Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype

(2015) Erik Ames et al.   JOURNAL OF IMMUNOLOGY

Split anergized Natural Killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion

(2015) Han-Ching Tseng et al.   Oncotarget

Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

(2015) Han-Ching Tseng et al.   Oncotarget

Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice

(2015) Han-Ching Tseng et al.   Frontiers in Immunology

Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

(2014) Yun-Peng Peng et al.   BMC CANCER

Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell–Cell Contact and Secreted Factors

(2014) Han-Ching Tseng et al.   Frontiers in Immunology

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Cellular and molecular pathways in the tumor immunoenvironment: 3rd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, 22–25 April 2013, Krakow, Poland

(2013) Michael R. Shurin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dual Functions of Natural Killer Cells in Selection and Differentiation of Stem Cells; Role in Regulation of Inflammation and Regeneration of Tissues

(2013) Anahid Jewett et al.   Journal of Cancer

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

(2012) Dimitrios N. Vatakis et al.   Jove-Journal of Visualized Experiments

Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition

(2011) E. Mamessier et al.   CANCER RESEARCH

Humanized tumor mice-A new model to study and manipulate the immune response in advanced cancer therapy

(2011) Anja K. Wege et al.   INTERNATIONAL JOURNAL OF CANCER

IL-15–High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15 −/− Mice

(2011) Katsumi Yoshizawa et al.   JOURNAL OF IMMUNOLOGY

Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection

(2011) Rikke Olesen et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

(2011) D. N. Vatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence

(2010) T. Strowig et al.   BLOOD

Characterization and IL-15 dependence of NK cells in humanized mice

(2010) Elisabeth A. Pek et al.   IMMUNOBIOLOGY

Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2R null Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells

(2010) M. C. Andre et al.   JOURNAL OF IMMUNOLOGY

Increased Lysis of Stem Cells but Not Their Differentiated Cells by Natural Killer Cells; De-Differentiation or Reprogramming Activates NK Cells

(2010) Han-Ching Tseng et al.   PLoS One

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

(2009) Trinidad Garcia-Iglesias et al.   BMC CANCER

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Development of Functional Human NK Cells in an Immunodeficient Mouse Model with the Ability to Provide Protection against Tumor Challenge

(2009) Amanda Kwant-Mitchell et al.   PLoS One

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-induced memory-like natural killer cells

(2009) Megan A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model

(2008) Asahi Ito et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral tumors by F(ab′)2 fragment of anti-CD16 antibody

(2008) Anahid Jewett et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE