Article
Biochemical Research Methods
Qiuya Zhang, Dan Wen, Qin Liu, Tanja Opriessnig, Xiaoya Yu, Yonghou Jiang
Summary: In this study, a novel multiplex PCR method was developed for the rapid and specific detection of single or mixed genotype infections of porcine astroviruses (PAstV). The method was evaluated using 273 pig fecal samples, and PAstV4 was found to be the most common genotype.
JOURNAL OF VIROLOGICAL METHODS
(2023)
Review
Chemistry, Multidisciplinary
Wenpeng Liu, Luke P. P. Lee
Summary: The global outbreaks of infectious diseases have led to a significant demand for rapid and accurate molecular diagnostics. However, the labor-intensive sample preparation and nucleic acid amplification steps make it challenging to carry out these diagnostics at home. This review discusses the advances and challenges in automatic solutions for sample preparation and on-chip nucleic acid amplification, as well as the potential for game-changing user-friendly approaches for next-generation home diagnostics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Haoze Chen, Shoujia Lin, Yongxia Wang, Shuqi Fu, Yueting Ma, Qianfeng Xia, Yingzi Lin
Summary: A new paper-based lateral flow nucleic acid test platform using asymmetric polymerase chain reaction for signal amplification was developed, enabling visual detection of Epstein-Barr virus nucleic acids with high specificity and low cost.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Jonas A. Otoo, Travis S. Schlappi
Summary: This review summarizes current diagnostic technologies for multiplexed detection and explores which methods are likely to meet all the REASSURED criteria.
Article
Biotechnology & Applied Microbiology
Baowei Li, Yanran Liu, Xiaodan Hao, Jinhua Dong, Limei Chen, Haimei Li, Wei Wu, Ying Liu, Jianxun Wang, Yin Wang, Peifeng Li
Summary: The UPIP-qPCR method is a cost-effective and highly accurate approach for SNP genotyping, utilizing only two types of fluorescence-labeled probes. It has high sensitivity, call rate, and accuracy, making it a reliable option for clinicians seeking to provide targeted medicine.
Article
Biochemical Research Methods
Baobao Lin, Zhi Geng, Yanjing Chen, Wu Zeng, Bao Li, Yan Zhang, Peng Liu
Summary: Adequate intake of folic acid is crucial during pregnancy, but certain genetic polymorphisms hinder its absorption, posing a threat to the lives of pregnant women and causing birth defects in newborns. Traditional laboratory testing for genetic variants related to folic acid metabolism is time-consuming and labor-intensive. However, a microfluidics-based molecular diagnostic system offers rapid, sensitive, high-throughput, and automated detection by integrating sample pre-processing and nucleic acid amplification on-chip.
Article
Chemistry, Analytical
Tzu-Yu Pan, Hwang-Shang Kou, Shou-Mei Wu, Chun-Chi Wang
Summary: A rapid method for genotyping of red and green pigment genes is developed in this study. Using fluorescence labeling and capillary electrophoresis analysis, this method can accurately detect individuals with color vision deficiencies and shows good agreement with DNA sequencing results.
