Article
Biochemistry & Molecular Biology
Mengxun Li, Quan Liu, Su Xie, Chong Fu, Jiaxuan Li, Cheng Tian, Xin Li, Changchun Li
Summary: In this study, it was found that the lncRNA TCONS_00323213 is upregulated during porcine skeletal muscle satellite cell (PSC) differentiation and plays a role in the proliferation and differentiation of PSC. The interaction between TCONS_00323213 and PKNOX2 promotes the expression of MyoG and enhances PSC differentiation. This finding provides insights into the molecular mechanisms by which lncRNAs regulate porcine myogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Silvia Pomella, Sara G. Danielli, Rita Alaggio, Willemijn B. Breunis, Ebrahem Hamed, Joanna Selfe, Marco Wachtel, Zoe S. Walters, Beat W. Schaefer, Rossella Rota, Janet M. Shipley, Simone Hettmer
Summary: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, characterized by aberrant muscle differentiation. Abnormalities in the regulatory transcription factors (MRFs) involved in skeletal muscle development contribute to tumorigenesis in RMS. Core regulatory circuitries (CRCs) and hierarchically organized subsets of cells play a role in maintaining the disease-driving fusion oncogene and promoting malignancy in RMS. Understanding the genetic and epigenetic framework of abnormal muscle differentiation in RMS provides insights into its mechanisms and potential therapeutic strategies.
Article
Physics, Fluids & Plasmas
Ayan Biswas
Summary: In this study, a biochemical assay was used to convert fan-in networks into feed-forward loops (FFLs). The researchers discovered that redundant information about the output gene product can be broken down into finer components mediated by the constituent pathways. They found that variance-based information within the linear noise regime played a role in quantifying these submodular redundancies. Contrary to conventional wisdom, they found that information redundancy depended nontrivially on inter-regulator correlation.
Article
Veterinary Sciences
Naomi Teramoto, Masanari Ikeda, Hidetoshi Sugihara, Takanori Shiga, Takashi Matsuwaki, Masugi Nishihara, Kazuyuki Uchida, Keitaro Yamanouchi
Summary: The study showed that double knock-out of p16 and dystrophin in rats leads to the development of pleomorphic RMS, offering an animal model for studying the developmental mechanism of pleomorphic RMS.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Biochemical Research Methods
Pascal A. Pieters, Bryan L. Nathalia, Ardjan J. van der Linden, Peng Yin, Jongmin Kim, Wilhelm T. S. Huck, Tom F. A. de Greef
Summary: Regulatory pathways in living cells use feed-forward architectures to process and interpret signals, with the ability to reduce noise and detect fold changes. Experimental study in bacterial cells using post-transcriptional regulation has implemented a synthetic feed-forward loop, showing effective repression of background activity but limited potential as a temporal filter.
ACS SYNTHETIC BIOLOGY
(2021)
Review
Pathology
Margaret A. T. Freeberg, Apostolos Perelas, Jane K. Rebman, Richard P. Phipps, Thomas H. Thatcher, Patricia J. Sime
Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Hui Hu, Wei Huang, Hong Zhang, Jianye Li, Qiong Zhang, Ya-Ru Miao, Fei-Fei Hu, Lu Gan, Zhenhong Su, Xiangliang Yang, An-Yuan Guo
Summary: The miR-9-5p/FOXO1/CPEB3 feed-forward loop was identified and found to play a critical role in the progression of hepatocellular carcinoma (HCC). This regulatory module could potentially serve as a new therapeutic target for HCC treatment.
Article
Chemistry, Multidisciplinary
Zhengze Lu, Yang Long, Jiaxin Li, Kebai Ren, Wei Zhao, Xuhui Wang, Chunyu Xia, Yashi Wang, Man Li, Zhirong Zhang, Qin He
Summary: The developed LA/DOX NP can inhibit inflammatory cell recruitment in the liver and lungs through multiple mechanisms, block NF-kappa B and STAT3 signaling pathways, thereby shutting down inflammatory feed-forward loops, providing a new therapeutic strategy for breast cancer and its metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Ao Sun, Xiaoqin Hu, Huijian Chen, Yulan Ma, Xiyue Yan, Dangsheng Peng, Jie Ping, Youe Yan
Summary: Research has shown that ursolic acid acts as an anti-obesity agent by increasing irisin secretion and promoting the beiging of white adipose tissue (WAT).
