Article
Immunology
Nilgun Sallakci, Ilhan Tahrali, Umut Can Kucuksezer, Esin Aktas Cetin, Ahmet Gul, Gunnur Deniz
Summary: This study investigated the activation status and function of NK cells in Behcet's disease patients. The results showed that patients in active and inactive phases displayed different activation levels of NK cells, indicating their potential association with immune attacks and remissions during the course of the disease.
IMMUNOLOGIC RESEARCH
(2022)
Article
Cell Biology
Dae Yoon Kim, Jae Kwon Lee
Summary: The article investigates the changes in Natural Killer (NK) cell activity under diabetic conditions. The study finds that high glucose conditions influence NK cell activity, leading to reduced cytotoxic activity against cancer cells and decreased expression of activation markers.
CELLULAR IMMUNOLOGY
(2022)
Review
Cell Biology
Philip Rosenstock, Thomas Kaufmann
Summary: Sialic acids play a crucial role in mediating the interaction between NK cells and target cells by influencing receptor activity and modulating NK cell function. NK cells can bind sialic acids on their surface, which in turn affects the activation or inhibition of NK cells during immune responses.
Article
Immunology
Maresa Lopez-Montano, Laura Jimenez-Ortega, Teresa Rocio Cruz-Hernandez, Victor Gabriel Hernandez-Chavez, Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jorge Vela-Ojeda
Summary: This study analyzed the role of NK cells, their activating receptors NKG2D and NKp46, and their ligands MIC-A and MIC-B, as well as soluble molecules sMIC-A and sMIC-B in dogs with Non-Hodkin's lymphoma. The study found that dogs with lymphoma had higher numbers of NK cells and increased levels of sMIC-A and sMIC-B.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2023)
Review
Cell Biology
Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
Summary: Natural Killer (NK) cells are natural cytotoxic cells of the innate immune system that can recognize and attack transformed or infected cells through their NKG2D receptor, which has significant immunological functions and clinical relevance.
Article
Immunology
Metin Yusuf Gelmez, Suzan cinar, Esin Aktas, Fatma Betul oktelik, Goncagul Babuna-Kobaner, Murat Erdugan, Ahmet Gul, Afet Akdag Kose, Gunnur Deniz
Summary: The study found no significant differences in the expression levels of NK cell-related genes between Behcet's disease patients and healthy individuals, but correlations were detected between different cell subtypes in Behcet's patients. Further functional studies are needed to investigate the potential role of these molecules in the pathogenesis of Behcet's Disease.
TURKISH JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Gloria Yareli Gutierrez-Silerio, Miriam Ruth Bueno-Topete, Alejandra Natali Vega-Magana, Blanca Estela Bastidas-Ramirez, Jorge Gutierrez-Franco, Marta Escarra-Senmarti, Eliza Julia Pedraza-Brindis, Marcela Pena-Rodriguez, Martha Eloisa Ramos-Marquez, Vidal Delgado-Rizo, Nehla Banu, Alan Guillermo Alejandre-Gonzalez, Mary Fafutis-Morris, Jesse Haramati, Susana del Toro-Arreola
Summary: The NKp30 receptor, encoded by the NCR3 gene, is expressed in NK cells and has three isoforms. Increased expression of these isoforms and low levels of the NKp30 ligand B7H6 have been associated with positive prognosis in different cancer types. In cervical cancer patients, a distinct immune down-modulation or non-fitness status was observed, with decreased NKp30(+) NK cells and lower perforin levels. Cervical cancer patients also exhibited decreased expression of the NKp30 C isoform and overexpression of soluble B7H6, highlighting the importance of understanding this immune response for the development of novel immunotherapies.
Article
Biochemistry & Molecular Biology
Sheila B. Powers, Nourhan G. Ahmed, Roslin Jose, Marissa Brezgiel, Subhash Aryal, W. Paul Bowman, Porunelloor A. Mathew, Stephen O. Mathew
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with B-cell ALL being more prevalent and T-cell ALL being more aggressive. The study showed increased expression of LLT1 in B-ALL and T-ALL patients. Surface LLT1 expression was significantly increased in T cells, monocytes, and NK cells of ALL patients. The study also observed increased expression of CS1 and NKp46 on monocytes at the diagnosis of ALL. Post-induction chemotherapy, there was a decrease in LLT1, 2B4, CS1, and NKp46 expression on T cells of ALL patients. The findings suggest that the differential expression of these receptors/ligands may play a role in T-cell- and NK-cell-mediated immune surveillance of pediatric ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Charlotte J. Imianowski, Sarah K. Whiteside, Teresa Lozano, Alexander C. Evans, Jayme D. Benson, Christina J. F. Courreges, Firas Sadiyah, Colleen M. Lau, Nordin D. Zandhuis, Francis M. Grant, Martijn J. Schuijs, Panagiota Vardaka, Paula Kuo, Elizabeth J. Soilleux, Jie Yang, Joseph C. Sun, Tomohiro Kurosaki, Klaus Okkenhaug, Timotheus Y. F. Halim, Rahul Roychoudhuri
Summary: The transcriptional repressor BACH2 acts as an intrinsic negative regulator of NK cell maturation and function, playing a critical role in immune surveillance and tumor immune surveillance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Nayoung Kim, Mi Yeon Kim, Woo Seon Choi, Eunbi Yi, Hyo Jung Lee, Hun Sik Kim
Summary: GSK-3 alpha primarily restrains the expression of activating receptor ligands on target cells, reducing their susceptibility to NK cells, suggesting a potential strategy to enhance tumor cell susceptibility to NK cells.
Article
Oncology
Zheng Zhu, Kun-Yu Teng, Jian Zhou, Yunyun Xu, Lifeng Zhang, Hua Zhao, Xueguang Zhang, Lei Tian, Zhiyao Li, Ting Lu, Shoubao Ma, Zhenlong Li, Zhenyu Dai, Jing Wang, Xingyu Chen, Xing Wu, Yihan Pan, Weiqiang Shi, Zhiqun You, Hanyu Chen, Vincent Chung, Jianhua Yu, Songbing He, Xin Zhao, Lei Cao, Dechun Li
Summary: B7H6, a member of the B7 family of immunoreceptors, is found to be highly expressed in pancreatic cancer tissues. Its soluble form can be detected in patients' sera, and higher levels are associated with poorer prognosis. In addition to serving as a prognostic marker, B7H6 also acts as an immune modulator in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Virology
Alexandra Duev-Cohen, Batya Isaacson, Orit Berhani, Yoav Charpak-Amikam, Nehemya Friedman, Yaron Drori, Michal Mandelboim, Ofer Mandelboim
Summary: The study found that NKp46 can recognize influenza B viruses, but the interaction strength is weaker compared to influenza A, and NKp46 is not crucial for eliminating influenza B.
Review
Virology
Jasmina M. Luczo, Sydney L. Ronzulli, Stephen M. Tompkins
Summary: NK cells are part of the innate immunity and function in recognizing and destroying tumorigenic and pathogen-infected cells through activation receptors. The activation receptors on NK cells include NKp46, NKp44, NKp30, NKG2D, and CD16.
Review
Immunology
Matthias Peipp, Katja Klausz, Ammelie Svea Boje, Tobias Zeller, Stefan Zielonka, Christian Kellner
Summary: NK cells play a crucial role in cancer immune surveillance by recognizing malignant cells and controlling their activation through the expression of activating and inhibitory receptors. The recruitment and activation of NK cells have great potential in cancer treatment. Targeting the ligands expressed on tumors is also a promising approach to unleash the cytotoxicity of NK cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Oncology
Natalia Colomar-Carando, Laurent Gauthier, Pietro Merli, Fabrizio Loiacono, Paolo Canevali, Michela Falco, Federica Galaverna, Benjamin Rossi, Frederic Bosco, Melody Caratini, Maria Cristina Mingari, Franco Locatelli, Eric Vivier, Raffaella Meazza, Daniela Pende
Summary: NK cells have promising potential in antitumor immunotherapy, especially in the treatment of hematologic malignancies. By targeting specific molecules on tumor cells, NK cell activity can be boosted to effectively kill tumor cells. NK cell engagers targeting CD19 have shown good efficacy.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Otorhinolaryngology
Brenda-Eugenia Martinez-Herrera, Benjamin Trujillo-Hernandez, Daniel Sat-Munoz, Faviola Gonzalez-Barba, Eduardo Cruz-Corona, Luis Hector Bayardo-Lopez, Alejandro Solorzano-Melendez, David-Abdiel Onate-Zubdia, Ruben-Eduardo Moran-Galaviz, Juan-Daniel Flores-Carlos, Carlos Davalos-Cobian, Mario Salazar-Paramo, Arnulfo-Hernan Nava-Zavala, Eduardo Gomez-Sanchez, Luz-Ma-Adriana Balderas-Pena
Summary: This study found that the prevalence of sarcopenia and sarcopenic obesity is high in head and neck cancer patients, and those with these conditions have lower quality of life, poorer physical performance, and higher levels of fatigue. Patients without sarcopenia perform better in these aspects.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Environmental Sciences
Daniel Sat-Munoz, Brenda-Eugenia Martinez-Herrera, Luis-Aaron Quiroga-Morales, Benjamin Trujillo-Hernandez, Javier-Andres Gonzalez-Rodriguez, Leonardo-Xicotencatl Gutierrez-Rodriguez, Caridad-Aurea Leal-Cortes, Eliseo Portilla-de-Buen, Benjamin Rubio-Jurado, Mario Salazar-Paramo, Eduardo Gomez-Sanchez, Raul Delgadillo-Cristerna, Gabriela-Guadalupe Carrillo-Nunez, Arnulfo-Hernan Nava-Zavala, Luz-Ma-Adriana Balderas-Pena
Summary: This study analyzed the impact of serum adipocytokines, insulin, and HOMA IR levels on the risk of benign breast disease and breast cancer. The results showed that higher adipsin and visfatin levels in lean women increased the risk of BBD. Additionally, overweight-obese women with higher levels of insulin and HOMA IR had an increased risk of BBD and breast cancer. This suggests that the interaction between adipose tissue and breast epithelium may trigger malignant transformation in overweight-obese women.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Oncology
Jorge Raul Vazquez-Urrutia, Maria Iyali Torres-Bustamante, Cesar Rodrigo Cerda-Cruz, Alejandro Bravo-Cuellar, Pablo Cesar Ortiz-Lazareno
Summary: Prostate cancer is the most common tumor in males and the second leading cause of cancer-related deaths. Current screening methods are not sensitive or specific enough, leading to unnecessary interventions. The current prognostic strategies are invasive and there is a lack of tools for predicting tumor progression and treatment response. miRNAs show promise as biomarkers for screening, surveillance, prognosis and treatment response in prostate cancer.
