Review
Chemistry, Multidisciplinary
Xiaocong Chang, Yiwen Feng, Bin Guo, Dekai Zhou, Longqiu Li
Summary: This review categorizes and summarizes nature-inspired micro/nanomotors, which are inspired by nature in terms of morphology, structure, and behavior, and possess interesting morphologies, novel preparation methods, innovative propulsion modes, and broad applications.
Review
Engineering, Biomedical
Shuanghu Wang, Jia Xu, Quan Zhou, Peiwu Geng, Bo Wang, Yunfang Zhou, Kun Liu, Fei Peng, Yingfeng Tu
Summary: This review summarizes recent progress in the biodegradability of micro/nanomotors (MNMs) and their potential applications, including different biodegradable materials and fabrication strategies. Current challenges and future perspectives are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Tianyi Liu, Lei Xie, Cameron-Alexander Hurd Price, Jian Liu, Qiang He, Biao Kong
Summary: Inspired by natural mobile microorganisms, researchers have developed micro/nanomotors (MNMs) that can autonomously move and have made tremendous progress in various biomedical applications. However, controversy and challenges still exist in propulsion mechanisms and motion manipulation of MNMs. Recently, diverse MNMs with different propulsion strategies, morphologies, sizes, porosities, and chemical structures have been fabricated and utilized for various purposes.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Jianting Zhang, Zhoujiang Chen, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: Self-propelling micro-/nano-motors (MNMs) show enormous potential in various applications, such as drug delivery, by overcoming the challenge of low permeation of biological barriers. Research progress and application of these innovative motor designs are expected to play a crucial role in future clinical practice.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-Gonzalez, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Felix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sanchez
Summary: Nanomotors, powered by enzymes and triggered by laser irradiation, can improve drug delivery efficiency and overcome biological barriers. These nanomotors can collectively displace and disrupt protein fibers in a blocked microchannel. This active motion and mechanical disruption provide a clear advantage for improving therapy.
Review
Chemistry, Physical
Miao Yan, Lei Xie, Jinyao Tang, Kang Liang, Yongfeng Mei, Biao Kong
Summary: The development of self-propelled micro/nanomotors (MNMs) has brought various opportunities in the biomedical field, but their biosafety and feasibility still need improvement. Heterosilica-based MNMs, incorporating diverse functional units and materials, offer new possibilities for practical biomedical applications.
CHEMISTRY OF MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Xi Wang, Dang Zhang, Yu Bai, Jian Zhang, Lei Wang
Summary: This review summarizes the recent progress in cancer treatment based on enzyme-driven micro/nanomotors, including their applications in crossing biological barriers, targeted drug delivery, and photothermal/starvation therapy. The challenges and future development trends in this field are also discussed.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Di Zhang, Shuyi Liu, Jianguo Guan, Fangzhi Mou
Summary: This review focuses on the recent developments of micro/nanorobots (MNRs) in the field of motile-targeting drug delivery. MNRs, with their autonomous movement and navigation, have the potential to deliver therapeutic payloads for effective and safe cancer treatment. The article summarizes the different types of MNRs and their propelling mechanisms, and discusses the challenges and future prospects in biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Materials Science, Biomaterials
Lingfeng Jiang, Xiaoxia Liu, Dongfang Zhao, Jinhong Guo, Xing Ma, Yong Wang
Summary: In the microscopic world, synthetic micro/nanomotors (MNMs) can convert energy sources into driving forces for various applications. These tiny machines have attracted great attention in fields like drug delivery and environmental management. By modifying their surface materials and functionalizing them with bioactive agents, MNMs can also be transformed into dynamic micro/nano-biosensors with high sensitivity.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Biotechnology & Applied Microbiology
Guanyu Mu, Yu Qiao, Mingyang Sui, Kenneth T. V. Grattan, Huijuan Dong, Jie Zhao
Summary: This article reviews the applications of acoustic manipulation techniques in the field of biomedical research, including cell manipulation, targeted drug release, and genetic disease diagnosis. Acoustic systems enable high precision positioning and faster transportation speeds, making them suitable for various biomedical tasks.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Shuhao Zhang, Chaoran Zhu, Wanting Huang, Hua Liu, Mingzhu Yang, Xuejiao Zeng, Zhenzhong Zhang, Junjie Liu, Jinjin Shi, Yurong Hu, Xiufang Shi, Zhi-Hao Wang
Summary: Oral administration is a convenient way to treat gastrointestinal diseases with good patient compliance, but the nonspecific distribution of drugs can lead to serious side effects. To overcome this, oral drug delivery systems (ODDS) have been developed, but they are limited by physiological barriers in the gastrointestinal tract. Micro/nanomotors (MNMs) have shown potential in targeted drug delivery, and this review comprehensively discusses their applications in overcoming physiological barriers in ODDS for gastrointestinal diseases. This review provides inspiration and direction for MNMs in the therapy of gastrointestinal diseases and advances the clinical application of MNMs in oral drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Amir Hossein Meisami, Milad Abbasi, Sareh Mosleh-Shirazi, Arezo Azari, Ali Mohammad Amani, Ahmad Vaez, Ali Golchin
Summary: Cancer is a dangerous and life-threatening disease, and micro/nanomotors play an important role in cancer treatment. This paper introduces the progress of micro/nanomotors in cancer detection and treatment, including targeted drug delivery and imaging-guided therapy, as well as discussing the challenges encountered in the medical process. Furthermore, this paper explores the potential growth of micro/nanomotors in medical applications and future research directions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Suliman Khan, Mohammad Mahdi Nejadi Babadaei, Anwarul Hasan, Zehra Edis, Farnoosh Attar, Rabeea Siddique, Qian Bai, Majid Sharifi, Mojtaba Falahati
Summary: This study explores the potential applications of enzyme-nanoparticle bio-conjugates in medical activities, providing hope for therapeutic enzymes immobilized on polymers, inorganic metal oxides, and hybrid compounds, and evaluating the use of ENBs in bioassay activities.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Engineering, Biomedical
Ruyi Lin, Wenqi Yu, Xianchun Chen, Huile Gao
Summary: This review highlights the recent progress in utilizing micro/nanomotors for tumor targeting delivery and therapy, focusing on their contributions to different stages of tumor targeting delivery and combination therapy. The current limitations and future directions for further development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Biomedical
Wei Wang, Chao Zhou
Summary: This article discusses the challenges faced by nanomotors, how current nanomotors meet or fall short of these requirements, and tentatively proposes a nanomotor design to conform to the SLOT guideline and inspire practical, functional nanorobots.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)