Article
Multidisciplinary Sciences
Qiuying Huang, Dongmei Chen, Chen Du, Qiaoqiao Liu, Su Lin, Lanlan Liang, Ye Xu, Yiqun Liao, Qingge Li
Summary: The article introduces a method called MeltArray, which allows for the detection of multiple targets in a single real-time PCR reaction. This method utilizes the enzyme activity of Taq DNA polymerase to generate fluorescent hybrids with different melting temperatures, enabling the detection of multiple targets. MeltArray has been validated with clinical samples and demonstrates the advantages of multiplicity, versatility, simplicity, and accessibility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Materials Science, Multidisciplinary
Vinayak Narasimhan, Hyunseo Kim, Seung Heon Lee, Hyukjoon Kang, Radwanul Hasan Siddique, Haeri Park, Yibing M. M. Wang, Hyuck Choo, Youngeun Kim, Shailabh Kumar
Summary: The ongoing pandemic and increasing frequency of infectious disease outbreaks have put great focus on nucleic acid amplification-based diagnostic technologies (NAAT). These methods can provide gold standard accuracy and sensitivity, but their availability is limited to centralized facilities, causing distress in times of need. Academic-industrial collaborations can play a major role in developing autonomous and affordable NAAT devices for widespread access to diagnostics in the future.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biophysics
Fengge Song, Yangdao Wei, Peng Wang, Xiaolin Ge, Chaoyang Li, Aimin Wang, Zhiqing Yang, Yi Wan, Jinghong Li
Summary: The study developed a universal nucleic acid magneto-DNA nanoparticle system using CRISPR-Cas14a, which can detect six different bacteria strains at 1 cfu/mL or 1 aM sensitivity. It offers fast, accurate, cost-effective, and sensitive diagnostic tools for environments with limited resources.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Microbiology
Enos C. Kline, Nuttada Panpradist, Ian T. Hull, Qin Wang, Amy K. Oreskovic, Peter D. Han, Lea M. Starita, Barry R. Lutz
Summary: During the COVID-19 pandemic, the prevalence of variant lineages has the potential to disrupt molecular diagnostics. To address this challenge, a robust Loop Mediated Isothermal Amplification assay with multiplexed multitarget redundancy and an internal amplification control was developed. The assay showed high coverage and sensitivity, making it a valuable tool in point-of-care molecular diagnostics.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Ferhat Guzel, Micol Romano, Erdi Keles, David Piskin, Seza Ozen, Hakan Poyrazoglu, Ozgur Kasapcopur, Erkan Demirkaya
Summary: This study describes the development and validation of an NGS-based multiplex array for targeted sequencing of nine genes associated with common AIDs, offering a cost-effective, comprehensive, and informative screening tool compared to other methods.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Wentao Chen, Hao Luo, Lihong Zeng, Yuying Pan, Jonathan B. Parr, Yinbo Jiang, Clark H. Cunningham, Kelly L. Hawley, Justin D. Radolf, Wujian Ke, Jiangli Ou, Jianjiang Yang, Bin Yang, Heping Zheng
Summary: This study develops a PCR-LwCas13a assay for the diagnosis of syphilis, which achieves better sensitivity and specificity compared to traditional methods. It also demonstrates the potential of CRISPR-based approaches for improving syphilis diagnosis and surveillance.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Melissa D. Morales-Moreno, Erick G. Valdes-Galindo, Mariana M. Reza, Tatiana Fiordelisio, Jorge Peon, Armando Hernandez-Garcia
Summary: Using 2-3 gRNAs in parallel can enhance the sensitivity and speed of SARS-CoV-2 detection, accurately detecting positive and negative samples in a short time.
Article
Chemistry, Analytical
Sumaira Nishat, Ali Turab Jafry, Andres W. Martinez, Fazli Rabbi Awan
Summary: Paper-based microfluidics is a branch of microfluidics that uses paper or other porous membranes to wick fluids, offering advantages like simpler fabrication, lower cost, and ease of disposal. Its most common application is in the development of point-of-care diagnostic devices, potentially replacing costly and time-consuming laboratory procedures.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Biomedical
Hongxing Liu, Chaoming Mei, Xuanru Deng, Weiqiang Lin, Lizhen He, Tianfeng Chen
Summary: The study developed a stable cancer-targeted selenium nanosystem for specifically recognizing and staining tumor cells without the need for antibodies, enabling differentiation of different pathological grades.
Article
Chemistry, Inorganic & Nuclear
Ling-Gui Liu, Yan-Mei Sun, Ze-Yu Liu, Yu-Hui Liao, Lei Zeng, Yong Ye, Hai-Yang Liu
Summary: Halogenated gallium corroles were synthesized and their interaction with calf thymus DNA was investigated, showing an outside binding mode. Among them, compound 3-Ga displayed low cytotoxicity to normal cells but high phototoxicity to liver cancer cells HepG2, inducing tumor cell apoptosis through generation of ROS and disruption of mitochondrial membrane potential upon light illumination.
INORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Zhijin Fan, Hongxing Liu, Yaohua Xue, Jingyan Lin, Yu Fu, Zhaohua Xia, Dongming Pan, Jian Zhang, Kun Qiao, Zhenzhen Zhang, Yuhui Liao
Summary: This study constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy using metal-organic frameworks, achieving GSH-controlled release of immunoadjuvants and activating the immune system to significantly enhance tumor cytotoxicity, leading to high cure rates.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jiani Liu, Jiayao Chen, Hongxing Liu, Ke Zhang, Qi Zeng, Shuai Yang, Zebo Jiang, Xiaoting Zhang, Tianfeng Chen, Dan Li, Hong Shan
Summary: The study developed a novel theranostic agent based on Bi/Se nanoparticles for sensitizing stereotactic body radiotherapy (SBRT) in mice with hepatocellular carcinoma (HCC), showing promising results in reversing the hypoxic and immune suppression status of HCC. This theranostic agent could accurately label the radiotherapy area in CT imaging and reshape tumor blood vessels, reduce tumor hypoxia, and increase tumor-infiltrating T lymphocytes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Chunping Liu, Zhijin Fan, Dongyue He, Huiqi Chen, Shihui Zhang, Sien Guo, Bojun Zheng, Huan Cen, Yunxuan Zhao, Hongxing Liu, Lei Wang
Summary: Acute myocardial infarction is a major health problem worldwide and the repair of damaged myocardium remains a significant challenge. Inflammatory response triggered by myocardial injury leads to severe inflammatory signaling and heart failure. Currently, there is no effective approach to reverse the inflammatory microenvironment in injured myocardium, highlighting the urgent need for new therapeutic strategies.
Article
Chemistry, Multidisciplinary
Zhijin Fan, Yichao Wang, Lanqing Li, Fanchu Zeng, Qiuping Shang, Yuhui Liao, Changhong Liang, Liming Nie
Summary: This study synthesized engineered cellular nanovesicles (ECNVs) with tumor-homing and immune-reprogramming functions for photoacoustic (PA) imaging-guided precision chemo-immunotherapy. The ECNVs effectively targeted tumor tissues and used the photothermal ability to release drugs. The combination of chemotherapy and immune response resulted in enhanced antitumor effects.
Article
Chemistry, Multidisciplinary
Yunxia Wu, Ronghua Yang, Qikang Wu, Mingxing Huang, Bowen Shu, Wenjie Wu, Baoqing Sun, Jinyu Xia, Xiaodong Chen, Yuhui Liao
Summary: Emerging infectious diseases have significant impacts on human society. This study developed a dendritic polymer probe-amplified imaging system for trace analysis of viral emerging infectious diseases. The system showed high sensitivity and specificity in detecting Zika virus and SARS-CoV-2.