Article
Genetics & Heredity
Noemi Magdalena Carreno-Saavedra, Itzel Viridiana Reyes-Perez, Andrea Carolina Machado-Sulbaran, Gloria Esther Martinez-Bonilla, Maria Guadalupe Ramirez-Duenas, Jose Francisco Munoz-Valle, Valeria Olaya-Valdiviezo, Trinidad Garcia-Iglesias, Erika Aurora Martinez-Garcia, Pedro Ernesto Sanchez-Hernandez
Summary: This study evaluated the association of IL-21/IL-21R polymorphisms and IL-21 serum levels with rheumatoid arthritis (RA). The results showed that IL-21 rs2255979 and IL-21R rs3093301 were associated with a higher risk of RA and could be genetic markers. Additionally, the elevated IL-21 levels in RA patients suggest that IL-21/IL-21R could be a therapeutic target for RA.
Article
Biochemistry & Molecular Biology
Brenda-Eugenia Martinez-Herrera, Leonardo-Xicotencatl Gutierrez-Rodriguez, Benjamin Trujillo-Hernandez, Michelle-Guadalupe Munoz-Garcia, Luz-Maria Cervantes-Gonzalez, Laura-Liliana Jose Ochoa, Javier-Andres Gonzalez-Rodriguez, Alejandro Solorzano-Melendez, Eduardo Gomez-Sanchez, Gabriela-Guadalupe Carrillo-Nunez, Mario Salazar-Paramo, Arnulfo-Hernan Nava-Zavala, Martha-Cecilia Velazquez-Flores, Carlos-M. Nuno-Guzman, Mario-Alberto Mireles-Ramirez, Luz-Ma. -Adriana Balderas-Pena, Daniel Sat-Munoz
Summary: This study focuses on the differences in phase angle as a predictor of prognosis, quality of life, and mortality in head and neck cancer patients. The results show that patients with low phase angle have worse nutritional and biochemical indicators, as well as lower quality of life scores. There are significant disparities between sexes, with malnourishment and tumor cachexia being more evident in women.