Article
Multidisciplinary Sciences
Carrie Easter, Ellouise Leadbeater, Matthew J. Hasenjager
Summary: This study uses an agent-based model to investigate how individual variation in activity and movement shapes the production of feed-forward loops in a simulated insect colony. The findings suggest that individual variation in activity drives the over-representation of feed-forward loops by determining the directionality of interactions. However, activity variation does not promote faster or more efficient information flow. On the other hand, individual variation in movement trajectory, although not involved in generating feed-forward loops, promotes fast and efficient information flow by linking otherwise unconnected regions.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mechanics
Tuhin Subhra Roy, Mintu Nandi, Pinaki Chaudhury, Sudip Chattopadhyay, Suman K. Banik
Summary: In this study, we propose a stochastic framework to analyze fluctuation propagation in classes of coherent feed-forward loops. We consider the contributions of direct and indirect pathways as well as additive and multiplicative integration mechanisms. The analysis of output fluctuations reveals the contributions of different fluctuation terms to the overall output fluctuations.
JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT
(2023)
Article
Oncology
Xiao Xiang, Huy-Dung Hoang, Victoria H. Gilchrist, Stephanie Langlois, Tommy Alain, Kyle N. Cowan
Summary: The natural plant flavonoid quercetin increases the protein levels of P2X7R in RMS cells by inducing re-expression of a specific transcript variant. This variant is also present in human skeletal muscle cells that highly express P2X7R. The ETV4 transcription factor regulates P2X7R expression by binding to its promoter region, and quercetin promotes RMS differentiation through increased binding of ETV4 to the promoter. Quercetin also shows potential as a therapeutic agent for RMS.
Article
Pharmacology & Pharmacy
Ning Guo, Yanling Yu, Yanru Chu, Qun Lou, Wei Huang, Liaowei Wu, Chenlu Fan, Mengyao Su, Meichen Zhang, Fanshuo Yin, Zhizhong Guan, Yanmei Yang, Yanhui Gao
Summary: In this study, it was found that miR-21-5p induced the activation of canonical Wnt signaling pathway by targeting PTEN and DKK2, providing important insights into the regulatory role of miR-21-5p in skeletal fluorosis.
Article
Engineering, Electrical & Electronic
Gang Liu, Haifeng Zhang, Xinda Song
Summary: This article investigates the position-estimation deviation issue of sensorless drive method based on SMO and PLL, and proposes a technology combining phase self-compensation SMO and feed-forward PLL to effectively address the problem.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2021)
Meeting Abstract
Oncology
Kalsi K. Heimdal, Edjay Ralph A. Hernandez, Heidi J. Gill Super
Article
Genetics & Heredity
Andrea M. Gross, Megan Frone, Karen W. Gripp, Bruce D. Gelb, Lisa Schoyer, Lisa Schill, Beth Stronach, Leslie G. Biesecker, Dominic Esposito, Edjay Ralph Hernandez, Eric Legius, Mignon L. Loh, Staci Martin, Deborah K. Morrison, Katherine A. Rauen, Pamela L. Wolters, Dina Zand, Frank McCormick, Sharon A. Savage, Douglas R. Stewart, Brigitte C. Widemann, Marielle E. Yohe
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2020)
Review
Cell Biology
Katie E. Hebron, Edjay Ralph Hernandez, Marielle E. Yohe
Summary: The RASopathies are a group of disorders caused by germline mutations in genes encoding components of the RAS/MAPK pathway. This review discusses the pathogenesis of RASopathy-associated genetic variants and the knowledge gained about RAS/MAPK signaling through studying RASopathies. It also explores cell and animal models of RASopathies, emerging RASopathy genes, and the potential use of targeted agents for treating RASopathies. Lastly, it discusses how drugs targeting RAS/MAPK-driven malignancies could be leveraged for patients with RASopathies.
DISEASE MODELS & MECHANISMS
(2022)
Article
Oncology
Joshua T. Kowalczyk, Xiaolin Wan, Edjay R. Hernandez, Ruibai Luo, Gaelyn C. Lyons, Kelli M. Wilson, Devorah C. Gallardo, Kristine A. Isanogle, Christina M. Robinson, Arnulfo Mendoza, Christine M. Heske, Jinqui-Qiu Chen, Xiaoling Luo, Alexander E. Kelly, Simone Difilippantinio, Robert W. Robey, Craig J. Thomas, Dan L. Sackett, Deborah K. Morrison, Paul A. Randazzo, Lisa M. Miller Jenkins, Marielle E. Yohe
Summary: Rigosertib inhibits the growth of rhabdomyosarcomas and neuroblastomas by interfering with mitotic spindle assembly, showing potential therapeutic value. Unlike vinca alkaloids, rigosertib does not induce cell death through inhibition of the RAS pathway in RAS-mutated cells, but a combination with the MEK inhibitor trametinib synergistically inhibits tumor growth in certain cell lines.
MOLECULAR CANCER THERAPEUTICS
(2021)