Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

(2019) Sara G. Romeo et al.   NATURE CELL BIOLOGY

PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation

(2018) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss

(2018) Brigitte Raynaud-Messina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse Cre Models for the Study of Bone Diseases

(2018) Sarah L. Dallas et al.   Current Osteoporosis Reports

Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs

(2018) Tamar Y. Feinberg et al.   DEVELOPMENTAL CELL

Erythro-myeloid progenitors contribute endothelial cells to blood vessels

(2018) Alice Plein et al.   NATURE

Bone protection by inhibition of microRNA-182

(2018) Kazuki Inoue et al.   Nature Communications

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

(2017) Matthew T Drake et al.   ENDOCRINE REVIEWS

Cathepsin K Controls Cortical Bone Formation by Degrading Periostin

(2017) Nicolas Bonnet et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences

(2016) Dieter Brömme et al.   Expert Opinion on Drug Discovery

MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis

(2016) Kyunghwan Kim et al.   GENES & DEVELOPMENT

Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation

(2016) Yi Tang et al.   NATURE CELL BIOLOGY

PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation

(2016) Wei Zou et al.   NATURE MEDICINE

Therapeutic implications of suppressing osteoclast formation versus function

(2016) Steven L. Teitelbaum   RHEUMATOLOGY

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

(2016) Hoi Leong Xavier Wong et al.   Nature Communications

Rapidly growing Brtl/+ mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment

(2015) Benjamin P. Sinder et al.   BONE

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

(2015) A. Gutierrez-Fernandez et al.   EMBO JOURNAL

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

(2014) Jose L. Orgaz et al.   Nature Communications

Cathepsin K: a unique collagenolytic cysteine peptidase

(2013) Marko Novinec et al.   BIOLOGICAL CHEMISTRY

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells

(2012) C. Nishida et al.   BLOOD

Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

(2012) Susanta K. Sarkar et al.   CURRENT BIOLOGY

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

(2012) Kui Ming Chan et al.   DEVELOPMENTAL CELL

MT1-MMP regulates the PI3K {middle dot}Mi-2/NuRD-dependent control of macrophage immune function

(2012) R. Shimizu-Hirota et al.   GENES & DEVELOPMENT

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking

(2011) P. Leung et al.   BONE

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development

(2011) Guoxiang Jin et al.   EMBO JOURNAL

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis

(2011) Aline G. Costa et al.   Nature Reviews Rheumatology

MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling

(2010) Pilar Gonzalo et al.   DEVELOPMENTAL CELL

Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone

(2010) Jeffry S Nyman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Inhibition of osteoclast formation and function by bicarbonate: Role of soluble adenylyl cyclase

(2009) Weidong Geng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Circulating matrix metalloproteinase-9 and osteoporosis in patients with chronic obstructive pulmonary disease

(2009) CE Bolton et al.   Chronic Respiratory Disease

Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion

(2008) Haibo Zhao et al.   DEVELOPMENTAL CELL

Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

(2008) Yanqing Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts

(2007) Karen Fuller et al.   BONE