Review
Biochemistry & Molecular Biology
Raquel Echavarria, Ernesto German Cardona-Munoz, Pablo Ortiz-Lazareno, Jorge Andrade-Sierra, Luis Francisco Gomez-Hermosillo, Jorge Casillas-Moreno, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Andres Garcia-Sanchez, Alejandra Guillermina Miranda-Diaz
Summary: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). This study explores the roles of oxidative stress, DNA damage, antioxidant enzymes, mitochondrial function, and mitophagy in LN. The study also discusses the importance of Toll-like receptors 7 and 9 in the development of LN, and provides information on conventional treatments and novel alternatives for improving renal function in LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Paola E. Oceguera-Basurto, Edgar B. Figueroa-Ochoa, Luis A. Anguiano-Sevilla, Dante R. Sanchez-Ramirez, Antonio Quintero-Ramos, Alicia del Toro-Arreola, Rocio I. Lopez-Roa, Pablo Taboada, Antonio Topete, Adrian Daneri-Navarro
Summary: Breast cancer has become the most diagnosed cancer, with a high mortality rate among women. Selective estrogen-receptor modulators (SERMs) have been used for the prevention and treatment of estrogen receptor-positive breast cancer, but their long-term oral administration has been associated with toxicity and side effects. This study explores the use of a polymeric gel-like solution as a topical administration route for the active metabolite of tamoxifen (EDX), which has shown significant antitumor efficacy and reduced toxicity compared to oral tamoxifen. This novel administration route could have a strong impact on breast cancer prevention and treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Denisse Stephania Becerra-Loaiza, Luisa Fernanda Flores, Luis Antonio Ochoa-Ramirez, Bricia M. Gutierrez-Zepeda, Alicia Del Toro-Arreola, Ramon Antonio Franco-Topete, Andres Moran-Mendoza, Antonio Oceguera-Villanueva, Antonio Topete, David Javalera, Antonio Quintero-Ramos, Adrian Daneri-Navarro
Summary: This study analyzed the relationship between genetic variations and breast cancer in a Mexican population. The rs66554220 variant was found to not be associated with breast cancer, but it may be related to advanced breast tumors. Further studies are needed for confirmation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Health Care Sciences & Services
Faviola Gonzalez-Barba, Luz-Ma. -Adriana Balderas-Pena, Benjamin Trujillo-Hernandez, Luz-Maria Cervantes-Gonzalez, Javier-Andres Gonzalez-Rodriguez, Leonardo-Xicotencatl Gutierrez-Rodriguez, Adriana Alvarado-Zermeno, Aldo-Antonio Alcaraz-Wong, Eduardo Gomez-Sanchez, Gabriela-Guadalupe Carrillo-Nunez, Mario Salazar-Paramo, Arnulfo-Hernan Nava-Zavala, Benjamin Rubio-Jurado, Mario-Alberto Mireles-Ramirez, Brenda-Eugenia Martinez-Herrera, Daniel Sat-Munoz
Summary: The phase angle, an indicator of muscle mass status and membrane cell integrity, has been found to be associated with negative outcomes in women with uterine cervical cancer. In a study with 65 participants, the low phase angle group exhibited higher levels of inflammation and poorer quality of life compared to the normal phase angle group. Additionally, the interaction between phase angle and obesity was found to be an important factor in different histologic subtypes of uterine cervical cancer.
Article
Medicine, Research & Experimental
Jose Alvaro Lomeli-Nieto, Jose Francisco Munoz-Valle, Christian Johana Banos-Hernandez, Jose Eduardo Navarro-Zarza, Juliana Marisol Godinez-Rubi, Samuel Garcia-Arellano, Maria Guadalupe Ramirez-Duenas, Isela Parra-Rojas, Arisbeth Villanueva-Perez, Jorge Hernandez-Bello
Summary: This study demonstrates a joint decrease of the three active TGF-beta isoforms in SSc patients. However, TGF-beta 1, TGF-beta R1, and TGF-beta R2 are possibly increased in clinically involved skin.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Meeting Abstract
Economics
L. X. Gutierrez-Rodriguez, D. Sat-Munoz, B. Martinez-Herrera, J. A. Gonzalez-Rodriguez, M. Mireles-Ramirez, B. Trujillo-Hernandez, L. A. Quiroga-Morales, A. A. Alcaraz-Wong, C. Davalos-Cobian, A. Solorzano-Melendez, J. D. Flores-Carlos, B. Rubio Jurado, M. Salazar-Paramo, E. Gomez-Sanchez, G. G. Carrillo-Nunez, A. H. Nava-Zavala, L. M. A. Balderas-Pena
Article
Oncology
Liz Maria de Almeida, Sandra Cortes, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian de Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S. Llera, Bettina Muller, Osvaldo L. Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia Bravo, Natalia Camejo, Dirce Maria Carraro, Monica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernandez, Jorge Fernandez, Wanda Fernandez, Ramon A. Franco-Topete, Fancy Gaete, Jorge Gomez, Leivy P. Gonzalez-Ramirez, Marisol Guerrero, Susan A. Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Miguez, Andres de J. Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M. Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M. Sendoya, Aida A. Silva-Garcia, Stella Vina, Livia Zagame, Beth Jones, Moyses Szklo
Summary: The molecular profile of breast cancer in Latin-American women was studied in five countries. The study described the socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes, and estimated the 60-month overall cumulative survival probabilities. Factors such as country of residence, intrinsic subtype, age, and tumor stage were found to be associated with overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Economics
B. Martinez-Herrera, B. Trujillo-Hernandez, D. Sat-Munoz, M. K. De-la-Torre-Segura, F. Gonzalez-Barba, E. Cruz, L. X. Gutierrez-Rodriguez, G. A. Hernandez-Chavez, L. H. Bayardo-Lopez, A. Solorzano-Melendez, D. A. Onate-Zubdia, A. Alvarado-Zermeno, R. E. Moran-Galaviz, J. D. Flores-Carlos, C. Davalos-Cobian, M. Salazar-Paramo, A. H. Nava-Zavala, J. Mora, E. Gomez-Sanchez, L. M. A. Balderas-Pena