Correction
Chemistry, Multidisciplinary
Zhijin Fan, Yichao Wang, Lanqing Li, Fanchu Zeng, Qiuping Shang, Yuhui Liao, Changhong Liang, Liming Nie
Article
Biophysics
Wenzhe Chen, Sicheng Wu, Guanlin Li, Xiaolu Duan, Xinyuan Sun, Shujue Li, Yan Zhao, Di Gu, Guohua Zeng, Hongxing Liu
Summary: Researchers developed an early detection platform for prostate cancer using RT-RAA and CRISPR-Cas9 technologies. They detected PCA3 and KLK3 genes simultaneously on nucleic acid test strips, improving the specificity and accuracy of diagnosis without the need for instruments. This study provides a simple strategy for prostate cancer early detection in resource-limited or other point-of-care testing environments.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biotechnology & Applied Microbiology
Jiwang Deng, Bangxian Yu, Zhenglin Chang, Sicheng Wu, Guanlin Li, Wenzhe Chen, Shujue Li, Xiaolu Duan, Wenqi Wu, Xinyuan Sun, Guohua Zeng, Hongxing Liu
Summary: Oxidative stress damage to renal epithelial cells plays a significant role in the formation of calcium oxalate calculi. In this study, porous nanorods CeO2 nanoparticles (CNPs) were used as an antioxidant reagent to suppress kidney calcium oxalate crystal depositions. The results showed that CNPs could effectively reduce oxidative damage, inhibit calcium oxalate crystallization, and protect renal epithelial cells from stress damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Physical
Guanlin Li, Sicheng Wu, Wenzhe Chen, Xiaolu Duan, Xinyuan Sun, Shujue Li, Zanlin Mai, Wenzheng Wu, Guohua Zeng, Hongxing Liu, Tianfeng Chen
Summary: Bladder cancer (BC) is a common malignant tumor of the genitourinary system with increasing incidence and high recurrence rate. Functional nanomaterials have been applied in high-sensitivity diagnosis and multimodality therapy of BC. This review summarizes the application of nanotechnology in BC diagnosis and therapy, providing guidance for the use of functional nanomaterials in precise diagnosis and treatment of BC.
Article
Biotechnology & Applied Microbiology
Fen Pi, Xuanru Deng, Qian Xue, Lan Zheng, Hongxing Liu, Fang Yang, Tianfeng Chen
Summary: To improve the efficiency of radiotherapy, a core-shell nanocomposite CeO2-MnO2 is designed as a novel radiosensitizer that can modulate the tumor microenvironment (TME) and thus improve the efficacy of radiation therapy. According to experiments, CeO2-MnO2 nanoparticles aggravate the killing effect on tumor cells by generating large amounts of ROS and disrupting the redox balance. The outer layer of MnO2 reacts with GSH and H2O2 in the tumor microenvironment to generate ROS and release oxygen, thus alleviating the hypoxic condition in the tumor area. The nanomaterial CeO2-MnO2 greatly improves the efficiency of cancer radiation therapy by improving the lack of oxygen in tumor and responding to the tumor microenvironment, providing an effective strategy for the construction of nanosystems with radiosensitizing function.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tiantian Wu, Yu Fu, Shuang Guo, Yanqiang Shi, Yuxin Zhang, Zhijin Fan, Bin Yang, Baoquan Ding, Yuhui Liao
Summary: A multifunctional DNA nanoplatform was constructed as a versatile carrier for bacteria-specific delivery of the clinical antibiotic ciprofloxacin (CIP) and classic nanoantibiotic silver nanoparticles (AgNP). The antibiotic delivery system, incorporating CIP and AgNP, exhibited excellent combined bactericidal properties with enhanced antibiotic accumulation and biofilm inhibition. It also promoted the healing of infected wounds in vivo. This DNA-based antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.
Article
Chemistry, Multidisciplinary
Xu Chen, Meijiao Zhao, Qihu Xie, Sitong Zhou, Xiaoping Zhong, Judun Zheng, Ronghua Yang, Xianjin Du, Jinyu Xia, Yuhui Liao
Summary: In this study, a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties, delivered via a click-chemistry hydrogel, was developed. The results showed that the method had beneficial effects on tissue remodeling and bacterial growth reduction, and was significant for deep burn wound repair.
Article
Materials Science, Biomaterials
Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao
Summary: We designed and synthesized a new fluorescent probe, PerqdOH, which can monitor intracellular O-2(center dot-) during T. pallidum infection in real time. In vitro infection experiments showed decreased green fluorescence and enhanced red fluorescence simultaneously. The probe also exhibited a remarkable signal in treponemal lesions in a rabbit model. PerqdOH has great potential for application in clarifying the infectious process caused by T. pallidum in real time.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)