi-Ling Zhang, Hanzhong Wang, Dai-Wen Pang
ANALYTICAL CHEMISTRY
(2020)
Article
Engineering, Environmental
Jiajia Wang, Xiaoya Liu, Yanfang Qi, Zonghua Liu, Yuepeng Cai, Renfeng Dong
Summary: This study describes an effective strategy for delivering intracellular antigens using ultrasound-propelled gold nanowires nanomotors modified with a model antigen. The nanomotors facilitate rapid internalization into antigen-presenting cells, leading to activation and cross-presentation of the cells with significant increase in MHC I and MHC II molecules expression levels. This novel vaccine delivery strategy based on AuNWs nanomotors is expected to enhance cellular immunity and provide a new approach to immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Qinglong Wang, Renfeng Dong, Qianxian Yang, Jiajia Wang, Shuyu Xu, Yuepeng Cai
NANOSCALE HORIZONS
(2020)
Article
Chemistry, Multidisciplinary
Jiajia Wang, Renfeng Dong, Qianxian Yang, Huiying Wu, Zijun Bi, Qiying Liang, Qinglong Wang, Chun Wang, Yongfeng Mei, Yuepeng Cai
Article
Automation & Control Systems
Jiajia Wang, Huiying Wu, Xiaoya Liu, Qiying Liang, Zijun Bi, Zicheng Wang, Yuepeng Cai, Renfeng Dong
ADVANCED INTELLIGENT SYSTEMS
(2020)
