Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond

(2015) Britta Vallazza et al.   Wiley Interdisciplinary Reviews-RNA

Intradermal vaccination for rabies prophylaxis: conceptualization, evolution, present status and future

(2014) Shampur Narayan Madhusudana et al.   Expert Review of Vaccines

Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics

(2011) Andreas N. Kuhn et al.   RNA Biology

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY